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Grant Details

Grant Number: 5U01CA202979-02 Interpret this number
Primary Investigator: Blot, William
Organization: Vanderbilt University Medical Center
Project Title: Southern Community Cohort Study
Fiscal Year: 2017
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Abstract

 DESCRIPTION (provided by applicant): This application proposes continuation of the Southern Community Cohort Study (SCCS), a landmark investigation tracking the cancer and other disease experience of a cohort of nearly 86,000 adults age 40-79 at cohort entry. By design, two-thirds of the cohort was chosen to be African American, the remainder predominantly non-Hispanic white. The higher proportion of blacks helps remedy the underrepresentation of African Americans in health studies and provides a basis for evaluation of cancer risk factors and outcomes among blacks, while the enrollment of whites enables direct comparisons of black-white differences and assessment of determinants of health disparities. Recruitment took place during 2002-2009 across 12 southern states mainly at Community Health Centers (CHCs), institutions providing basic health and preventative services in underserved areas. Our recruitment strategy resulted in the SCCS comprising a vulnerable segment of the American population at elevated cancer risk seldom if ever included in large numbers in other cohorts. Associating with CHCs also facilitated creation of the unique SCCS Biospecimen Repository, with bloods obtained and stored for approximately 40,000, mouth cells for 39,000, urines for 24,000 and DNA available for nearly 90%. No other cohort has a collection of baseline blood, buccal cell, and urine specimens from African Americans as comprehensive as the SCCS. The SCCS up until now has been funded via an initial and two competing renewal R01 grants. Here, in the first application under the U01 cancer cohort infrastructure mechanism, we seek funding to continue the operational aspects of this highly successful study. The SCCS is poised to produce even greater benefit in the coming years as the cohort matures and larger numbers of cancer events occur. We propose to continue both passive (via linkage with national mortality, Centers for Medicare and Medicaid Services, state cancer registries and other health record databases) and active (via questionnaire survey) follow up of the cohort. In addition, we propose not only to maintain and make available for research the collected biologic samples, but also to enhance our Biospecimen Repository by newly collecting stool specimens from a projected 22,000 participants and tumor blocks from incident cancer cases. The stool samples will enable future study of fecal biomarkers and of gut microbiota (we believe for the first time in any cancer cohort of African Americans), and the tumor tissue specimens future study of somatic mutations in cancer risk and outcome. The Repository has been exceptionally important to date in genetic and molecular studies, since the SCCS provides one of the few resources available for discovery-stage analyses and for independent replication of findings in an African American population. Continuation of the SCCS will enable full utilization of the investment made thus far in this unique national resource and enhance its richness. The follow up of the cohort will accrue additional cancer and other disease outcomes enabling critical hypothesis-driven research (to be funded separately) into the causes of cancer among African Americans and the determinants of disparities among underserved groups.

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Publications

Polypill for Cardiovascular Disease Prevention in an Underserved Population.
Authors: Muñoz D. , Uzoije P. , Reynolds C. , Miller R. , Walkley D. , Pappalardo S. , Tousey P. , Munro H. , Gonzales H. , Song W. , et al. .
Source: The New England journal of medicine, 2019-09-19; 381(12), p. 1114-1123.
PMID: 31532959
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The association of exercise and sedentary behaviours with incident end-stage renal disease: the Southern Community Cohort Study.
Authors: Pike M. , Taylor J. , Kabagambe E. , Stewart T.G. , Robinson-Cohen C. , Morse J. , Akwo E. , Abdel-Kader K. , Siew E.D. , Blot W.J. , et al. .
Source: BMJ open, 2019-08-30; 9(8), p. e030661.
EPub date: 2019-08-30.
PMID: 31471443
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Does religious involvement affect mortality in low-income Americans? A prospective cohort study.
Authors: Wen W. , Schlundt D. , Andersen S.W. , Blot W.J. , Zheng W. .
Source: BMJ open, 2019-07-09; 9(7), p. e028200.
EPub date: 2019-07-09.
PMID: 31289078
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Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).
Authors: Huang J.Y. , Larose T.L. , Luu H.N. , Wang R. , Fanidi A. , Alcala K. , Stevens V.L. , Weinstein S.J. , Albanes D. , Caporaso N.E. , et al. .
Source: International journal of cancer, 2019-07-05; , .
EPub date: 2019-07-05.
PMID: 31276202
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Diabetes, obesity, and subsequent risk of postmenopausal breast cancer among white and black women in the Southern Community Cohort Study.
Authors: Sanderson M. , Lipworth L. , Shrubsole M.J. , Andersen S.W. , Shu X.O. , Zheng W. , Hargreaves M.K. , Blot W.J. .
Source: Cancer causes & control : CCC, 2019 May; 30(5), p. 425-433.
EPub date: 2019-04-02.
PMID: 30941541
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Food intake of folate, folic acid and other B vitamins with lung cancer risk in a low-income population in the Southeastern United States.
Authors: Takata Y. , Shu X.O. , Buchowski M.S. , Munro H.M. , Wen W. , Steinwandel M.D. , Hargreaves M.K. , Blot W.J. , Cai Q. .
Source: European journal of nutrition, 2019-03-05; , .
EPub date: 2019-03-05.
PMID: 30838435
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Association of oral health with lung cancer risk in a low-income population of African Americans and European Americans in the Southeastern United States.
Authors: Yoon H.S. , Wen W. , Long J. , Zheng W. , Blot W.J. , Cai Q. .
Source: Lung cancer (Amsterdam, Netherlands), 2019 01; 127, p. 90-95.
EPub date: 2018-11-23.
PMID: 30642558
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Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations.
Authors: Yang Y. , Cai Q. , Shu X.O. , Steinwandel M.D. , Blot W.J. , Zheng W. , Long J. .
Source: International journal of cancer, 2019-05-15; 144(10), p. 2381-2389.
EPub date: 2018-12-11.
PMID: 30365870
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Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States.
Authors: Butt J. , Varga M.G. , Blot W.J. , Teras L. , Visvanathan K. , Le Marchand L. , Haiman C. , Chen Y. , Bao Y. , Sesso H.D. , et al. .
Source: Gastroenterology, 2019 01; 156(1), p. 175-186.e2.
EPub date: 2018-10-06.
PMID: 30296434
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Baseline Prostate-specific Antigen Level in Midlife and Aggressive Prostate Cancer in Black Men.
Authors: Preston M.A. , Gerke T. , Carlsson S.V. , Signorello L. , Sjoberg D.D. , Markt S.C. , Kibel A.S. , Trinh Q.D. , Steinwandel M. , Blot W. , et al. .
Source: European urology, 2019 03; 75(3), p. 399-407.
EPub date: 2018-09-17.
PMID: 30237027
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Neighbourhood deprivation and lung cancer risk: a nested case-control study in the USA.
Authors: Sanderson M. , Aldrich M.C. , Levine R.S. , Kilbourne B. , Cai Q. , Blot W.J. .
Source: BMJ open, 2018-09-10; 8(9), p. e021059.
EPub date: 2018-09-10.
PMID: 30206077
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CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations.
Authors: McWilliams R.R. , Wieben E.D. , Chaffee K.G. , Antwi S.O. , Raskin L. , Olopade O.I. , Li D. , Highsmith W.E. , Colon-Otero G. , Khanna L.G. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 11; 27(11), p. 1364-1370.
EPub date: 2018-07-23.
PMID: 30038052
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Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium.
Authors: Butt J. , Blot W.J. , Teras L.R. , Visvanathan K. , Le Marchand L. , Haiman C.A. , Chen Y. , Bao Y. , Sesso H.D. , Wassertheil-Smoller S. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 10; 27(10), p. 1186-1194.
EPub date: 2018-07-23.
PMID: 30038049
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Predictors of Colorectal Cancer Screening in Two Underserved U.S. Populations: A Parallel Analysis.
Authors: Bernardo B.M. , Gross A.L. , Young G. , Baltic R. , Reisinger S. , Blot W.J. , Paskett E.D. .
Source: Frontiers in oncology, 2018; 8, p. 230.
EPub date: 2018-06-19.
PMID: 29971216
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Racial Disparities in Lung Cancer Survival: The Contribution of Stage, Treatment, and Ancestry.
Authors: Jones C.C. , Mercaldo S.F. , Blume J.D. , Wenzlaff A.S. , Schwartz A.G. , Chen H. , Deppen S.A. , Bush W.S. , Crawford D.C. , Chanock S.J. , et al. .
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018 10; 13(10), p. 1464-1473.
EPub date: 2018-06-06.
PMID: 29885480
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The obesity epidemic and rising diabetes incidence in a low-income racially diverse southern US cohort.
Authors: Conway B.N. , Han X. , Munro H.M. , Gross A.L. , Shu X.O. , Hargreaves M.K. , Zheng W. , Powers A.C. , Blot W.J. .
Source: PloS one, 2018; 13(1), p. e0190993.
EPub date: 2018-01-11.
PMID: 29324894
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Neighborhood Deprivation Predicts Heart Failure Risk in a Low-Income Population of Blacks and Whites in the Southeastern United States.
Authors: Akwo E.A. , Kabagambe E.K. , Harrell F.E. , Blot W.J. , Bachmann J.M. , Wang T.J. , Gupta D.K. , Lipworth L. .
Source: Circulation. Cardiovascular quality and outcomes, 2018 01; 11(1), p. e004052.
PMID: 29317456
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Impaired functional vitamin B6 status is associated with increased risk of lung cancer.
Authors: Theofylaktopoulou D. , Midttun Ø. , Ueland P.M. , Meyer K. , Fanidi A. , Zheng W. , Shu X.O. , Xiang Y.B. , Prentice R. , Pettinger M. , et al. .
Source: International journal of cancer, 2018-06-15; 142(12), p. 2425-2434.
EPub date: 2018-01-04.
PMID: 29238985
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The impact of sociodemographic factors and PSA screening among low-income Black and White men: data from the Southern Community Cohort Study.
Authors: Moses K.A. , Zhao Z. , Bi Y. , Acquaye J. , Holmes A. , Blot W.J. , Fowke J.H. .
Source: Prostate cancer and prostatic diseases, 2017 12; 20(4), p. 424-429.
EPub date: 2017-07-11.
PMID: 28695916
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Total and Free Circulating Vitamin D and Vitamin D-Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans.
Authors: Andersen S.W. , Shu X.O. , Cai Q. , Khankari N.K. , Steinwandel M.D. , Jurutka P.W. , Blot W.J. , Zheng W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 08; 26(8), p. 1242-1247.
EPub date: 2017-05-08.
PMID: 28483970
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