Grant Details
Grant Number: |
5R01CA172119-05 Interpret this number |
Primary Investigator: |
Ahles, Tim |
Organization: |
Sloan-Kettering Inst Can Research |
Project Title: |
Cognition in Older Breast Cancer Survivors: Treatment Exposure, Apoe, & Smoking |
Fiscal Year: |
2017 |
Abstract
DESCRIPTION (provided by applicant): Cognitive decline is one of the most feared consequences of aging among older adults and even minor changes in cognitive function can seriously impact function, ability to live independently, and quality of life. The trajectory of cognitive change with normal aging is influenced by factors including genetics, cognitive reserve, lifestyle, frailty, and comorbid medical conditions. Although there are compelling data suggesting a relationship between cancer, cancer therapy, and cognitive impairment the vast majority of these studies have focused on younger patients (<65 years old) and few studies have focused on 5+ year survivors. However, the majority of cancer survivors are older adults. Furthermore, those who were treated at an older age may be more vulnerable to cognitive decline because factors that influence normal cognitive aging may interact with cancer treatments to increase vulnerability. The objective of this application is to unite the fields of geriatrics, neuropsychology, oncology, and genetics to study the prevalence and trajectory of cognitive impairment in a cohort of older, long-term (5-15 years) survivors of breast cancer and matched healthy controls. Using a prospective, longitudinal study design, we will pursue the following specific aims while controlling for comorbidity and frailty: Aim 1: Examine the association of APOE status, smoking history, and therapeutic exposures on the cognitive performance among older breast cancer survivors compared to controls (age-, race- and education-matched) Aim 2: Utilize Growth Mixture Modeling techniques to determine trajectories of longitudinal change in cognitive function among older breast cancer survivors and controls (age-, race- and education-matched): Aim 3: Explore associations among cognitive reserve, APOE, smoking history and therapeutic exposures on cognitive functioning at study entry and the pattern of longitudinal change. This study is significant because it will fill a major gap in knowledge regarding the factors that increase risk for cognitive decline in older breast cancer survivors. These data are critical in order to weigh the risks and benefits of cancer treatment in the growing aging population. This study is innovative because it will examine the interactions of therapeutic exposures, genetic polymorphisms, and smoking history in predicting differences in cognitive performance between breast cancer survivors and controls controlling for burden of comorbidity and frailty. Furthermore, the longitudinal design will inform whether the trajectory of
cognitive change for cancer survivors parallels healthy controls (phase shift hypothesis) or demonstrates a steeper slope (accelerated aging hypothesis). These data will serve as a foundation to identify older breast cancer survivors at risk for cognitive impairment and guide the
development of rationale interventions to decrease this risk, with the ultimate goal of preserving the cognitive function and well-being of older survivors of cancer.
Publications
Physical Activity and Cognition: Longitudinal findings from the Thinking and Living with Cancer Study.
Authors: Artese A.L.
, Zhou X.
, Tometich D.B.
, Small B.J.
, Ahles T.A.
, Ahn J.
, Bethea T.N.
, Breen E.C.
, Cohen H.J.
, Extermann M.
, et al.
.
Source: Journal Of The National Cancer Institute, 2024-08-06 00:00:00.0; , .
EPub date: 2024-08-06 00:00:00.0.
PMID: 39107910
Related Citations
Altered gyrification in chemotherapy-treated older long-term breast cancer survivors.
Authors: Daniel E.
, Deng F.
, Patel S.K.
, Sedrak M.S.
, Kim H.
, Razavi M.
, Sun C.L.
, Root J.C.
, Ahles T.A.
, Dale W.
, et al.
.
Source: Brain And Behavior, 2024 Aug; 14(8), p. e3634.
PMID: 39169605
Related Citations
Brain white matter microstructural changes in chemotherapy-treated older long-term breast cancer survivors.
Authors: Daniel E.
, Deng F.
, Patel S.K.
, Sedrak M.S.
, Kim H.
, Razavi M.
, Sun C.L.
, Root J.C.
, Ahles T.A.
, Dale W.
, et al.
.
Source: Cancer Medicine, 2023-12-28 00:00:00.0; , .
EPub date: 2023-12-28 00:00:00.0.
PMID: 38152038
Related Citations
Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study.
Authors: Nakamura Z.M.
, Small B.J.
, Zhai W.
, Ahles T.A.
, Ahn J.
, Artese A.L.
, Bethea T.N.
, Breen E.C.
, Cohen H.J.
, Extermann M.
, et al.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2023-11-04 00:00:00.0; , .
EPub date: 2023-11-04 00:00:00.0.
PMID: 37924476
Related Citations
Cognitive Aging in Older Breast Cancer Survivors.
Authors: Root J.C.
, Li Y.
, Schofield E.
, Orlow I.
, Ryan E.
, Traina T.
, Patel S.K.
, Ahles T.A.
.
Source: Cancers, 2023-06-16 00:00:00.0; 15(12), .
EPub date: 2023-06-16 00:00:00.0.
PMID: 37370818
Related Citations
Epigenetic aging in older breast cancer survivors and non-cancer controls: preliminary findings from the Thinking and Living with Cancer (TLC) Study.
Authors: Rentscher K.E.
, Bethea T.N.
, Zhai W.
, Small B.J.
, Zhou X.
, Ahles T.A.
, Ahn J.
, Breen E.C.
, Cohen H.J.
, Extermann M.
, et al.
.
Source: Cancer, 2023-06-01 00:00:00.0; , .
EPub date: 2023-06-01 00:00:00.0.
PMID: 37259669
Related Citations
Genetic Variants Associated with Longitudinal Cognitive Performance in Older Breast Cancer Patients and Controls.
Authors: Nudelman K.
, Nho K.
, Zhang M.
, McDonald B.C.
, Zhai W.
, Small B.J.
, Wegel C.E.
, Jacobsen P.B.
, Jim H.S.L.
, Patel S.K.
, et al.
.
Source: Cancers, 2023-05-23 00:00:00.0; 15(11), .
EPub date: 2023-05-23 00:00:00.0.
PMID: 37296840
Related Citations
Plasma levels of interleukin-6 mediate neurocognitive performance in older breast cancer survivors: The Thinking and Living With Cancer study.
Authors: Mandelblatt J.S.
, Small B.J.
, Zhou X.
, Nakamura Z.M.
, Cohen H.J.
, Ahles T.A.
, Ahn J.
, Bethea T.N.
, Extermann M.
, Graham D.
, et al.
.
Source: Cancer, 2023-04-25 00:00:00.0; , .
EPub date: 2023-04-25 00:00:00.0.
PMID: 37096888
Related Citations
Altered gyrification in chemotherapy-treated older long-term breast cancer survivors.
Authors: Daniel E.
, Deng F.
, Patel S.K.
, Sedrak M.S.
, Kim H.
, Razavi M.
, Sun C.L.
, Root J.C.
, Ahles T.A.
, Dale W.
, et al.
.
Source: Research Square, 2023-04-10 00:00:00.0; , .
EPub date: 2023-04-10 00:00:00.0.
PMID: 37090667
Related Citations
An Examination of the Longitudinal Relationship Between Cognitive Function and Physical Activity Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study.
Authors: Tometich D.B.
, Mosher C.E.
, Cyders M.
, McDonald B.C.
, Saykin A.J.
, Small B.J.
, Zhai W.
, Zhou X.
, Jim H.S.L.
, Jacobsen P.
, et al.
.
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2023-04-05 00:00:00.0; 57(3), p. 237-248.
PMID: 36356044
Related Citations
Cognitive function is mediated by deficit accumulation in older, long-term breast cancer survivors.
Authors: Ahles T.A.
, Schofield E.
, Li Y.
, Ryan E.
, Orlow I.
, Patel S.K.
, Traina T.
, Root J.C.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2023-03-24 00:00:00.0; , .
EPub date: 2023-03-24 00:00:00.0.
PMID: 36964293
Related Citations
Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.
Authors: Carroll J.E.
, Nakamura Z.M.
, Small B.J.
, Zhou X.
, Cohen H.J.
, Ahles T.A.
, Ahn J.
, Bethea T.N.
, Extermann M.
, Graham D.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2023-01-10 00:00:00.0; 41(2), p. 295-306.
EPub date: 2022-09-30 00:00:00.0.
PMID: 36179271
Related Citations
Cortical thinning in chemotherapy-treated older long-term breast cancer survivors.
Authors: Daniel E.
, Deng F.
, Patel S.K.
, Sedrak M.S.
, Kim H.
, Razavi M.
, Sun C.L.
, Root J.C.
, Ahles T.A.
, Dale W.
, et al.
.
Source: Brain Imaging And Behavior, 2022-11-11 00:00:00.0; , .
EPub date: 2022-11-11 00:00:00.0.
PMID: 36369620
Related Citations
The impact of APOE and smoking history on cognitive function in older, long-term breast cancer survivors.
Authors: Ahles T.A.
, Orlow I.
, Schofield E.
, Li Y.
, Ryan E.
, Root J.C.
, Patel S.K.
, McNeal K.
, Gaynor A.
, Tan H.
, et al.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2022-10-24 00:00:00.0; , .
EPub date: 2022-10-24 00:00:00.0.
PMID: 36279076
Related Citations
Signal Variability and Cognitive Function in Older Long-Term Survivors of Breast Cancer with Exposure to Chemotherapy: A Prospective Longitudinal Resting-State fMRI Study.
Authors: Chen B.T.
, Chen Z.
, Deng F.
, Patel S.K.
, Sedrak M.S.
, Root J.C.
, Ahles T.A.
, Razavi M.
, Kim H.
, Sun C.L.
, et al.
.
Source: Brain Sciences, 2022-09-23 00:00:00.0; 12(10), .
EPub date: 2022-09-23 00:00:00.0.
PMID: 36291217
Related Citations
Associating persistent self-reported cognitive decline with neurocognitive decline in older breast cancer survivors using machine learning: The Thinking and Living with Cancer study.
Authors: Van Dyk K.
, Ahn J.
, Zhou X.
, Zhai W.
, Ahles T.A.
, Bethea T.N.
, Carroll J.E.
, Cohen H.J.
, Dilawari A.A.
, Graham D.
, et al.
.
Source: Journal Of Geriatric Oncology, 2022-08-24 00:00:00.0; , .
EPub date: 2022-08-24 00:00:00.0.
PMID: 36030173
Related Citations
Multimodal MRI examination of structural and functional brain changes in older women with breast cancer in the first year of antiestrogen hormonal therapy.
Authors: McDonald B.C.
, Van Dyk K.
, Deardorff R.L.
, Bailey J.N.
, Zhai W.
, Carroll J.E.
, Root J.C.
, Ahles T.A.
, Mandelblatt J.S.
, Saykin A.J.
.
Source: Breast Cancer Research And Treatment, 2022 Jul; 194(1), p. 113-126.
EPub date: 2022-04-27 00:00:00.0.
PMID: 35476252
Related Citations
Association of markers of tumor aggressivity and cognition in women with breast cancer before adjuvant treatment: The Thinking and Living with Cancer Study.
Authors: Root J.C.
, Zhou X.
, Ahn J.
, Small B.J.
, Zhai W.
, Bethea T.
, Carroll J.E.
, Cohen H.J.
, Dilawari A.
, Extermann M.
, et al.
.
Source: Breast Cancer Research And Treatment, 2022-05-19 00:00:00.0; , .
EPub date: 2022-05-19 00:00:00.0.
PMID: 35587324
Related Citations
Associations between longitudinal changes in sleep disturbance and depressive and anxiety symptoms during the COVID-19 virus pandemic among older women with and without breast cancer in the thinking and living with breast cancer study.
Authors: Bethea T.N.
, Zhai W.
, Zhou X.
, Ahles T.A.
, Ahn J.
, Cohen H.J.
, Dilawari A.A.
, Graham D.M.A.
, Jim H.S.L.
, McDonald B.C.
, et al.
.
Source: Cancer Medicine, 2022-03-22 00:00:00.0; , .
EPub date: 2022-03-22 00:00:00.0.
PMID: 35315588
Related Citations
Relationship between cognitive functioning and frailty in older breast cancer survivors.
Authors: Ahles T.A.
, Schofield E.
, Li Y.
, Ryan E.
, Root J.C.
, Patel S.K.
, McNeal K.
, Gaynor A.
, Tan H.
, Katheria V.
, et al.
.
Source: Journal Of Geriatric Oncology, 2022 01; 13(1), p. 27-32.
EPub date: 2021-08-05 00:00:00.0.
PMID: 34366276
Related Citations
Impact of taxane-based chemotherapy among older women with breast cancer on cognition and quality of life: a longitudinal pooled analysis.
Authors: Small B.J.
, Lange M.
, Zhai W.
, Ahn J.
, Ahles T.A.
, Carroll J.E.
, Cohen H.J.
, Graham D.
, Extermann M.
, Heutte N.
, et al.
.
Source: Breast Cancer Research And Treatment, 2021-11-24 00:00:00.0; , .
EPub date: 2021-11-24 00:00:00.0.
PMID: 34817750
Related Citations
Medical care disruptions during the first six months of the COVID-19 pandemic: the experience of older breast cancer survivors.
Authors: Dilawari A.
, Rentscher K.E.
, Zhai W.
, Zhou X.
, Ahles T.A.
, Ahn J.
, Bethea T.N.
, Carroll J.E.
, Cohen H.J.
, Graham D.A.
, et al.
.
Source: Breast Cancer Research And Treatment, 2021-09-13 00:00:00.0; , .
EPub date: 2021-09-13 00:00:00.0.
PMID: 34515905
Related Citations
Initial encoding deficits with intact memory retention in older long-term breast cancer survivors.
Authors: Gaynor A.M.
, Ahles T.A.
, Ryan E.
, Schofield E.
, Li Y.
, Patel S.K.
, McNeal K.
, Traina T.
, Root J.C.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2021-08-06 00:00:00.0; , .
EPub date: 2021-08-06 00:00:00.0.
PMID: 34357556
Related Citations
Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers: Review and Research Recommendations.
Authors: Mandelblatt J.S.
, Ahles T.A.
, Lippman M.E.
, Isaacs C.
, Adams-Campbell L.
, Saykin A.J.
, Cohen H.J.
, Carroll J.
.
Source: Jama Oncology, 2021-08-05 00:00:00.0; , .
EPub date: 2021-08-05 00:00:00.0.
PMID: 34351358
Related Citations
Sensory Filtering and Sensory Memory in Breast Cancer Survivors.
Authors: Melara R.D.
, Root J.C.
, Bibi R.
, Ahles T.A.
.
Source: Clinical Eeg And Neuroscience, 2021 Jul; 52(4), p. 246-253.
EPub date: 2020-11-10 00:00:00.0.
PMID: 33167713
Related Citations
Sensory Filtering and Sensory Memory in Breast Cancer Survivors.
Authors: Melara R.D.
, Root J.C.
, Bibi R.
, Ahles T.A.
.
Source: Clinical Eeg And Neuroscience, 2021 Jul; 52(4), p. 246-253.
EPub date: 2020-11-10 00:00:00.0.
PMID: 33167713
Related Citations
Loneliness and mental health during the COVID-19 pandemic in older breast cancer survivors and noncancer controls.
Authors: Rentscher K.E.
, Zhao X.
, Small B.J.
, Cohen H.J.
, Dilawari A.A.
, Patel S.K.
, Bethea T.N.
, Van Dyk K.M.
, Nakamura Z.M.
, Ahn J.
, et al.
.
Source: Cancer, 2021-06-23 00:00:00.0; , .
EPub date: 2021-06-23 00:00:00.0.
PMID: 34161601
Related Citations
Medical Care Disruptions During the First Six-Months of the COVID19 Pandemic: The Experience of Older Breast Cancer Survivors.
Authors: Dilawari A.
, Rentscher K.E.
, Zhai W.
, Zhou X.
, Ahles T.A.
, Ahn J.
, Bethea T.N.
, Carroll J.E.
, Cohen H.J.
, Graham D.A.
, et al.
.
Source: Research Square, 2021-04-14 00:00:00.0; , .
EPub date: 2021-04-14 00:00:00.0.
PMID: 33880464
Related Citations
Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.
Authors: Van Dyk K.
, Zhou X.
, Small B.J.
, Ahn J.
, Zhai W.
, Ahles T.
, Graham D.
, Jacobsen P.B.
, Jim H.
, McDonald B.C.
, et al.
.
Source: Jnci Cancer Spectrum, 2021 Apr; 5(2), p. pkab013.
EPub date: 2021-01-27 00:00:00.0.
PMID: 33748669
Related Citations
Strategies to Prevent or Remediate Cancer and Treatment-Related Aging.
Authors: Guida J.L.
, Agurs-Collins T.
, Ahles T.A.
, Campisi J.
, Dale W.
, Demark-Wahnefried W.
, Dietrich J.
, Fuldner R.
, Gallicchio L.
, Green P.A.
, et al.
.
Source: Journal Of The National Cancer Institute, 2021-02-01 00:00:00.0; 113(2), p. 112-122.
PMID: 32348501
Related Citations
Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study.
Authors: Mandelblatt J.S.
, Zhai W.
, Ahn J.
, Small B.J.
, Ahles T.A.
, Carroll J.E.
, Denduluri N.
, Dilawari A.
, Extermann M.
, Graham D.
, et al.
.
Source: Cancer, 2019-12-20 00:00:00.0; , .
EPub date: 2019-12-20 00:00:00.0.
PMID: 31860135
Related Citations
Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype.
Authors: Carroll J.E.
, Small B.J.
, Tometich D.B.
, Zhai W.
, Zhou X.
, Luta G.
, Ahles T.A.
, Saykin A.J.
, Nudelman K.N.H.
, Clapp J.D.
, et al.
.
Source: Cancer, 2019-12-15 00:00:00.0; 125(24), p. 4516-4524.
EPub date: 2019-09-25 00:00:00.0.
PMID: 31553501
Related Citations
Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.
Authors: Guida J.L.
, Ahles T.A.
, Belsky D.
, Campisi J.
, Cohen H.J.
, DeGregori J.
, Fuldner R.
, Ferrucci L.
, Gallicchio L.
, Gavrilov L.
, et al.
.
Source: Journal Of The National Cancer Institute, 2019-07-18 00:00:00.0; , .
EPub date: 2019-07-18 00:00:00.0.
PMID: 31321426
Related Citations
Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study.
Authors: Chen B.T.
, Jin T.
, Patel S.K.
, Ye N.
, Ma H.
, Wong C.W.
, Rockne R.C.
, Root J.C.
, Saykin A.J.
, Ahles T.A.
, et al.
.
Source: Breast Cancer Research And Treatment, 2019 Jul; 176(1), p. 181-189.
EPub date: 2019-04-13 00:00:00.0.
PMID: 30989462
Related Citations
Subcortical brain iron deposition and cognitive performance in older women with breast cancer receiving adjuvant chemotherapy: A pilot MRI study.
Authors: Chen B.T.
, Ghassaban K.
, Jin T.
, Patel S.K.
, Ye N.
, Sun C.L.
, Kim H.
, Rockne R.C.
, Mark Haacke E.
, Root J.C.
, et al.
.
Source: Magnetic Resonance Imaging, 2018 12; 54, p. 218-224.
EPub date: 2018-08-02 00:00:00.0.
PMID: 30076946
Related Citations
Cognitive Effects of Cancer and Cancer Treatments.
Authors: Ahles T.A.
, Root J.C.
.
Source: Annual Review Of Clinical Psychology, 2018-05-07 00:00:00.0; 14, p. 425-451.
EPub date: 2018-01-18 00:00:00.0.
PMID: 29345974
Related Citations
Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study.
Authors: Chen B.T.
, Sethi S.K.
, Jin T.
, Patel S.K.
, Ye N.
, Sun C.L.
, Rockne R.C.
, Haacke E.M.
, Root J.C.
, Saykin A.J.
, et al.
.
Source: Breast Cancer Research : Bcr, 2018-05-02 00:00:00.0; 20(1), p. 38.
EPub date: 2018-05-02 00:00:00.0.
PMID: 29720224
Related Citations
The Impact of Using Different Reference Populations on Measurement of Breast Cancer-Related Cognitive Impairment Rates.
Authors: Clapp J.D.
, Luta G.
, Small B.J.
, Ahles T.A.
, Root J.C.
, Graham D.
, Hurria A.
, Jacobsen P.B.
, Jim H.
, McDonald B.C.
, et al.
.
Source: Archives Of Clinical Neuropsychology : The Official Journal Of The National Academy Of Neuropsychologists, 2018-02-17 00:00:00.0; , .
EPub date: 2018-02-17 00:00:00.0.
PMID: 29471454
Related Citations
New Challenges in Psycho-Oncology Research IV: Cognition and cancer: Conceptual and methodological issues and future directions.
Authors: Ahles T.A.
, Hurria A.
.
Source: Psycho-oncology, 2018 01; 27(1), p. 3-9.
PMID: 29044730
Related Citations
Integrating Frailty Research into the Medical Specialties-Report from a U13 Conference.
Authors: Walston J.
, Robinson T.N.
, Zieman S.
, McFarland F.
, Carpenter C.R.
, Althoff K.N.
, Andrew M.K.
, Blaum C.S.
, Brown P.J.
, Buta B.
, et al.
.
Source: Journal Of The American Geriatrics Society, 2017 Oct; 65(10), p. 2134-2139.
EPub date: 2017-04-19 00:00:00.0.
PMID: 28422280
Related Citations
Aging, the Medical Subspecialties, and Career Development: Where We Were, Where We Are Going.
Authors: Hurria A.
, High K.P.
, Mody L.
, McFarland Horne F.
, Escobedo M.
, Halter J.
, Hazzard W.
, Schmader K.
, Klepin H.
, Lee S.
, et al.
.
Source: Journal Of The American Geriatrics Society, 2017 Apr; 65(4), p. 680-687.
EPub date: 2017-01-16 00:00:00.0.
PMID: 28092400
Related Citations
Learning and memory performance in breast cancer survivors 2 to 6 years post-treatment: the role of encoding versus forgetting.
Authors: Root J.C.
, Andreotti C.
, Tsu L.
, Ellmore T.M.
, Ahles T.A.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2016 06; 10(3), p. 593-9.
EPub date: 2015-12-12 00:00:00.0.
PMID: 26658913
Related Citations
Examining the Association between Patient-Reported Symptoms of Attention and Memory Dysfunction with Objective Cognitive Performance: A Latent Regression Rasch Model Approach.
Authors: Li Y.
, Root J.C.
, Atkinson T.M.
, Ahles T.A.
.
Source: Archives Of Clinical Neuropsychology : The Official Journal Of The National Academy Of Neuropsychologists, 2016 Jun; 31(4), p. 365-77.
PMID: 27193366
Related Citations
Reliable change in neuropsychological assessment of breast cancer survivors.
Authors: Andreotti C.
, Root J.C.
, Schagen S.B.
, McDonald B.C.
, Saykin A.J.
, Atkinson T.M.
, Li Y.
, Ahles T.A.
.
Source: Psycho-oncology, 2016 Jan; 25(1), p. 43-50.
PMID: 25808921
Related Citations
Learning and memory performance in a cohort of clinically referred breast cancer survivors: the role of attention versus forgetting in patient-reported memory complaints.
Authors: Root J.C.
, Ryan E.
, Barnett G.
, Andreotti C.
, Bolutayo K.
, Ahles T.
.
Source: Psycho-oncology, 2015 May; 24(5), p. 548-55.
PMID: 25044928
Related Citations
Cognitive effects of cancer systemic therapy: implications for the care of older patients and survivors.
Authors: Mandelblatt J.S.
, Jacobsen P.B.
, Ahles T.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2014-08-20 00:00:00.0; 32(24), p. 2617-26.
EPub date: 2014-08-20 00:00:00.0.
PMID: 25071135
Related Citations
Cognitive Impairment In Older Patients With Breast Cancer Before Systemic Therapy: Is There An Interaction Between Cancer And Comorbidity?
Authors: Mandelblatt J.S.
, Stern R.A.
, Luta G.
, McGuckin M.
, Clapp J.D.
, Hurria A.
, Jacobsen P.B.
, Faul L.A.
, Isaacs C.
, Denduluri N.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2014-06-20 00:00:00.0; 32(18), p. 1909-18.
PMID: 24841981
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