Grant Number:	5R01DA035160-10 Interpret this number
Primary Investigator:	Maziak, Wasim
Organization:	Florida International University
Project Title:	Advancing Addiction Research and Capacity to Guide Tobacco Control in the Eastern
Fiscal Year:	2017

DESCRIPTION (provided by applicant): Tobacco smoking continues to be the number 1 preventable cause of morbidity and mortality, contributing to millions of deaths every year and wreaking havoc on the welfare of families and communities worldwide. Although smokers are usually aware of smoking risks, they find quitting difficult due to the formidable grip of nicotine dependence (ND). So far, ND research has primarily focused on cigarettes, yet for many youth worldwide, tobacco addiction can be maintained by means other than the cigarette. In particular, over the past decade, water pipe (WP) smoking (a.k.a. hookah, shisha, narwhal) has dramatically become a worldwide phenomenon among youth. WP's worrisome trends have been monitored closely at the Syrian Center for Tobacco Studies (SCTS), where some of the pioneer evidence about its harmful and addictive properties was generated. Despite this, evidence-based solutions to the WP epidemic still lag behind. Obviously, interventions are needed to discourage WP initiation among youth, treat dependent WP smokers, and advance policy and product regulations. Unfortunately, this is hindered in part by the lack of knowledge on how ND develops and manifests in WP smokers. Characterizing ND in WP smokers will help guide the timing and composition of cessation treatments, as well as to counter deceptive product labeling, and drive public health policies to limit WP promotion and youth access. Most studies of ND in WP smokers to date are limited by cross sectional designs, instruments that are geared towards the cigarette, or failure to account for important personal and contextual factors. Thus, an approach that is rooted in common theoretical models of ND, and applies WP- sensitive tools within a longitudinal design has the potential of capturing the full spectrum of ND in young WP smokers. We will adopt this approach to test the following hypotheses: (1) symptoms of ND will appear despite intermittent use patterns in the majority of WP smokers and will predict important clinical outcomes (failed quitting, escalation), (2) the trajectory of ND inWP smokers differs from that of cigarette, and (3) the progression to ND in WP smokers is influenced by personal and contextual factors. For this purpose, we will recruit 250 WP smokers and nonsmokers susceptible to WP, and similar numbers for cigarettes, from 10th graders in Aleppo-Syria (H15 years at baseline) and follow them twice/year for 3 yrs. We plan to test these hypotheses by 1- detecting the first symptoms and diagnosis of ND among WP smokers, 2- comparing common trajectories of ND symptoms among WP smokers, cigarette smokers, and dual smokers, and 3- determining factors that predict ND development in young WP smokers. This project will allow us also to train researchers in Syria and the EMR in tobacco addiction science through a combination of training workshops, seed grants, and extended mentorship. We hope through this project to gain experience about ND in young WP smokers that can guide the development of interventions to reduce WP use and curtail WP-related morbidity and mortality.




Effect of harm perception on ENDS initiation among US adolescents and young adults: Longitudinal findings from the population assessment of tobacco and health (PATH) study, 2013-2018.
Authors: Li W. , Osibogun O. , Gautam P. , Li T. , Cano M.Á. , Maziak W. .
Source: Drug And Alcohol Dependence, 2023-03-01 00:00:00.0; 244, p. 109784.
EPub date: 2023-01-24 00:00:00.0.
PMID: 36706674
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The effect of exposure to tobacco smoking-related media messages on youths' smoking behavior in Jordan: A longitudinal, school-based study.
Authors: Shukr B. , Bartelli D. , Ward K.D. , Ray M. , Maziak W. , Mzayek F. .
Source: Preventive Medicine, 2023 Jan; 166, p. 107386.
EPub date: 2022-12-09 00:00:00.0.
PMID: 36503015
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E-cigarette Transitions Among US Youth and Adults: Results from the Population Assessment of Tobacco and Health Study (2013-2018).
Authors: Osibogun O. , Chapman S. , Peters M. , Bursac Z. , Maziak W. .
Source: Journal Of Prevention (2022), 2022-05-05 00:00:00.0; , .
EPub date: 2022-05-05 00:00:00.0.
PMID: 35513733
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Impact of pictorial health warning labels on smoking beliefs and perceptions among waterpipe smokers: an online randomised cross-over experimental study.
Authors: Jebai R. , Asfar T. , Nakkash R. , Chehab S. , Wu W. , Bursac Z. , Maziak W. .
Source: Tobacco Control, 2022-04-20 00:00:00.0; , .
EPub date: 2022-04-20 00:00:00.0.
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The Effects of Pictorial Health Warning Label on Waterpipe (Low- and High-Frequency) Smokers' Experiences, Toxicant Exposures, and Puffing Behavior.
Authors: Gautam P. , Kalan M.E. , Li W. , Taleb Z.B. , Vargas-Rivera M. , Jebai R. , Osibogun O. , Maziak W. .
Source: International Journal Of Behavioral Medicine, 2022-03-08 00:00:00.0; , .
EPub date: 2022-03-08 00:00:00.0.
PMID: 35260948
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Changes in harm perception of ENDS and their predictors among US adolescents: findings from the population assessment of tobacco and health (PATH) study, 2013-2018.
Authors: Li W. , Osibogun O. , Li T. , Sutherland M.T. , Maziak W. .
Source: Preventive Medicine, 2022 02; 155, p. 106957.
EPub date: 2022-01-21 00:00:00.0.
PMID: 35065977
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Changes in harm perception of ENDS and their predictors among US adolescents: findings from the population assessment of tobacco and health (PATH) study, 2013-2018.
Authors: Li W. , Osibogun O. , Li T. , Sutherland M.T. , Maziak W. .
Source: Preventive Medicine, 2022 02; 155, p. 106957.
EPub date: 2022-01-21 00:00:00.0.
PMID: 35065977
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Markers of oxidative stress and toxicant exposure among young waterpipe smokers in the USA.
Authors: Jebai R. , Ebrahimi Kalan M. , Vargas-Rivera M. , Osibogun O. , Li W. , Gautam P. , Chao M.R. , Hu C.W. , Bursac Z. , Maziak W. .
Source: Environmental Science And Pollution Research International, 2021-01-25 00:00:00.0; , .
EPub date: 2021-01-25 00:00:00.0.
PMID: 33491143
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Natural Course of Nicotine Dependence Among Adolescent Waterpipe and Cigarette Smokers.
Authors: Ebrahimi Kalan M. , Behaleh R. , DiFranza J.R. , Bursac Z. , Ben Taleb Z. , Tleis M. , Asfar T. , Nakkash R. , Ward K.D. , Eissenberg T. , et al. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2020 Dec; 67(6), p. 859-867.
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The Syrian Center for Tobacco Studies-13 (SCTS-13): Psychometric evaluation of a waterpipe-specific nicotine dependence instrument.
Authors: Alam M.M. , Ward K.D. , Bahelah R. , Kalan M.E. , Asfar T. , Eissenberg T. , Maziak W. .
Source: Drug And Alcohol Dependence, 2020-10-01 00:00:00.0; 215, p. 108192.
EPub date: 2020-07-25 00:00:00.0.
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Cessation outcomes in adult dual users of e-cigarettes and cigarettes: the Population Assessment of Tobacco and Health cohort study, USA, 2013-2016.
Authors: Osibogun O. , Bursac Z. , Mckee M. , Li T. , Maziak W. .
Source: International Journal Of Public Health, 2020-07-24 00:00:00.0; , .
EPub date: 2020-07-24 00:00:00.0.
PMID: 32710136
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E-Cigarette Use and Regular Cigarette Smoking Among Youth: Population Assessment of Tobacco and Health Study (2013-2016).
Authors: Osibogun O. , Bursac Z. , Maziak W. .
Source: American Journal Of Preventive Medicine, 2020 May; 58(5), p. 657-665.
EPub date: 2020-03-05 00:00:00.0.
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The impact and relevance of tobacco control research in low-and middle-income countries globally and to the US.
Authors: Berg C.J. , Fong G.T. , Thrasher J.F. , Cohen J.E. , Maziak W. , Lando H. , Drope J. , Mejia R. , Barnoya J. , Nakkash R. , et al. .
Source: Addictive Behaviors, 2018 Dec; 87, p. 162-168.
EPub date: 2018-07-17 00:00:00.0.
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Determinants of progression of nicotine dependence symptoms in adolescent waterpipe smokers.
Authors: Bahelah R. , Ward K.D. , Ben Taleb Z. , DiFranza J.R. , Eissenberg T. , Jaber R. , Maziak W. .
Source: Tobacco Control, 2018-06-12 00:00:00.0; , .
EPub date: 2018-06-12 00:00:00.0.
PMID: 29895703
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Strengthening Policy-Relevant Tobacco Research Capacity in Low- and Middle-Income Countries: Challenges, Opportunities and Lessons Learned.
Authors: Berg C.J. , Thrasher J.F. , Barnoya J. , Cohen J.E. , Maziak W. , Lando H. , Drope J. , Mejia R. , Foley K. , Nakkash R. , et al. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2018-06-05 00:00:00.0; , .
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Correlates of poly-tobacco use among youth and young adults: Findings from the Population Assessment of Tobacco and Health study, 2013-2014.
Authors: Osibogun O. , Taleb Z.B. , Bahelah R. , Salloum R.G. , Maziak W. .
Source: Drug And Alcohol Dependence, 2018-04-10 00:00:00.0; 187, p. 160-164.
EPub date: 2018-04-10 00:00:00.0.
PMID: 29674249
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The Gateway Effect of e-cigarettes; Reflections on main Criticisms.
Authors: Chapman S. , Bareham D. , Maziak W. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2018-04-06 00:00:00.0; , .
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Waterpipe tobacco smoking among sexual minorities in the United States: Evidence from the National Adult Tobacco Survey (2012-2014).
Authors: Ortiz K. , Mamkherzi J. , Salloum R. , Matthews A.K. , Maziak W. .
Source: Addictive Behaviors, 2017 Nov; 74, p. 98-105.
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Waterpipe smoking patterns and symptoms of nicotine dependence: The Waterpipe Dependence in Lebanese Youth Study.
Authors: Bahelah R. , DiFranza J.R. , Ward K.D. , Eissenberg T. , Fouad F.M. , Taleb Z.B. , Jaber R. , Maziak W. .
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Patterns of Waterpipe Tobacco Smoking Among U.S. Young Adults, 2013-2014.
Authors: Salloum R.G. , Thrasher J.F. , Getz K.R. , Barnett T.E. , Asfar T. , Maziak W. .
Source: American Journal Of Preventive Medicine, 2017 Apr; 52(4), p. 507-512.
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Reflections on 15 Years in the Global Tobacco Trenches.
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Perception, intention and attempts to quit smoking among Jordanian adolescents from the Irbid Longitudinal Study.
Authors: Jaber R. , Taleb Z.B. , Bahelah R. , Madhivanan P. , Maziak W. .
Source: The International Journal Of Tuberculosis And Lung Disease : The Official Journal Of The International Union Against Tuberculosis And Lung Disease, 2016 Dec; 20(12), p. 1689-1694.
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Toward A Regulatory Framework For The Waterpipe
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Source: American Journal Of Public Health, 2016 Oct; 106(10), p. 1773-7.
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Correlates Of Nicotine Dependence Among Adolescent Waterpipe Smokers
Authors: Bahelah R. , DiFranza J.R. , Ward K.D. , Fouad F.M. , Eissenberg T. , Ben Taleb Z. , Jaber R. , Osibogun O. , Maziak W. .
Source: Drug And Alcohol Dependence, 2016-09-29 00:00:00.0; 168, p. 230-238.
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Building Evidence-based Tobacco Treatment In The Eastern Mediterranean Region: Lessons Learned By The Syrian Center For Tobacco Studies
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Source: Journal Of Smoking Cessation, 2016 Jun; 11(2), p. 116-123.
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Consensus Statement On Assessment Of Waterpipe Smoking In Epidemiological Studies
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Early Symptoms Of Nicotine Dependence Among Adolescent Waterpipe Smokers
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Predictors of Cigarette Smoking Progression Among a School-Based Sample of Adolescents in Irbid, Jordan: A Longitudinal Study (2008-2011).
Authors: Jaber R. , Mzayek F. , Madhivanan P. , Khader Y. , Maziak W. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2016 Apr; 18(4), p. 403-9.
PMID: 25957340
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Effectiveness Of Health Warnings For Waterpipe Tobacco Smoking Among College Students
Authors: Islam F. , Salloum R.G. , Nakkash R. , Maziak W. , Thrasher J.F. .
Source: International Journal Of Public Health, 2016-03-14 00:00:00.0; , .
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Geographic Proximity Of Waterpipe Smoking Establishments To Colleges In The U.s
Authors: Kates F.R. , Salloum R.G. , Thrasher J.F. , Islam F. , Fleischer N.L. , Maziak W. .
Source: American Journal Of Preventive Medicine, 2016 Jan; 50(1), p. e9-e14.
PMID: 26346294
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Waterpipe Tobacco Smoking And Susceptibility To Cigarette Smoking Among Young Adults In The United States, 2012-2013
Authors: Salloum R.G. , Haider M.R. , Barnett T.E. , Guo Y. , Getz K.R. , Thrasher J.F. , Maziak W. .
Source: Preventing Chronic Disease, 2016; 13, p. E24.
PMID: 26890407
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How Popular Is Waterpipe Tobacco Smoking? Findings From Internet Search Queries
Authors: Salloum R.G. , Osman A. , Maziak W. , Thrasher J.F. .
Source: Tobacco Control, 2015 Sep; 24(5), p. 509-13.
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Predictors of waterpipe smoking progression among youth in Irbid, Jordan: A longitudinal study (2008-2011).
Authors: Jaber R. , Madhivanan P. , Khader Y. , Mzayek F. , Ward K.D. , Maziak W. .
Source: Drug And Alcohol Dependence, 2015-08-01 00:00:00.0; 153, p. 265-70.
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Authors: Haider M.R. , Salloum R.G. , Islam F. , Ortiz K.S. , Kates F.R. , Maziak W. .
Source: Drug And Alcohol Dependence, 2015-08-01 00:00:00.0; 153, p. 359-63.
PMID: 26036602
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Predictors of adherence to pharmacological and behavioral treatment in a cessation trial among smokers in Aleppo, Syria.
Authors: Ben Taleb Z. , Ward K.D. , Asfar T. , Bahelah R. , Maziak W. .
Source: Drug And Alcohol Dependence, 2015-08-01 00:00:00.0; 153, p. 167-72.
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PMID: 26077603
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Interventions for waterpipe smoking cessation.
Authors: Maziak W. , Jawad M. , Jawad S. , Ward K.D. , Eissenberg T. , Asfar T. .
Source: The Cochrane Database Of Systematic Reviews, 2015-07-31 00:00:00.0; (7), p. CD005549.
EPub date: 2015-07-31 00:00:00.0.
PMID: 26228266
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Determinants of cigarette smoking initiation in Jordanian schoolchildren: longitudinal analysis.
Authors: McKelvey K. , Attonito J. , Madhivanan P. , Yi Q. , Mzayek F. , Maziak W. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2015 May; 17(5), p. 552-8.
PMID: 25143297
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Waterpipe a gateway to cigarette smoking initiation among adolescents in Irbid, Jordan: a longitudinal study.
Authors: Jaber R. , Madhivanan P. , Veledar E. , Khader Y. , Mzayek F. , Maziak W. .
Source: The International Journal Of Tuberculosis And Lung Disease : The Official Journal Of The International Union Against Tuberculosis And Lung Disease, 2015 Apr; 19(4), p. 481-7.
PMID: 25860006
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A comparative study of systemic carcinogen exposure in waterpipe smokers, cigarette smokers and non-smokers.
Authors: Al Ali R. , Rastam S. , Ibrahim I. , Bazzi A. , Fayad S. , Shihadeh A.L. , Zaatari G.S. , Maziak W. .
Source: Tobacco Control, 2015 Mar; 24(2), p. 125-7.
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The Global Epidemiology Of Waterpipe Smoking
Authors: Maziak W. , Taleb Z.B. , Bahelah R. , Islam F. , Jaber R. , Auf R. , Salloum R.G. .
Source: Tobacco Control, 2015 Mar; 24 Suppl 1, p. i3-i12.
PMID: 25298368
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Water Pipe Tobacco Smoking In The United States: Findings From The National Adult Tobacco Survey
Authors: Salloum R.G. , Thrasher J.F. , Kates F.R. , Maziak W. .
Source: Preventive Medicine, 2015 Feb; 71, p. 88-93.
PMID: 25535678
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The relationship between waterpipe smoking and body weight: population-based findings from Syria.
Authors: Ward K.D. , Ahn S. , Mzayek F. , Al Ali R. , Rastam S. , Asfar T. , Fouad F. , Maziak W. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2015 Jan; 17(1), p. 34-40.
PMID: 25096252
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Eliciting Preferences For Waterpipe Tobacco Smoking Using A Discrete Choice Experiment: Implications For Product Regulation
Authors: Salloum R.G. , Maziak W. , Hammond D. , Nakkash R. , Islam F. , Cheng X. , Thrasher J.F. .
Source: Bmj Open, 2015; 5(9), p. e009497.
PMID: 26353876
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Harm Reduction At The Crossroads: The Case Of E-cigarettes
Authors: Maziak W. .
Source: American Journal Of Preventive Medicine, 2014 Oct; 47(4), p. 505-7.
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Tobacco in the Arab world: old and new epidemics amidst policy paralysis.
Authors: Maziak W. , Nakkash R. , Bahelah R. , Husseini A. , Fanous N. , Eissenberg T. .
Source: Health Policy And Planning, 2014 Sep; 29(6), p. 784-94.
PMID: 23958628
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Authors: McKelvey K. , Attonito J. , Madhivanan P. , Jaber R. , Yi Q. , Mzayek F. , Maziak W. .
Source: Drug And Alcohol Dependence, 2014-09-01 00:00:00.0; 142, p. 307-13.
EPub date: 2014-09-01 00:00:00.0.
PMID: 25060962
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Behavioral cessation treatment of waterpipe smoking: The first pilot randomized controlled trial.
Authors: Asfar T. , Al Ali R. , Rastam S. , Maziak W. , Ward K.D. .
Source: Addictive Behaviors, 2014 Jun; 39(6), p. 1066-74.
PMID: 24629480
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The waterpipe: a new way of hooking youth on tobacco.
Authors: Maziak W. .
Source: The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions, 2014 Mar-Apr; 23(2), p. 103-7.
PMID: 25187045
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Time trends of cigarette and waterpipe smoking among a cohort of school children in Irbid, Jordan, 2008-11.
Authors: McKelvey K.L. , Wilcox M.L. , Madhivanan P. , Mzayek F. , Khader Y.S. , Maziak W. .
Source: European Journal Of Public Health, 2013 Oct; 23(5), p. 862-7.
PMID: 24078649
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The waterpipe: an emerging global risk for cancer.
Authors: Maziak W. .
Source: Cancer Epidemiology, 2013 Feb; 37(1), p. 1-4.
PMID: 23196170
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