||5R03CA201806-02 Interpret this number
||University Of Washington
||Obstructive Sleep Apnea and Cancer Burden: Impact of Apnea Severity and Treatment
PROJECT SUMMARY / ABSTRACT
Obstructive sleep apnea (OSA) affects approximately 18 to 22 million adults in the United States. As the
prevalence of OSA continues to increase with the growing obesity epidemic, so too has our understanding of
the far-reaching health consequences of OSA, including an increased risk of hypertension, heart disease,
stroke, diabetes, occupational injuries, motor vehicle injuries, and overall mortality. Recently, evidence
suggestive of yet another important disease burden associated with OSA has begun to emerge: increased risk
of incident cancer and cancer mortality. Given that OSA is a highly treatable condition, such evidence suggests
an important opportunity for cancer prevention. Few epidemiologic studies, however, have explored the
possible link between OSA and cancer, and no studies, to date, have assessed the impact of OSA treatment
on cancer rates. The objective of this project is to evaluate the relationship of obstructive sleep apnea with
cancer incidence and survival, placing particular focus on the impact of obstructive sleep apnea severity and
treatment on cancer rates. In Aim 1, we will characterize ways in which the severity of OSA, captured in the
form of five clinical measurements recorded during diagnostic sleep studies, relates to cancer incidence (1a)
and to cancer survival and prognostic tumor characteristics (1b). In Aim 2, we will examine the association of
continuous positive airway pressure (CPAP) treatment use for OSA, and CPAP treatment compliance, with
cancer incidence (2a) and cancer survival (2b). In pursuit of these Aims, this project efficiently leverages an
ongoing linkage between medical records from the University of Washington (UW) Sleep Center and the
Surveillance, Epidemiology, and End Results (SEER) cancer registry serving western Washington State.
Building on this linkage, detailed medical record review will be conducted on a subset of the >15,000 patients
diagnosed with OSA at the UW Sleep Center between 2005-2011, including all such patients diagnosed with
cancer after being diagnosed with OSA (N~920) and a subset of OSA patients not diagnosed with cancer
(N~720). Through this detailed medical record review and by extracting data from electronic medical records,
information will be collected on demographic factors, comorbidities, body mass index, and smoking history, as
well as measures of OSA severity collected at the time of OSA diagnosis, and indicators of CPAP use and
compliance collected at UW Sleep Center follow-up visits. Information on cancer attributes from the SEER
registry, such as tumor site and stage at cancer diagnosis, will facilitate further detailed analyses. This study
will mark one of the largest, and the most comprehensive investigation into the relationship between OSA and
cancer to date. Informed interventions to improve the diagnosis of OSA and encourage proper OSA treatment
could provide an efficient approach to reducing cancer incidence and improving cancer survival. Insights
gained through this novel study could thus motivate important opportunities for primary, secondary, and tertiary
prevention of cancer morbidity and death through OSA screening and treatment.
Addressing the need for validation of a touchscreen psychomotor vigilance task: important considerations for sleep health research.
, Watson N.F.
, Kay M.
, Ocaño D.
, Kientz J.A.
Sleep Health, 2018 Oct; 4(5), p. 387-389.
Sleep apnea and subsequent cancer incidence.
, Watson N.F.
, Schwartz S.M.
, Gozal D.
, Phipps A.I.
Cancer Causes & Control : Ccc, 2018-08-17 00:00:00.0; , .