Skip to main content
Grant Details

Grant Number: 5R01CA173551-05 Interpret this number
Primary Investigator: Abrantes, Ana
Organization: Butler Hospital (Providence, Ri)
Project Title: Aerobic Exercise for Smokers with Depressive Symptomatology
Fiscal Year: 2017


DESCRIPTION (provided by applicant): There exists a well-established relationship between smoking and depressive symptomatology. The problem of relapse continues to plague public health efforts to reduce the prevalence of cigarette smoking among smokers with elevated depressive symptoms. Intervening to increase aerobic exercise among smokers with elevated depressive symptoms represents one potentially efficacious approach for it may directly influence cessation outcomes and have ancillary physical and mental health benefits in this population. In a small pilot trial (K23 DA019950; PI Ana Abrantes, PhD), we demonstrated that the subgroup of smokers with elevated depressive symptoms who participated in the exercise condition (relative to the health education contact control) had higher abstinence rates at end of treatment and up to the 12-month follow-up. In addition, participants in the exercise condition also demonstrated significantly lower negative affect related withdrawal symptoms as well as depressive symptoms in the early weeks of smoking cessation. This preliminary work is the first study to demonstrate that an at-risk group of smokers with elevated depressive symptoms could uniquely benefit from exercise while quitting smoking. We propose to conduct a randomized, controlled trial with 250 smokers with currently elevated depressive symptoms to test the efficacy of a 12-week, moderate-intensity aerobic exercise intervention (AE) vs. a 12- session, health education comparison (HEC) condition. Both conditions will be equated for therapist and participant contact time. Participants in both conditions will receive identical smoking cessation sessions - 8 weeks of telephone counseling with transdermal nicotine patch (TNP). While capitalizing on the synergistic effects of exercise for both reducing depressive symptoms and promoting smoking cessation, the long-term goal of this program of research is to develop an effective, disseminable exercise intervention that can aid smokers with elevated depressive symptoms quit smoking. We expect that the results of this study will establish the AE intervention as efficacious for tobacco cessation in smokers with elevated depressive symptoms and will produce valuable scientific knowledge regarding the psychological and biological mechanisms of action. The public health significance of this program of research lies in the potential for adapting the AE intervention for future dissemination to community fitness venues (e.g., YMCA, local health club/gym), primary care settings and for use in conjunction with state tobacco quitlines, in the hopes of decreasing the overall prevalence of cigarette smoking, thereby reducing smoking-related morbidity and mortality.


Circulating Cell-Free Mitochondrial DNA and Depressive Symptoms Among Low-Active Adults Who Smoke.
Authors: Daniels T.E. , Zitkovsky E.K. , Laumann L.E. , Kunicki Z.J. , Price D.J. , Peterson A.L. , Dennery P.A. , Kao H.T. , Parade S.H. , Price L.H. , et al. .
Source: Psychosomatic medicine, 2024-01-01; 86(1), p. 37-43.
EPub date: 2023-09-29.
PMID: 37769227
Related Citations

An examination of the effects of distress intolerance and rating of perceived exertion on changes in mood and anxiety following aerobic exercise among treatment-seeking smokers.
Authors: Borges A.M. , Uebelacker L.A. , Brown R.A. , Price L.H. , Abrantes A.M. .
Source: Psychology, health & medicine, 2023 Jul-Dec; 28(7), p. 1720-1728.
EPub date: 2022-05-31.
PMID: 35642263
Related Citations

Associations of circulating cell-free DNA, C-reactive protein, and cardiometabolic risk among low-active smokers with elevated depressive symptoms.
Authors: Daniels T.E. , Zitkovsky E.K. , Kunicki Z.J. , Price D.J. , Peterson A.L. , Dennery P.A. , Kao H.T. , Price L.H. , Tyrka A.R. , Abrantes A.M. .
Source: Brain, behavior, & immunity - health, 2022 Nov; 25, p. 100519.
EPub date: 2022-09-19.
PMID: 36164463
Related Citations

Examining the effect of exercise on the relationship between affect and cravings among smokers engaged in cessation treatment.
Authors: Kunicki Z.J. , Hallgren M. , Uebelacker L.A. , Brown R.A. , Price L.H. , Abrantes A.M. .
Source: Addictive behaviors, 2022 Feb; 125, p. 107156.
EPub date: 2021-10-19.
PMID: 34710842
Related Citations

Anxiety sensitivity and daily cigarette smoking in relation to sleep disturbances in treatment-seeking smokers.
Authors: Farris S.G. , Matsko S.V. , Uebelacker L.A. , Brown R.A. , Price L.H. , Abrantes A.M. .
Source: Cognitive behaviour therapy, 2020 Mar; 49(2), p. 137-148.
EPub date: 2019-04-05.
PMID: 30947621
Related Citations

Anxiety Sensitivity is Associated with Lower Enjoyment and an Anxiogenic Response to Physical Activity in Smokers.
Authors: Farris S.G. , Legasse A. , Uebelacker L. , Brown R.A. , Price L.H. , Abrantes A.M. .
Source: Cognitive therapy and research, 2019 Feb; 43(1), p. 78-87.
EPub date: 2018-07-27.
PMID: 31073255
Related Citations

Pain worsening with physical activity during migraine attacks in women with overweight/obesity: A prospective evaluation of frequency, consistency, and correlates.
Authors: Farris S.G. , Thomas J.G. , Abrantes A.M. , Lipton R.B. , Pavlovic J. , Smitherman T.A. , Irby M.B. , Penzien D.B. , Roth J. , O'Leary K.C. , et al. .
Source: Cephalalgia : an international journal of headache, 2018 Oct; 38(11), p. 1707-1715.
EPub date: 2017-12-13.
PMID: 29237284
Related Citations

Effects of Negative Affect, Urge to Smoke, and Working Memory Performance (n-back) on Nicotine Dependence.
Authors: Lechner W.V. , L Gunn R. , Minto A. , Philip N.S. , Brown R.A. , Uebelacker L.A. , Price L.H. , Abrantes A.M. .
Source: Substance use & misuse, 2018-06-07; 53(7), p. 1177-1183.
EPub date: 2017-11-29.
PMID: 29185837
Related Citations

Anxiety sensitivity predicts increased perceived exertion during a 1-mile walk test among treatment-seeking smokers.
Authors: Farris S.G. , Uebelacker L.A. , Brown R.A. , Price L.H. , Desaulniers J. , Abrantes A.M. .
Source: Journal of behavioral medicine, 2017 Dec; 40(6), p. 886-893.
EPub date: 2017-04-27.
PMID: 28451904
Related Citations

The Role of Physical Activity Enjoyment on the Acute Mood Experience of Exercise among Smokers with Elevated Depressive Symptoms.
Authors: Abrantes A.M. , Farris S.G. , Garnaat S.L. , Minto A. , Brown R.A. , Price L.H. , Uebelacker L.A. .
Source: Mental health and physical activity, 2017 Mar; 12, p. 37-43.
EPub date: 2017-02-10.
PMID: 28989344
Related Citations

Back to Top