Grant Details
Grant Number: |
1R01CA214805-01 Interpret this number |
Primary Investigator: |
Beyer, Kirsten |
Organization: |
Medical College Of Wisconsin |
Project Title: |
Racism, Residential Racial Segregation, and Breast Cancer Survival Disparities Among Black, Hispanic and Non-Hispanic White Women |
Fiscal Year: |
2017 |
Abstract
TITLE: Racism, Residential Racial Segregation, and Breast Cancer Survival Disparities among Black, Hispanic
and non-Hispanic White Women
ABSTRACT/SUMMARY
Racial disparities in breast cancer survival are significant, with only 68% of US Black women diagnosed with
breast cancer remaining alive 10 years post-diagnosis, compared to 84% of White women. However, the size
of the racial disparity in breast cancer mortality varies geographically across the US, from no observable state-
level disparity between Black and White women in Minnesota and Massachusetts, to a mortality rate ratio of
over 1.60 in Mississippi, Louisiana, and Wisconsin. Further, although the national survival gap between
Hispanics and non-Hispanic Whites is small, national numbers mask substantial variation among
subpopulations of Hispanics and poorer outcomes among Hispanics in some localities. Such geographical
variation suggests that disparities are not inevitable, and this variation has not been explained. Racism and
racial residential segregation are widely considered to contribute to health disparities, and may partially explain
geographical variation in the size of the disparity. While some studies have shown that segregation is related to
poor survival, others have found that this is not always the case, and some studies highlight the case of ethnic
enclaves, which may be protective. Additionally, we have recently shown that a measure of racial bias in
housing is associated with breast cancer survival among Black women in the Milwaukee area. We propose to
build upon our previous work to undertake a national study of segregation and breast cancer survival with three
aims: (1) Construct new and existing metrics of racism and segregation at the local level for the largest US
metropolitan areas, and determine (a) how measures co-vary, (b) whether segregation measures predict
stressors, social resources and opportunities at the local level, and (c) whether relationships differ by
metropolitan area, (2) Determine whether measures of segregation are related to breast cancer survival
disparities among Black, Hispanic and Non-Hispanic White women, and whether relationships are mediated by
local stressors, social resources, or opportunities, and (3) Explore the ways in which Black and Hispanic breast
cancer survivors in a highly segregated metropolitan area navigate cancer survivorship in the context of
segregation. The interdisciplinary research team is well-positioned to conduct this work, with expertise in
breast cancer, health disparities, geography, biostatistics, epidemiology, large database analysis, mediation
analysis, qualitative research, and community engaged research. Further, we have established partnerships
with numerous local community organizations working directly with breast cancer survivors in the Milwaukee
area through a regional community advisory board, and have drawn upon these relationships to convene an
advisory board specific to this project, engaged to guide and support data collection and interpret and
disseminate research findings. The successful completion of the proposed work will support the development
of future multi-sectoral interventions to reduce disparities by targeting local systems and policies.
Publications
Effects of housing stability and contemporary mortgage lending bias on breast cancer stage at diagnosis among older women in the United States.
Authors: Rademacher N.
, Zhou Y.
, McGinley E.L.
, Laud P.W.
, Yen T.W.F.
, Ponce S.B.
, Nattinger A.B.
, Beyer K.M.M.
.
Source: Cancer Medicine, 2024 Jul; 13(14), p. e7397.
PMID: 39030995
Related Citations
Disparities in Cardiovascular Disease-Related Outcomes Among Cancer Survivors in the United States: A Systematic Review of the Literature.
Authors: Bikomeye J.C.
, Awoyinka I.
, Kwarteng J.L.
, Beyer A.M.
, Rine S.
, Beyer K.M.M.
.
Source: Heart, Lung & Circulation, 2024 May; 33(5), p. 576-604.
EPub date: 2024-01-05 00:00:00.0.
PMID: 38184426
Related Citations
Isolation and survival: The impact of local and MSA isolation on survival among non-Hispanic Black women diagnosed with breast cancer in the United States using a SEER-Medicare cohort.
Authors: Canales B.
, Laud P.W.
, Tarima S.
, Zhou Y.
, Bikomeye J.C.
, McGinley E.L.
, Yen T.W.F.
, Bemanian A.
, Beyer K.M.M.
.
Source: Health & Place, 2023 Sep; 83, p. 103090.
EPub date: 2023-07-31 00:00:00.0.
PMID: 37531804
Related Citations
Historical Redlining and Breast Cancer Treatment and Survival among older Women in the US.
Authors: Bikomeye J.C.
, Zhou Y.
, McGinley E.L.
, Canales B.
, Yen T.W.F.
, Tarima S.
, Ponce S.B.
, Beyer K.M.M.
.
Source: Journal Of The National Cancer Institute, 2023-02-16 00:00:00.0; , .
EPub date: 2023-02-16 00:00:00.0.
PMID: 36794919
Related Citations
Redlining-associated methylation in breast tumors: the impact of contemporary structural racism on the tumor epigenome.
Authors: Miller-Kleinhenz J.M.
, Moubadder L.
, Beyer K.M.
, Zhou Y.
, Gaglioti A.H.
, Collin L.J.
, Gohar J.
, Do W.
, Conneely K.
, Krishnamurti U.
, et al.
.
Source: Frontiers In Oncology, 2023; 13, p. 1154554.
EPub date: 2023-08-09 00:00:00.0.
PMID: 37621676
Related Citations
Association Between Residence in Historically Redlined Districts Indicative of Structural Racism and Racial and Ethnic Disparities in Breast Cancer Outcomes.
Authors: Plascak J.J.
, Beyer K.
, Xu X.
, Stroup A.M.
, Jacob G.
, Llanos A.A.M.
.
Source: Jama Network Open, 2022-07-01 00:00:00.0; 5(7), p. e2220908.
EPub date: 2022-07-01 00:00:00.0.
PMID: 35802373
Related Citations
Greenspace, Inflammation, Cardiovascular Health, and Cancer: A Review and Conceptual Framework for Greenspace in Cardio-Oncology Research.
Authors: Bikomeye J.C.
, Beyer A.M.
, Kwarteng J.L.
, Beyer K.M.M.
.
Source: International Journal Of Environmental Research And Public Health, 2022-02-19 00:00:00.0; 19(4), .
EPub date: 2022-02-19 00:00:00.0.
PMID: 35206610
Related Citations
Home mortgage discrimination and incidence of triple-negative and Luminal A breast cancer among non-Hispanic Black and non-Hispanic White females in California, 2006-2015.
Authors: Michaels E.K.
, Canchola A.J.
, Beyer K.M.M.
, Zhou Y.
, Shariff-Marco S.
, Gomez S.L.
.
Source: Cancer Causes & Control : Ccc, 2022-02-03 00:00:00.0; , .
EPub date: 2022-02-03 00:00:00.0.
PMID: 35113296
Related Citations
Persistence of mortgage lending bias in the United States: 80 years after the Home Owners' Loan Corporation security maps.
Authors: Namin S.
, Zhou Y.
, Xu W.
, McGinley E.
, Jankowski C.
, Laud P.
, Beyer K.
.
Source: Journal Of Race, Ethnicity And The City, 2022; 3(1), p. 70-94.
EPub date: 2022-03-08 00:00:00.0.
PMID: 35992214
Related Citations
The impact of greenspace or nature-based interventions on cardiovascular health or cancer-related outcomes: A systematic review of experimental studies.
Authors: Bikomeye J.C.
, Balza J.S.
, Kwarteng J.L.
, Beyer A.M.
, Beyer K.M.M.
.
Source: Plos One, 2022; 17(11), p. e0276517.
EPub date: 2022-11-23 00:00:00.0.
PMID: 36417344
Related Citations
Mortgage Lending Bias and Breast Cancer Survival Among Older Women in the United States.
Authors: Beyer K.M.M.
, Zhou Y.
, Laud P.W.
, McGinley E.L.
, Yen T.W.F.
, Jankowski C.
, Rademacher N.
, Namin S.
, Kwarteng J.
, Beltrán Ponce S.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2021-09-01 00:00:00.0; 39(25), p. 2749-2757.
EPub date: 2021-06-15 00:00:00.0.
PMID: 34129388
Related Citations
Neighborhood Characteristics and Cancer Survivorship: An Overview of the Current Literature on Neighborhood Landscapes and Cancer Care.
Authors: Namin S.
, Zhou Y.
, Neuner J.
, Beyer K.
.
Source: International Journal Of Environmental Research And Public Health, 2021-07-05 00:00:00.0; 18(13), .
EPub date: 2021-07-05 00:00:00.0.
PMID: 34281129
Related Citations
Neighborhood-Level Redlining and Lending Bias Are Associated with Breast Cancer Mortality in a Large and Diverse Metropolitan Area.
Authors: Collin L.J.
, Gaglioti A.H.
, Beyer K.M.
, Zhou Y.
, Moore M.A.
, Nash R.
, Switchenko J.M.
, Miller-Kleinhenz J.M.
, Ward K.C.
, McCullough L.E.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-10-02 00:00:00.0; , .
EPub date: 2020-10-02 00:00:00.0.
PMID: 33008873
Related Citations
Housing discrimination and racial cancer disparities among the 100 largest US metropolitan areas.
Authors: Beyer K.M.M.
, Laud P.W.
, Zhou Y.
, Nattinger A.B.
.
Source: Cancer, 2019-07-09 00:00:00.0; , .
EPub date: 2019-07-09 00:00:00.0.
PMID: 31287559
Related Citations