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Grant Details

Grant Number: 5U01CA195565-02 Interpret this number
Primary Investigator: Kushi, Lawrence
Organization: Kaiser Foundation Research Institute
Project Title: Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship
Fiscal Year: 2017
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´╗┐ DESCRIPTION (provided by applicant): The Pathways Study is a prospective cohort study of women diagnosed with first primary invasive breast cancers in the Kaiser Permanente Northern California (KPNC) medical care system. Enrolled from January, 2006 through May, 2013, the 4,505 women in the cohort are diverse racially and ethnically, and include 358 (8.0%) African American, 557 (12.4%) Latina, and 578 (12.8%) Asian women. Data have been collected on food intake, physical activity, use of nutritional supplements and complementary and alternative modalities (CAM), and patient-reported factors such as quality of life, social support, and doctor-patient communications. Biospecimens collected from almost all cohort members and banked in the study biorepository at Roswell Park Cancer Institute (RPCI) include blood (n=4,034, or 90% of the cohort), saliva (n=4,310, or 96%), and extracted germline DNA (n=4,437, or 99%). Baseline addresses have been geocoded and linked to contextual databases to create neighborhood-level social and built environment variables. The KPNC setting provides access to electronic medical records (EMRs), with data available on diagnostic characteristics, treatment such as specific chemotherapy agents and doses, hormone therapy, high-grade toxicities, and comorbid conditions. As of December 31, 2014, 369 recurrences, 213 second primary invasive cancers, and 469 deaths have been identified in this cohort, with 751 women with at least one of these outcomes. In this infrastructure grant, we propose to maintain and augment the Pathways Study to support a growing research program that builds upon this resource. Study participants will continue to be followed for occurrence of outcomes through KP medical records and annual follow-up questionnaires. Follow-up for updated quality-of-life and other patient-reported measures such as changes in lifestyle factors will continue through 96 months post-enrollment for those who have not yet passed that milestone. We will augment biospecimen resources with a follow-up blood sample for examination of long-term molecular factors, establishing a tumor specimen bank from all cohort members, and by immunohistochemistry assays to subtype tumors. We will enhance data resources with ongoing linkage with databases from KP electronic medical records; by incorporating genotypic data to be obtained from the Center for Inherited Disease Research (separate grant received an Impact Score of 23); and by updating contextual data for the cohort. We will establish an external advisory board and a community and participant advisory board to help guide infrastructure activities and prioritize research use of this cohort. We will also establish a consortium of breas cancer prognosis epidemiology cohort studies to enhance the ability to examine associations in subgroups of breast cancers. Ongoing support will enhance the unique and outstanding resource that is the Pathways Study, and facilitate its availability for the broader research community.

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Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study.
Authors: Larsen V. , Barlow W.E. , Yang J.J. , Zhu Q. , Liu S. , Kwan M.L. , Ergas I.J. , Roh J.M. , Hutchins L.F. , Kadlubar S.A. , et al. .
Source: Clinical breast cancer, 2019 Aug; 19(4), p. 225-235.e2.
EPub date: 2019-03-06.
PMID: 30928413
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Early-onset triple-negative breast cancer in multiracial/ethnic populations: Distinct trends of prevalence of truncation mutations.
Authors: Liu Q. , Yao S. , Zhao H. , Hu Q. , Kwan M.L. , Roh J.M. , Ambrosone C.B. , Kushi L.H. , Liu S. , Zhu Q. .
Source: Cancer medicine, 2019 Apr; 8(4), p. 1845-1853.
EPub date: 2019-03-12.
PMID: 30864286
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Opportunities to Improve Detection and Treatment of Depression Among Patients With Breast Cancer Treated in an Integrated Delivery System.
Authors: Check D.K. , Kwan M.L. , Chawla N. , Dusetzina S.B. , Valice E. , Ergas I.J. , Roh J.M. , Kolevska T. , Rosenstein D.L. , Kushi L.H. .
Source: Journal of pain and symptom management, 2019 Mar; 57(3), p. 587-595.
EPub date: 2018-12-01.
PMID: 30508637
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Medical Care Costs for Recurrent versus De Novo Stage IV Cancer by Age at Diagnosis.
Authors: Ritzwoller D.P. , Fishman P.A. , Banegas M.P. , Carroll N.M. , O'Keeffe-Rosetti M. , Cronin A.M. , Uno H. , Hornbrook M.C. , Hassett M.J. .
Source: Health services research, 2018 12; 53(6), p. 5106-5128.
EPub date: 2018-07-24.
PMID: 30043542
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Personal and clinical social support and adherence to adjuvant endocrine therapy among hormone receptor-positive breast cancer patients in an integrated health care system.
Authors: Kroenke C.H. , Hershman D.L. , Gomez S.L. , Adams S.R. , Eldridge E.H. , Kwan M.L. , Ergas I.J. , Kubo A. , Kushi L.H. .
Source: Breast cancer research and treatment, 2018 Aug; 170(3), p. 623-631.
EPub date: 2018-04-18.
PMID: 29671113
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Understanding racial/ethnic differences in breast cancer-related physical well-being: the role of patient-provider interactions.
Authors: Check D.K. , Chawla N. , Kwan M.L. , Pinheiro L. , Roh J.M. , Ergas I.J. , Stewart A.L. , Kolevska T. , Ambrosone C. , Kushi L.H. .
Source: Breast cancer research and treatment, 2018 Aug; 170(3), p. 593-603.
EPub date: 2018-04-05.
PMID: 29623576
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Changes in bone mineral density in women with breast cancer receiving aromatase inhibitor therapy.
Authors: Kwan M.L. , Yao S. , Laurent C.A. , Roh J.M. , Quesenberry C.P. , Kushi L.H. , Lo J.C. .
Source: Breast cancer research and treatment, 2018 Apr; 168(2), p. 523-530.
EPub date: 2017-12-16.
PMID: 29249058
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Development, Validation, and Dissemination of a Breast Cancer Recurrence Detection and Timing Informatics Algorithm.
Authors: Ritzwoller D.P. , Hassett M.J. , Uno H. , Cronin A.M. , Carroll N.M. , Hornbrook M.C. , Kushi L.C. .
Source: Journal of the National Cancer Institute, 2018-03-01; 110(3), p. 273-281.
PMID: 29873757
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Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15.
Authors: Madsen M.J. , Knight S. , Sweeney C. , Factor R. , Salama M. , Stijleman I.J. , Rajamanickam V. , Welm B.E. , Arunachalam S. , Jones B. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 06; 27(6), p. 644-652.
EPub date: 2018-04-12.
PMID: 29650789
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Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study.
Authors: Engmann N.J. , Ergas I.J. , Yao S. , Kwan M.L. , Roh J.M. , Ambrosone C.B. , Kushi L.H. , Fejerman L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 09; 26(9), p. 1466-1469.
PMID: 28864455
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Body mass index, PAM50 subtype, recurrence, and survival among patients with nonmetastatic breast cancer.
Authors: Cespedes Feliciano E.M. , Kwan M.L. , Kushi L.H. , Chen W.Y. , Weltzien E.K. , Castillo A.L. , Sweeney C. , Bernard P.S. , Caan B.J. .
Source: Cancer, 2017-07-01; 123(13), p. 2535-2542.
EPub date: 2017-03-13.
PMID: 28295245
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Patterns and reasons for switching classes of hormonal therapy among women with early-stage breast cancer.
Authors: Kwan M.L. , Roh J.M. , Laurent C.A. , Lee J. , Tang L. , Hershman D. , Kushi L.H. , Yao S. .
Source: Cancer causes & control : CCC, 2017 Jun; 28(6), p. 557-562.
EPub date: 2017-03-27.
PMID: 28349440
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Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors.
Authors: Cespedes Feliciano E.M. , Kwan M.L. , Kushi L.H. , Weltzien E.K. , Castillo A.L. , Caan B.J. .
Source: Breast cancer research and treatment, 2017 04; 162(3), p. 549-557.
EPub date: 2017-02-07.
PMID: 28176174
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Impact of Social and Built Environment Factors on Body Size among Breast Cancer Survivors: The Pathways Study.
Authors: Shariff-Marco S. , Von Behren J. , Reynolds P. , Keegan T.H. , Hertz A. , Kwan M.L. , Roh J.M. , Thomsen C. , Kroenke C.H. , Ambrosone C. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 04; 26(4), p. 505-515.
EPub date: 2017-02-02.
PMID: 28154107
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Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis.
Authors: Yao S. , Zhang Y. , Tang L. , Roh J.M. , Laurent C.A. , Hong C.C. , Hahn T. , Lo J.C. , Ambrosone C.B. , Kushi L.H. , et al. .
Source: Breast cancer research and treatment, 2017 02; 161(3), p. 501-513.
EPub date: 2016-12-03.
PMID: 27915435
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Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival: A Case-Cohort Analysis in the Pathways Study.
Authors: Yao S. , Kwan M.L. , Ergas I.J. , Roh J.M. , Cheng T.D. , Hong C.C. , McCann S.E. , Tang L. , Davis W. , Liu S. , et al. .
Source: JAMA oncology, 2017-03-01; 3(3), p. 351-357.
PMID: 27832250
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BMI, Lifestyle Factors and Taxane-Induced Neuropathy in Breast Cancer Patients: The Pathways Study.
Authors: Greenlee H. , Hershman D.L. , Shi Z. , Kwan M.L. , Ergas I.J. , Roh J.M. , Kushi L.H. .
Source: Journal of the National Cancer Institute, 2017 02; 109(2), .
EPub date: 2016-10-28.
PMID: 27794123
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Exercise and Prognosis on the Basis of Clinicopathologic and Molecular Features in Early-Stage Breast Cancer: The LACE and Pathways Studies.
Authors: Jones L.W. , Kwan M.L. , Weltzien E. , Chandarlapaty S. , Sternfeld B. , Sweeney C. , Bernard P.S. , Castillo A. , Habel L.A. , Kroenke C.H. , et al. .
Source: Cancer research, 2016-09-15; 76(18), p. 5415-22.
EPub date: 2016-08-03.
PMID: 27488523
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Race/ethnicity, genetic ancestry, and breast cancer-related lymphedema in the Pathways Study.
Authors: Kwan M.L. , Yao S. , Lee V.S. , Roh J.M. , Zhu Q. , Ergas I.J. , Liu Q. , Zhang Y. , Kutner S.E. , Quesenberry C.P. , et al. .
Source: Breast cancer research and treatment, 2016 08; 159(1), p. 119-29.
EPub date: 2016-07-22.
PMID: 27449493
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A prospective cohort study of early discontinuation of adjuvant chemotherapy in women with breast cancer: the breast cancer quality of care study (BQUAL).
Authors: Neugut A.I. , Hillyer G.C. , Kushi L.H. , Lamerato L. , Buono D.L. , Nathanson S.D. , Bovbjerg D.H. , Mandelblatt J.S. , Tsai W.Y. , Jacobson J.S. , et al. .
Source: Breast cancer research and treatment, 2016 07; 158(1), p. 127-138.
EPub date: 2016-06-10.
PMID: 27287779
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Association Between Complementary and Alternative Medicine Use and Breast Cancer Chemotherapy Initiation: The Breast Cancer Quality of Care (BQUAL) Study.
Authors: Greenlee H. , Neugut A.I. , Falci L. , Hillyer G.C. , Buono D. , Mandelblatt J.S. , Roh J.M. , Ergas I.J. , Kwan M.L. , Lee M. , et al. .
Source: JAMA oncology, 2016-09-01; 2(9), p. 1170-6.
PMID: 27243607
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Exercise and Risk of Cardiovascular Events in Women With Nonmetastatic Breast Cancer.
Authors: Jones L.W. , Habel L.A. , Weltzien E. , Castillo A. , Gupta D. , Kroenke C.H. , Kwan M.L. , Quesenberry C.P. , Scott J. , Sternfeld B. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-08-10; 34(23), p. 2743-9.
EPub date: 2016-05-23.
PMID: 27217451
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