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Grant Details

Grant Number: 5U01CA164975-06 Interpret this number
Primary Investigator: Platz, Elizabeth
Organization: Johns Hopkins University
Project Title: Enhancing Aric Infrastructure to Yield a New Cancer Epidemiology Cohort
Fiscal Year: 2017
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Abstract

DESCRIPTION (provided by applicant): We propose to enhance the infrastructure of ARIC; the Atherosclerosis Risk in Communities, cohort to yield a new Cancer Epidemiology Cohort that brings novel features to cancer epidemiology research. In 1987, 15,792 participants aged 45-64 years were recruited from Forsyth Co., NC; Jackson, MS; Minneapolis, MN; and Washington Co., MD. 55% are women and 27% are African-American. Participants underwent 4 clinical exams; a 5th is scheduled for 2011. Blood and urine specimens have been banked, medications recorded, and a food frequency questionnaire completed. Participants were interviewed by phone annually and now semi-annually to obtain updated health information. The response at year 21 is 91%. Because ARIC has never been viewed as a Cancer Epidemiology Cohort and infrastructure and cost constraints, only cancer diagnosis has been systematically recorded. By 2006, 3,145 participants were diagnosed with an incident first primary and 376 with a 2nd / 3rd primary. Information, such as stage, grade, and histology, location in organ, laterality, receptor status, treatment, recurrence, and re-treatment, needed to address contemporary questions is not currently available. Tissue needed for molecular/genetic studies has not been collected. Thus, we propose: 1) Starting 2012, to prospectively identify cases from semi-annual phone interviews and collect medical/pathology records pertaining to cancer diagnosis, treatment, recurrence, and retreatment and tissue blocks. 2) To retrospectively collect information characterizing cancer diagnoses and recurrences before 2012 from cancer registries in the 4 ARIC states (consent already obtained) and medical records, and collect tissue blocks. By 2016, we expect 4,900 fully annotated incident cases. We established a Cancer Working Group to develop protocols for adjudicating cancer endpoints and prioritize research using the resource. With enhanced infrastructure, we expect that research questions such as these are addressable uniquely in ARIC: 1) What is the association between timing of the natural history of diabetes using 4 fasting glucose and 2 HbAlc measurements and timing of cancer diagnosis? 2) Using GWAS and sequencing data, is there a set of risk variants shared by major cancers or are variants specific to each site?

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Publications

Longer-term Lipid-lowering Drug Use and Risk of Incident and Fatal Prostate Cancer in Black and White Men in the ARIC Study.
Authors: Mondul A.M. , Joshu C.E. , Barber J.R. , Prizment A.E. , Bhavsar N.A. , Selvin E. , Folsom A.R. , Platz E.A. .
Source: Cancer prevention research (Philadelphia, Pa.), 2018 Dec; 11(12), p. 779-788.
EPub date: 2018-10-16.
PMID: 30327368
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Aspirin and Non-Aspirin NSAID Use and Prostate Cancer Incidence, Mortality, and Case-Fatality in the Atherosclerosis Risk in Communities Study.
Authors: Hurwitz L.M. , Joshu C.E. , Barber J.R. , Prizment A.E. , Vitolins M.Z. , Jones M.R. , Folsom A.R. , Han M. , Platz E.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018-11-28 00:00:00.0; , .
EPub date: 2018-11-28 00:00:00.0.
PMID: 30487131
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The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes.
Authors: Lee A.K. , Warren B. , Lee C.J. , McEvoy J.W. , Matsushita K. , Huang E.S. , Sharrett A.R. , Coresh J. , Selvin E. .
Source: Diabetes Care, 2018 Jan; 41(1), p. 104-111.
EPub date: 2017-11-10 00:00:00.0.
PMID: 29127240
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Enhancing the Infrastructure of the Atherosclerosis Risk in Communities (ARIC) Study for Cancer Epidemiology Research: ARIC Cancer.
Authors: Joshu C.E. , Barber J.R. , Coresh J. , Couper D.J. , Mosley T.H. , Vitolins M.Z. , Butler K.R. , Nelson H.H. , Prizment A.E. , Selvin E. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-12-20 00:00:00.0; , .
EPub date: 2017-12-20 00:00:00.0.
PMID: 29263187
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Physical Activity And Lifetime Risk Of Cardiovascular Disease And Cancer
Authors: Kubota Y. , Evenson K.R. , MacLehose R.F. , Roetker N.S. , Joshu C.E. , Folsom A.R. .
Source: Medicine And Science In Sports And Exercise, 2017-03-27 00:00:00.0; , .
PMID: 28350711
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The George W. Comstock Center for Public Health Research and Prevention: A Century of Collaboration, Innovation, and Translation.
Authors: Coresh J. , Platz E.A. .
Source: American Journal Of Epidemiology, 2016-03-01 00:00:00.0; 183(5), p. 362-6.
EPub date: 2016-03-01 00:00:00.0.
PMID: 26872712
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Body mass index at early adulthood, subsequent weight change and cancer incidence and mortality.
Authors: Han X. , Stevens J. , Truesdale K.P. , Bradshaw P.T. , Kucharska-Newton A. , Prizment A.E. , Platz E.A. , Joshu C.E. .
Source: International Journal Of Cancer, 2014-12-15 00:00:00.0; 135(12), p. 2900-9.
EPub date: 2014-12-15 00:00:00.0.
PMID: 24771654
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Functional status declines among cancer survivors: trajectory and contributing factors.
Authors: Petrick J.L. , Reeve B.B. , Kucharska-Newton A.M. , Foraker R.E. , Platz E.A. , Stearns S.C. , Han X. , Windham B.G. , Irwin D.E. .
Source: Journal Of Geriatric Oncology, 2014-10-01 00:00:00.0; 5(4), p. 359-67.
EPub date: 2014-10-01 00:00:00.0.
PMID: 24981125
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Trajectory of overall health from self-report and factors contributing to health declines among cancer survivors.
Authors: Petrick J.L. , Foraker R.E. , Kucharska-Newton A.M. , Reeve B.B. , Platz E.A. , Stearns S.C. , Han X. , Windham B.G. , Irwin D.E. .
Source: Cancer Causes & Control : Ccc, 2014 Sep; 25(9), p. 1179-86.
PMID: 24986768
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Smoking behavior and lung cancer in a biracial cohort: the Atherosclerosis Risk in Communities study.
Authors: Prizment A.E. , Yatsuya H. , Lutsey P.L. , Lubin J.H. , Woodward M. , Folsom A.R. , Huxley R.R. .
Source: American Journal Of Preventive Medicine, 2014 Jun; 46(6), p. 624-32.
PMID: 24842739
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Reflections on success in multidisciplinary, translational science: working together to answer the right questions.
Authors: Platz E.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Apr; 23(4), p. 573-4.
PMID: 24448509
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Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study.
Authors: Prizment A.E. , Folsom A.R. , Dreyfus J. , Anderson K.E. , Visvanathan K. , Joshu C.E. , Platz E.A. , Pankow J.S. .
Source: Cancer Causes & Control : Ccc, 2013 Dec; 24(12), p. 2077-87.
PMID: 24036889
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Circulating Beta-2 Microglobulin and Risk of Cancer: The Atherosclerosis Risk in Communities Study (ARIC).
Authors: Prizment A.E. , Linabery A.M. , Lutsey P.L. , Selvin E. , Nelson H.H. , Folsom A.R. , Church T.R. , Drake C.G. , Platz E.A. , Joshu C. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016 04; 25(4), p. 657-64.
PMID: 26908438
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