Skip to main content
Grant Details

Grant Number: 5U01CA164975-06 Interpret this number
Primary Investigator: Platz, Elizabeth
Organization: Johns Hopkins University
Project Title: Enhancing Aric Infrastructure to Yield a New Cancer Epidemiology Cohort
Fiscal Year: 2017
Back to top


Abstract

DESCRIPTION (provided by applicant): We propose to enhance the infrastructure of ARIC; the Atherosclerosis Risk in Communities, cohort to yield a new Cancer Epidemiology Cohort that brings novel features to cancer epidemiology research. In 1987, 15,792 participants aged 45-64 years were recruited from Forsyth Co., NC; Jackson, MS; Minneapolis, MN; and Washington Co., MD. 55% are women and 27% are African-American. Participants underwent 4 clinical exams; a 5th is scheduled for 2011. Blood and urine specimens have been banked, medications recorded, and a food frequency questionnaire completed. Participants were interviewed by phone annually and now semi-annually to obtain updated health information. The response at year 21 is 91%. Because ARIC has never been viewed as a Cancer Epidemiology Cohort and infrastructure and cost constraints, only cancer diagnosis has been systematically recorded. By 2006, 3,145 participants were diagnosed with an incident first primary and 376 with a 2nd / 3rd primary. Information, such as stage, grade, and histology, location in organ, laterality, receptor status, treatment, recurrence, and re-treatment, needed to address contemporary questions is not currently available. Tissue needed for molecular/genetic studies has not been collected. Thus, we propose: 1) Starting 2012, to prospectively identify cases from semi-annual phone interviews and collect medical/pathology records pertaining to cancer diagnosis, treatment, recurrence, and retreatment and tissue blocks. 2) To retrospectively collect information characterizing cancer diagnoses and recurrences before 2012 from cancer registries in the 4 ARIC states (consent already obtained) and medical records, and collect tissue blocks. By 2016, we expect 4,900 fully annotated incident cases. We established a Cancer Working Group to develop protocols for adjudicating cancer endpoints and prioritize research using the resource. With enhanced infrastructure, we expect that research questions such as these are addressable uniquely in ARIC: 1) What is the association between timing of the natural history of diabetes using 4 fasting glucose and 2 HbAlc measurements and timing of cancer diagnosis? 2) Using GWAS and sequencing data, is there a set of risk variants shared by major cancers or are variants specific to each site?

Back to top


Publications

Prospective Association of Serum and Dietary Magnesium with Colorectal Cancer Incidence.
Authors: Polter E.J. , Onyeaghala G. , Lutsey P.L. , Folsom A.R. , Joshu C.E. , Platz E.A. , Prizment A.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 Aug; 28(8), p. 1292-1299.
EPub date: 2019-06-05.
PMID: 31167754
Related Citations

Association between greater leg length and increased incidence of colorectal cancer: the atherosclerosis risk in communities (ARIC) study.
Authors: Onyeaghala G. , Lutsey P.L. , Demerath E.W. , Folsom A.R. , Joshu C.E. , Platz E.A. , Prizment A.E. .
Source: Cancer causes & control : CCC, 2019 Aug; 30(8), p. 791-797.
EPub date: 2019-06-04.
PMID: 31165420
Related Citations

Serum Urate, Genetic Variation, and Prostate Cancer Risk: Atherosclerosis Risk in Communities (ARIC) Study.
Authors: Wang A. , Barber J.R. , Tin A. , De Marzo A.M. , Kottgen A. , Joshu C.E. , Platz E.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 Jul; 28(7), p. 1259-1261.
PMID: 31263056
Related Citations

Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study.
Authors: Han P. , Bidulescu A. , Barber J.R. , Zeisel S.H. , Joshu C.E. , Prizment A.E. , Vitolins M.Z. , Platz E.A. .
Source: Cancer causes & control : CCC, 2019 Apr; 30(4), p. 343-354.
EPub date: 2019-03-01.
PMID: 30825046
Related Citations

Cancer Survivorship and Subclinical Myocardial Damage: The Atherosclerosis Risk in Communities (ARIC) Study.
Authors: Florido R. , Lee A.K. , McEvoy J.W. , Hoogeveen R.C. , Koton S. , Vitolins M.Z. , Shenoy C. , Russell S.D. , Blumenthal R.S. , Ndumele C.E. , et al. .
Source: American journal of epidemiology, 2019-03-30; , .
EPub date: 2019-03-30.
PMID: 30927355
Related Citations

Aspirin and Non-Aspirin NSAID Use and Prostate Cancer Incidence, Mortality, and Case Fatality in the Atherosclerosis Risk in Communities Study.
Authors: Hurwitz L.M. , Joshu C.E. , Barber J.R. , Prizment A.E. , Vitolins M.Z. , Jones M.R. , Folsom A.R. , Han M. , Platz E.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 Mar; 28(3), p. 563-569.
EPub date: 2018-11-28.
PMID: 30487131
Related Citations

Hyperglycemia, Classified with Multiple Biomarkers Simultaneously in Men without Diabetes, and Risk of Fatal Prostate Cancer.
Authors: Marrone M.T. , Selvin E. , Barber J.R. , Platz E.A. , Joshu C.E. .
Source: Cancer prevention research (Philadelphia, Pa.), 2019 Feb; 12(2), p. 103-112.
EPub date: 2018-12-11.
PMID: 30538098
Related Citations

Longer-term Lipid-lowering Drug Use and Risk of Incident and Fatal Prostate Cancer in Black and White Men in the ARIC Study.
Authors: Mondul A.M. , Joshu C.E. , Barber J.R. , Prizment A.E. , Bhavsar N.A. , Selvin E. , Folsom A.R. , Platz E.A. .
Source: Cancer prevention research (Philadelphia, Pa.), 2018 12; 11(12), p. 779-788.
EPub date: 2018-10-16.
PMID: 30327368
Related Citations

Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study.
Authors: Michaud D.S. , Lu J. , Peacock-Villada A.Y. , Barber J.R. , Joshu C.E. , Prizment A.E. , Beck J.D. , Offenbacher S. , Platz E.A. .
Source: Journal of the National Cancer Institute, 2018-08-01; 110(8), p. 843-854.
PMID: 29342298
Related Citations

Enhancing the Infrastructure of the Atherosclerosis Risk in Communities (ARIC) Study for Cancer Epidemiology Research: ARIC Cancer.
Authors: Joshu C.E. , Barber J.R. , Coresh J. , Couper D.J. , Mosley T.H. , Vitolins M.Z. , Butler K.R. , Nelson H.H. , Prizment A.E. , Selvin E. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 03; 27(3), p. 295-305.
EPub date: 2017-12-20.
PMID: 29263187
Related Citations

The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes.
Authors: Lee A.K. , Warren B. , Lee C.J. , McEvoy J.W. , Matsushita K. , Huang E.S. , Sharrett A.R. , Coresh J. , Selvin E. .
Source: Diabetes care, 2018 01; 41(1), p. 104-111.
EPub date: 2017-11-10.
PMID: 29127240
Related Citations

Physical Activity and Lifetime Risk of Cardiovascular Disease and Cancer.
Authors: Kubota Y. , Evenson K.R. , Maclehose R.F. , Roetker N.S. , Joshu C.E. , Folsom A.R. .
Source: Medicine and science in sports and exercise, 2017 08; 49(8), p. 1599-1605.
PMID: 28350711
Related Citations

Circulating Beta-2 Microglobulin and Risk of Cancer: The Atherosclerosis Risk in Communities Study (ARIC).
Authors: Prizment A.E. , Linabery A.M. , Lutsey P.L. , Selvin E. , Nelson H.H. , Folsom A.R. , Church T.R. , Drake C.G. , Platz E.A. , Joshu C. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016 04; 25(4), p. 657-64.
EPub date: 2016-02-05.
PMID: 26908438
Related Citations

The George W. Comstock Center for Public Health Research and Prevention: A Century of Collaboration, Innovation, and Translation.
Authors: Coresh J. , Platz E.A. .
Source: American journal of epidemiology, 2016-03-01; 183(5), p. 362-6.
EPub date: 2016-02-11.
PMID: 26872712
Related Citations

Body mass index at early adulthood, subsequent weight change and cancer incidence and mortality.
Authors: Han X. , Stevens J. , Truesdale K.P. , Bradshaw P.T. , Kucharska-Newton A. , Prizment A.E. , Platz E.A. , Joshu C.E. .
Source: International journal of cancer, 2014-12-15; 135(12), p. 2900-9.
EPub date: 2014-05-08.
PMID: 24771654
Related Citations

Functional status declines among cancer survivors: trajectory and contributing factors.
Authors: Petrick J.L. , Reeve B.B. , Kucharska-Newton A.M. , Foraker R.E. , Platz E.A. , Stearns S.C. , Han X. , Windham B.G. , Irwin D.E. .
Source: Journal of geriatric oncology, 2014-10-01; 5(4), p. 359-67.
EPub date: 2014-06-26.
PMID: 24981125
Related Citations

Trajectory of overall health from self-report and factors contributing to health declines among cancer survivors.
Authors: Petrick J.L. , Foraker R.E. , Kucharska-Newton A.M. , Reeve B.B. , Platz E.A. , Stearns S.C. , Han X. , Windham B.G. , Irwin D.E. .
Source: Cancer causes & control : CCC, 2014 Sep; 25(9), p. 1179-86.
EPub date: 2014-07-02.
PMID: 24986768
Related Citations

Smoking behavior and lung cancer in a biracial cohort: the Atherosclerosis Risk in Communities study.
Authors: Prizment A.E. , Yatsuya H. , Lutsey P.L. , Lubin J.H. , Woodward M. , Folsom A.R. , Huxley R.R. .
Source: American journal of preventive medicine, 2014 Jun; 46(6), p. 624-32.
PMID: 24842739
Related Citations

Reflections on success in multidisciplinary, translational science: working together to answer the right questions.
Authors: Platz E.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Apr; 23(4), p. 573-4.
EPub date: 2014-01-21.
PMID: 24448509
Related Citations

Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study.
Authors: Prizment A.E. , Folsom A.R. , Dreyfus J. , Anderson K.E. , Visvanathan K. , Joshu C.E. , Platz E.A. , Pankow J.S. .
Source: Cancer causes & control : CCC, 2013 Dec; 24(12), p. 2077-87.
EPub date: 2013-09-14.
PMID: 24036889
Related Citations




Back to Top