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Grant Details

Grant Number: 5UH3CA188640-05 Interpret this number
Primary Investigator: Coronado, Gloria
Organization: Kaiser Foundation Research Institute
Project Title: Strategies and Opportunities to Stop Colon Cancer in Priority Populations
Fiscal Year: 2017


Abstract

DESCRIPTION: The federal government has set a Healthy People 2020 goal of a 70.5% screening rate for colorectal cancer (CRC), but almost half of eligible U.S. adults are not up to date on their screenings. Among minority and low-income populations, the CRC screening rate is extremely low. To address this disparity, we will develop and test a culturally tailored, health care system-based program to improve CRC screening rates in OCHIN, a community-based collaborative network of more than 200 Federally Qualified Health Centers (FQHCs). Racial and ethnic minorities, along with low-income and medically underserved populations, increasingly receive their primary care at FQHCs, which serve nearly 19 million patients annually throughout the United States. OCHIN is the largest national FQHC network. Its integrated electronic health record system combining medical, laboratory, and claims data will serve as a novel and robust data source for our study. In Phase I (Year 01), we will pilot-test an evidence-based approach to improving participation in CRC screening in two OCHIN FQHCs. This phase will include an assessment of the intervention s feasibility, effectiveness, and cost. In Phase II (Years 02 05), we will conduct a comparative effectiveness pragmatic clinical trial, using a mixed-methods approach to evaluate the adoption, implementation, and maintenance of our CRC screening program designed explicitly for FQHC clinics. Throughout the project, we will work with a diverse planning advisory group of OCHIN clinicians and patients, community representatives, state policy makers, and researchers, using principles of Community-Based Participatory Research. Because OCHIN is the largest single FQHC network and serves patients who are diverse in race, ethnicity, and insurance status, our results will play a transformative role in accelerating CRC screening research in underserved populations. Our program will expand meaningful use of electronic health information; synergistically meet national goals to improve cancer screening rates, address health disparities, and reduce health care costs; and act as a catalyst for future systems-based approaches to improve care delivery in FQHCs and other health systems.



Publications

Sample size requirements for testing treatment effect heterogeneity in cluster randomized trials with binary outcomes.
Authors: Maleyeff L. , Wang R. , Haneuse S. , Li F. .
Source: Statistics In Medicine, 2023-11-30 00:00:00.0; 42(27), p. 5054-5083.
EPub date: 2023-09-14 00:00:00.0.
PMID: 37974475
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Improving sandwich variance estimation for marginal Cox analysis of cluster randomized trials.
Authors: Wang X. , Turner E.L. , Li F. .
Source: Biometrical Journal. Biometrische Zeitschrift, 2022-12-25 00:00:00.0; , p. e2200113.
EPub date: 2022-12-25 00:00:00.0.
PMID: 36567265
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Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory.
Authors: Richesson R.L. , Marsolo K.S. , Douthit B.J. , Staman K. , Ho P.M. , Dailey D. , Boyd A.D. , McTigue K.M. , Ezenwa M.O. , Schlaeger J.M. , et al. .
Source: Journal Of The American Medical Informatics Association : Jamia, 2021-10-01 00:00:00.0; , .
EPub date: 2021-10-01 00:00:00.0.
PMID: 34597383
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Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies.
Authors: Tuzzio L. , Meyers C.M. , Dember L.M. , Grudzen C.R. , Melnick E.R. , Staman K.L. , Huang S.S. , Richards J. , DeBar L. , Vazquez M.A. , et al. .
Source: Healthcare (amsterdam, Netherlands), 2021 Jun; 8 Suppl 1, p. 100432.
EPub date: 2021-06-23 00:00:00.0.
PMID: 34175091
Related Citations

The influence of multi-morbidities on colorectal cancer screening recommendations and completion.
Authors: Coronado G.D. , Nielson C.M. , Keast E.M. , Petrik A.F. , Suls J.M. .
Source: Cancer Causes & Control : Ccc, 2021-03-09 00:00:00.0; , .
EPub date: 2021-03-09 00:00:00.0.
PMID: 33687606
Related Citations

Development of a multivariable prediction model to identify patients unlikely to complete a colonoscopy following an abnormal FIT test in community clinics.
Authors: Petrik A.F. , Keast E. , Johnson E.S. , Smith D.H. , Coronado G.D. .
Source: Bmc Health Services Research, 2020-11-10 00:00:00.0; 20(1), p. 1028.
EPub date: 2020-11-10 00:00:00.0.
PMID: 33172444
Related Citations

Factors Influencing Implementation of a Colorectal Cancer Screening Improvement Program in Community Health Centers: an Applied Use of Configurational Comparative Methods.
Authors: Petrik A.F. , Green B. , Schneider J. , Miech E.J. , Coury J. , Retecki S. , Coronado G.D. .
Source: Journal Of General Internal Medicine, 2020-10-26 00:00:00.0; , .
EPub date: 2020-10-26 00:00:00.0.
PMID: 33107003
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Barriers and Facilitators to Timely Colonoscopy Completion for Safety Net Clinic Patients.
Authors: Schneider J.L. , Rivelli J.S. , Gruss I. , Petrik A.F. , Nielson C.M. , Green B.B. , Coronado G.D. .
Source: American Journal Of Health Behavior, 2020-07-01 00:00:00.0; 44(4), p. 460-472.
PMID: 32553027
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Moderators of the effectiveness of an intervention to increase colorectal cancer screening through mailed fecal immunochemical test kits: results from a pragmatic randomized trial.
Authors: O'Connor E.A. , Vollmer W.M. , Petrik A.F. , Green B.B. , Coronado G.D. .
Source: Trials, 2020-01-15 00:00:00.0; 21(1), p. 91.
EPub date: 2020-01-15 00:00:00.0.
PMID: 31941527
Related Citations

Challenges in assessing population reach in a pragmatic trial.
Authors: Green B.B. , Vollmer W.M. , Keast E. , Petrik A.F. , Coronado G.D. .
Source: Preventive Medicine Reports, 2019 Sep; 15, p. 100910.
EPub date: 2019-05-29 00:00:00.0.
PMID: 31198661
Related Citations

Factors Affecting Adherence in a Pragmatic Trial of Annual Fecal Immunochemical Testing for Colorectal Cancer.
Authors: Nielson C.M. , Vollmer W.M. , Petrik A.F. , Keast E.M. , Green B.B. , Coronado G.D. .
Source: Journal Of General Internal Medicine, 2019 Jun; 34(6), p. 978-985.
EPub date: 2019-01-25 00:00:00.0.
PMID: 30684199
Related Citations

Using a continuum of hybrid effectiveness-implementation studies to put research-tested colorectal screening interventions into practice.
Authors: Green B.B. , Coronado G.D. , Schwartz M. , Coury J. , Baldwin L.M. .
Source: Implementation Science : Is, 2019-05-29 00:00:00.0; 14(1), p. 53.
EPub date: 2019-05-29 00:00:00.0.
PMID: 31142348
Related Citations

Colorectal cancer screening in newly insured Medicaid members: a review of concurrent federal and state policies.
Authors: O'Leary M.C. , Lich K.H. , Gu Y. , Wheeler S.B. , Coronado G.D. , Bartelmann S.E. , Lind B.K. , Mayorga M.E. , Davis M.M. .
Source: Bmc Health Services Research, 2019-05-09 00:00:00.0; 19(1), p. 298.
EPub date: 2019-05-09 00:00:00.0.
PMID: 31072316
Related Citations

Pragmatic clinical trials offer unique opportunities for disseminating, implementing, and sustaining evidence-based practices into clinical care: Proceedings of a workshop.
Authors: Tuzzio L. , Larson E.B. , Chambers D.A. , Coronado G.D. , Curtis L.H. , Weber W.J. , Zatzick D.F. , Meyers C.M. .
Source: Healthcare (amsterdam, Netherlands), 2019 Mar; 7(1), p. 51-57.
EPub date: 2018-12-26 00:00:00.0.
PMID: 30594497
Related Citations

A cost-effectiveness analysis of a colorectal cancer screening program in safety net clinics.
Authors: Meenan R.T. , Coronado G.D. , Petrik A. , Green B.B. .
Source: Preventive Medicine, 2019 Mar; 120, p. 119-125.
EPub date: 2019-01-24 00:00:00.0.
PMID: 30685318
Related Citations

A Survey of Provider Attitudes, Beliefs, and Perceived Barriers Regarding a Centralized Direct-Mail Colorectal Cancer Screening Approach at Community Health Centers.
Authors: Thompson J.H. , Schneider J.L. , Rivelli J.S. , Petrik A.F. , Vollmer W.M. , Fuoco M.J. , Coronado G.D. .
Source: Journal Of Primary Care & Community Health, 2019 Jan-Dec; 10, p. 2150132719890950.
PMID: 31779517
Related Citations

Effectiveness of automated and live phone reminders after mailed-FIT outreach in a pilot randomized trial.
Authors: Nielson C.M. , Rivelli J.S. , Fuoco M.J. , Gawlik V.R. , Jimenez R. , Petrik A.F. , Coronado G.D. .
Source: Preventive Medicine Reports, 2018 Dec; 12, p. 210-213.
EPub date: 2018-10-17 00:00:00.0.
PMID: 30364785
Related Citations

Two Medicaid health plans' models and motivations for improving colorectal cancer screening rates.
Authors: Coury J.K. , Schneider J.L. , Green B.B. , Baldwin L.M. , Petrik A.F. , Rivelli J.S. , Schwartz M.R. , Coronado G.D. .
Source: Translational Behavioral Medicine, 2018-11-16 00:00:00.0; , .
EPub date: 2018-11-16 00:00:00.0.
PMID: 30445511
Related Citations

Effectiveness of a Mailed Colorectal Cancer Screening Outreach Program in Community Health Clinics: The STOP CRC Cluster Randomized Clinical Trial.
Authors: Coronado G.D. , Petrik A.F. , Vollmer W.M. , Taplin S.H. , Keast E.M. , Fields S. , Green B.B. .
Source: Jama Internal Medicine, 2018-09-01 00:00:00.0; 178(9), p. 1174-1181.
PMID: 30083752
Related Citations

Positive predictive values of fecal immunochemical tests used in the STOP CRC pragmatic trial.
Authors: Nielson C.M. , Petrik A.F. , Jacob L. , Vollmer W.M. , Keast E.M. , Schneider J.L. , Rivelli J.S. , Kapka T.J. , Meenan R.T. , Mummadi R.R. , et al. .
Source: Cancer Medicine, 2018 Sep; 7(9), p. 4781-4790.
EPub date: 2018-08-13 00:00:00.0.
PMID: 30101513
Related Citations

Effect of Reminding Patients to Complete Fecal Immunochemical Testing: A Comparative Effectiveness Study of Automated and Live Approaches.
Authors: Coronado G.D. , Rivelli J.S. , Fuoco M.J. , Vollmer W.M. , Petrik A.F. , Keast E. , Barker S. , Topalanchik E. , Jimenez R. .
Source: Journal Of General Internal Medicine, 2018 Jan; 33(1), p. 72-78.
EPub date: 2017-10-10 00:00:00.0.
PMID: 29019046
Related Citations

Data Sharing and Embedded Research.
Authors: Simon G.E. , Coronado G. , DeBar L.L. , Dember L.M. , Green B.B. , Huang S.S. , Jarvik J.G. , Mor V. , Ramsberg J. , Septimus E.J. , et al. .
Source: Annals Of Internal Medicine, 2017-11-07 00:00:00.0; 167(9), p. 668-670.
EPub date: 2017-10-03 00:00:00.0.
PMID: 28973353
Related Citations

Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory.
Authors: Weinfurt K.P. , Hernandez A.F. , Coronado G.D. , DeBar L.L. , Dember L.M. , Green B.B. , Heagerty P.J. , Huang S.S. , James K.T. , Jarvik J.G. , et al. .
Source: Bmc Medical Research Methodology, 2017-09-18 00:00:00.0; 17(1), p. 144.
EPub date: 2017-09-18 00:00:00.0.
PMID: 28923013
Related Citations

Pragmatic (trial) informatics: a perspective from the NIH Health Care Systems Research Collaboratory.
Authors: Richesson R.L. , Green B.B. , Laws R. , Puro J. , Kahn M.G. , Bauck A. , Smerek M. , Van Eaton E.G. , Zozus M. , Hammond W.E. , et al. .
Source: Journal Of The American Medical Informatics Association : Jamia, 2017-09-01 00:00:00.0; 24(5), p. 996-1001.
PMID: 28340241
Related Citations

Predictors of Colorectal Cancer Screening Prior to Implementation of a Large Pragmatic Trial in Federally Qualified Health Centers.
Authors: Petrik A.F. , Le T. , Keast E. , Rivelli J. , Bigler K. , Green B. , Vollmer W.M. , Coronado G. .
Source: Journal Of Community Health, 2017-07-25 00:00:00.0; , .
EPub date: 2017-07-25 00:00:00.0.
PMID: 28744716
Related Citations

Mapping Multi-Site Clinic Workflows to Design Systems-Enabled Interventions.
Authors: Coronado G.D. , Retecki S. , Petrik A.F. , Coury J. , Aguirre J. , Taplin S.H. , Burdick T. , Green B.B. .
Source: Egems (washington, Dc), 2017-06-14 00:00:00.0; 5(1), p. 13.
EPub date: 2017-06-14 00:00:00.0.
PMID: 29930961
Related Citations

Implementation successes and challenges in participating in a pragmatic study to improve colon cancer screening: perspectives of health center leaders.
Authors: Coronado G.D. , Schneider J.L. , Petrik A. , Rivelli J. , Taplin S. , Green B.B. .
Source: Translational Behavioral Medicine, 2017-02-01 00:00:00.0; , .
EPub date: 2017-02-01 00:00:00.0.
PMID: 28150097
Related Citations

The validation of electronic health records in accurately identifying patients eligible for colorectal cancer screening in safety net clinics.
Authors: Petrik A.F. , Green B.B. , Vollmer W.M. , Le T. , Bachman B. , Keast E. , Rivelli J. , Coronado G.D. .
Source: Family Practice, 2016 12; 33(6), p. 639-643.
EPub date: 2016-07-28 00:00:00.0.
PMID: 27471224
Related Citations

Statistical Lessons Learned For Designing Cluster Randomized Pragmatic Clinical Trials From The Nih Health Care Systems Collaboratory Biostatistics And Design Core
Authors: Cook A.J. , Delong E. , Murray D.M. , Vollmer W.M. , Heagerty P.J. .
Source: Clinical Trials (london, England), 2016 Oct; 13(5), p. 504-12.
PMID: 27179253
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Trials without tribulations: Minimizing the burden of pragmatic research on healthcare systems.
Authors: Larson E.B. , Tachibana C. , Thompson E. , Coronado G.D. , DeBar L. , Dember L.M. , Honda S. , Huang S.S. , Jarvik J.G. , Nelson C. , et al. .
Source: Healthcare (amsterdam, Netherlands), 2016 Sep; 4(3), p. 138-41.
PMID: 27637816
Related Citations

Timeliness Of Colonoscopy After Abnormal Fecal Test Results In A Safety Net Practice
Authors: Oluloro A. , Petrik A.F. , Turner A. , Kapka T. , Rivelli J. , Carney P.A. , Saha S. , Coronado G.D. .
Source: Journal Of Community Health, 2016 Aug; 41(4), p. 864-70.
PMID: 26874943
Related Citations

Recruiting community health centers into pragmatic research: Findings from STOP CRC.
Authors: Coronado G.D. , Retecki S. , Schneider J. , Taplin S.H. , Burdick T. , Green B.B. .
Source: Clinical Trials (london, England), 2016 Apr; 13(2), p. 214-22.
PMID: 26419905
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Use of PRECIS ratings in the National Institutes of Health (NIH) Health Care Systems Research Collaboratory.
Authors: Johnson K.E. , Neta G. , Dember L.M. , Coronado G.D. , Suls J. , Chambers D.A. , Rundell S. , Smith D.H. , Liu B. , Taplin S. , et al. .
Source: Trials, 2016-01-16 00:00:00.0; 17, p. 32.
EPub date: 2016-01-16 00:00:00.0.
PMID: 26772801
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Preparing For The Icd-10-cm Transition: Automated Methods For Translating Icd Codes In Clinical Phenotype Definitions
Authors: Fung K.W. , Richesson R. , Smerek M. , Pereira K.C. , Green B.B. , Patkar A. , Clowse M. , Bauck A. , Bodenreider O. .
Source: Egems (washington, Dc), 2016; 4(1), p. 1211.
PMID: 27195309
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Reasons for non-response to a direct-mailed FIT kit program: lessons learned from a pragmatic colorectal-cancer screening study in a federally sponsored health center.
Authors: Coronado G.D. , Schneider J.L. , Sanchez J.J. , Petrik A.F. , Green B. .
Source: Translational Behavioral Medicine, 2015 Mar; 5(1), p. 60-7.
PMID: 25729454
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Health Policy to Promote Colorectal Cancer Screening: Improving Access and Aligning Federal and State Incentives.
Authors: Coronado G.D. , Petrik A.F. , Bartelmann S.E. , Coyner L.A. , Coury J. .
Source: Clinical Researcher (alexandria, Va.), 2015 Feb; 29(1), p. 50-55.
PMID: 27135047
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Analytic Challenges Arising From The Stop Crc Trial: Pragmatic Solutions For Pragmatic Problems
Authors: Vollmer W.M. , Green B.B. , Coronado G.D. .
Source: Egems (washington, Dc), 2015; 3(1), p. 1200.
PMID: 26793738
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A guide to research partnerships for pragmatic clinical trials.
Authors: Johnson K.E. , Tachibana C. , Coronado G.D. , Dember L.M. , Glasgow R.E. , Huang S.S. , Martin P.J. , Richards J. , Rosenthal G. , Septimus E. , et al. .
Source: Bmj (clinical Research Ed.), 2014-12-01 00:00:00.0; 349, p. g6826.
EPub date: 2014-12-01 00:00:00.0.
PMID: 25446054
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"BeneFITs" to increase colorectal cancer screening in priority populations.
Authors: Green B.B. , Coronado G.D. .
Source: Jama Internal Medicine, 2014 Aug; 174(8), p. 1242-3.
PMID: 24934255
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Strategies and Opportunities to STOP Colon Cancer in Priority Populations: design of a cluster-randomized pragmatic trial.
Authors: Coronado G.D. , Vollmer W.M. , Petrik A. , Taplin S.H. , Burdick T.E. , Meenan R.T. , Green B.B. .
Source: Contemporary Clinical Trials, 2014 Jul; 38(2), p. 344-9.
PMID: 24937017
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Navigating the murky waters of colorectal cancer screening and health reform.
Authors: Green B.B. , Coronado G.D. , Devoe J.E. , Allison J. .
Source: American Journal Of Public Health, 2014 Jun; 104(6), p. 982-6.
PMID: 24825195
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Advantages of wordless instructions on how to complete a fecal immunochemical test: lessons from patient advisory council members of a federally qualified health center.
Authors: Coronado G.D. , Sanchez J. , Petrik A. , Kapka T. , DeVoe J. , Green B. .
Source: Journal Of Cancer Education : The Official Journal Of The American Association For Cancer Education, 2014 Mar; 29(1), p. 86-90.
PMID: 24057692
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Strategies and opportunities to STOP colon cancer in priority populations: pragmatic pilot study design and outcomes.
Authors: Coronado G.D. , Vollmer W.M. , Petrik A. , Aguirre J. , Kapka T. , Devoe J. , Puro J. , Miers T. , Lembach J. , Turner A. , et al. .
Source: Bmc Cancer, 2014-02-26 00:00:00.0; 14, p. 55.
EPub date: 2014-02-26 00:00:00.0.
PMID: 24571550
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Using an Automated Data-driven, EHR-Embedded Program for Mailing FIT kits: Lessons from the STOP CRC Pilot Study.
Authors: Coronado G.D. , Burdick T. , Petrik A. , Kapka T. , Retecki S. , Green B. .
Source: Journal Of General Practice (los Angeles, Calif.), 2014-01-05 00:00:00.0; 2, .
PMID: 25411657
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