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Grant Details

Grant Number: 1R01CA211707-01 Interpret this number
Primary Investigator: Gayther, Simon
Organization: Cedars-Sinai Medical Center
Project Title: Functional Effects of Ovarian Cancer Risk Variants
Fiscal Year: 2017


Abstract

Abstract Genome wide association studies (GWAS) have so far identified more than 20 common low penetrance variants for ovarian cancer; but it is estimated that thousands more risk variants await discovery. In the post-GWAS era a complex set of challenges for the identification, functional characterization and utility of susceptibility alleles have emerged including: (i) Identifying the causal genetic variants and regulatory targets driving cancer development at risk loci; (ii) Identifying the susceptibility genes associated with risk variants; (iii) Establishing if there are common biological networks that explain the functional mechanisms underlying multiple risk loci. Clinically, identifying the genetic risk component of ovarian cancer will likely lead to improved disease prevention through population screening and disease prevention strategies; and understanding the function of risk loci may lead to the discovery of clinical biomarkers and novel targeted therapies, analogous to the paradigm of PARP therapy for BRCA1 or BRCA2 mutation carriers. The current proposal is designed to address many of these challenges for ovarian cancer in the post- GWAS era including: (1) Identifying additional novel, common variant susceptibility alleles for the different histological subtypes of ovarian cancer; (2) Establishing the functional mechanisms driving disease at ovarian cancer risk loci based on the identification and characterization of the likely casual SNPs and targets susceptibility genes are risk loci; (3) Using genome wide profiling of functional models based on perturbation of ovarian cancer susceptibility genes, to identify common mechanisms and biological pathways driving tumorigenesis; (4) To integrate functional datasets with genetic association datasets to improve the power of these studies to identify additional ovarian cancer susceptibility loci.



Publications

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.
Authors: Dareng E.O. , Coetzee S.G. , Tyrer J.P. , Peng P.C. , Rosenow W. , Chen S. , Davis B.D. , Dezem F.S. , Seo J.H. , Nameki R. , et al. .
Source: American Journal Of Human Genetics, 2024-05-07 00:00:00.0; , .
EPub date: 2024-05-07 00:00:00.0.
PMID: 38723632
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Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors.
Authors: Tak Y.E. , Boulay G. , Lee L. , Iyer S. , Perry N.T. , Schultz H.T. , Garcia S.P. , Broye L. , Horng J.E. , Rengarajan S. , et al. .
Source: Cell Genomics, 2022-04-13 00:00:00.0; 2(4), .
PMID: 35967079
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A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.
Authors: Mortlock S. , Corona R.I. , Kho P.F. , Pharoah P. , Seo J.H. , Freedman M.L. , Gayther S.A. , Siedhoff M.T. , Rogers P.A.W. , Leuchter R. , et al. .
Source: Cell Reports. Medicine, 2022-03-15 00:00:00.0; 3(3), p. 100542.
EPub date: 2022-03-15 00:00:00.0.
PMID: 35492879
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Augmenting and directing long-range CRISPR-mediated activation in human cells.
Authors: Tak Y.E. , Horng J.E. , Perry N.T. , Schultz H.T. , Iyer S. , Yao Q. , Zou L.S. , Aryee M.J. , Pinello L. , Joung J.K. .
Source: Nature Methods, 2021-08-05 00:00:00.0; , .
EPub date: 2021-08-05 00:00:00.0.
PMID: 34354266
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Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube.
Authors: Dinh H.Q. , Lin X. , Abbasi F. , Nameki R. , Haro M. , Olingy C.E. , Chang H. , Hernandez L. , Gayther S.A. , Wright K.N. , et al. .
Source: Cell Reports, 2021-04-13 00:00:00.0; 35(2), p. 108978.
PMID: 33852846
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Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites.
Authors: Jones M.R. , Peng P.C. , Coetzee S.G. , Tyrer J. , Reyes A.L.P. , Corona R.I. , Davis B. , Chen S. , Dezem F. , Seo J.H. , et al. .
Source: American Journal Of Human Genetics, 2020-10-01 00:00:00.0; 107(4), p. 622-635.
EPub date: 2020-09-17 00:00:00.0.
PMID: 32946763
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Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function.
Authors: Cruz L. , György B. , Cheah P.S. , Kleinstiver B.P. , Eimer W.A. , Garcia S.P. , Sharma N. , Ozelius L.J. , Bragg D.C. , Joung J.K. , et al. .
Source: Molecular Therapy. Nucleic Acids, 2020-09-04 00:00:00.0; 21, p. 1-12.
EPub date: 2020-05-15 00:00:00.0.
PMID: 32502938
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A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development.
Authors: Lawrenson K. , Fonseca M.A.S. , Liu A.Y. , Segato Dezem F. , Lee J.M. , Lin X. , Corona R.I. , Abbasi F. , Vavra K.C. , Dinh H.Q. , et al. .
Source: Cell Reports, 2019-12-10 00:00:00.0; 29(11), p. 3726-3735.e4.
PMID: 31825847
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Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
Authors: Lawrenson K. , Song F. , Hazelett D.J. , Kar S.P. , Tyrer J. , Phelan C.M. , Corona R.I. , Rodríguez-Malavé N.I. , Seo J.H. , Adler E. , et al. .
Source: Gynecologic Oncology, 2019 05; 153(2), p. 343-355.
EPub date: 2019-03-19 00:00:00.0.
PMID: 30898391
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A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants.
Authors: Gusev A. , Lawrenson K. , Lin X. , Lyra P.C. , Kar S. , Vavra K.C. , Segato F. , Fonseca M.A.S. , Lee J.M. , Pejovic T. , et al. .
Source: Nature Genetics, 2019 05; 51(5), p. 815-823.
EPub date: 2019-05-01 00:00:00.0.
PMID: 31043753
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A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk.
Authors: Lu Y. , Beeghly-Fadiel A. , Wu L. , Guo X. , Li B. , Schildkraut J.M. , Im H.K. , Chen Y.A. , Permuth J.B. , Reid B.M. , et al. .
Source: Cancer Research, 2018-07-27 00:00:00.0; , .
EPub date: 2018-07-27 00:00:00.0.
PMID: 30054336
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Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells.
Authors: Lakshminarasimhan R. , Andreu-Vieyra C. , Lawrenson K. , Duymich C.E. , Gayther S.A. , Liang G. , Jones P.A. .
Source: Cancer Letters, 2017-08-10 00:00:00.0; 401, p. 11-19.
EPub date: 2017-05-06 00:00:00.0.
PMID: 28483516
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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Authors: Phelan C.M. , Kuchenbaecker K.B. , Tyrer J.P. , Kar S.P. , Lawrenson K. , Winham S.J. , Dennis J. , Pirie A. , Riggan M.J. , Chornokur G. , et al. .
Source: Nature Genetics, 2017 May; 49(5), p. 680-691.
EPub date: 2017-03-27 00:00:00.0.
PMID: 28346442
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Enrichment Of Putative Pax8 Target Genes At Serous Epithelial Ovarian Cancer Susceptibility Loci
Authors: Kar S.P. , Adler E. , Tyrer J. , Hazelett D. , Anton-Culver H. , Bandera E.V. , Beckmann M.W. , Berchuck A. , Bogdanova N. , Brinton L. , et al. .
Source: British Journal Of Cancer, 2017-02-14 00:00:00.0; 116(4), p. 524-535.
PMID: 28103614
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