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Grant Details

Grant Number: 5R01CA166646-05 Interpret this number
Primary Investigator: Bricker, Jonathan
Organization: Fred Hutchinson Cancer Research Center
Project Title: Randomized Trial of Web-Delivered Acceptance Therapy for Smoking Cessation
Fiscal Year: 2017
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DESCRIPTION (provided by applicant): Smoking cessation intervention websites are now reaching millions of adults 24 hours a day. Unfortunately, currently available smoking cessation websites have low effectiveness. Their average quit rates are 7 to 10%. Now is the time to test a new intervention model with potential to boost quit rates of smoking cessation websites. To start a new research paradigm focusing on innovative web-based intervention content, the current study will test a promising treatment approach called Acceptance & Commitment Therapy (ACT). We recently developed the first ACT smoking cessation website and pilot tested it in a randomized controlled trial comparing it with a national-level current standard website following US Clinical Practice Guidelines ( The trial design was proven feasible, with successful national recruitment (N = 222) and balanced randomization. The ACT intervention was feasible, with higher participant utilization and satisfaction, as compared to The ACT intervention showed promising results on cessation processes and outcomes at short term follow-up (i.e., 3 months). Building on these results, a randomized trial with a larger sample size (N = 2554) and longer term follow-up (i.e., 12 months) is now needed to definitively determine whether the ACT website provides more robust quit rates than currently available smoking cessation websites. Accordingly, we propose to conduct a randomized controlled trial comparing the ACT smoking cessation website with, in order to: (1) Demonstrate that web-based ACT has significantly higher smoking cessation rates than a national-level current standard website ( Primary outcome: 30-day point prevalence abstinence at 12 months post randomization; (2) Demonstrate that the web-based ACT (but not smoking cessation outcomes are mediated by three psychological processes that are central to the theoretical model underlying ACT: acceptance of internal (a) sensations, (b) emotions, and (c) thoughts that cue smoking. This study, well-motivated by promising pilot results, will provide a definitive test of the web-based ACT for smoking cessation program and its underlying mediational processes. Positive results could provide current standard web-based interventions a new intervention paradigm and significantly improve long term cessation rates for smokers in a low cost public health intervention.

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Smokers with bipolar disorder, other affective disorders, and no mental health conditions: Comparison of baseline characteristics and success at quitting in a large 12-month behavioral intervention randomized trial.
Authors: Heffner J.L. , Mull K.E. , Watson N.L. , McClure J.B. , Bricker J.B. .
Source: Drug And Alcohol Dependence, 2018-10-10 00:00:00.0; 193, p. 35-41.
EPub date: 2018-10-10 00:00:00.0.
PMID: 30340143
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Participant Recruitment and Retention in Remote eHealth Intervention Trials: Methods and Lessons Learned From a Large Randomized Controlled Trial of Two Web-Based Smoking Interventions.
Authors: Watson N.L. , Mull K.E. , Heffner J.L. , McClure J.B. , Bricker J.B. .
Source: Journal Of Medical Internet Research, 2018-08-24 00:00:00.0; 20(8), p. e10351.
EPub date: 2018-08-24 00:00:00.0.
PMID: 30143479
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Trajectories of 12-Month Usage Patterns for Two Smoking Cessation Websites: Exploring How Users Engage Over Time.
Authors: Bricker J.B. , Sridharan V. , Zhu Y. , Mull K.E. , Heffner J.L. , Watson N.L. , McClure J.B. , Di C. .
Source: Journal Of Medical Internet Research, 2018-04-20 00:00:00.0; 20(4), p. e10143.
EPub date: 2018-04-20 00:00:00.0.
PMID: 29678799
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Improving Quit Rates of Web-Delivered Interventions for Smoking Cessation: Full Scale Randomized Trial of versus
Authors: Bricker J.B. , Mull K.E. , McClure J.B. , Watson N.L. , Heffner J.L. .
Source: Addiction (abingdon, England), 2017-12-13 00:00:00.0; , .
EPub date: 2017-12-13 00:00:00.0.
PMID: 29235186
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Differential Prevalence Of Established Risk Factors For Poor Cessation Outcomes Among Smokers By Level Of Social Anxiety
Authors: Watson N.L. , Heffner J.L. , McClure J.B. , Mull K.E. , Bricker J.B. .
Source: The American Journal On Addictions, 2017 Mar; 26(2), p. 176-182.
PMID: 28191916
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Single-arm Trial Of The Second Version Of An Acceptance & Commitment Therapy Smartphone Application For Smoking Cessation
Authors: Bricker J.B. , Copeland W. , Mull K.E. , Zeng E.Y. , Watson N.L. , Akioka K.J. , Heffner J.L. .
Source: Drug And Alcohol Dependence, 2017-01-01 00:00:00.0; 170, p. 37-42.
PMID: 27870987
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Get With The Program: Adherence To A Smartphone App For Smoking Cessation
Authors: Zeng E.Y. , Heffner J.L. , Copeland W.K. , Mull K.E. , Bricker J.B. .
Source: Addictive Behaviors, 2016 Dec; 63, p. 120-4.
PMID: 27454354
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Predictors of Utilization of a Novel Smoking Cessation Smartphone App.
Authors: Zeng E.Y. , Vilardaga R. , Heffner J.L. , Mull K.E. , Bricker J.B. .
Source: Telemedicine Journal And E-health : The Official Journal Of The American Telemedicine Association, 2015 Dec; 21(12), p. 998-1004.
PMID: 26171733
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Feature-level analysis of a novel smartphone application for smoking cessation.
Authors: Heffner J.L. , Vilardaga R. , Mercer L.D. , Kientz J.A. , Bricker J.B. .
Source: The American Journal Of Drug And Alcohol Abuse, 2015 Jan; 41(1), p. 68-73.
PMID: 25397860
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Web-based acceptance and commitment therapy smoking cessation treatment for smokers with depressive symptoms.
Authors: Jones H.A. , Heffner J.L. , Mercer L. , Wyszynski C.M. , Vilardaga R. , Bricker J.B. .
Source: Journal Of Dual Diagnosis, 2015; 11(1), p. 56-62.
PMID: 25671683
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Randomized trial of telephone-delivered acceptance and commitment therapy versus cognitive behavioral therapy for smoking cessation: a pilot study.
Authors: Bricker J.B. , Bush T. , Zbikowski S.M. , Mercer L.D. , Heffner J.L. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2014 Nov; 16(11), p. 1446-54.
PMID: 24935757
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Randomized, controlled pilot trial of a smartphone app for smoking cessation using acceptance and commitment therapy.
Authors: Bricker J.B. , Mull K.E. , Kientz J.A. , Vilardaga R. , Mercer L.D. , Akioka K.J. , Heffner J.L. .
Source: Drug And Alcohol Dependence, 2014-10-01 00:00:00.0; 143, p. 87-94.
EPub date: 2014-10-01 00:00:00.0.
PMID: 25085225
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Practical considerations in the design and development of smartphone apps for behavior change.
Authors: Roth W.R. , Vilardaga R. , Wolfe N. , Bricker J.B. , McDonell M.G. .
Source: Journal Of Contextual Behavioral Science, 2014-10-01 00:00:00.0; 3(4), p. 269-272.
PMID: 25485231
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Pilot randomized controlled trial of web-based acceptance and commitment therapy for smoking cessation.
Authors: Bricker J. , Wyszynski C. , Comstock B. , Heffner J.L. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2013 Oct; 15(10), p. 1756-64.
PMID: 23703730
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