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Grant Details

Grant Number: 1R01CA207216-01 Interpret this number
Primary Investigator: Shih, Ya-Chen
Organization: University Of Tx Md Anderson Can Ctr
Project Title: Technology Diffusion in Cancer: Geographic Variations, Facilitators, Outcomes, and Costs
Fiscal Year: 2016


Abstract

PROJECT SUMMARY Cancer is the second leading cause of death in the United States, accounting for approximately 25% of deaths. The national medical expenditures of cancer reached $125 billion in 2010, and are projected to increase to $158 billion by 2020. A recent Institute of Medicine report, entitled “Delivering high-quality cancer care: Charting a new course for a system in crisis,” expressed major concerns over the unsustainable increase in the cost of cancer care, identifying rapid diffusion of new technologies and the aging demographic as key cost drivers. The objective of the proposed study is to examine the impact of technology diffusion in medical, radiation, and surgical oncology on the costs and outcomes of cancer care. Specific aims of the study are: (1) to describe the pattern of technology diffusion in medical, radiation, and surgical oncology in the top five most expensive cancers and assess the geographic variation of the diffusion pattern; (2) to examine factors associated with the diffusion of new technologies and those that contribute to the geographic variations in new technology diffusion; (3) to evaluate the impact of the diffusion of new oncologic technologies on health outcomes and whether the impact would be modified by guideline adherence; and (4) to estimate the effect of the diffusion of new oncologic technologies on the cost of cancer care and geographic variation in healthcare spending, and to explore for each cancer whether these new technologies are substitute or complementary to existing treatment. We will address our research questions using a cohort of cancer patients extracted from the SEER-Medicare and MarketScan databases, focusing on the top five most expensive cancers: female breast, colorectal, lymphoma, lung, and prostate cancer. Our study will provide a comprehensive evaluation of the current state of technology diffusion for all modalities involved in the treatment of cancer, paying special attention to market and organizational characteristics tied to providers’ financial incentives. The choice of cancer to study technology diffusion offers a unique opportunity to understand the complicated interactions between new and existing technologies and allows us to explore the substitution or complementary effect of new technologies, both within the same class of technology and across classes. Findings from our study will assist policy makers in the design and planning dissemination and implementation strategies to maximize the benefit of effective new treatments while taking into consideration of the cost implications to the cancer care delivery system.



Publications

Long-term Patient-Reported Outcomes in a Population-Based Cohort Following Radiotherapy vs Surgery for Oropharyngeal Cancer.
Authors: Dohopolski M.J. , Diao K. , Hutcheson K.A. , Akhave N.S. , Goepfert R.P. , He W. , Lei X.J. , Peterson S.K. , Shen Y. , Sumer B.D. , et al. .
Source: Jama Otolaryngology-- Head & Neck Surgery, 2023-08-01 00:00:00.0; 149(8), p. 697-707.
PMID: 37382943
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Current Trends in the Utilization of Preoperative Breast Magnetic Resonance Imaging Among Women With Newly Diagnosed Breast Cancer.
Authors: Pan I.W. , Yen T.W.F. , Bedrosian I. , Shih Y.T. .
Source: Jco Oncology Practice, 2023 Jul; 19(7), p. 446-455.
EPub date: 2023-04-17 00:00:00.0.
PMID: 37071025
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Comparisons of Medical Cost Trajectories Between Non-Hispanic Black and Non-Hispanic White Patients With Newly Diagnosed Localized Prostate Cancer.
Authors: Liu Y. , Wang S. , Li L. , Xu Y. , Shen Y. , Tina Shih Y.C. .
Source: Value In Health : The Journal Of The International Society For Pharmacoeconomics And Outcomes Research, 2023-06-20 00:00:00.0; , .
EPub date: 2023-06-20 00:00:00.0.
PMID: 37348833
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Patient-Reported Quality of Life after Breast Conserving Surgery with Radiotherapy versus Mastectomy and Reconstruction.
Authors: Diao K. , Lei X. , He W. , Jagsi R. , Giordano S.H. , Smith G.L. , Caudle A. , Shen Y. , Peterson S. , Smith B.D. .
Source: Annals Of Surgery, 2023-05-26 00:00:00.0; , .
EPub date: 2023-05-26 00:00:00.0.
PMID: 37232937
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Ecological and individualistic fallacies in health disparities research.
Authors: Shih Y.T. , Bradley C. , Yabroff K.R. .
Source: Journal Of The National Cancer Institute, 2023-05-08 00:00:00.0; 115(5), p. 488-491.
PMID: 36912704
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Socioeconomic Barriers to Randomized Clinical Trial Retention in Patients Treated With Adjuvant Radiation for Early-Stage Breast Cancer.
Authors: Shi J.J. , Lei X. , Chen Y.S. , Chavez-MacGregor M. , Bloom E. , Schlembach P. , Shaitelman S.F. , Buchholz T.A. , Kaiser K. , Ku K. , et al. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2023-05-01 00:00:00.0; 116(1), p. 122-131.
EPub date: 2023-01-29 00:00:00.0.
PMID: 36724858
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Patient-Reported Financial Toxicity in a Population-Based Cohort of Oropharynx Cancer Survivors.
Authors: Diao K. , Lei X. , Smith G.L. , Jagsi R. , Peterson S.E. , Sumer B.D. , Smith B.D. , Sher D.J. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2023-05-01 00:00:00.0; 116(1), p. 142-153.
EPub date: 2022-10-25 00:00:00.0.
PMID: 36812043
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Optimizing Preventive Adjuvant Linac-Based (OPAL) Radiation: A Phase 2 Trial of Daily Partial Breast Irradiation.
Authors: Reddy J.P. , Lei X. , Bloom E.S. , Reed V.K. , Schlembach P.J. , Arzu I. , Mayo L. , Chun S.G. , Ahmad N.R. , Stauder M.C. , et al. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2023-03-01 00:00:00.0; 115(3), p. 629-644.
EPub date: 2022-10-08 00:00:00.0.
PMID: 36216274
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Predicting future cancer incidence by age, race, ethnicity, and sex.
Authors: Garner W.B. , Smith B.D. , Ludmir E.B. , Wakefield D.V. , Shabason J. , Williams G.R. , Martin M.Y. , Wang Y. , Ballo M.T. , VanderWalde N.A. .
Source: Journal Of Geriatric Oncology, 2023 Jan; 14(1), p. 101393.
EPub date: 2022-10-28 00:00:00.0.
PMID: 36692964
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Vertical Integration in Oncology: What Does It Mean for Patients with Cancer?
Authors: Tak H.J. , Shih Y.T. .
Source: Journal Of The National Cancer Institute, 2022-12-30 00:00:00.0; , .
EPub date: 2022-12-30 00:00:00.0.
PMID: 36583541
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Prescription Drug Provisions in the Inflation Reduction Act: Any Relief of Financial Hardship for Patients With Cancer?
Authors: Shih Y.T. , Yabroff K.R. , Bradley C.J. .
Source: Jama Oncology, 2022-12-08 00:00:00.0; , .
EPub date: 2022-12-08 00:00:00.0.
PMID: 36480188
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Disparity in checkpoint inhibitor utilization among commercially insured adult patients with metastatic lung cancer.
Authors: Li M. , Liao K. , Chen A.J. , Cascone T. , Shen Y. , Lu Q. , Shih Y.T. .
Source: Journal Of The National Cancer Institute, 2022-11-08 00:00:00.0; , .
EPub date: 2022-11-08 00:00:00.0.
PMID: 36346180
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Growing Financial Burden From High-Cost Targeted Oral Anticancer Medicines Among Medicare Beneficiaries With Cancer.
Authors: Li M. , Liao K. , Pan I.W. , Shih Y.T. .
Source: Jco Oncology Practice, 2022 Nov; 18(11), p. e1739-e1749.
EPub date: 2022-09-13 00:00:00.0.
PMID: 36099549
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Assessment of Uptake Appropriateness of Computed Tomography for Lung Cancer Screening According to Patients Meeting Eligibility Criteria of the US Preventive Services Task Force.
Authors: Liu Y. , Pan I.E. , Tak H.J. , Vlahos I. , Volk R. , Shih Y.T. .
Source: Jama Network Open, 2022-11-01 00:00:00.0; 5(11), p. e2243163.
EPub date: 2022-11-01 00:00:00.0.
PMID: 36409492
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Costs Around the First Year of Diagnosis for 4 Common Cancers Among the Privately Insured.
Authors: Shih Y.T. , Xu Y. , Bradley C. , Giordano S.H. , Yao J. , Yabroff K.R. .
Source: Journal Of The National Cancer Institute, 2022-09-13 00:00:00.0; , .
EPub date: 2022-09-13 00:00:00.0.
PMID: 36099068
Related Citations

Costs Around the First Year of Diagnosis for 4 Common Cancers Among the Privately Insured.
Authors: Shih Y.T. , Xu Y. , Bradley C. , Giordano S.H. , Yao J. , Yabroff K.R. .
Source: Journal Of The National Cancer Institute, 2022-09-13 00:00:00.0; , .
EPub date: 2022-09-13 00:00:00.0.
PMID: 36099068
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Health Economics Research in Cancer Screening: Research Opportunities, Challenges, and Future Directions.
Authors: Shih Y.T. , Sabik L.M. , Stout N.K. , Halpern M.T. , Lipscomb J. , Ramsey S. , Ritzwoller D.P. .
Source: Journal Of The National Cancer Institute. Monographs, 2022-07-05 00:00:00.0; 2022(59), p. 42-50.
PMID: 35788368
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Methods and Study Design for Cancer Health Economics Research: Summary of Discussions From a Breakout Session.
Authors: Henk H.J. , Shih Y.T. , Borah B.J. .
Source: Journal Of The National Cancer Institute. Monographs, 2022-07-05 00:00:00.0; 2022(59), p. 95-101.
PMID: 35788374
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Locoregional Management and Prognostic Factors in Breast Cancer With Ipsilateral Internal Mammary and Axillary Lymph Node Involvement.
Authors: Andring L.M. , Diao K. , Sun S. , Patel M. , Whitman G.J. , Schlembach P. , Arzu I. , Joyner M.M. , Shaitelman S.F. , Hoffman K. , et al. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2022-07-01 00:00:00.0; 113(3), p. 552-560.
EPub date: 2022-03-04 00:00:00.0.
PMID: 35248602
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Health Care Resource Utilization for Esophageal Cancer Using Proton versus Photon Radiation Therapy.
Authors: Lin S.H. , Liao K. , Lei X. , Verma V. , Shaaban S. , Lee P. , Chen A.B. , Koong A.C. , Hoftstetter W.L. , Frank S.J. , et al. .
Source: International Journal Of Particle Therapy, 2022 Summer; 9(1), p. 18-27.
EPub date: 2022-06-23 00:00:00.0.
PMID: 35774487
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Long-term Quality of Life in Patients With Breast Cancer After Breast Conservation vs Mastectomy and Reconstruction.
Authors: Hanson S.E. , Lei X. , Roubaud M.S. , DeSnyder S.M. , Caudle A.S. , Shaitelman S.F. , Hoffman K.E. , Smith G.L. , Jagsi R. , Peterson S.K. , et al. .
Source: Jama Surgery, 2022-06-01 00:00:00.0; 157(6), p. e220631.
EPub date: 2022-06-08 00:00:00.0.
PMID: 35416926
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Impact of race-specific screening guideline on the uptake of colorectal cancer screening among young African Americans.
Authors: Tak H.J. , Pan I.W. , Halpern M.T. , Shih Y.T. .
Source: Cancer Medicine, 2022-05-29 00:00:00.0; , .
EPub date: 2022-05-29 00:00:00.0.
PMID: 35644919
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Financial toxicity impact on younger versus older adults with cancer in the setting of care delivery.
Authors: Corrigan K.L. , Fu S. , Chen Y.S. , Kaiser K. , Roth M. , Peterson S.K. , Shih Y.T. , Jagsi R. , Giordano S.H. , Volk R.J. , et al. .
Source: Cancer, 2022-04-13 00:00:00.0; , .
EPub date: 2022-04-13 00:00:00.0.
PMID: 35417565
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Patient, physician, and policy factors underlying variation in use of telemedicine for radiation oncology cancer care.
Authors: De B. , Fu S. , Chen Y.S. , Das P. , Ku K. , Maroongroge S. , Woodhouse K.D. , Hoffman K.E. , Nguyen Q.N. , Reed V.K. , et al. .
Source: Cancer Medicine, 2022-03-16 00:00:00.0; , .
EPub date: 2022-03-16 00:00:00.0.
PMID: 35297210
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Geographic Access to Radiation Therapy Facilities in the United States.
Authors: Maroongroge S. , Wallington D.G. , Taylor P.A. , Zhu D. , Guadagnolo B.A. , Smith B.D. , Yu J.B. , Ballas L.K. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2022-03-01 00:00:00.0; 112(3), p. 600-610.
EPub date: 2021-11-08 00:00:00.0.
PMID: 34762972
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Smoking cessation services and shared decision-making practices among lung cancer screening facilities: A cross-sectional study.
Authors: Lowenstein L.M. , Nishi S.P.E. , Lopez-Olivo M.A. , Crocker L.C. , Choi N. , Kim B. , Shih Y.T. , Volk R.J. .
Source: Cancer, 2022-02-14 00:00:00.0; , .
EPub date: 2022-02-14 00:00:00.0.
PMID: 35157302
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Treating the Whole Patient With Cancer: The Critical Importance of Understanding and Addressing the Trajectory of Medical Financial Hardship.
Authors: Yabroff K.R. , Shih Y.T. , Bradley C.J. .
Source: Journal Of The National Cancer Institute, 2022-01-04 00:00:00.0; , .
EPub date: 2022-01-04 00:00:00.0.
PMID: 34981116
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Contemporary Outcomes After Multimodality Therapy in Patients With Breast Cancer Presenting With Ipsilateral Supraclavicular Node Involvement.
Authors: Diao K. , Andring L.M. , Barcenas C.H. , Singh P. , Carisa Le-Petross H. , Reed V.K. , Reddy J.P. , Bloom E.S. , Ahmad N.R. , Mayo L.L. , et al. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2022-01-01 00:00:00.0; 112(1), p. 66-74.
EPub date: 2021-10-25 00:00:00.0.
PMID: 34710521
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Sensitivity of Psychosocial Distress Screening to Identify Cancer Patients at Risk for Financial Hardship During Care Delivery.
Authors: Maldonado J.A. , Fu S. , Chen Y.S. , Acquati C. , Yabroff K.R. , Banegas M.P. , Chang S. , Conti R.M. , Checka C.M. , Peterson S.K. , et al. .
Source: Jco Oncology Practice, 2021 Dec; 17(12), p. e1856-e1865.
EPub date: 2021-05-27 00:00:00.0.
PMID: 34043452
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Increased Incidence of Human Papillomavirus-Related Precancer or Second Malignancy Among Allogeneic Stem Cell Transplantation Patients: A SEER-Medicare Population Study.
Authors: Zhao H. , Duan Z. , Li M. , Chiao E. , Ahmed S. , Shih Y.T. , Hwang J.P. .
Source: Transplantation And Cellular Therapy, 2021 Dec; 27(12), p. 1016.e1-1016.e9.
EPub date: 2021-08-30 00:00:00.0.
PMID: 34474166
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A look at the gynecologic oncologist workforce - Are we meeting patient demand?
Authors: Ackroyd S.A. , Shih Y.T. , Kim B. , Lee N.K. , Halpern M.T. .
Source: Gynecologic Oncology, 2021 Nov; 163(2), p. 229-236.
EPub date: 2021-08-27 00:00:00.0.
PMID: 34456058
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Addressing Cancer Financial Hardship Begins With Comprehensive Assessment of Patient Economic Burden.
Authors: Shih Y.T. , Lipscomb J. .
Source: Journal Of The National Cancer Institute, 2021-10-26 00:00:00.0; , .
EPub date: 2021-10-26 00:00:00.0.
PMID: 34698844
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Financial Hardship in Survivorship Care Delivery.
Authors: Smith G.L. , Mendoza T.R. , Lowenstein L.M. , Shih Y.T. .
Source: Journal Of The National Cancer Institute. Monographs, 2021-09-03 00:00:00.0; 2021(57), p. 10-14.
PMID: 34478512
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Financial Burden of Discarded Weight-based Antineoplastic Drugs to Payers and Patients in the Private Insurance Market.
Authors: Shih Y.T. , Xu Y. , Zhao H. , Schrag D. , Yao J. .
Source: Jnci Cancer Spectrum, 2021 Aug; 5(4), p. pkab045.
EPub date: 2021-05-18 00:00:00.0.
PMID: 34350376
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Cost-Sharing and Out-of-Pocket Cost for Women Who Received MRI for Breast Cancer Screening.
Authors: Pan I.W. , Oeffinger K.C. , Shih Y.T. .
Source: Journal Of The National Cancer Institute, 2021-07-28 00:00:00.0; , .
EPub date: 2021-07-28 00:00:00.0.
PMID: 34320199
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Financial Toxicity in Head and Neck Cancer Patients Treated With Proton Therapy.
Authors: Smith G.L. , Shih Y.T. , Frank S.J. .
Source: International Journal Of Particle Therapy, 2021 Summer; 8(1), p. 366-373.
EPub date: 2021-06-25 00:00:00.0.
PMID: 34285962
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Identifying Preferred Breast Cancer Risk Predictors: A Holistic Perspective.
Authors: Etzioni R. , Shen Y. , Shih Y.T. .
Source: Journal Of The National Cancer Institute, 2021-06-01 00:00:00.0; 113(6), p. 660-661.
PMID: 33301010
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Five-Year Longitudinal Analysis of Patient-Reported Outcomes and Cosmesis in a Randomized Trial of Conventionally Fractionated Versus Hypofractionated Whole-Breast Irradiation.
Authors: Weng J.K. , Lei X. , Schlembach P. , Bloom E.S. , Shaitelman S.F. , Arzu I.Y. , Chronowski G. , Dvorak T. , Grade E. , Hoffman K. , et al. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2021-05-13 00:00:00.0; , .
EPub date: 2021-05-13 00:00:00.0.
PMID: 33992718
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Incorporating Baseline Breast Density When Screening Women at Average Risk for Breast Cancer : A Cost-Effectiveness Analysis.
Authors: Shih Y.T. , Dong W. , Xu Y. , Etzioni R. , Shen Y. .
Source: Annals Of Internal Medicine, 2021 May; 174(5), p. 602-612.
EPub date: 2021-02-09 00:00:00.0.
PMID: 33556275
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Influence of Geography on Prostate Cancer Treatment.
Authors: Tang C. , Lei X. , Smith G.L. , Pan H.Y. , Hoffman K.E. , Kumar R. , Chapin B.F. , Shih Y.T. , Frank S.J. , Smith B.D. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 2021-04-01 00:00:00.0; 109(5), p. 1286-1295.
EPub date: 2020-12-13 00:00:00.0.
PMID: 33316361
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Variation in Use of High-Cost Technologies for Palliative Radiation Therapy by Radiation Oncologists.
Authors: Chen A.B. , Niu J. , Cronin A.M. , Shih Y.T. , Giordano S. , Schrag D. .
Source: Journal Of The National Comprehensive Cancer Network : Jnccn, 2021 04; 19(4), p. 421-431.
EPub date: 2021-02-12 00:00:00.0.
PMID: 33578375
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State of Physician and Pharmacist Oncology Workforce in the United States in 2019.
Authors: Shih Y.T. , Kim B. , Halpern M.T. .
Source: Jco Oncology Practice, 2021 01; 17(1), p. e1-e10.
EPub date: 2020-12-03 00:00:00.0.
PMID: 33270520
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Implementation of Shared Decision Making for Lung Cancer Screening Among the Privately Insured Nonelderly.
Authors: Shih Y.T. , Xu Y. , Lowenstein L.M. , Volk R.J. .
Source: Mdm Policy & Practice, 2021 Jan-Jun; 6(1), p. 2381468320984773.
EPub date: 2021-01-27 00:00:00.0.
PMID: 33598545
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Updated Analysis of Complication Rates Associated With Invasive Diagnostic Procedures After Lung Cancer Screening.
Authors: Zhao H. , Xu Y. , Huo J. , Burks A.C. , Ost D.E. , Shih Y.T. .
Source: Jama Network Open, 2020-12-01 00:00:00.0; 3(12), p. e2029874.
EPub date: 2020-12-01 00:00:00.0.
PMID: 33326023
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Time to add screening for financial hardship as a quality measure?
Authors: Bradley C.J. , Yabroff K.R. , Zafar S.Y. , Shih Y.T. .
Source: Ca: A Cancer Journal For Clinicians, 2020-11-23 00:00:00.0; , .
EPub date: 2020-11-23 00:00:00.0.
PMID: 33226648
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Quantitative 3-Dimensional Photographic Assessment of Breast Cosmesis After Whole Breast Irradiation for Early Stage Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Authors: Chapman B.V. , Lei X. , Patil P. , Tripathi S. , Nicklaus K.M. , Grossberg A.J. , Shaitelman S.F. , Thompson A.M. , Hunt K.K. , Buchholz T.A. , et al. .
Source: Advances In Radiation Oncology, 2020 Sep-Oct; 5(5), p. 824-833.
EPub date: 2020-05-21 00:00:00.0.
PMID: 33083644
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The impact of co-surgeons on complication rates and healthcare cost in patients undergoing microsurgical breast reconstruction: analysis of 8680 patients.
Authors: Asaad M. , Xu Y. , Chu C.K. , Shih Y.T. , Mericli A.F. .
Source: Breast Cancer Research And Treatment, 2020-08-16 00:00:00.0; , .
EPub date: 2020-08-16 00:00:00.0.
PMID: 32803638
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Choice of local therapy for young women with early-stage breast cancer who have young-aged children.
Authors: Pan I.W. , Yen T.W.F. , Huo J. , Chen C. , Smith B.D. , Shih Y.T. .
Source: Cancer, 2020-08-05 00:00:00.0; , .
EPub date: 2020-08-05 00:00:00.0.
PMID: 32757314
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Multidisciplinary Management of Breast Cancer With Extensive Regional Nodal Involvement.
Authors: Smith B.D. , Goetz M.P. , Boughey J.C. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2020-07-10 00:00:00.0; 38(20), p. 2290-2298.
EPub date: 2020-05-22 00:00:00.0.
PMID: 32442073
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Understanding Financial Hardship Among Cancer Survivors in the United States: Strategies for Prevention and Mitigation.
Authors: Yabroff K.R. , Bradley C. , Shih Y.T. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2020-02-01 00:00:00.0; 38(4), p. 292-301.
EPub date: 2019-12-05 00:00:00.0.
PMID: 31804869
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