Grant Details
Grant Number: |
1R01CA207130-01 Interpret this number |
Primary Investigator: |
Irwin, Michael |
Organization: |
University Of California Los Angeles |
Project Title: |
Sleep Disturbance, Inflammation, and Cellular Aging in Breast Cancer Survivors |
Fiscal Year: |
2016 |
Abstract
Project Summary/Abstract
Advances in cancer treatment have resulted in a growing number of cancer survivors in the United States.
Despite the success of cancer treatments, survivors face long-term changes in health, with twice the likelihood
of disability as those without a cancer history, greater risk for second primary cancers, more age-related
comorbid disorders, and 28% reduction in life expectancy. This study hypothesizes that the increased risk of
morbidity and mortality in cancer survivors is due to accelerated biological aging. Furthermore given that the
risk for the late effects of cancer diagnosis and treatment show considerable variability, individual differences
may either confer protection or promote vulnerability. Given our preliminary data that sleep disturbance leads
to greater increases in inflammation and telomere erosion over a one year period, we further hypothesize that
sleep disturbance and depression history serve as susceptibility factors to accelerate biological aging. To
examine these questions, this study leverages an existing project (CA160245) of a Kaiser Permanente
Southern California (KPSC) SEER-affiliated tumor registry-based sample of 300 (>55 years) breast cancer
survivors, includes biological aging outcomes of cellular and transcriptional markers of inflammation and
telomere erosion, and recruits a KPSC comparison cohort of 300 older women without a cancer history. Both
KPSC groups will be examined at baseline and prospectively followed at 8, 16, 24, and 32 months to address
three specific aims: 1) to examine differences at baseline and in prospective rate of change of cellular and
transcriptional markers of inflammation and telomere length as a function of breast cancer survivorship; 2) to
examine differences at baseline and in prospective rate of change of cellular and transcriptional markers of
inflammation and telomere length as a function of sleep disturbance and breast cancer survivorship; 3) to
examine differences at baseline and in prospective rate of change of cellular and transcriptional markers of
inflammation and telomere length as a function of depression history and breast cancer survivorship
This study will determine whether biological aging is driven by breast cancer status, by independent effects of
sleep disturbance or depression history, or by the interaction of these behavioral factors with breast cancer
status. Such information is necessary to define the risk population (i.e., breast cancer survivors, depression
history) and/or risk factors (i.e., sleep disturbance) in the design, implementation, and delivery of treatments,
which selectively target biological aging with greatest efficacy with the potential to reduce risk of age-related
morbidities.
Publications
Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature.
Authors: Irwin M.R.
.
Source: Temperature (austin, Tex.), 2023; 10(2), p. 198-234.
EPub date: 2022-08-21 00:00:00.0.
PMID: 37332305
Related Citations
Association of Physical Activity With Risk of Mortality Among Breast Cancer Survivors.
Authors: Chen L.H.
, Irwin M.R.
, Olmstead R.
, Haque R.
.
Source: Jama Network Open, 2022-11-01 00:00:00.0; 5(11), p. e2242660.
EPub date: 2022-11-01 00:00:00.0.
PMID: 36394875
Related Citations
Accelerated mononuclear cell telomere attrition in breast cancer survivors with depression history: A 2-year longitudinal cohort study.
Authors: Carroll J.E.
, Olmstead R.
, Haque R.
, Irwin M.R.
.
Source: Cancer, 2022-06-07 00:00:00.0; , .
EPub date: 2022-06-07 00:00:00.0.
PMID: 35670038
Related Citations
Insomnia and Susceptibility to Depressive Symptoms and Fatigue in Diverse Breast Cancer Survivors.
Authors: Haque R.
, Hsu J.W.
, Avila C.
, Olmstead R.
, Carroll J.E.
, Irwin M.R.
.
Source: Journal Of Women's Health (2002), 2021 11; 30(11), p. 1604-1615.
EPub date: 2020-10-09 00:00:00.0.
PMID: 33035108
Related Citations
Motivation and sensitivity to monetary reward in late-life insomnia: moderating role of sex and the inflammatory marker CRP.
Authors: Boyle C.C.
, Cho J.H.
, Eisenberger N.I.
, Olmstead R.E.
, Piber D.
, Sadeghi N.
, Tazhibi M.
, Irwin M.R.
.
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2020 09; 45(10), p. 1664-1671.
EPub date: 2020-06-16 00:00:00.0.
PMID: 32544926
Related Citations
Novel neuroimmunologic therapeutics in depression: A clinical perspective on what we know so far.
Authors: Roman M.
, Irwin M.R.
.
Source: Brain, Behavior, And Immunity, 2020 Jan; 83, p. 7-21.
EPub date: 2019-09-21 00:00:00.0.
PMID: 31550500
Related Citations
Sleep and inflammation: partners in sickness and in health.
Authors: Irwin M.R.
.
Source: Nature Reviews. Immunology, 2019 11; 19(11), p. 702-715.
PMID: 31289370
Related Citations
Daily interpersonal stress, sleep duration, and gene regulation during late adolescence.
Authors: Chiang J.J.
, Cole S.W.
, Bower J.E.
, Irwin M.R.
, Taylor S.E.
, Arevalo J.
, Fuligni A.J.
.
Source: Psychoneuroendocrinology, 2019 05; 103, p. 147-155.
EPub date: 2018-12-28 00:00:00.0.
PMID: 30690224
Related Citations
Cognitive performance in survivors of breast cancer and markers of biological aging.
Authors: Carroll J.E.
, Van Dyk K.
, Bower J.E.
, Scuric Z.
, Petersen L.
, Schiestl R.
, Irwin M.R.
, Ganz P.A.
.
Source: Cancer, 2018-11-26 00:00:00.0; , .
EPub date: 2018-11-26 00:00:00.0.
PMID: 30474160
Related Citations
Insomnia and inflammation: a two hit model of depression risk and prevention.
Authors: Irwin M.R.
, Piber D.
.
Source: World Psychiatry : Official Journal Of The World Psychiatric Association (wpa), 2018 Oct; 17(3), p. 359-361.
PMID: 30229570
Related Citations
A longitudinal investigation of internalized stigma, constrained disclosure, and quality of life across 12 weeks in lung cancer patients on active oncologic treatment.
Authors: Williamson T.J.
, Choi A.K.
, Kim J.C.
, Garon E.B.
, Shapiro J.R.
, Irwin M.R.
, Goldman J.W.
, Bornyazan K.
, Carroll J.M.
, Stanton A.L.
.
Source: Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer, 2018-07-05 00:00:00.0; , .
EPub date: 2018-07-05 00:00:00.0.
PMID: 29981926
Related Citations
Sleep disturbance and kynurenine metabolism in depression.
Authors: Cho H.J.
, Savitz J.
, Dantzer R.
, Teague T.K.
, Drevets W.C.
, Irwin M.R.
.
Source: Journal Of Psychosomatic Research, 2017 Aug; 99, p. 1-7.
EPub date: 2017-05-22 00:00:00.0.
PMID: 28712413
Related Citations