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Grant Details

Grant Number: 4R01CA179977-04 Interpret this number
Primary Investigator: Kerr, Jacqueline
Organization: University Of California, San Diego
Project Title: (PQA4) Gps Exposure to Environments & Relations with Biomarkers of Cancer Risk
Fiscal Year: 2016


Abstract

DESCRIPTION (provided by applicant): Physical inactivity, an unhealthy diet, and obesity are related to breast and colon cancer directly and through insulin and inflammation pathways. Greater access to healthy environments in residential neighborhoods is associated with higher physical activity (PA), a healthier diet, lower BMI, and in one study lower insulin resistance. Despite some significant findings, the effect sizes in built environment research have been small likely because of a mismatch between the environment assessed (home neighborhoods only) and location where the behaviors occur. Temporal variation in behaviors and locations within and across days has also been ignored. We propose to advance methods of cancer risk exposure assessment by measuring both neighborhood access and total environment exposure to healthy environments by dynamically integrating Global Positioning System (GPS) data with Geographical Information System (GIS) data. We hypothesize that dynamic GPS based measures of environmental exposure will be more strongly related to behavior and insulin and inflammation biomarkers than static addressed based GIS measures of access. We will study a large sample of adults (N=700), 40-75 years old, who have lived at their residence at least one year. We will recruit participants from census blocks specially selected to vary by income, walkability, and food environments to ensure environmental variability not achieved in a random sample. We will ensure balanced recruitment by census block type (walkability & food environments) across ethnicity, gender, age, and season. Half the sample will be Hispanic to explore potential interaction effects by ethnicity. Participants will complete surveys about their PA, sedentary behavior, environmental perceptions, self-selection, cancer risk, and demographics. PA and sedentary behavior will also be assessed by accelerometry and Machine Learning techniques will be employed to objectively identify specific behaviors likely related to the built environment e.g. walking, biking, riding in a car, screen time etc. Participants will complete the ASA 24 to assess diet, total calories and fat calories. A subsample (N=50) will wear a SenseCam to assess social context, validate GIS built environment measures, and validate the Machine Learned categories. Dynamic GIS measures of exposure will be created from 7 day person worn GPS data matched to GIS indicators of supportive PA and food environments (e.g. parks, walkable streets, fresh produce markets etc.) weighted by time, speed, transportation mode and features of the environment e.g. parcel size. Static residential GIS buffers of access to neighborhood resources will be created within a 1km street network buffer around a participant's home. Using multilevel statistical models adjusting for clustering, we will investigate whether GPS based Dynamic GIS measures of exposure to healthy food and PA supportive environments are more strongly associated with breast and colon cancer risk factors - including behaviors (PA, sedentary behavior, & diet), BMI, and biomarkers of insulin resistance and inflammation (e.g. CRP, IL-6, HOMA-IR) than Static GIS measures of access to neighborhood resources.



Publications

Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women.
Authors: Chang Y.J. , Tuz-Zahra F. , Godbole S. , Avitia Y. , Bellettiere J. , Rock C.L. , Jankowska M.M. , Allison M.A. , Dunstan D.W. , Rana B. , et al. .
Source: Scientific reports, 2021-06-03; 11(1), p. 11766.
EPub date: 2021-06-03.
PMID: 34083573
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Device-Measured and Self-Reported Active Travel Associations with Cardiovascular Disease Risk Factors in an Ethnically Diverse Sample of Adults.
Authors: Crist K. , Benmarhnia T. , Zamora S. , Yang J.A. , Sears D.D. , Natarajan L. , Dillon L. , Sallis J.F. , Jankowska M.M. .
Source: International journal of environmental research and public health, 2021-04-08; 18(8), .
EPub date: 2021-04-08.
PMID: 33917841
Related Citations

Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers.
Authors: Chang Y.J. , Bellettiere J. , Godbole S. , Keshavarz S. , Maestas J.P. , Unkart J.T. , Ervin D. , Allison M.A. , Rock C.L. , Patterson R.E. , et al. .
Source: Journal of the American Heart Association, 2020-02-18; 9(4), p. e013403.
EPub date: 2020-02-17.
PMID: 32063113
Related Citations

Changes in Moderate Intensity Physical Activity Are Associated With Better Cognition in the Multilevel Intervention for Physical Activity in Retirement Communities (MIPARC) Study.
Authors: Zlatar Z.Z. , Godbole S. , Takemoto M. , Crist K. , Sweet C.M.C. , Kerr J. , Rosenberg D.E. .
Source: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019 10; 27(10), p. 1110-1121.
EPub date: 2019-04-29.
PMID: 31138456
Related Citations

Protocol for a cross sectional study of cancer risk, environmental exposures and lifestyle behaviors in a diverse community sample: the Community of Mine study.
Authors: Jankowska M.M. , Sears D.D. , Natarajan L. , Martinez E. , Anderson C.A.M. , Sallis J.F. , Matthews S.A. , Crist K. , Dillon L. , Johnson E. , et al. .
Source: BMC public health, 2019-02-13; 19(1), p. 186.
EPub date: 2019-02-13.
PMID: 30760246
Related Citations

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.
Authors: McAllister K. , Mechanic L.E. , Amos C. , Aschard H. , Blair I.A. , Chatterjee N. , Conti D. , Gauderman W.J. , Hsu L. , Hutter C.M. , et al. .
Source: American journal of epidemiology, 2017-10-01; 186(7), p. 753-761.
PMID: 28978193
Related Citations

Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors.
Authors: Jankowska M.M. , Natarajan L. , Godbole S. , Meseck K. , Sears D.D. , Patterson R.E. , Kerr J. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 07; 26(7), p. 1078-1084.
EPub date: 2017-03-03.
PMID: 28258052
Related Citations

"Spatial Energetics": Integrating Data From GPS, Accelerometry, and GIS to Address Obesity and Inactivity.
Authors: James P. , Jankowska M. , Marx C. , Hart J.E. , Berrigan D. , Kerr J. , Hurvitz P.M. , Hipp J.A. , Laden F. .
Source: American journal of preventive medicine, 2016 11; 51(5), p. 792-800.
EPub date: 2016-08-12.
PMID: 27528538
Related Citations

Is missing geographic positioning system data in accelerometry studies a problem, and is imputation the solution?
Authors: Meseck K. , Jankowska M.M. , Schipperijn J. , Natarajan L. , Godbole S. , Carlson J. , Takemoto M. , Crist K. , Kerr J. .
Source: Geospatial health, 2016-05-31; 11(2), p. 403.
EPub date: 2016-05-31.
PMID: 27245796
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