Skip to main content
Grant Details

Grant Number: 4P01CA168530-05 Interpret this number
Primary Investigator: Le Marchand, Loic
Organization: University Of Hawaii At Manoa
Project Title: Obesity, Body Fat Distribution, and Cancer Risk in the Multiethnic Cohort
Fiscal Year: 2016
Back to top


DESCRIPTION (provided by applicant): Obesity explains approximately 20% of all cancers in the U.S. Our current understanding of the mechanisms involved is only partial, and has not led to effective interventions. As the current obesity epidemic continues unabated, especially among the poor and lower middle class, it is feared that recent progress in lowering cancer rates may be reversed, and health disparities worsened. Markedly different patterns of adiposity exist among the five ethnic/racial populations of the Multiethnic Cohort (MEC) Study (African Americans, Japanese Americans, Latinos, Native Hawaiians, whites). Most surprisingly, we observed striking ethnic differences in the association of BMI with cancer. For example, for breast cancer, the association was strongest, and occurred starting at low levels of BMI (>25 kg/m2), for Japanese Americans and Native Hawaiians, two groups with more central adiposity. In contrast, the association in the other ethnic groups occurred only at high BMI levels (>30 kg/m2). We interpret these differences as supporting an important role for body fat distribution, i addition to amount. Our preliminary data also suggest that considering lifestyle variables and biomarkers in addition to BMI and waist measures improves the size predictions for central adiposity, intra-abdominal visceral fat, and liver fat, as assessed by DXA and MRI. Thus far, there has been no comprehensive study of obesity patterns and their determinants in U.S. ethnic/racial minorities and of their relationships with cancer risk. We propose a new program of research that will: 1) describe the amount and distribution of body fat in 5 major U.S. ethnic/racial populations using whole body DXA and abdominal MRI; 2) identify nutritional, behavioral, biochemical, genetic, metabolomic and gut microbiome predictors of these fat distribution patterns; 3) investigate inter-relationships among these predictors to better understand the causes of obesity; 4) build integrated predictive models for these body fat distributions phenotypes; and 5) test prospectively these predicted phenotypes for associations with breast and colorectal cancer risks in the MEC. A better understanding of the causes of obesity in ethnic/racial minorities may open new avenues for prevention and treatment and help in reducing health disparities.

Back to top


Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups.
Authors: Lim U. , Monroe K.R. , Buchthal S. , Fan B. , Cheng I. , Kristal B.S. , Lampe J.W. , Hullar M.A. , Franke A.A. , Stram D.O. , et al. .
Source: Gastroenterology, 2018-11-13 00:00:00.0; , .
EPub date: 2018-11-13 00:00:00.0.
PMID: 30445012
Related Citations

Optimization of ESI-Source Parameters for Lipidomics Reduces Misannotation of In-Source Fragments as Precursor Ions.
Authors: Gathungu R.M. , Larrea P. , SniatynskI M.J. , Marur V.R. , Bowden J.A. , Koelmel J.P. , Starke-Reed P. , Hubbard V.S. , Kristal B.S. .
Source: Analytical Chemistry, 2018-09-28 00:00:00.0; , .
EPub date: 2018-09-28 00:00:00.0.
PMID: 30265528
Related Citations

The integration of LC-MS and NMR for the analysis of low molecular weight trace analytes in complex matrices.
Authors: Gathungu R.M. , Kautz R. , Kristal B.S. , Bird S.S. , Vouros P. .
Source: Mass Spectrometry Reviews, 2018-07-19 00:00:00.0; , .
EPub date: 2018-07-19 00:00:00.0.
PMID: 30024655
Related Citations

Authors: Randolph T.W. , Zhao S. , Copeland W. , Hullar M. , Shojaie A. .
Source: The Annals Of Applied Statistics, 2018 Mar; 12(1), p. 540-566.
EPub date: 2018-03-09 00:00:00.0.
PMID: 30224943
Related Citations

Plasma lipopolysaccharide-binding protein and colorectal cancer risk: a nested case-control study in the Multiethnic Cohort.
Authors: Citronberg J.S. , Wilkens L.R. , Le Marchand L. , Lim U. , Monroe K.R. , Hullar M.A.J. , White E. , Newcomb P.A. , Lampe J.W. .
Source: Cancer Causes & Control : Ccc, 2017-11-30 00:00:00.0; , .
EPub date: 2017-11-30 00:00:00.0.
PMID: 29189972
Related Citations

Diet Quality in Midadulthood Predicts Visceral Adiposity and Liver Fatness in Older Ages: The Multiethnic Cohort Study.
Authors: Maskarinec G. , Lim U. , Jacobs S. , Monroe K.R. , Ernst T. , Buchthal S.D. , Shepherd J.A. , Wilkens L.R. , Le Marchand L. , Boushey C.J. .
Source: Obesity (silver Spring, Md.), 2017 Aug; 25(8), p. 1442-1450.
PMID: 28745024
Related Citations

Simple LC-MS Method for Differentiation of Isobaric Phosphatidylserines and Phosphatidylcholines with Deuterated Mobile Phase Additives.
Authors: Gathungu R.M. , Stavrovskaya I.G. , Larrea P. , Sniatynski M.J. , Kristal B.S. .
Source: Analytical Chemistry, 2016-09-20 00:00:00.0; 88(18), p. 9103-10.
EPub date: 2016-08-26 00:00:00.0.
PMID: 27532481
Related Citations

Reliability of plasma lipopolysaccharide-binding protein (LBP) from repeated measures in healthy adults.
Authors: Citronberg J.S. , Wilkens L.R. , Lim U. , Hullar M.A. , White E. , Newcomb P.A. , Le Marchand L. , Lampe J.W. .
Source: Cancer Causes & Control : Ccc, 2016 Sep; 27(9), p. 1163-6.
PMID: 27392432
Related Citations

Characterization of the gut microbiome in epidemiologic studies: the multiethnic cohort experience.
Authors: Fu B.C. , Randolph T.W. , Lim U. , Monroe K.R. , Cheng I. , Wilkens L.R. , Le Marchand L. , Hullar M.A. , Lampe J.W. .
Source: Annals Of Epidemiology, 2016 May; 26(5), p. 373-9.
PMID: 27039047
Related Citations

Mechanisms Linking The Gut Microbiome And Glucose Metabolism
Authors: Utzschneider K.M. , Kratz M. , Damman C.J. , Hullarg M. .
Source: The Journal Of Clinical Endocrinology And Metabolism, 2016 Apr; 101(4), p. 1445-54.
PMID: 26938201
Related Citations

Sex and Ethnic Differences in the Association of Obesity With Risk of Hepatocellular Carcinoma.
Authors: Setiawan V.W. , Lim U. , Lipworth L. , Lu S.C. , Shepherd J. , Ernst T. , Wilkens L.R. , Henderson B.E. , Le Marchand L. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2016 Feb; 14(2), p. 309-16.
PMID: 26404865
Related Citations

Identification of metabolites from liquid chromatography-coulometric array detection profiling: gas chromatography-mass spectrometry and refractionation provide essential information orthogonal to LC-MS/microNMR.
Authors: Gathungu R.M. , Bird S.S. , Sheldon D.P. , Kautz R. , Vouros P. , Matson W.R. , Kristal B.S. .
Source: Analytical Biochemistry, 2014-06-01 00:00:00.0; 454, p. 23-32.
EPub date: 2014-06-01 00:00:00.0.
PMID: 24657819
Related Citations

Diet, the gut microbiome, and epigenetics.
Authors: Hullar M.A. , Fu B.C. .
Source: Cancer Journal (sudbury, Mass.), 2014 May-Jun; 20(3), p. 170-5.
PMID: 24855003
Related Citations

Comparative Study Of Computational Methods For Reconstructing Genetic Networks Of Cancer-related Pathways
Authors: Sedaghat N. , Saegusa T. , Randolph T. , Shojaie A. .
Source: Cancer Informatics, 2014; 13(Suppl 2), p. 55-66.
PMID: 25288880
Related Citations

University of Hawai'i Cancer Center Connection: bias in self-reported anthropometry in relation to adiposity and adulthood weight gain among postmenopausal Caucasian and Japanese American Women.
Authors: Lim U. , Wilkens L.R. , Albright C.L. , Novotny R. , Le Marchand L. , Kolonel L.N. .
Source: Hawai'i Journal Of Medicine & Public Health : A Journal Of Asia Pacific Medicine & Public Health, 2013 Dec; 72(12), p. 445-9.
PMID: 24377081
Related Citations

Back to Top