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Grant Details

Grant Number: 4R01CA160245-05 Interpret this number
Primary Investigator: Irwin, Michael
Organization: University Of California Los Angeles
Project Title: Sleep, Inflamation, and Depression Occurrence in Breast Cancer Survivors
Fiscal Year: 2016
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Abstract

DESCRIPTION (provided by applicant): In 2006, there were over 11.4 million cancer survivors in the US. However for many individuals with cancer, improved survival is complicated by long-term behavioral effects including depression. Indeed, the prevalence of depression in breast cancer survivors is nearly three to five times greater than the general population. Yet, the unique clinical, behavioral, and biological factors that prospectively contribute to increased depression risk in breast cancer survivors is not known. In older adults, we have found that sleep disturbance independently contributes to depression occurrence, and this prospective risk is specific to those with a history of depression. Breast cancer status may add to that risk, as we have found that breast cancer survivors with insomnia have a prevalence of depression history that is nearly twice that in older women with insomnia; yet, other factors in the prior risk model do not generalize to breast cancer survivors. There are no published prospective data that have examined the independent contribution of sleep disturbance on depression occurrence in breast cancer survivors. Increasing evidence also implicates sleep disturbance in the activation of inflammatory signaling, which serves as a biological mechanism that contributes to depression. Hence, in this SEER-affiliated tumor registry-based study, we will evaluate 300 early stage-, older adult (>55 years) breast cancer survivors and 300 age-matched comparison women, stratified by a history of major depression. All participants will be community members of Kaiser Permanente Southern California (KPSC), a large nonprofit health plan that serves over 3 million members. In a prospective cohort study, older adult breast cancer survivors vs. comparisons, stratified by depression history will be evaluated at baseline (i.e., 1 year post- primary treatmen for breast cancer survivors) and at 6, 12, 18, and 24 months with the following aims: 1) to determine the prospective association between sleep disturbance and depression occurrence; 2) to evaluate the prospective association between sleep disturbance and cellular and genomic markers of inflammation; and 3) to examine the prospective relationships between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence. Understanding the cancer-specific clinical, behavioral, and biological factors that prospectively contribute to depression risk in breast cancer survivors vs. comparison older women will substantially alter clinical management by leading to the development of a targeted intervention for depression prevention, specific for breast cancer survivors.

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Publications

Cognitive performance in survivors of breast cancer and markers of biological aging.
Authors: Carroll J.E. , Van Dyk K. , Bower J.E. , Scuric Z. , Petersen L. , Schiestl R. , Irwin M.R. , Ganz P.A. .
Source: Cancer, 2018-11-26 00:00:00.0; , .
EPub date: 2018-11-26 00:00:00.0.
PMID: 30474160
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Insomnia and inflammation: a two hit model of depression risk and prevention.
Authors: Irwin M.R. , Piber D. .
Source: World Psychiatry : Official Journal Of The World Psychiatric Association (wpa), 2018 Oct; 17(3), p. 359-361.
PMID: 30229570
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A longitudinal investigation of internalized stigma, constrained disclosure, and quality of life across 12 weeks in lung cancer patients on active oncologic treatment.
Authors: Williamson T.J. , Choi A.K. , Kim J.C. , Garon E.B. , Shapiro J.R. , Irwin M.R. , Goldman J.W. , Bornyazan K. , Carroll J.M. , Stanton A.L. .
Source: Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer, 2018-07-05 00:00:00.0; , .
EPub date: 2018-07-05 00:00:00.0.
PMID: 29981926
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Inflammation and Improvement of Depression Following Electroconvulsive Therapy in Treatment-Resistant Depression.
Authors: Kruse J.L. , Congdon E. , Olmstead R. , Njau S. , Breen E.C. , Narr K.L. , Espinoza R. , Irwin M.R. .
Source: The Journal Of Clinical Psychiatry, 2018 Mar/Apr; 79(2), .
PMID: 29489077
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Tai Chi Chih Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia in Survivors of Breast Cancer: A Randomized, Partially Blinded, Noninferiority Trial.
Authors: Irwin M.R. , Olmstead R. , Carrillo C. , Sadeghi N. , Nicassio P. , Ganz P.A. , Bower J.E. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-08-10 00:00:00.0; 35(23), p. 2656-2665.
EPub date: 2017-05-10 00:00:00.0.
PMID: 28489508
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Sleep disturbance and kynurenine metabolism in depression.
Authors: Cho H.J. , Savitz J. , Dantzer R. , Teague T.K. , Drevets W.C. , Irwin M.R. .
Source: Journal Of Psychosomatic Research, 2017 Aug; 99, p. 1-7.
EPub date: 2017-05-22 00:00:00.0.
PMID: 28712413
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Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study.
Authors: Carroll J.E. , Irwin M.R. , Levine M. , Seeman T.E. , Absher D. , Assimes T. , Horvath S. .
Source: Biological Psychiatry, 2017-01-15 00:00:00.0; 81(2), p. 136-144.
EPub date: 2016-07-26 00:00:00.0.
PMID: 27702440
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Reciprocal Relationship Between Sleep Macrostructure and Evening and Morning Cellular Inflammation in Rheumatoid Arthritis.
Authors: Bjurström M.F. , Olmstead R. , Irwin M.R. .
Source: Psychosomatic Medicine, 2017 Jan; 79(1), p. 24-33.
PMID: 27428854
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Exposure to an inflammatory challenge enhances neural sensitivity to negative and positive social feedback.
Authors: Muscatell K.A. , Moieni M. , Inagaki T.K. , Dutcher J.M. , Jevtic I. , Breen E.C. , Irwin M.R. , Eisenberger N.I. .
Source: Brain, Behavior, And Immunity, 2016 Oct; 57, p. 21-9.
PMID: 27032568
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Daily family stress and HPA axis functioning during adolescence: The moderating role of sleep.
Authors: Chiang J.J. , Tsai K.M. , Park H. , Bower J.E. , Almeida D.M. , Dahl R.E. , Irwin M.R. , Seeman T.E. , Fuligni A.J. .
Source: Psychoneuroendocrinology, 2016 Sep; 71, p. 43-53.
EPub date: 2016-05-09 00:00:00.0.
PMID: 27235639
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Has adult sleep duration declined over the last 50+ years?
Authors: Youngstedt S.D. , Goff E.E. , Reynolds A.M. , Kripke D.F. , Irwin M.R. , Bootzin R.R. , Khan N. , Jean-Louis G. .
Source: Sleep Medicine Reviews, 2016 Aug; 28, p. 69-85.
PMID: 26478985
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Yearning for connection? Loneliness is associated with increased ventral striatum activity to close others.
Authors: Inagaki T.K. , Muscatell K.A. , Moieni M. , Dutcher J.M. , Jevtic I. , Irwin M.R. , Eisenberger N.I. .
Source: Social Cognitive And Affective Neuroscience, 2016 Jul; 11(7), p. 1096-101.
PMID: 26084531
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Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation.
Authors: Irwin M.R. , Olmstead R. , Carroll J.E. .
Source: Biological Psychiatry, 2016-07-01 00:00:00.0; 80(1), p. 40-52.
EPub date: 2016-07-01 00:00:00.0.
PMID: 26140821
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Polysomnographic measures of sleep in cocaine dependence and alcohol dependence: Implications for age-related loss of slow wave, stage 3 sleep.
Authors: Irwin M.R. , Bjurstrom M.F. , Olmstead R. .
Source: Addiction (abingdon, England), 2016 Jun; 111(6), p. 1084-92.
PMID: 26749502
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Polysomnographic characteristics in nonmalignant chronic pain populations: A review of controlled studies.
Authors: Bjurstrom M.F. , Irwin M.R. .
Source: Sleep Medicine Reviews, 2016 Apr; 26, p. 74-86.
PMID: 26140866
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Preexisting mild sleep disturbance as a vulnerability factor for inflammation-induced depressed mood: a human experimental study.
Authors: Cho H.J. , Eisenberger N.I. , Olmstead R. , Breen E.C. , Irwin M.R. .
Source: Translational Psychiatry, 2016-03-08 00:00:00.0; 6, p. e750.
EPub date: 2016-03-08 00:00:00.0.
PMID: 26954978
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Mind-body therapies and control of inflammatory biology: A descriptive review.
Authors: Bower J.E. , Irwin M.R. .
Source: Brain, Behavior, And Immunity, 2016 Jan; 51, p. 1-11.
PMID: 26116436
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Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans.
Authors: Carroll J.E. , Cole S.W. , Seeman T.E. , Breen E.C. , Witarama T. , Arevalo J.M. , Ma J. , Irwin M.R. .
Source: Brain, Behavior, And Immunity, 2016 Jan; 51, p. 223-9.
PMID: 26336034
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Trait sensitivity to social disconnection enhances pro-inflammatory responses to a randomized controlled trial of endotoxin.
Authors: Moieni M. , Irwin M.R. , Jevtic I. , Breen E.C. , Cho H.J. , Arevalo J.M. , Ma J. , Cole S.W. , Eisenberger N.I. .
Source: Psychoneuroendocrinology, 2015 Dec; 62, p. 336-42.
PMID: 26360770
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Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late-life insomnia: a randomized controlled trial.
Authors: Irwin M.R. , Olmstead R. , Breen E.C. , Witarama T. , Carrillo C. , Sadeghi N. , Arevalo J.M. , Ma J. , Nicassio P. , Bootzin R. , et al. .
Source: Biological Psychiatry, 2015-11-15 00:00:00.0; 78(10), p. 721-9.
EPub date: 2015-11-15 00:00:00.0.
PMID: 25748580
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Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder.
Authors: Coccaro E.F. , Lee R. , Breen E.C. , Irwin M.R. .
Source: Psychiatry Research, 2015-10-30 00:00:00.0; 229(3), p. 844-9.
EPub date: 2015-10-30 00:00:00.0.
PMID: 26277033
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Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin.
Authors: Moieni M. , Irwin M.R. , Jevtic I. , Breen E.C. , Eisenberger N.I. .
Source: Brain, Behavior, And Immunity, 2015 Aug; 48, p. 132-8.
PMID: 25770082
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Blocking opioids attenuates physical warmth-induced feelings of social connection.
Authors: Inagaki T.K. , Irwin M.R. , Eisenberger N.I. .
Source: Emotion (washington, D.c.), 2015 Aug; 15(4), p. 494-500.
PMID: 26098729
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Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans.
Authors: Irwin M.R. , Witarama T. , Caudill M. , Olmstead R. , Breen E.C. .
Source: Brain, Behavior, And Immunity, 2015 Jul; 47, p. 86-92.
PMID: 25451613
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Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression.
Authors: Moieni M. , Irwin M.R. , Jevtic I. , Olmstead R. , Breen E.C. , Eisenberger N.I. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2015 Jun; 40(7), p. 1709-16.
PMID: 25598426
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Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial.
Authors: Black D.S. , O'Reilly G.A. , Olmstead R. , Breen E.C. , Irwin M.R. .
Source: Jama Internal Medicine, 2015 Apr; 175(4), p. 494-501.
PMID: 25686304
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Socioeconomic status, daily affective and social experiences, and inflammation during adolescence.
Authors: Chiang J.J. , Bower J.E. , Almeida D.M. , Irwin M.R. , Seeman T.E. , Fuligni A.J. .
Source: Psychosomatic Medicine, 2015 Apr; 77(3), p. 256-66.
PMID: 25829237
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Opioid treatment of experimental pain activates nuclear factor-¿B.
Authors: Compton P. , Griffis C. , Breen E.C. , Torrington M. , Sadakane R. , Tefera E. , Irwin M.R. .
Source: Journal Of Opioid Management, 2015 Mar-Apr; 11(2), p. 115-25.
PMID: 25901477
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Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging.
Authors: Carroll J.E. , Carrillo C. , Olmstead R. , Witarama T. , Breen E.C. , Yokomizo M. , Seeman T. , Irwin M.R. .
Source: Sleep, 2015-02-01 00:00:00.0; 38(2), p. 205-11.
EPub date: 2015-02-01 00:00:00.0.
PMID: 25325509
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The role of the ventral striatum in inflammatory-induced approach toward support figures.
Authors: Inagaki T.K. , Muscatell K.A. , Irwin M.R. , Moieni M. , Dutcher J.M. , Jevtic I. , Breen E.C. , Eisenberger N.I. .
Source: Brain, Behavior, And Immunity, 2015 Feb; 44, p. 247-52.
PMID: 25459101
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Why sleep is important for health: a psychoneuroimmunology perspective.
Authors: Irwin M.R. .
Source: Annual Review Of Psychology, 2015-01-03 00:00:00.0; 66, p. 143-72.
EPub date: 2015-01-03 00:00:00.0.
PMID: 25061767
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Sleep and multisystem biological risk: a population-based study.
Authors: Carroll J.E. , Irwin M.R. , Stein Merkin S. , Seeman T.E. .
Source: Plos One, 2015; 10(2), p. e0118467.
PMID: 25714703
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Approach and avoidance coping: diurnal cortisol rhythm in prostate cancer survivors.
Authors: Hoyt M.A. , Marin-Chollom A.M. , Bower J.E. , Thomas K.S. , Irwin M.R. , Stanton A.L. .
Source: Psychoneuroendocrinology, 2014 Nov; 49, p. 182-6.
PMID: 25108161
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Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial.
Authors: Irwin M.R. , Olmstead R. , Breen E.C. , Witarama T. , Carrillo C. , Sadeghi N. , Arevalo J.M. , Ma J. , Nicassio P. , Ganz P.A. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Nov; 2014(50), p. 295-301.
PMID: 25749595
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Mindfulness-based intervention for prodromal sleep disturbances in older adults: design and methodology of a randomized controlled trial.
Authors: Black D.S. , O'Reilly G.A. , Olmstead R. , Breen E.C. , Irwin M.R. .
Source: Contemporary Clinical Trials, 2014 Sep; 39(1), p. 22-7.
PMID: 24993561
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From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.
Authors: Slavich G.M. , Irwin M.R. .
Source: Psychological Bulletin, 2014 May; 140(3), p. 774-815.
PMID: 24417575
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The effects of mind-body therapies on the immune system: meta-analysis.
Authors: Morgan N. , Irwin M.R. , Chung M. , Wang C. .
Source: Plos One, 2014; 9(7), p. e100903.
PMID: 24988414
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Tai chi meditation effects on nuclear factor-¿B signaling in lonely older adults: a randomized controlled trial.
Authors: Black D.S. , Irwin M.R. , Olmstead R. , Ji E. , Crabb Breen E. , Motivala S.J. .
Source: Psychotherapy And Psychosomatics, 2014; 83(5), p. 315-7.
PMID: 25116908
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The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer.
Authors: Pomykala K.L. , Ganz P.A. , Bower J.E. , Kwan L. , Castellon S.A. , Mallam S. , Cheng I. , Ahn R. , Breen E.C. , Irwin M.R. , et al. .
Source: Brain Imaging And Behavior, 2013 Dec; 7(4), p. 511-23.
PMID: 23835929
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Depression and insomnia in cancer: prevalence, risk factors, and effects on cancer outcomes.
Authors: Irwin M.R. .
Source: Current Psychiatry Reports, 2013 Nov; 15(11), p. 404.
PMID: 24078066
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Chronic moderate sleep restriction in older long sleepers and older average duration sleepers: a randomized controlled trial.
Authors: Youngstedt S.D. , Jean-Louis G. , Bootzin R.R. , Kripke D.F. , Cooper J. , Dean L.R. , Catao F. , James S. , Vining C. , Williams N.J. , et al. .
Source: Contemporary Clinical Trials, 2013 Sep; 36(1), p. 175-86.
PMID: 23811325
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Cytokine genetic variations and fatigue among patients with breast cancer.
Authors: Bower J.E. , Ganz P.A. , Irwin M.R. , Castellon S. , Arevalo J. , Cole S.W. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2013-05-01 00:00:00.0; 31(13), p. 1656-61.
EPub date: 2013-05-01 00:00:00.0.
PMID: 23530106
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Sleep disturbance, inflammation and depression risk in cancer survivors.
Authors: Irwin M.R. , Olmstead R.E. , Ganz P.A. , Haque R. .
Source: Brain, Behavior, And Immunity, 2013 Mar; 30 Suppl, p. S58-67.
PMID: 22634367
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When grief makes you sick: bereavement induced systemic inflammation is a question of genotype.
Authors: Schultze-Florey C.R. , Martínez-Maza O. , Magpantay L. , Breen E.C. , Irwin M.R. , Gündel H. , O'Connor M.F. .
Source: Brain, Behavior, And Immunity, 2012 Oct; 26(7), p. 1066-71.
PMID: 22735772
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Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults.
Authors: Elderkin-Thompson V. , Irwin M.R. , Hellemann G. , Kumar A. .
Source: The American Journal Of Geriatric Psychiatry : Official Journal Of The American Association For Geriatric Psychiatry, 2012 Sep; 20(9), p. 753-63.
PMID: 22892560
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Inflammation at the intersection of behavior and somatic symptoms.
Authors: Irwin M.R. .
Source: The Psychiatric Clinics Of North America, 2011 Sep; 34(3), p. 605-20.
PMID: 21889682
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Opioids And Social Bonding: Naltrexone Reduces Feelings Of Social Connection
Authors: Inagaki T.K. , Ray L.A. , Irwin M.R. , Way B.M. , Eisenberger N.I. .
Source: Social Cognitive And Affective Neuroscience, 2016 05; 11(5), p. 728-35.
PMID: 26796966
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In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior.
Authors: Eisenberger N.I. , Moieni M. , Inagaki T.K. , Muscatell K.A. , Irwin M.R. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2017 01; 42(1), p. 242-253.
EPub date: 2016-08-02 00:00:00.0.
PMID: 27480575
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Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity.
Authors: Irwin M.R. , Opp M.R. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2017 01; 42(1), p. 129-155.
EPub date: 2016-08-11 00:00:00.0.
PMID: 27510422
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Context-Dependent Effects of Inflammation: Reduced Reward Responding is Not an Invariant Outcome of Sickness.
Authors: Irwin M.R. , Eisenberger N.I. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2017 03; 42(4), p. 785-786.
EPub date: 2016-10-25 00:00:00.0.
PMID: 27779206
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