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Grant Details

Grant Number: 5R21CA185811-02 Interpret this number
Primary Investigator: Hashibe, Mia
Organization: University Of Utah
Project Title: Population-Based Cohort of Endometrial Cancer Survivors in Utah
Fiscal Year: 2016
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Abstract

 DESCRIPTION (provided by applicant): Endometrial cancer is the second most common cancer among female cancer survivors in the United States. There are an estimated 600,000 endometrial cancer survivors today. Additionally, 49,560 incident endometrial cancer cases are diagnosed each year. Endometrial cancer has been identified by the NCI as an understudied cancer site and late effects research on endometrial cancer patients is very limited to our knowledge. Late effects are of concern among cancer patients due to the toxic effects of chemotherapy and radiotherapy. Specific late effects of concern include second primary cancers, osteoporosis, cardio-toxicity, neuro-toxicity, cognitive deficits, depression, chronic fatigue, chronic pain, infertility and sexual dysfunction. The Utah Population Database (UPDB) provides a unique and excellent resource for epidemiologic research, and links data from the Utah Cancer Registry, hospital electronic medical records, Medicare, driver licenses, voter registration, family history records, and birth certificates. We have successfully completed a study of late effects of 1,001 testicular cancer patients with the same study design (93.2% successfully followed up through the EMR). Within the UPDB linked data with the Utah Cancer Registry, we propose to construct a population- based endometrial cancer patient cohort covering the state of Utah. Our specific aims are: (1) To assemble a population-based cohort of 3,400 endometrial cancer patients and 17,000 age-matched cancer-free women for a comparison group, to investigate the incidence of long-term health effects due to endometrial cancer treatment, (2) To assess the feasibility of administering questionnaires to assess lifestyle factors in a sample of the endometrial cancer survivors (n=500) and cancer-free women for a comparison group (n=500), (3) To determine the feasibility of collecting detailed cancer treatment information such as chemotherapy agents from medical records by conducting medical record abstraction among a sample of endometrial cancer patients (n=200), (4) To compare the quality of information obtained from the existing records and the self-report from the questionnaire on late effects, comorbidities, and cancer treatment (n=1,000). The aim 1 late effects analysis is based on existing data (linkage of cancer registry and EMR) and we are able to obtain late effects information on >90% of cancer patients in Utah. Our project addresses the priority research areas highlighted by the NCI: assessment of late effects, study of survivors with comorbidities, and focusing on an understudied cancer. We will assemble an unprecedented high-quality population-based cohort of 3,400 endometrial cancer patients to study late effects for the first time, at a very low cost due to existing linked databases within te UPDB. This application will also lay important foundation work for a future large-scale population-based endometrial cancer survivorship project. Understanding the long-term effects of cancer treatment and their determinants will be extremely valuable for the 600,000 endometrial cancer survivors and the 49,560 women who will be diagnosed this year.

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Publications

Prognostic factors for rural endometrial cancer patients in a population-based cohort.
Authors: Blackburn B.E. , Soisson S. , Rowe K. , Snyder J. , Fraser A. , Deshmukh V. , Newman M. , Smith K. , Herget K. , Kirchhoff A.C. , et al. .
Source: BMC public health, 2019-07-10; 19(1), p. 921.
EPub date: 2019-07-10.
PMID: 31291920
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Predictors of Response Outcomes for Research Recruitment Through a Central Cancer Registry: Evidence From 17 Recruitment Efforts for Population-Based Studies.
Authors: Millar M.M. , Kinney A.Y. , Camp N.J. , Cannon-Albright L.A. , Hashibe M. , Penson D.F. , Kirchhoff A.C. , Neklason D.W. , Gilsenan A.W. , Dieck G.S. , et al. .
Source: American journal of epidemiology, 2019-05-01; 188(5), p. 928-939.
PMID: 30689685
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Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated With Decreased Overall Survival.
Authors: Lloyd S. , Baraghoshi D. , Tao R. , Garrido-Laguna I. , Gilcrease G.W. , Whisenant J. , Weis J.R. , Scaife C. , Pickron T.B. , Huang L.C. , et al. .
Source: American journal of clinical oncology, 2019 Apr; 42(4), p. 355-362.
PMID: 30844850
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Endocrine and Metabolic Diseases among Colorectal Cancer Survivors in a Population-Based Cohort.
Authors: Hawkins M.L. , Blackburn B.E. , Rowe K. , Snyder J. , Deshmukh V.G. , Newman M. , Fraser A. , Smith K. , Herget K. , Ganz P.A. , et al. .
Source: Journal of the National Cancer Institute, 2019-03-27; , .
EPub date: 2019-03-27.
PMID: 30918958
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Reproductive and gynecological complication risks among thyroid cancer survivors.
Authors: Blackburn B.E. , Ganz P.A. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Herget K. , et al. .
Source: Journal of cancer survivorship : research and practice, 2018 10; 12(5), p. 702-711.
EPub date: 2018-08-21.
PMID: 30128858
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Long-term Cardiovascular Outcomes Among Endometrial Cancer Survivors in a Large, Population-Based Cohort Study.
Authors: Soisson S. , Ganz P.A. , Gaffney D. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , et al. .
Source: Journal of the National Cancer Institute, 2018-12-01; 110(12), p. 1342-1351.
PMID: 29741696
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Risk Factors for Cardiovascular Disease Among Thyroid Cancer Survivors: Findings From the Utah Cancer Survivors Study.
Authors: Park J. , Blackburn B.E. , Ganz P.A. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , et al. .
Source: The Journal of clinical endocrinology and metabolism, 2018-07-01; 103(7), p. 2468-2477.
PMID: 29850817
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Rural-metropolitan disparities in ovarian cancer survival: a statewide population-based study.
Authors: Park J. , Blackburn B.E. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Herget K. , et al. .
Source: Annals of epidemiology, 2018 06; 28(6), p. 377-384.
EPub date: 2018-04-12.
PMID: 29705053
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Long-term, adverse genitourinary outcomes among endometrial cancer survivors in a large, population-based cohort study.
Authors: Soisson S. , Ganz P.A. , Gaffney D. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , et al. .
Source: Gynecologic oncology, 2018 03; 148(3), p. 499-506.
EPub date: 2017-12-27.
PMID: 29289418
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Aging-Related Disease Risks among Young Thyroid Cancer Survivors.
Authors: Blackburn B.E. , Ganz P.A. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Herget K. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017 12; 26(12), p. 1695-1704.
EPub date: 2017-11-22.
PMID: 29167277
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