Grant Number:	5R21CA185811-02 Interpret this number
Primary Investigator:	Hashibe, Mia
Organization:	University Of Utah
Project Title:	Population-Based Cohort of Endometrial Cancer Survivors in Utah
Fiscal Year:	2016

 DESCRIPTION (provided by applicant): Endometrial cancer is the second most common cancer among female cancer survivors in the United States. There are an estimated 600,000 endometrial cancer survivors today. Additionally, 49,560 incident endometrial cancer cases are diagnosed each year. Endometrial cancer has been identified by the NCI as an understudied cancer site and late effects research on endometrial cancer patients is very limited to our knowledge. Late effects are of concern among cancer patients due to the toxic effects of chemotherapy and radiotherapy. Specific late effects of concern include second primary cancers, osteoporosis, cardio-toxicity, neuro-toxicity, cognitive deficits, depression, chronic fatigue, chronic pain, infertility and sexual dysfunction. The Utah Population Database (UPDB) provides a unique and excellent resource for epidemiologic research, and links data from the Utah Cancer Registry, hospital electronic medical records, Medicare, driver licenses, voter registration, family history records, and birth certificates. We have successfully completed a study of late effects of 1,001 testicular cancer patients with the same study design (93.2% successfully followed up through the EMR). Within the UPDB linked data with the Utah Cancer Registry, we propose to construct a population- based endometrial cancer patient cohort covering the state of Utah. Our specific aims are: (1) To assemble a population-based cohort of 3,400 endometrial cancer patients and 17,000 age-matched cancer-free women for a comparison group, to investigate the incidence of long-term health effects due to endometrial cancer treatment, (2) To assess the feasibility of administering questionnaires to assess lifestyle factors in a sample of the endometrial cancer survivors (n=500) and cancer-free women for a comparison group (n=500), (3) To determine the feasibility of collecting detailed cancer treatment information such as chemotherapy agents from medical records by conducting medical record abstraction among a sample of endometrial cancer patients (n=200), (4) To compare the quality of information obtained from the existing records and the self-report from the questionnaire on late effects, comorbidities, and cancer treatment (n=1,000). The aim 1 late effects analysis is based on existing data (linkage of cancer registry and EMR) and we are able to obtain late effects information on >90% of cancer patients in Utah. Our project addresses the priority research areas highlighted by the NCI: assessment of late effects, study of survivors with comorbidities, and focusing on an understudied cancer. We will assemble an unprecedented high-quality population-based cohort of 3,400 endometrial cancer patients to study late effects for the first time, at a very low cost due to existing linked databases within te UPDB. This application will also lay important foundation work for a future large-scale population-based endometrial cancer survivorship project. Understanding the long-term effects of cancer treatment and their determinants will be extremely valuable for the 600,000 endometrial cancer survivors and the 49,560 women who will be diagnosed this year.




Adverse Health Outcomes among Rural and Urban Breast Cancer Survivors: A Population-Based Cohort Study.
Authors: Koric A. , Mark B. , Chang C.P. , Lloyd S. , Dodson M. , Deshmukh V.G. , Newman M. , Date A. , Gren L.H. , Porucznik C.A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-10-02 00:00:00.0; 32(10), p. 1302-1311.
PMID: 37462723
Related Citations

Comparing Active Surveillance and Watchful Waiting With Radical Treatment Using Machine Learning Models Among Patients With Prostate Cancer.
Authors: Hu S. , Chang C.P. , Snyder J. , Deshmukh V. , Newman M. , Date A. , Galvao C. , Porucznik C.A. , Gren L.H. , Sanchez A. , et al. .
Source: Jco Clinical Cancer Informatics, 2023 Sep; 7, p. e2300083.
PMID: 37988640
Related Citations

Breast cancer survivorship and sexual dysfunction: a population-based cohort study.
Authors: Chang C.P. , Ho T.F. , Snyder J. , Dodson M. , Deshmukh V. , Newman M. , Date A. , Henry N.L. , Hashibe M. .
Source: Breast Cancer Research And Treatment, 2023-05-09 00:00:00.0; , .
EPub date: 2023-05-09 00:00:00.0.
PMID: 37160510
Related Citations

Sexual dysfunction among gynecologic cancer survivors in a population-based cohort study.
Authors: Chang C.P. , Wilson C.M. , Rowe K. , Snyder J. , Dodson M. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Date A. , et al. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2022-12-17 00:00:00.0; 31(1), p. 51.
EPub date: 2022-12-17 00:00:00.0.
PMID: 36526929
Related Citations

Mental health disorders among ovarian cancer survivors in a population-based cohort.
Authors: Hu S. , Baraghoshi D. , Chang C.P. , Rowe K. , Snyder J. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Peoples A.R. , et al. .
Source: Cancer Medicine, 2022-06-30 00:00:00.0; , .
EPub date: 2022-06-30 00:00:00.0.
PMID: 35773781
Related Citations

Cardiovascular disease risk in long-term breast cancer survivors: A population-based cohort study.
Authors: Koric A. , Chang C.P. , Mark B. , Rowe K. , Snyder J. , Dodson M. , Deshmukh V.G. , Newman M.G. , Fraser A.M. , Smith K.R. , et al. .
Source: Cancer, 2022-05-13 00:00:00.0; , .
EPub date: 2022-05-13 00:00:00.0.
PMID: 35561317
Related Citations

Age-Related Disease Risks in Younger versus Older B-Cell Non-Hodgkin's Lymphoma Survivors.
Authors: Ocier K. , Abdelaziz S. , Kim S. , Rowe K. , Snyder J. , Deshmukh V.G. , Newman M. , Fraser A. , Smith K.R. , Porucznik C.A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021 12; 30(12), p. 2268-2277.
EPub date: 2021-11-03 00:00:00.0.
PMID: 34732401
Related Citations

Cardiovascular disease risks in younger versus older adult B-cell non-Hodgkin's lymphoma survivors.
Authors: Ocier K. , Abdelaziz S. , Kim S. , Rowe K. , Snyder J. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Porucznik C.A. , et al. .
Source: Cancer Medicine, 2021-05-12 00:00:00.0; , .
EPub date: 2021-05-12 00:00:00.0.
PMID: 33979029
Related Citations

Disparities in Cardiovascular Disease Risk Among Hispanic Breast Cancer Survivors in a Population-Based Cohort.
Authors: Hu Q. , Chang C.P. , Rowe K. , Snyder J. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Gren L.H. , Porucznik C. , et al. .
Source: Jnci Cancer Spectrum, 2021 04; 5(2), .
EPub date: 2021-02-15 00:00:00.0.
PMID: 33889806
Related Citations

Genitourinary disease risks among ovarian cancer survivors in a population-based cohort study.
Authors: Chang C.P. , Chen Y. , Blackburn B. , Abdelaziz S. , Rowe K. , Snyder J. , Dodson M. , Deshmukh V. , Newman M. , Stanford J.B. , et al. .
Source: Gynecologic Oncology, 2020 05; 157(2), p. 529-535.
EPub date: 2020-02-29 00:00:00.0.
PMID: 32122688
Related Citations

Rural-urban disparities in colorectal cancer survival and risk among men in Utah: a statewide population-based study.
Authors: Rogers C.R. , Blackburn B.E. , Huntington M. , Curtin K. , Thorpe R.J. , Rowe K. , Snyder J. , Deshmukh V. , Newman M. , Fraser A. , et al. .
Source: Cancer Causes & Control : Ccc, 2020-01-30 00:00:00.0; , .
EPub date: 2020-01-30 00:00:00.0.
PMID: 32002718
Related Citations

Long-term diabetes risk among endometrial cancer survivors in a population-based cohort study.
Authors: Kim S. , Park J. , Chen Y. , Rowe K. , Snyder J. , Fraser A. , Smith K. , Deshmukh V.G. , Newman M. , Herget K. , et al. .
Source: Gynecologic Oncology, 2020 Jan; 156(1), p. 185-193.
EPub date: 2019-12-12 00:00:00.0.
PMID: 31839336
Related Citations

Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study.
Authors: Kawakita D. , Abdelaziz S. , Chen Y. , Rowe K. , Snyder J. , Fraser A. , Smith K. , Herget K. , Deshmukh V. , Newman M. , et al. .
Source: Cancer, 2019-11-13 00:00:00.0; , .
EPub date: 2019-11-13 00:00:00.0.
PMID: 31721181
Related Citations

Prognostic factors for rural endometrial cancer patients in a population-based cohort.
Authors: Blackburn B.E. , Soisson S. , Rowe K. , Snyder J. , Fraser A. , Deshmukh V. , Newman M. , Smith K. , Herget K. , Kirchhoff A.C. , et al. .
Source: Bmc Public Health, 2019-07-10 00:00:00.0; 19(1), p. 921.
EPub date: 2019-07-10 00:00:00.0.
PMID: 31291920
Related Citations

Predictors of Response Outcomes for Research Recruitment Through a Central Cancer Registry: Evidence From 17 Recruitment Efforts for Population-Based Studies.
Authors: Millar M.M. , Kinney A.Y. , Camp N.J. , Cannon-Albright L.A. , Hashibe M. , Penson D.F. , Kirchhoff A.C. , Neklason D.W. , Gilsenan A.W. , Dieck G.S. , et al. .
Source: American Journal Of Epidemiology, 2019-05-01 00:00:00.0; 188(5), p. 928-939.
PMID: 30689685
Related Citations

Mental Health Disorders are More Common in Colorectal Cancer Survivors and Associated With Decreased Overall Survival.
Authors: Lloyd S. , Baraghoshi D. , Tao R. , Garrido-Laguna I. , Gilcrease G.W. , Whisenant J. , Weis J.R. , Scaife C. , Pickron T.B. , Huang L.C. , et al. .
Source: American Journal Of Clinical Oncology, 2019 Apr; 42(4), p. 355-362.
PMID: 30844850
Related Citations

Endocrine and Metabolic Diseases among Colorectal Cancer Survivors in a Population-Based Cohort.
Authors: Hawkins M.L. , Blackburn B.E. , Rowe K. , Snyder J. , Deshmukh V.G. , Newman M. , Fraser A. , Smith K. , Herget K. , Ganz P.A. , et al. .
Source: Journal Of The National Cancer Institute, 2019-03-27 00:00:00.0; , .
EPub date: 2019-03-27 00:00:00.0.
PMID: 30918958
Related Citations

Long-term Cardiovascular Outcomes Among Endometrial Cancer Survivors in a Large, Population-Based Cohort Study.
Authors: Soisson S. , Ganz P.A. , Gaffney D. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , et al. .
Source: Journal Of The National Cancer Institute, 2018-12-01 00:00:00.0; 110(12), p. 1342-1351.
PMID: 29741696
Related Citations

Reproductive and gynecological complication risks among thyroid cancer survivors.
Authors: Blackburn B.E. , Ganz P.A. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Herget K. , et al. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2018-08-21 00:00:00.0; , .
EPub date: 2018-08-21 00:00:00.0.
PMID: 30128858
Related Citations

Risk Factors for Cardiovascular Disease Among Thyroid Cancer Survivors: Findings From the Utah Cancer Survivors Study.
Authors: Park J. , Blackburn B.E. , Ganz P.A. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , et al. .
Source: The Journal Of Clinical Endocrinology And Metabolism, 2018-07-01 00:00:00.0; 103(7), p. 2468-2477.
PMID: 29850817
Related Citations

Rural-metropolitan disparities in ovarian cancer survival: a statewide population-based study.
Authors: Park J. , Blackburn B.E. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Herget K. , et al. .
Source: Annals Of Epidemiology, 2018 Jun; 28(6), p. 377-384.
EPub date: 2018-04-12 00:00:00.0.
PMID: 29705053
Related Citations

Disparities in cancer survival and incidence by metropolitan versus rural residence in Utah.
Authors: Hashibe M. , Kirchhoff A.C. , Kepka D. , Kim J. , Millar M. , Sweeney C. , Herget K. , Monroe M. , Henry N.L. , Lopez A.M. , et al. .
Source: Cancer Medicine, 2018 Apr; 7(4), p. 1490-1497.
EPub date: 2018-03-13 00:00:00.0.
PMID: 29533005
Related Citations

Long-term, adverse genitourinary outcomes among endometrial cancer survivors in a large, population-based cohort study.
Authors: Soisson S. , Ganz P.A. , Gaffney D. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , et al. .
Source: Gynecologic Oncology, 2018 Mar; 148(3), p. 499-506.
EPub date: 2017-12-27 00:00:00.0.
PMID: 29289418
Related Citations

Aging-Related Disease Risks among Young Thyroid Cancer Survivors.
Authors: Blackburn B.E. , Ganz P.A. , Rowe K. , Snyder J. , Wan Y. , Deshmukh V. , Newman M. , Fraser A. , Smith K. , Herget K. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 Dec; 26(12), p. 1695-1704.
EPub date: 2017-11-22 00:00:00.0.
PMID: 29167277
Related Citations