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Grant Details

Grant Number: 5R03CA197879-02 Interpret this number
Primary Investigator: Wu, Kana
Organization: Harvard School Of Public Health
Project Title: Early Life Risk Factors and Risk of Colorectal Neoplasia
Fiscal Year: 2016


Abstract

¿ DESCRIPTION (provided by applicant): Three recent commentaries and a summary of the 2011 NCI Expert Panel Workshop on "Early-life Events and Cancer" have emphasized the urgent need for more epidemiological research on early life exposures and adult cancers. Puberty is associated with a physiological decrease in insulin sensitivity and during the growth period concentrations of growth factors such as insulin-like growth factor 1 (IGF1) are up to four times higher than during adulthood. Thus, childhood and adolescence may represent periods with higher susceptibility to risk factors associated with hyperinsulinemia, increased IGF1 levels or increased DNA damage and inefficient DNA repair. The vast majority of studies on risk factors and colorectal cancer (CRC) have focused on exposures in mid- to late life and very little is known about timing of exposure, i.e. at which stage(s) during the life cycle a given exposure is etiologically relevant; or the effect of cumulative exposure. We previously found that in the Nurses' Health Study II (NHS II), independent of adult exposures, higher body fatness during childhood and a "western dietary pattern" during adolescence was associated with higher risk of colorectal adenoma. We propose to utilize the unique data resources of the NHS II and examine the association between early life risk factors and risk of adenoma and CRC. The NHS II was started in 1989 when over 116,000 female nurses provided information on lifestyle and medical history. Starting in 1991, we also collected information on diet. Information on lifestyle was updated every two years and diet and activity every four years. In 1997, we collected data on lifetime physical activity and in 1998 about 45,000 women completed a 124-item semi-quantitative food frequency questionnaire on their diet during high school. Aim 1 will assess the association between amount, intensity of physical activity and sedentary behavior during childhood and adolescence and risk of colorectal neoplasia. Aims 2 and 3 will focus on two dietary factors (milk and folate) hypothesized to exert differential effects on carcinogenesis depending on the timing of exposure. Crucial components of this proposal include: a) availability of both early life and adult exposures, allowing us to examine independent and joint associations, which will help to improve cancer prevention strategies, e.g., whether a higher risk conferred by diet and lifestyle during childhood or adolescence can be mitigated by modifications to diet and lifestyle during adulthood; and b) assessment of CRC and its intermediate adenoma as outcome, which will also help to better understand pathways underlying the transformation from adenoma to carcinoma. Thus, our proposal will provide more insight into the etiology of CRC and inform cancer prevention strategies, e.g., whether to shift the focus of some interventions in mid- to late adulthood to interventions that start in earlier stages of the life course and whether to use information on risk factors throughout the life course to guide prevention counseling.



Publications

Simple Prediction Model for Colorectal Serrated Polyps: Development and External Validation Study in U.S. Prospective Cohorts.
Authors: Lyu Z. , Hang D. , He X. , Wu K. , Cao Y. , Rosner B. , Chan A.T. , Ogino S. , Li N. , Dai M. , et al. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2023-05-01 00:00:00.0; 16(5), p. 293-302.
PMID: 36857746
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Fructose consumption from different food sources and cardiometabolic biomarkers: cross-sectional associations in US men and women.
Authors: Li X. , Joh H.K. , Hur J. , Song M. , Zhang X. , Cao Y. , Wu K. , Giovannucci E.L. .
Source: The American Journal Of Clinical Nutrition, 2023 Mar; 117(3), p. 490-498.
EPub date: 2023-01-13 00:00:00.0.
PMID: 36811469
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Fructose consumption from different food sources and cardiometabolic biomarkers: cross-sectional associations in US men and women.
Authors: Li X. , Joh H.K. , Hur J. , Song M. , Zhang X. , Cao Y. , Wu K. , Giovannucci E.L. .
Source: The American Journal Of Clinical Nutrition, 2023 Mar; 117(3), p. 490-498.
EPub date: 2023-01-13 00:00:00.0.
PMID: 36811469
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Ultra-processed food consumption and risk of colorectal cancer precursors: results from 3 prospective cohorts.
Authors: Hang D. , Wang L. , Fang Z. , Du M. , Wang K. , He X. , Khandpur N. , Rossato S.L. , Wu K. , Hu Z. , et al. .
Source: Journal Of The National Cancer Institute, 2023-02-08 00:00:00.0; 115(2), p. 155-164.
PMID: 36477589
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Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor-infiltrating lymphocyte levels.
Authors: Ugai T. , Liu L. , Tabung F.K. , Hamada T. , Langworthy B.W. , Akimoto N. , Haruki K. , Takashima Y. , Okadome K. , Kawamura H. , et al. .
Source: Clinical And Translational Medicine, 2022 Nov; 12(11), p. e1114.
PMID: 36437503
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Total calcium, dairy foods and risk of colorectal cancer: a prospective cohort study of younger US women.
Authors: Kim H. , Hur J. , Wu K. , Song M. , Wang M. , Smith-Warner S.A. , Zhang X. , Giovannucci E.L. .
Source: International Journal Of Epidemiology, 2022-10-31 00:00:00.0; , .
EPub date: 2022-10-31 00:00:00.0.
PMID: 36315018
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Adherence to a healthy lifestyle in relation to colorectal cancer incidence and all-cause mortality after endoscopic polypectomy: A prospective study in three U.S. cohorts.
Authors: Wang L. , Knudsen M.D. , Lo C.H. , Wang K. , He M. , Polychronidis G. , Hang D. , He X. , Zhong R. , Wu K. , et al. .
Source: International Journal Of Cancer, 2022-06-18 00:00:00.0; , .
EPub date: 2022-06-18 00:00:00.0.
PMID: 35716133
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Sugar-sweetened beverage and sugar consumption and colorectal cancer incidence and mortality according to anatomic subsite.
Authors: Yuan C. , Joh H.K. , Wang Q.L. , Zhang Y. , Smith-Warner S.A. , Wang M. , Song M. , Cao Y. , Zhang X. , Zoltick E.S. , et al. .
Source: The American Journal Of Clinical Nutrition, 2022-04-25 00:00:00.0; , .
EPub date: 2022-04-25 00:00:00.0.
PMID: 35470384
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Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment.
Authors: Väyrynen J.P. , Haruki K. , Lau M.C. , Väyrynen S.A. , Ugai T. , Akimoto N. , Zhong R. , Zhao M. , Dias Costa A. , Borowsky J. , et al. .
Source: Cancer Immunology Research, 2021-12-22 00:00:00.0; , .
EPub date: 2021-12-22 00:00:00.0.
PMID: 34937729
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Gallstone Disease and Risk of Conventional Adenomas and Serrated Polyps: A Prospective Study.
Authors: Polychronidis G. , Wang K. , Lo C.H. , Wang L. , He M. , Knudsen M.D. , Wu K. , Joshi A.D. , Ogino S. , Giovannucci E.L. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-10-07 00:00:00.0; , .
EPub date: 2021-10-07 00:00:00.0.
PMID: 34620626
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Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival.
Authors: Zoltick E.S. , Smith-Warner S.A. , Yuan C. , Wang M. , Fuchs C.S. , Meyerhardt J.A. , Chan A.T. , Ng K. , Ogino S. , Stampfer M.J. , et al. .
Source: British Journal Of Cancer, 2021-07-15 00:00:00.0; , .
EPub date: 2021-07-15 00:00:00.0.
PMID: 34267328
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The sulfur microbial diet is associated with increased risk of early-onset colorectal cancer precursors.
Authors: Nguyen L.H. , Cao Y. , Hur J. , Mehta R.S. , Sikavi D.R. , Wang Y. , Ma W. , Wu K. , Song M. , Giovannucci E.L. , et al. .
Source: Gastroenterology, 2021-07-14 00:00:00.0; , .
EPub date: 2021-07-14 00:00:00.0.
PMID: 34273347
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Changes in lifestyle factors after endoscopic screening: a prospective study in the US.
Authors: Knudsen M.D. , Wang L. , Wang K. , Wu K. , Ogino S. , Chan A.T. , Giovannucci E. , Song M. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2021-07-10 00:00:00.0; , .
EPub date: 2021-07-10 00:00:00.0.
PMID: 34256146
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Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors.
Authors: Kim H. , Lipsyc-Sharf M. , Zong X. , Wang X. , Hur J. , Song M. , Wang M. , Smith-Warner S.A. , Fuchs C. , Ogino S. , et al. .
Source: Gastroenterology, 2021-07-07 00:00:00.0; , .
EPub date: 2021-07-07 00:00:00.0.
PMID: 34245763
Related Citations

Discovery and features of an alkylating signature in colorectal cancer.
Authors: Gurjao C. , Zhong R. , Haruki K. , Li Y.Y. , Spurr L.F. , Lee-Six H. , Reardon B. , Ugai T. , Zhang X. , Cherniack A.D. , et al. .
Source: Cancer Discovery, 2021-06-17 00:00:00.0; , .
EPub date: 2021-06-17 00:00:00.0.
PMID: 34140290
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Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.
Authors: Hur J. , Otegbeye E. , Joh H.K. , Nimptsch K. , Ng K. , Ogino S. , Meyerhardt J.A. , Chan A.T. , Willett W.C. , Wu K. , et al. .
Source: Gut, 2021-05-06 00:00:00.0; , .
EPub date: 2021-05-06 00:00:00.0.
PMID: 33958435
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Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment.
Authors: Väyrynen J.P. , Haruki K. , Väyrynen S.A. , Lau M.C. , Dias Costa A. , Borowsky J. , Zhao M. , Ugai T. , Kishikawa J. , Akimoto N. , et al. .
Source: Journal For Immunotherapy Of Cancer, 2021 Apr; 9(4), .
PMID: 33931472
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Simple Sugar and Sugar-Sweetened Beverage Intake During Adolescence and Risk of Colorectal Cancer Precursors.
Authors: Joh H.K. , Lee D.H. , Hur J. , Nimptsch K. , Chang Y. , Joung H. , Zhang X. , Rezende L.F.M. , Lee J.E. , Ng K. , et al. .
Source: Gastroenterology, 2021-03-19 00:00:00.0; , .
EPub date: 2021-03-19 00:00:00.0.
PMID: 33753105
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Alcohol intake in early adulthood and risk of colorectal cancer: three large prospective cohort studies of men and women in the United States.
Authors: Hur J. , Smith-Warner S.A. , Rimm E.B. , Willett W.C. , Wu K. , Cao Y. , Giovannucci E. .
Source: European Journal Of Epidemiology, 2021-02-15 00:00:00.0; , .
EPub date: 2021-02-15 00:00:00.0.
PMID: 33586078
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Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes.
Authors: Wang L. , He X. , Ugai T. , Haruki K. , Lo C.H. , Hang D. , Akimoto N. , Fujiyoshi K. , Wang M. , Fuchs C.S. , et al. .
Source: Jnci Cancer Spectrum, 2021 02; 5(1), .
EPub date: 2020-10-07 00:00:00.0.
PMID: 33442661
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Dairy intake during adolescence and risk of colorectal adenoma later in life.
Authors: Nimptsch K. , Lee D.H. , Zhang X. , Song M. , Farvid M.S. , Rezende L.F.M. , Cao Y. , Chan A.T. , Fuchs C. , Meyerhardt J. , et al. .
Source: British Journal Of Cancer, 2021-01-04 00:00:00.0; , .
EPub date: 2021-01-04 00:00:00.0.
PMID: 33398066
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Rising incidence of early-onset colorectal cancer - a call to action.
Authors: Akimoto N. , Ugai T. , Zhong R. , Hamada T. , Fujiyoshi K. , Giannakis M. , Wu K. , Cao Y. , Ng K. , Ogino S. .
Source: Nature Reviews. Clinical Oncology, 2020-11-20 00:00:00.0; , .
EPub date: 2020-11-20 00:00:00.0.
PMID: 33219329
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Glucosamine and chondroitin supplements and risk of colorectal adenoma and serrated polyp.
Authors: Lee D.H. , Cao C. , Zong X. , Zhang X. , O'Connell K. , Song M. , Wu K. , Du M. , Cao Y. , Giovannucci E.L. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-10-14 00:00:00.0; , .
EPub date: 2020-10-14 00:00:00.0.
PMID: 33055203
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The prognostic role of macrophage polarization in the colorectal cancer microenvironment.
Authors: Väyrynen J.P. , Haruki K. , Lau M.C. , Väyrynen S.A. , Zhong R. , Dias Costa A. , Borowsky J. , Zhao M. , Fujiyoshi K. , Arima K. , et al. .
Source: Cancer Immunology Research, 2020-10-06 00:00:00.0; , .
EPub date: 2020-10-06 00:00:00.0.
PMID: 33023967
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Post-diagnosis dietary insulinemic potential and survival outcomes among colorectal cancer patients.
Authors: Tabung F.K. , Noonan A. , Lee D.H. , Song M. , Clinton S.K. , Spakowicz D. , Wu K. , Cheng E. , Meyerhardt J.A. , Fuchs C.S. , et al. .
Source: Bmc Cancer, 2020-08-27 00:00:00.0; 20(1), p. 817.
EPub date: 2020-08-27 00:00:00.0.
PMID: 32854644
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Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas.
Authors: Lo C.H. , Nguyen L.H. , Wu K. , Ogino S. , Chan A.T. , Giovannucci E.L. , Song M. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2020-07-29 00:00:00.0; , .
EPub date: 2020-07-29 00:00:00.0.
PMID: 32727821
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Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study.
Authors: Lo C.H. , Kwon S. , Wang L. , Polychronidis G. , Knudsen M.D. , Zhong R. , Cao Y. , Wu K. , Ogino S. , Giovannucci E.L. , et al. .
Source: Gut, 2020-07-20 00:00:00.0; , .
EPub date: 2020-07-20 00:00:00.0.
PMID: 32690603
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A prospective study of erythrocyte polyunsaturated fatty acids and risk of colorectal serrated polyps and conventional adenomas.
Authors: Wang L. , Hang D. , He X. , Lo C.H. , Wu K. , Chan A.T. , Ogino S. , Giovannucci E.L. , Song M. .
Source: International Journal Of Cancer, 2020-07-07 00:00:00.0; , .
EPub date: 2020-07-07 00:00:00.0.
PMID: 32638350
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Prognostic significance of immune cell populations identified by machine learning in colorectal cancer using routine hematoxylin & eosin stained sections.
Authors: Väyrynen J.P. , Lau M.C. , Haruki K. , Väyrynen S.A. , Dias Costa A. , Borowsky J. , Zhao M. , Fujiyoshi K. , Arima K. , Twombly T.S. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2020-05-21 00:00:00.0; , .
EPub date: 2020-05-21 00:00:00.0.
PMID: 32439699
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Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer.
Authors: Zheng X. , Wu K. , Song M. , Ogino S. , Fuchs C.S. , Chan A.T. , Giovannucci E.L. , Cao Y. , Zhang X. .
Source: Gut, 2020 May; 69(5), p. 970-972.
EPub date: 2019-06-17 00:00:00.0.
PMID: 31209182
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Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum.
Authors: Wang L. , Lo C.H. , He X. , Hang D. , Wang M. , Wu K. , Chan A.T. , Ogino S. , Giovannucci E.L. , Song M. .
Source: Gastroenterology, 2020-04-01 00:00:00.0; , .
EPub date: 2020-04-01 00:00:00.0.
PMID: 32247020
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Body fatness over the life course and risk of serrated polyps and conventional adenomas.
Authors: Lo C.H. , He X. , Hang D. , Wu K. , Ogino S. , Chan A.T. , Giovannucci E.L. , Song M. .
Source: International Journal Of Cancer, 2020-03-09 00:00:00.0; , .
EPub date: 2020-03-09 00:00:00.0.
PMID: 32150293
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Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
Authors: He X. , Hang D. , Wu K. , Nayor J. , Drew D.A. , Giovannucci E.L. , Ogino S. , Chan A.T. , Song M. .
Source: Gastroenterology, 2019-07-11 00:00:00.0; , .
EPub date: 2019-07-11 00:00:00.0.
PMID: 31302144
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Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II.
Authors: Rezende L.F.M. , Lee D.H. , Keum N. , Nimptsch K. , Song M. , Lee I.M. , Eluf-Neto J. , Ogino S. , Fuchs C. , Meyerhardt J. , et al. .
Source: British Journal Of Cancer, 2019-05-22 00:00:00.0; , .
EPub date: 2019-05-22 00:00:00.0.
PMID: 31114018
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Dietary intake of fiber, whole grains and risk of colorectal cancer: An updated analysis according to food sources, tumor location and molecular subtypes in two large US cohorts.
Authors: He X. , Wu K. , Zhang X. , Nishihara R. , Cao Y. , Fuchs C.S. , Giovannucci E.L. , Ogino S. , Chan A.T. , Song M. .
Source: International Journal Of Cancer, 2019-05-01 00:00:00.0; , .
EPub date: 2019-05-01 00:00:00.0.
PMID: 31044426
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Is Timing Important? The Role of Diet and Lifestyle during Early Life on Colorectal Neoplasia.
Authors: Nimptsch K. , Wu K. .
Source: Current Colorectal Cancer Reports, 2018 Feb; 14(1), p. 1-11.
EPub date: 2018-01-18 00:00:00.0.
PMID: 30140177
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