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Grant Details

Grant Number: 5R01CA163805-06 Interpret this number
Primary Investigator: Juon, Hee-Soon
Organization: Thomas Jefferson University
Project Title: Lay Health Worker Model to Reduce Liver Cancer Disparities in Asian Americans
Fiscal Year: 2016


DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) infection is globally most common and serious viral infection of the liver. It can cause premature death from liver diseases or liver cancer. Chronic HBV infection and liver cancer caused by HBV among Asian Americans and Pacific Islanders (AAPIs) is one of the most serious - but frequently neglected-health disparity issues in the U.S. AAPIs account for over half of the 1.3 million chronic hepatitis B cases and deaths from HBV infection. This excess risk can be attributed to high rates of HBV infection (particularly among first-generation immigrants) in combination with low rates of HBV screening and vaccination due to cultural, linguistic, and financial barriers. HBV infection affect Asian Americans disproportionately, and thus it leads to a huge liver cancer disparity among Asian Americans compared to other racial/ethnic groups. In response to these cancer disparities, the objective of this project is to build a sustainable, community-based, participator program of lay health workers (LHWs) who can promote liver cancer prevention programs among high-risk groups of Asian Americans. This proposed study attempts to implement culturally integrated liver cancer prevention programs for Chinese, Korean, and Vietnamese Americans through outreach, screening, education, research, and training in the Baltimore-Washington Metropolitan Area. The specific aims are: (1) To develop a training protocol and certificate program for LHWs; (2) To assess the prevalence of HBV infection; (3) To implement intervention programs, based on screening test results; and (4) To evaluate the effectiveness of LHW intervention on adherence to HBV vaccinations among those unprotected. A total of 600 Asian American adults (200 Chinese, Koreans, and Vietnamese in each group), 18 years of age and older will be recruited from the community. Trained and certified LHWs will recruit participants at community-based organizations and hep B free screening events. All the eligible participants will complete a self-administered questionnaire and receive liver cancer education. Then, they will receive hepatitis B test. Every participant will receive the results of screening tests by mail or phone. We will provide referral services for treatment to those infected. For those unprotected, we will implement intervention programs to increase a series of vaccinations within 6 months using a randomized controlled design. Seven months after mailing the results, we will conduct telephone interviews among those unprotected. Upon completing follow-up, those in the control will receive the delayed LHW intervention. The insights gained from this proposed LHW intervention will be valuable in implementing liver cancer prevention programs for other high-risk non-English speaking populations and will address health disparities among immigrant populations.


Racial Discrimination and Health-Related Quality of Life: An Examination Among Asian American Immigrants.
Authors: Jung M.Y. , Juon H.S. , Slopen N. , He X. , Thomas S.B. , Lee S. .
Source: Journal of racial and ethnic health disparities, 2022 Aug; 9(4), p. 1262-1275.
EPub date: 2021-06-04.
PMID: 34086197
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Assessment of Hepatitis B Virus Screening Behaviors among Asian-Americans through the Lens of Social Cognitive Theory.
Authors: Le D. , Hong A. , Hui S.A. , Rimal R.N. , Juon H.S. .
Source: Californian journal of health promotion, 2021 Jul; 19(1), p. 76-83.
PMID: 34566536
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Hypertension Prevalence, Treatment, and Related Behaviors Among Asian Americans: An Examination by Method of Measurement and Disaggregated Subgroups.
Authors: Jung M.Y. , Lee S. , Thomas S.B. , Juon H.S. .
Source: Journal of racial and ethnic health disparities, 2019 Jun; 6(3), p. 584-593.
EPub date: 2019-01-07.
PMID: 30618006
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The Association Between Perceived Stress and Hypertension Among Asian Americans: Does Social Support and Social Network Make a Difference?
Authors: Lu X. , Juon H.S. , He X. , Dallal C.M. , Wang M.Q. , Lee S. .
Source: Journal of community health, 2019 Jun; 44(3), p. 451-462.
PMID: 30604222
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Prevalence of Viral Hepatitis in Foreign-Born Populations in the Baltimore-Washington Metropolitan Area, 2009-2015.
Authors: Juon H.S. , Ha E. , Kim F. , Trang A. , Pan J. , Blanchard J. .
Source: Journal of community health, 2019 Apr; 44(2), p. 203-207.
PMID: 30259234
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The association of perceived discrimination and depressive symptoms among Chinese, Korean, and Vietnamese Americans.
Authors: Chau V. , Bowie J.V. , Juon H.S. .
Source: Cultural diversity & ethnic minority psychology, 2018 Jul; 24(3), p. 389-399.
EPub date: 2018-02-01.
PMID: 29389149
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Predictors of Colorectal Cancer Knowledge and Screening Among Asian Americans Aged 50-75 years old.
Authors: Juon H.S. , Guo J. , Kim J. , Lee S. .
Source: Journal of racial and ethnic health disparities, 2018 Jun; 5(3), p. 545-552.
EPub date: 2017-06-29.
PMID: 28664503
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Social Norm, Family Communication, and HBV Screening among Asian Americans.
Authors: Juon H.S. , Rimal R.N. , Klassen A. , Lee S. .
Source: Journal of health communication, 2017 Dec; 22(12), p. 981-989.
EPub date: 2017-11-27.
PMID: 29173103
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Lay Health Worker Intervention Improved Compliance with Hepatitis B Vaccination in Asian Americans: Randomized Controlled Trial.
Authors: Juon H.S. , Strong C. , Kim F. , Park E. , Lee S. .
Source: PloS one, 2016; 11(9), p. e0162683.
EPub date: 2016-09-12.
PMID: 27617742
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Depression among Asian-American Adults in the Community: Systematic Review and Meta-Analysis.
Authors: Kim H.J. , Park E. , Storr C.L. , Tran K. , Juon H.S. .
Source: PloS one, 2015; 10(6), p. e0127760.
EPub date: 2015-06-01.
PMID: 26029911
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