Skip to main content

COVID-19 Resources

What people with cancer should know:

Guidance for cancer researchers:

Get the latest public health information from CDC:

Get the latest research information from NIH:

Grant Details

Grant Number: 4R01CA161780-05 Interpret this number
Primary Investigator: Schiffman, Joshua
Organization: University Of Utah
Project Title: Genetic Risk Factors for Ewing's Sarcoma
Fiscal Year: 2016


DESCRIPTION (provided by applicant): Ewing's sarcoma is the second most common bone tumor in children and adolescents. When presenting with metastases or relapse, it is an often fatal disease. Unfortunately, little is known about the epidemiology or genetic risks for this deadly cancer. Ewing's sarcoma almost always contains a specific translocation between EWS-FLI1, are another fusion partner with the EWS gene. Recent laboratory investigations have revealed that a minimum number of microsatellite repeats are necessary in the promoter regions of the genes affected by the EWS-FLI1 translocation protein. These microsatellite repeats are necessary for Ewing's sarcoma tumors to develop in vitro. Another commonly reported feature of Ewing's sarcoma includes a very strong Caucasian predominance (the disease rarely occurs in Asian or African-American patients and only occasionally occurs in Hispanic patients) and also the association of increased hernias in patients who develop Ewing's sarcoma. For this study, we will collect DNA from 550 cases of Ewing's sarcoma in North America, along with DNA from both parents when available. We will then investigate: 1) whether children who develop Ewing's sarcoma have inherited longer microsatellite regions from their parents, 2) if non-Caucasian cases of Ewing's sarcoma actually contain genetic Caucasian ancestral markers, and 3) if cases of Ewing's sarcoma have inherited genomic variants associated with Ewing's sarcoma translocation genes and hernia-development. This study will help to explain the genetic risks for Ewing's sarcoma, one of the most deadly cancers in children and young adults.


EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma.
Authors: Tanner J.M. , Bensard C. , Wei P. , Krah N.M. , Schell J.C. , Gardiner J. , Schiffman J. , Lessnick S.L. , Rutter J. .
Source: Molecular cancer research : MCR, 2017 11; 15(11), p. 1517-1530.
EPub date: 2017-07-18.
PMID: 28720588
Related Citations

20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities.
Authors: Woo D. , Debette S. , Anderson C. .
Source: Neurology. Genetics, 2017 Mar; 3(1 Suppl 1), p. S12-S18.
EPub date: 2017-03-30.
PMID: 28428978
Related Citations

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.
Authors: Monument M.J. , Johnson K.M. , McIlvaine E. , Abegglen L. , Watkins W.S. , Jorde L.B. , Womer R.B. , Beeler N. , Monovich L. , Lawlor E.R. , et al. .
Source: PloS one, 2014; 9(8), p. e104378.
EPub date: 2014-08-05.
PMID: 25093581
Related Citations

Connecting molecular pathways to hereditary cancer risk syndromes.
Authors: Testa J.R. , Malkin D. , Schiffman J.D. .
Source: American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2013; , p. 81-90.
PMID: 23714463
Related Citations

Back to Top