Skip to main content

COVID-19 Resources

What people with cancer should know: https://www.cancer.gov/coronavirus

Guidance for cancer researchers: https://www.cancer.gov/coronavirus-researchers

Get the latest public health information from CDC: https://www.cdc.gov/coronavirus

Get the latest research information from NIH: https://www.covid19.nih.gov

Grant Details

Grant Number: 5R21CA191965-02 Interpret this number
Primary Investigator: Mccormack, Valerie
Organization: International Agency For Res On Cancer
Project Title: Esophageal Cancer in West Kenya
Fiscal Year: 2016


Abstract

¿ DESCRIPTION (provided by applicant): Cancer of the esophagus is one of the most frequently diagnosed cancers in parts of East Africa, yet this cancer is extremely rare in West Africa. West Kenya, a region at altitude in Africa's Rift Valley, is one of East Africa's endemic areas. Typically patients are diagnosed at very late stages, and most die within months. No large-scale studies have been conducted to systematically investigate the potential causes of this cancer. Building on a successfully conducted pilot case-control study in which esophageal cancer patients are compared to non-cancer patients, we propose to continue and expand this study to investigate potential risk factors for the disease. Risk factors are obtained through interviews with participants, and include information on alcohol, tobacco, exposures to indoor pollution and hot beverage drinking. We also aim to investigate a novel hypothesis that deficiencies of some minerals in the diet may contribute to this disease in this area. The co-location of the East African esophageal cancer belt with the African rift valley suggest the dietary deficiencies may play a role as the diet is locally-source and cereal/plant based. Dietary deficiencies are difficult to evaluate in esophageal cancer patients, as patients have typically lost considerable weight by the time of diagnosis so urine and blood levels of vitamins and minerals are affected by their disease. As household members often have very similar diets, we will evaluate whether nutrient levels in such a household member can be used to approximate the patient's levels usual nutrient levels before they were ill. The factors being studied are all modifiable, thus if they are found to be causes of esophageal cancer in West Kenya, interventions could be implemented to remove exposures to carcinogens (e.g. advice on alcohol intake, particularly stronger spirits), or through fortification of fertilizers.



Publications

Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers.
Authors: Talukdar F.R. , Soares Lima S.C. , Khoueiry R. , Laskar R.S. , Cuenin C. , Sorroche B.P. , Boisson A.C. , Abedi-Ardekani B. , Carreira C. , Menya D. , et al. .
Source: Cancer research, 2021-05-15; 81(10), p. 2612-2624.
EPub date: 2021-03-19.
PMID: 33741694
Related Citations

The multimorbidity profile of South African women newly diagnosed with breast cancer.
Authors: Ayeni O.A. , Norris S.A. , Joffe M. , Cubasch H. , Nietz S. , Buccimazza I. , Singh U. , Čačala S. , Stopforth L. , Chen W.C. , et al. .
Source: International journal of cancer, 2020-07-15; 147(2), p. 361-374.
EPub date: 2019-10-25.
PMID: 31600408
Related Citations

Dental fluorosis and oral health in the African Esophageal Cancer Corridor: Findings from the Kenya ESCCAPE case-control study and a pan-African perspective.
Authors: Menya D. , Maina S.K. , Kibosia C. , Kigen N. , Oduor M. , Some F. , Chumba D. , Ayuo P. , Middleton D.R.S. , Osano O. , et al. .
Source: International journal of cancer, 2019-07-01; 145(1), p. 99-109.
EPub date: 2019-01-12.
PMID: 30582155
Related Citations

Hot beverages and oesophageal cancer risk in western Kenya: Findings from the ESCCAPE case-control study.
Authors: Middleton D.R. , Menya D. , Kigen N. , Oduor M. , Maina S.K. , Some F. , Chumba D. , Ayuo P. , Osano O. , Schüz J. , et al. .
Source: International journal of cancer, 2019-06-01; 144(11), p. 2669-2676.
EPub date: 2019-01-27.
PMID: 30496610
Related Citations

Intra-household agreement of urinary elemental concentrations in Tanzania and Kenya: potential surrogates in case-control studies.
Authors: Middleton D.R.S. , McCormack V.A. , Munishi M.O. , Menya D. , Marriott A.L. , Hamilton E.M. , Mwasamwaja A.O. , Mmbaga B.T. , Samoei D. , Osano O. , et al. .
Source: Journal of exposure science & environmental epidemiology, 2019 04; 29(3), p. 335-343.
EPub date: 2018-09-21.
PMID: 30242267
Related Citations

Traditional and commercial alcohols and esophageal cancer risk in Kenya.
Authors: Menya D. , Kigen N. , Oduor M. , Maina S.K. , Some F. , Chumba D. , Ayuo P. , Osano O. , Middleton D.R. , Schüz J. , et al. .
Source: International journal of cancer, 2019-02-01; 144(3), p. 459-469.
EPub date: 2018-11-12.
PMID: 30117158
Related Citations

Cancer epidemiology fieldwork in a resource-limited setting: Experience from the western Kenya ESCCAPE esophageal cancer case-control pilot study.
Authors: Menya D. , Oduor M. , Kigen N. , Maina S.K. , Some F. , Kibosia C. , Chumba D. , Murgor F.A. , Carel R.S. , Middleton D.R.S. , et al. .
Source: Cancer epidemiology, 2018 12; 57, p. 45-52.
EPub date: 2018-10-06.
PMID: 30300838
Related Citations

Esophageal cancer male to female incidence ratios in Africa: A systematic review and meta-analysis of geographic, time and age trends.
Authors: Middleton D.R.S. , Bouaoun L. , Hanisch R. , Bray F. , Dzamalala C. , Chasimpha S. , Menya D. , Mbalawa C.G. , N'Da G. , Woldegeorgis M.A. , et al. .
Source: Cancer epidemiology, 2018 04; 53, p. 119-128.
EPub date: 2018-02-06.
PMID: 29414631
Related Citations

International cancer seminars: a focus on esophageal squamous cell carcinoma.
Authors: Murphy G. , McCormack V. , Abedi-Ardekani B. , Arnold M. , Camargo M.C. , Dar N.A. , Dawsey S.M. , Etemadi A. , Fitzgerald R.C. , Fleischer D.E. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2017-09-01; 28(9), p. 2086-2093.
PMID: 28911061
Related Citations

Informing etiologic research priorities for squamous cell esophageal cancer in Africa: A review of setting-specific exposures to known and putative risk factors.
Authors: McCormack V.A. , Menya D. , Munishi M.O. , Dzamalala C. , Gasmelseed N. , Leon Roux M. , Assefa M. , Osano O. , Watts M. , Mwasamwaja A.O. , et al. .
Source: International journal of cancer, 2017-01-15; 140(2), p. 259-271.
EPub date: 2016-08-24.
PMID: 27466161
Related Citations

Africa's oesophageal cancer corridor: Do hot beverages contribute?
Authors: Munishi M.O. , Hanisch R. , Mapunda O. , Ndyetabura T. , Ndaro A. , Schüz J. , Kibiki G. , McCormack V. .
Source: Cancer causes & control : CCC, 2015 Oct; 26(10), p. 1477-86.
EPub date: 2015-08-06.
PMID: 26245249
Related Citations

Correction: Africa's Oesophageal Cancer Corridor: Geographic Variations in Incidence Correlate with Certain Micronutrient Deficiencies.
Authors: Schaafsma T. , Wakefield J. , Hanisch R. , Bray F. , Schüz J. , Joy E.J. , Watts M.J. , McCormack V. .
Source: PloS one, 2015; 10(11), p. e0142648.
EPub date: 2015-11-13.
PMID: 26565803
Related Citations

Africa's Oesophageal Cancer Corridor: Geographic Variations in Incidence Correlate with Certain Micronutrient Deficiencies.
Authors: Schaafsma T. , Wakefield J. , Hanisch R. , Bray F. , Schüz J. , Joy E.J. , Watts M.J. , McCormack V. .
Source: PloS one, 2015; 10(10), p. e0140107.
EPub date: 2015-10-08.
PMID: 26448405
Related Citations




Back to Top