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Grant Details

Grant Number: 5R21CA182041-02 Interpret this number
Primary Investigator: Rosser, B. R. Simon
Organization: University Of Minnesota
Project Title: Understanding the Effects of Prostate Cancer on Gay and Bisexual Men
Fiscal Year: 2015


Abstract

DESCRIPTION (provided by applicant): This application is in response to PA-12-113, Research on the Health of LGBTI Populations, which "encourages researchers to investigate new questions related to LGBTI health" with "high priority placed on research on interventions for [LGBTI] individuals." Survivorship of prostate cancer (PCa) is one such area. Across the lifespan, 1-in-6 gay and bisexual men (GBM) and 1-in-3 male couples will be diagnosed with PCa, making PCa the most common cancer affecting GBM. Yet, almost no research has examined the effects of PCa treatment on GBM's sexual functioning. Sexual dysfunction is the major sequela of PCa treatment, which is deeply distressing in itself, and negatively impacts quality of life post-treatment, resulting in serious negative mental health outcomes. Recent studies indicate sexual outcomes of PCa treatment are significantly worse for GBM than heterosexual men. Physiological differences between anal sex and vaginal sex likely explain, at least in part, this health disparity. Tailored treatment needs to be developed, but is almost entirely unexplored. Missing is research to evaluate the effects of PCa treatment on GBM sexual functioning, research on rehabilitation outcomes, and research to guide development of new treatments tailored to GBM and sex between men. The long-term objective of this research is to develop the first evidence-based PCa rehabilitation curriculum tailored for GBM. As a first step, in this R21 we will conduct the formative research needed to estimate the extent of poor outcomes, confirm need, and assess acceptability and feasibility. There are three specific aims. In Aim 1, we will investigate, in-depth, the experience of PCa treatment on the sexual lives of GBM, their partners, and their relationships. We will conduct a semi-structured, chat or phone interview study of up to 48 GBM PCa patients, partners, and couples, nationally. In Aim 2, we will refine definitions and develop the measures needed to assess sexual dysfunction in GBM. In Aim 3, we will conduct an online quantitative survey of 220 GBM with PCa, which will a) quantify sexual challenges post-treatment, b) assess needs and priorities for rehabilitation, c) develop a new scale to measure sexual functioning in GBM and d) assess the acceptability and feasibility of a new rehabilitation curriculum for GBM with PCa.



Publications

Discrimination of Sexual and Gender Minority Patients in Prostate Cancer Treatment: Results from the Restore-1 Study.
Authors: Ross M.W. , Rosser B.R.S. , Polter E.J. , Bates A.J. , Wheldon C.W. , Haggart R. , West W. , Kohli N. , Konety B.R. , Mitteldorf D. , et al. .
Source: Stigma And Health, 2023 Feb; 8(1), p. 85-92.
EPub date: 2022-01-20 00:00:00.0.
PMID: 36779009
Related Citations

The Effects of Prostate Cancer Treatment on Role-In-Sex in Gay and Bisexual Men: Mixed Methods Results from the Restore-1 and Restore-2 Studies.
Authors: Tatum A. , Rosser B.R.S. , Wheldon C.W. , Torres M.B. , Bates A.J. , Haggart R. , Konety B.R. , Mitteldorf D. , Polter E.J. , Ross M.W. , et al. .
Source: Journal Of Sex Research, 2022-10-06 00:00:00.0; , p. 1-10.
EPub date: 2022-10-06 00:00:00.0.
PMID: 36200951
Related Citations

Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors.
Authors: Bates A.J. , Rosser B.R.S. , Polter E.J. , Wheldon C.W. , Talley K.M.C. , Haggart R. , Wright M. , Mitteldorf D. , West W. , Ross M.W. , et al. .
Source: Frontiers In Oncology, 2022; 12, p. 833197.
EPub date: 2022-04-13 00:00:00.0.
PMID: 35494011
Related Citations

Comorbidity Prevalence and Impact on Quality of Life in Gay and Bisexual Men Following Prostate Cancer Treatment.
Authors: Haggart R. , Polter E. , Ross M. , Kohli N. , Konety B.R. , Mitteldorf D. , West W. , Rosser B.R.S. .
Source: Sexual Medicine, 2021 Dec; 9(6), p. 100439.
EPub date: 2021-10-08 00:00:00.0.
PMID: 34634579
Related Citations

Prostate cancer disclosure and sexual orientation: Understanding outness to healthcare providers as a situational or consistent phenomenon.
Authors: Wells-Prado D.R. , Ross M.W. , Rosser B.R.S. , Polter E.J. , Capistrant B.D. , Haggart R. , Kohli N. , Konety B.R. , Mitteldorf D. , Talley K.M.C. , et al. .
Source: Patient Education And Counseling, 2021-11-24 00:00:00.0; , .
EPub date: 2021-11-24 00:00:00.0.
PMID: 34865891
Related Citations

Pain and Loss of Pleasure in Receptive Anal Sex for Gay and Bisexual Men following Prostate Cancer Treatment: Results from the Restore-1 Study.
Authors: Wheldon C.W. , Polter E.J. , Rosser B.R.S. , Kapoor A. , Talley K.M.C. , Haggart R. , Kohli N. , Konety B.R. , Mitteldorf D. , Ross M.W. , et al. .
Source: Journal Of Sex Research, 2021-07-03 00:00:00.0; , p. 1-8.
EPub date: 2021-07-03 00:00:00.0.
PMID: 34219559
Related Citations

Every urologist and oncologist should know about treating sexual and gender minority prostate cancer patients: translating research findings into clinical practice.
Authors: Rosser B.R.S. , Rider G.N. , Kapoor A. , Talley K.M.C. , Haggart R. , Kohli N. , Konety B.R. , Mitteldorf D. , Polter E.J. , Ross M.W. , et al. .
Source: Translational Andrology And Urology, 2021 Jul; 10(7), p. 3208-3225.
PMID: 34430423
Related Citations

The Reliability of Self-Reported Gleason Scores in Studies of Sexual Minority Prostate Cancer Survivors.
Authors: Rosser B.R.S. , Konety B.R. , Capistrant B.D. , Kapoor A. , Polter E. .
Source: Urology Practice, 2020 May; 7(3), p. 224-227.
EPub date: 2020-05-01 00:00:00.0.
PMID: 34355044
Related Citations

Understanding Prostate Cancer in Gay, Bisexual, and Other Men Who Have Sex with Men and Transgender Women: A Review of the Literature.
Authors: Rosser B.R.S. , Hunt S.L. , Capistrant B.D. , Kohli N. , Konety B.R. , Mitteldorf D. , Ross M.W. , Talley K.M. , West W. .
Source: Current Sexual Health Reports, 2019 Dec; 11(4), p. 430-441.
EPub date: 2019-11-08 00:00:00.0.
PMID: 31929765
Related Citations

The Influence of Companion Animals on Quality of Life of Gay and Bisexual Men Diagnosed with Prostate Cancer.
Authors: Wright M.M. , Schreiner P. , Rosser B.R.S. , Polter E.J. , Mitteldorf D. , West W. , Ross M.W. .
Source: International Journal Of Environmental Research And Public Health, 2019-11-13 00:00:00.0; 16(22), .
EPub date: 2019-11-13 00:00:00.0.
PMID: 31766206
Related Citations

Health-related quality of life by human immunodeficiency virus status in a cross-sectional survey of gay and bisexual prostate cancer survivors.
Authors: Polter E.J. , Wheldon C.W. , Rosser B.R.S. , Kohli N. , Capistrant B.D. , Kapoor A. , Konety B. , Mitteldorf D. , Ross M. , Talley K.M.C. , et al. .
Source: Psycho-oncology, 2019-09-13 00:00:00.0; , .
EPub date: 2019-09-13 00:00:00.0.
PMID: 31518042
Related Citations

The Sexual Functioning of Gay and Bisexual Men Following Prostate Cancer Treatment: Results from the Restore Study.
Authors: Rosser B.R.S. , Kohli N. , Polter E.J. , Lesher L. , Capistrant B.D. , Konety B.R. , Mitteldorf D. , West W. , Dewitt J. , Kilian G. .
Source: Archives Of Sexual Behavior, 2019-04-23 00:00:00.0; , .
EPub date: 2019-04-23 00:00:00.0.
PMID: 31016492
Related Citations

Social Support and Health-Related Quality of Life Among Gay and Bisexual Men With Prostate Cancer.
Authors: Capistrant B.D. , Lesher L. , Kohli N. , Merengwa E.N. , Konety B. , Mitteldorf D. , West W.G. , Rosser B.R.S. .
Source: Oncology Nursing Forum, 2018-07-02 00:00:00.0; 45(4), p. 439-455.
PMID: 29947351
Related Citations

What Gay and Bisexual Men Treated for Prostate Cancer Want in a Sexual Rehabilitation Program: Results of the Restore Needs Assessment.
Authors: Rosser B.R.S. , Kohli N. , Lesher L. , Capistrant B.D. , DeWitt J. , Kilian G. , Konety B.R. , Merengwa E. , Mitteldorf D. , West W. .
Source: Urology Practice, 2018 May; 5(3), p. 192-197.
EPub date: 2017-04-21 00:00:00.0.
PMID: 35261917
Related Citations

What Gay and Bisexual Men Treated for Prostate Cancer Are Offered and Attempt as Sexual Rehabilitation for Prostate Cancer: Results from the Restore Study.
Authors: Rosser B.R.S. , Konety B.R. , Mitteldorf D. , Kohli N. , Lesher L. , West W. , Capistrant B.D. , Dewitt J. , Merengwa E. , Kilian G. .
Source: Urology Practice, 2018 May; 5(3), p. 187-191.
PMID: 35296068
Related Citations

Addressing Participant Validity in a Small Internet Health Survey (The Restore Study): Protocol and Recommendations for Survey Response Validation.
Authors: Dewitt J. , Capistrant B. , Kohli N. , Rosser B.R.S. , Mitteldorf D. , Merengwa E. , West W. .
Source: Jmir Research Protocols, 2018-04-24 00:00:00.0; 7(4), p. e96.
EPub date: 2018-04-24 00:00:00.0.
PMID: 29691203
Related Citations

Caregiving and social support for gay and bisexual men with prostate cancer.
Authors: Capistrant B.D. , Torres B. , Merengwa E. , West W.G. , Mitteldorf D. , Rosser B.R. .
Source: Psycho-oncology, 2016 Nov; 25(11), p. 1329-1336.
EPub date: 2016-09-15 00:00:00.0.
PMID: 27530377
Related Citations

Online Versus Telephone Methods To Recruit And Interview Older Gay And Bisexual Men Treated For Prostate Cancer: Findings From The Restore Study
Authors: Rosser B.R.S. , Capistrant B. .
Source: Jmir Cancer, 2016-07-19 00:00:00.0; 2(2), p. e9.
PMID: 28410183
Related Citations

The Effects Of Radical Prostatectomy On Gay And Bisexual Men's Mental Health, Sexual Identity And Relationships: Qualitative Results From The Restore Study
Authors: Rosser B.R. , Capistrant B. , Torres B. , Konety B. , Merengwa E. , Mitteldorf D. , West W. .
Source: Sexual And Relationship Therapy : Journal Of The British Association For Sexual And Relationship Therapy, 2016; 31(4), p. 446-461.
PMID: 27942251
Related Citations

The effects of radical prostatectomy on gay and bisexual men's sexual functioning and behavior: qualitative results from the restore study.
Authors: Rosser B.R.S. , Capistrant B. , Torres M.B. , Konety B. , Merengwa E. , Mitteldorf D. , West W. .
Source: Sexual And Relationship Therapy : Journal Of The British Association For Sexual And Relationship Therapy, 2016; 31(4), p. 432-445.
EPub date: 2016-08-29 00:00:00.0.
PMID: 30111985
Related Citations



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