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Grant Details

Grant Number: 5R21CA182041-02 Interpret this number
Primary Investigator: Rosser, B. R. Simon
Organization: University Of Minnesota
Project Title: Understanding the Effects of Prostate Cancer on Gay and Bisexual Men
Fiscal Year: 2015


DESCRIPTION (provided by applicant): This application is in response to PA-12-113, Research on the Health of LGBTI Populations, which "encourages researchers to investigate new questions related to LGBTI health" with "high priority placed on research on interventions for [LGBTI] individuals." Survivorship of prostate cancer (PCa) is one such area. Across the lifespan, 1-in-6 gay and bisexual men (GBM) and 1-in-3 male couples will be diagnosed with PCa, making PCa the most common cancer affecting GBM. Yet, almost no research has examined the effects of PCa treatment on GBM's sexual functioning. Sexual dysfunction is the major sequela of PCa treatment, which is deeply distressing in itself, and negatively impacts quality of life post-treatment, resulting in serious negative mental health outcomes. Recent studies indicate sexual outcomes of PCa treatment are significantly worse for GBM than heterosexual men. Physiological differences between anal sex and vaginal sex likely explain, at least in part, this health disparity. Tailored treatment needs to be developed, but is almost entirely unexplored. Missing is research to evaluate the effects of PCa treatment on GBM sexual functioning, research on rehabilitation outcomes, and research to guide development of new treatments tailored to GBM and sex between men. The long-term objective of this research is to develop the first evidence-based PCa rehabilitation curriculum tailored for GBM. As a first step, in this R21 we will conduct the formative research needed to estimate the extent of poor outcomes, confirm need, and assess acceptability and feasibility. There are three specific aims. In Aim 1, we will investigate, in-depth, the experience of PCa treatment on the sexual lives of GBM, their partners, and their relationships. We will conduct a semi-structured, chat or phone interview study of up to 48 GBM PCa patients, partners, and couples, nationally. In Aim 2, we will refine definitions and develop the measures needed to assess sexual dysfunction in GBM. In Aim 3, we will conduct an online quantitative survey of 220 GBM with PCa, which will a) quantify sexual challenges post-treatment, b) assess needs and priorities for rehabilitation, c) develop a new scale to measure sexual functioning in GBM and d) assess the acceptability and feasibility of a new rehabilitation curriculum for GBM with PCa.


The Sexual Functioning of Gay and Bisexual Men Following Prostate Cancer Treatment: Results from the Restore Study.
Authors: Rosser B.R.S. , Kohli N. , Polter E.J. , Lesher L. , Capistrant B.D. , Konety B.R. , Mitteldorf D. , West W. , Dewitt J. , Kilian G. .
Source: Archives of sexual behavior, 2020 07; 49(5), p. 1589-1600.
EPub date: 2019-04-23.
PMID: 31016492
Related Citations

The Reliability of Self-Reported Gleason Scores in Studies of Sexual Minority Prostate Cancer Survivors.
Authors: Rosser B.R.S. , Konety B.R. , Capistrant B.D. , Kapoor A. , Polter E. .
Source: Urology practice, 2020 May; 7(3), p. 224-227.
EPub date: 2020-05-01.
PMID: 34355044
Related Citations

Understanding Prostate Cancer in Gay, Bisexual, and Other Men Who Have Sex with Men and Transgender Women: A Review of the Literature.
Authors: Rosser B.R.S. , Hunt S.L. , Capistrant B.D. , Kohli N. , Konety B.R. , Mitteldorf D. , Ross M.W. , Talley K.M. , West W. .
Source: Current sexual health reports, 2019 Dec; 11(4), p. 430-441.
EPub date: 2019-11-08.
PMID: 31929765
Related Citations

Health-related quality of life by human immunodeficiency virus status in a cross-sectional survey of gay and bisexual prostate cancer survivors.
Authors: Polter E.J. , Wheldon C.W. , Rosser B.R.S. , Kohli N. , Capistrant B.D. , Kapoor A. , Konety B. , Mitteldorf D. , Ross M. , Talley K.M.C. , et al. .
Source: Psycho-oncology, 2019 12; 28(12), p. 2351-2357.
EPub date: 2019-11-11.
PMID: 31518042
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The Influence of Companion Animals on Quality of Life of Gay and Bisexual Men Diagnosed with Prostate Cancer.
Authors: Wright M.M. , Schreiner P. , Rosser B.R.S. , Polter E.J. , Mitteldorf D. , West W. , Ross M.W. .
Source: International journal of environmental research and public health, 2019-11-13; 16(22), .
EPub date: 2019-11-13.
PMID: 31766206
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Social Support and Health-Related Quality of Life Among Gay and Bisexual Men With Prostate Cancer.
Authors: Capistrant B.D. , Lesher L. , Kohli N. , Merengwa E.N. , Konety B. , Mitteldorf D. , West W.G. , Rosser B.R.S. .
Source: Oncology nursing forum, 2018-07-02; 45(4), p. 439-455.
PMID: 29947351
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Addressing Participant Validity in a Small Internet Health Survey (The Restore Study): Protocol and Recommendations for Survey Response Validation.
Authors: Dewitt J. , Capistrant B. , Kohli N. , Rosser B.R.S. , Mitteldorf D. , Merengwa E. , West W. .
Source: JMIR research protocols, 2018-04-24; 7(4), p. e96.
EPub date: 2018-04-24.
PMID: 29691203
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Caregiving and social support for gay and bisexual men with prostate cancer.
Authors: Capistrant B.D. , Torres B. , Merengwa E. , West W.G. , Mitteldorf D. , Rosser B.R. .
Source: Psycho-oncology, 2016 11; 25(11), p. 1329-1336.
EPub date: 2016-09-15.
PMID: 27530377
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Online Versus Telephone Methods to Recruit and Interview Older Gay and Bisexual Men Treated for Prostate Cancer: Findings from the Restore Study.
Authors: Rosser B.R.S. , Capistrant B. .
Source: JMIR cancer, 2016-07-19; 2(2), p. e9.
EPub date: 2016-07-19.
PMID: 28410183
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The Effects of Radical Prostatectomy on Gay and Bisexual Men's Mental Health, Sexual Identity and Relationships: Qualitative Results from the Restore Study.
Authors: Rosser B.R. , Capistrant B. , Torres B. , Konety B. , Merengwa E. , Mitteldorf D. , West W. .
Source: Sexual and relationship therapy : journal of the British Association for Sexual and Relationship Therapy, 2016; 31(4), p. 446-461.
EPub date: 2016-09-09.
PMID: 27942251
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The effects of radical prostatectomy on gay and bisexual men's sexual functioning and behavior: qualitative results from the restore study.
Authors: Rosser B.R.S. , Capistrant B. , Torres M.B. , Konety B. , Merengwa E. , Mitteldorf D. , West W. .
Source: Sexual and relationship therapy : journal of the British Association for Sexual and Relationship Therapy, 2016; 31(4), p. 432-445.
EPub date: 2016-08-29.
PMID: 30111985
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