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Grant Details

Grant Number: 5UM1CA164917-04 Interpret this number
Primary Investigator: Lacey, James
Organization: Beckman Research Institute/City Of Hope
Project Title: New Biospecimens to Enhance Research in the California Teachers Study Cohort
Fiscal Year: 2015
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Abstract

DESCRIPTION (provided by applicant): Prospective cancer epidemiology cohorts (CECs) can simultaneously investigate how genes, biomarkers, the environment, and lifestyle together affect cancer incidence, mortality, and clinical outcomes. The prospective California Teachers Study (CTS) began in 1995, when 133,479 female public school professionals completed a self-administered questionnaire. Participants have since completed three more questionnaires on lifestyle and environmental exposures. CTS data are regularly linked with California databases to identify essentially all incident cancers, hospitalizations, and deaths. CTS participants have donated 5,428 blood and 7,549 saliva samples in targeted projects to date. To enable broader etiologic, clinical, and translational research on genetic, molecular, and environmental predictors of cancer incidence, mortality, and outcomes, this project will collect pre diagnostic biospecimens from 27,625 CTS participants who have not previously donated a biospecimen. The specific aim is to collect, process, and store 1) a venous blood or saliva sample and 2) an overnight urine specimen from participants who are <70 years old and living in California. Coordinated teams of experienced field staff based at three CTS centers (City of Hope, Cancer Prevention Institute of California, and University of California, Irvine) will visit participants i person and collect, process, and store biospecimens using proven and standardized protocols. Adding this large group of pre diagnostic biospecimens to the extensive existing and future CTS risk-factor, cancer, hospitalization, and mortality data will directly facilitate numerous high-impact research projects in the CTS and in established large-scale consortia. This is an optimal time to collect new biospecimens because these participants will soon reach the age groups of peak cancer incidence. Combining the extensive exposure and lifestyle data collected in the CTS since 1995 with genetic, epigenetic, and other biomarkers in blood, urine, and saliva will directly facilitate future research on gene-environment interactions, natural history and progression, early detection, risk-prediction models, factors that affect response to treatment, and other emerging areas in cancer research.

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Publications

Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium.
Authors: Kapoor P.M. , Lindström S. , Behrens S. , Wang X. , Michailidou K. , Bolla M.K. , Wang Q. , Dennis J. , Dunning A.M. , Pharoah P.D.P. , et al. .
Source: International journal of epidemiology, 2020-02-01; 49(1), p. 216-232.
PMID: 31605532
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Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women.
Authors: Lee E. , Kinninger A. , Ursin G. , Tseng C. , Hurley S. , Wang M. , Wang Y. , Park J.S. , Petreas M. , Deapen D. , et al. .
Source: International journal of environmental research and public health, 2020-01-17; 17(2), .
EPub date: 2020-01-17.
PMID: 31963577
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A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Authors: Escala-Garcia M. , Abraham J. , Andrulis I.L. , Anton-Culver H. , Arndt V. , Ashworth A. , Auer P.L. , Auvinen P. , Beckmann M.W. , Beesley J. , et al. .
Source: Nature communications, 2020-01-16; 11(1), p. 312.
EPub date: 2020-01-16.
PMID: 31949161
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Two truncating variants in FANCC and breast cancer risk.
Authors: Dörk T. , Peterlongo P. , Mannermaa A. , Bolla M.K. , Wang Q. , Dennis J. , Ahearn T. , Andrulis I.L. , Anton-Culver H. , Arndt V. , et al. .
Source: Scientific reports, 2019-08-29; 9(1), p. 12524.
EPub date: 2019-08-29.
PMID: 31467304
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Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium.
Authors: Fortner R.T. , Poole E.M. , Wentzensen N.A. , Trabert B. , White E. , Arslan A.A. , Patel A.V. , Setiawan V.W. , Visvanathan K. , Weiderpass E. , et al. .
Source: International journal of cancer, 2019-07-01; 145(1), p. 58-69.
EPub date: 2019-01-14.
PMID: 30561796
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Shared heritability and functional enrichment across six solid cancers.
Authors: Jiang X. , Finucane H.K. , Schumacher F.R. , Schmit S.L. , Tyrer J.P. , Han Y. , Michailidou K. , Lesseur C. , Kuchenbaecker K.B. , Dennis J. , et al. .
Source: Nature communications, 2019-01-25; 10(1), p. 431.
EPub date: 2019-01-25.
PMID: 30683880
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.
Authors: Figlioli G. , Bogliolo M. , Catucci I. , Caleca L. , Lasheras S.V. , Pujol R. , Kiiski J.I. , Muranen T.A. , Barnes D.R. , Dennis J. , et al. .
Source: NPJ breast cancer, 2019; 5, p. 38.
EPub date: 2019-11-01.
PMID: 31700994
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Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study.
Authors: Pacheco L.S. , Anderson C.A.M. , Lacey J.V. , Giovannucci E.L. , Lemus H. , Araneta M.R.G. , Sears D.D. , Talavera G.A. , Martinez M.E. .
Source: PloS one, 2019; 14(10), p. e0223638.
EPub date: 2019-10-09.
PMID: 31596902
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Chronotype and postmenopausal breast cancer risk among women in the California Teachers Study.
Authors: Hurley S. , Goldberg D. , Von Behren J. , Clague DeHart J. , Wang S. , Reynolds P. .
Source: Chronobiology international, 2019 11; 36(11), p. 1504-1514.
EPub date: 2019-08-27.
PMID: 31452403
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Genome-wide association study of germline variants and breast cancer-specific mortality.
Authors: Escala-Garcia M. , Guo Q. , Dörk T. , Canisius S. , Keeman R. , Dennis J. , Beesley J. , Lecarpentier J. , Bolla M.K. , Wang Q. , et al. .
Source: British journal of cancer, 2019 03; 120(6), p. 647-657.
EPub date: 2019-02-21.
PMID: 30787463
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Authors: Milne R.L. , Kuchenbaecker K.B. , Michailidou K. , Beesley J. , Kar S. , Lindström S. , Hui S. , Lemaçon A. , Soucy P. , Dennis J. , et al. .
Source: Nature genetics, 2017 Dec; 49(12), p. 1767-1778.
EPub date: 2017-10-23.
PMID: 29058716
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Association analysis identifies 65 new breast cancer risk loci.
Authors: Michailidou K. , Lindström S. , Dennis J. , Beesley J. , Hui S. , Kar S. , Lemaçon A. , Soucy P. , Glubb D. , Rostamianfar A. , et al. .
Source: Nature, 2017-11-02; 551(7678), p. 92-94.
EPub date: 2017-10-23.
PMID: 29059683
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rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.
Authors: Liu J. , Lončar I. , Collée J.M. , Bolla M.K. , Dennis J. , Michailidou K. , Wang Q. , Andrulis I.L. , Barile M. , Beckmann M.W. , et al. .
Source: Scientific reports, 2016-11-15; 6, p. 36874.
EPub date: 2016-11-15.
PMID: 27845421
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50 % Response rates: half-empty, or half-full?
Authors: Lacey J.V. , Savage K.E. .
Source: Cancer causes & control : CCC, 2016 06; 27(6), p. 805-8.
EPub date: 2016-04-21.
PMID: 27100357
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