Grant Number:	5U01CA163304-05 Interpret this number
Primary Investigator:	Barlow, William
Organization:	Fred Hutchinson Cancer Research Center
Project Title:	Prospr Statistical Coordinating Center (PSCC)
Fiscal Year:	2015

The success of the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) program critically relies on a highly talented and committed PROSPR Statistical Coordinating Center (PSCC) to coordinate the research of PROSPR Research Centers (PRCs) to achieve PROSPR's mission of evaluating and improving the cancer screening process (recruitment, screening, diagnosis, and referral for treatment). This PSCC application is from a team of investigators with extensive experience in statistics, data and coordinating center management, and research focused on the screening of breast, colon, and cervical cancers at the Fred Hutchinson Cancer Research (FHCRC) and University of Washington (UW), built upon the infrastructure and expertises from three large NCI-funded coordinating centers over multiple funding cycles: the Early Detection Research Network (EDRN), Breast Cancer Surveillance Consortium (BCSC), and the Transdisciplinary Research on Energetics and Cancer (TREC) Consortium. The overall objectives of the PSCC are to be accomplished by 1) Providing logistic support for PROSPR meetings and enhance communications and collaborations via a secure PROSPR web portal and a dedicated operations team; 2) Providing scientific, clinical, and statistical leadership to enhance PROSPR's scientific vigor and productivity via three organ specific PSCC working groups with the extensive expertise in statistics, clinics, and epidemiology; 3) Providing study design, data collection, and data management expertise to enable appropriate pooling of data from studies across PRCs and to lead trans-network cross organ site studies via a statistical team with extensive experience in developing new statistical methodology and in designing and analyzing data for screening studies; 4) Providing statistical consultations for PRCs and lead data analyses for pooled PROSPR studies and trans-network studies; and 5) Serving as a resource to the scientific community for dissemination and outreach of PROSPR data and findings via a PROSPR public portal. RELEVANCE (See instructions): Improving screening process for breast, colon, and cervical cancers will reduce mortality, motbidity, and health care cost associated with these cancers in US.




Screening Beyond the Evidence: Patterns of Age and Comorbidity for Breast, Cervical, and Colorectal Cancer Screening.
Authors: Onega T. , Garcia M. , Beaber E.F. , Haas J.S. , Breslau E.S. , Tosteson A.N.A. , Halm E. , Chao C.R. , Barlow W.E. .
Source: Journal Of General Internal Medicine, 2023-12-14 00:00:00.0; , .
EPub date: 2023-12-14 00:00:00.0.
PMID: 38097863
Related Citations

Provider- and Facility-Level Variation in Pre-Cancerous Cervical Biopsy Diagnoses.
Authors: Del Vecchio N.J. , Beaber E.F. , Garcia M.P. , Wheeler C.M. , Kamineni A. , Chao C. , Chubak J. , Corley D.A. , Owens C.L. , Winer R.L. , et al. .
Source: Journal Of Lower Genital Tract Disease, 2023-01-17 00:00:00.0; , .
EPub date: 2023-01-17 00:00:00.0.
PMID: 36728078
Related Citations

Gaps in the screening process for women diagnosed with cervical cancer in four diverse US health care settings.
Authors: Chao C.R. , Chubak J. , Beaber E.F. , Kamineni A. , Mao C. , Silverberg M.J. , Tiro J.A. , Skinner C. , Garcia M. , Corley D.A. , et al. .
Source: Cancer Medicine, 2022-09-15 00:00:00.0; , .
EPub date: 2022-09-15 00:00:00.0.
PMID: 36106421
Related Citations

Colonoscopy Indication Algorithm Performance Across Diverse Health Care Systems in the PROSPR Consortium.
Authors: Burnett-Hartman A.N. , Kamineni A. , Corley D.A. , Singal A.G. , Halm E.A. , Rutter C.M. , Chubak J. , Lee J.K. , Doubeni C.A. , Inadomi J.M. , et al. .
Source: Egems (washington, Dc), 2019-08-02 00:00:00.0; 7(1), p. 37.
EPub date: 2019-08-02 00:00:00.0.
PMID: 31531383
Related Citations

Evaluating screening participation, follow-up and outcomes for breast, cervical and colorectal cancer in the PROSPR consortium.
Authors: Barlow W.E. , Beaber E.F. , Geller B.M. , Kamineni A. , Zheng Y. , Haas J.S. , Chao C.R. , Rutter C.M. , Zauber A.G. , Sprague B.L. , et al. .
Source: Journal Of The National Cancer Institute, 2019-07-11 00:00:00.0; , .
EPub date: 2019-07-11 00:00:00.0.
PMID: 31292633
Related Citations

Association of Digital Breast Tomosynthesis vs Digital Mammography With Cancer Detection and Recall Rates by Age and Breast Density.
Authors: Conant E.F. , Barlow W.E. , Herschorn S.D. , Weaver D.L. , Beaber E.F. , Tosteson A.N.A. , Haas J.S. , Lowry K.P. , Stout N.K. , Trentham-Dietz A. , et al. .
Source: Jama Oncology, 2019-05-01 00:00:00.0; 5(5), p. 635-642.
PMID: 30816931
Related Citations

Time to Follow-up After Colorectal Cancer Screening by Health Insurance Type.
Authors: Breen N. , Skinner C.S. , Zheng Y. , Inrig S. , Corley D.A. , Beaber E.F. , Garcia M. , Chubak J. , Doubeni C. , Quinn V.P. , et al. .
Source: American Journal Of Preventive Medicine, 2019 May; 56(5), p. e143-e152.
PMID: 31003603
Related Citations

Multilevel Predictors of Continued Adherence to Breast Cancer Screening Among Women Ages 50-74 Years in a Screening Population.
Authors: Beaber E.F. , Sprague B.L. , Tosteson A.N.A. , Haas J.S. , Onega T. , Schapira M.M. , McCarthy A.M. , Li C.I. , Herschorn S.D. , Lehman C.D. , et al. .
Source: Journal Of Women's Health (2002), 2018-11-27 00:00:00.0; , .
EPub date: 2018-11-27 00:00:00.0.
PMID: 30481098
Related Citations

Receipt of Colonoscopy Following Diagnosis of Advanced Adenomas: An Analysis within Integrated Healthcare Delivery Systems.
Authors: Chubak J. , McLerran D. , Zheng Y. , Singal A.G. , Corley D.A. , Doria-Rose V.P. , Doubeni C.A. , Kamineni A. , Haas J.S. , Halm E.A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018-11-20 00:00:00.0; , .
EPub date: 2018-11-20 00:00:00.0.
PMID: 30459208
Related Citations

Cervical Cancer Screening Research in the PROSPR I Consortium: Rationale, Methods, and Baseline Findings from a U.S. Cohort.
Authors: Kamineni A. , Tiro J.A. , Beaber E.F. , Silverberg M.J. , Wheeler C.M. , Chao C.R. , Chubak J. , Skinner C.S. , Corley D.A. , Kim J.J. , et al. .
Source: International Journal Of Cancer, 2018-10-24 00:00:00.0; , .
EPub date: 2018-10-24 00:00:00.0.
PMID: 30353911
Related Citations

Communication Practices of Mammography Facilities and Timely Follow-up of a Screening Mammogram with a BI-RADS 0 Assessment.
Authors: Schapira M.M. , Barlow W.E. , Conant E.F. , Sprague B.L. , Tosteson A.N.A. , Haas J.S. , Onega T. , Beaber E.F. , Goodrich M. , McCarthy A.M. , et al. .
Source: Academic Radiology, 2018 Sep; 25(9), p. 1118-1127.
EPub date: 2018-02-09 00:00:00.0.
PMID: 29433892
Related Citations

Breast Cancer With a Poor Prognosis Diagnosed After Screening Mammography With Negative Results.
Authors: McCarthy A.M. , Barlow W.E. , Conant E.F. , Haas J.S. , Li C.I. , Sprague B.L. , Armstrong K. , PROSPR Consortium .
Source: Jama Oncology, 2018-07-01 00:00:00.0; 4(7), p. 998-1001.
PMID: 29801067
Related Citations

Patterns and predictors of repeat fecal immunochemical and occult blood test screening in four large health care systems in the United States.
Authors: Singal A.G. , Corley D.A. , Kamineni A. , Garcia M. , Zheng Y. , Doria-Rose P.V. , Quinn V.P. , Jensen C.D. , Chubak J. , Tiro J. , et al. .
Source: The American Journal Of Gastroenterology, 2018 May; 113(5), p. 746-754.
EPub date: 2018-02-27 00:00:00.0.
PMID: 29487413
Related Citations

Primary Care Providers' Beliefs And Recommendations And Use Of Screening Mammography By Their Patients
Authors: Haas J.S. , Barlow W.E. , Schapira M.M. , MacLean C.D. , Klabunde C.N. , Sprague B.L. , Beaber E.F. , Chen J.S. , Bitton A. , Onega T. , et al. .
Source: Journal Of General Internal Medicine, 2017 Apr; 32(4), p. 449-457.
PMID: 28070772
Related Citations

Racial/ethnic Differences In Obesity And Comorbidities Between Safety-net- And Non Safety-net Integrated Health Systems
Authors: Balasubramanian B.A. , Garcia M.P. , Corley D.A. , Doubeni C.A. , Haas J.S. , Kamineni A. , Quinn V.P. , Wernli K. , Zheng Y. , Skinner C.S. .
Source: Medicine, 2017 Mar; 96(11), p. e6326.
PMID: 28296752
Related Citations

Breast cancer screening initiation after turning 40 years of age within the PROSPR consortium.
Authors: Beaber E.F. , Tosteson A.N. , Haas J.S. , Onega T. , Sprague B.L. , Weaver D.L. , McCarthy A.M. , Doubeni C.A. , Quinn V.P. , Skinner C.S. , et al. .
Source: Breast Cancer Research And Treatment, 2016 Nov; 160(2), p. 323-331.
EPub date: 2016-09-24 00:00:00.0.
PMID: 27665586
Related Citations

Challenges With Identifying Indication For Examination In Breast Imaging As A Key Clinical Attribute In Practice, Research, And Policy
Authors: Weiss J.E. , Goodrich M. , Harris K.A. , Chicoine R.E. , Synnestvedt M.B. , Pyle S.J. , Chen J.S. , Herschorn S.D. , Beaber E.F. , Haas J.S. , et al. .
Source: Journal Of The American College Of Radiology : Jacr, 2016-10-12 00:00:00.0; , .
PMID: 27744009
Related Citations

Variation in Mammographic Breast Density Assessments Among Radiologists in Clinical Practice: A Multicenter Observational Study.
Authors: Sprague B.L. , Conant E.F. , Onega T. , Garcia M.P. , Beaber E.F. , Herschorn S.D. , Lehman C.D. , Tosteson A.N. , Lacson R. , Schnall M.D. , et al. .
Source: Annals Of Internal Medicine, 2016-10-04 00:00:00.0; 165(7), p. 457-464.
EPub date: 2016-10-04 00:00:00.0.
PMID: 27428568
Related Citations

Racial/Ethnic Disparities in Colorectal Cancer Screening Across Healthcare Systems.
Authors: Burnett-Hartman A.N. , Mehta S.J. , Zheng Y. , Ghai N.R. , McLerran D.F. , Chubak J. , Quinn V.P. , Skinner C.S. , Corley D.A. , Inadomi J.M. , et al. .
Source: American Journal Of Preventive Medicine, 2016 Oct; 51(4), p. e107-15.
PMID: 27050413
Related Citations

Follow-Up of Abnormal Breast and Colorectal Cancer Screening by Race/Ethnicity.
Authors: McCarthy A.M. , Kim J.J. , Beaber E.F. , Zheng Y. , Burnett-Hartman A. , Chubak J. , Ghai N.R. , McLerran D. , Breen N. , Conant E.F. , et al. .
Source: American Journal Of Preventive Medicine, 2016 Oct; 51(4), p. 507-12.
PMID: 27132628
Related Citations

Inadequate Systems To Support Breast And Cervical Cancer Screening In Primary Care Practice
Authors: Schapira M.M. , Sprague B.L. , Klabunde C.N. , Tosteson A.N. , Bitton A. , Chen J.S. , Beaber E.F. , Onega T. , MacLean C.D. , Harris K. , et al. .
Source: Journal Of General Internal Medicine, 2016 Oct; 31(10), p. 1148-55.
PMID: 27251058
Related Citations

Association Between Primary Care Visits and Colorectal Cancer Screening Outcomes in the Era of Population Health Outreach.
Authors: Halm E.A. , Beaber E.F. , McLerran D. , Chubak J. , Corley D.A. , Rutter C.M. , Doubeni C.A. , Haas J.S. , Balasubramanian B.A. .
Source: Journal Of General Internal Medicine, 2016 10; 31(10), p. 1190-7.
EPub date: 2016-06-08 00:00:00.0.
PMID: 27279097
Related Citations

Influence of Age and Comorbidity on Colorectal Cancer Screening in the Elderly.
Authors: Klabunde C.N. , Zheng Y. , Quinn V.P. , Beaber E.F. , Rutter C.M. , Halm E.A. , Chubak J. , Doubeni C.A. , Haas J.S. , Kamineni A. , et al. .
Source: American Journal Of Preventive Medicine, 2016 Sep; 51(3), p. e67-75.
PMID: 27344108
Related Citations

Reducing Variation in the "Standard of Care" for Cancer Screening: Recommendations From the PROSPR Consortium.
Authors: Corley D.A. , Haas J.S. , Kobrin S. .
Source: Jama, 2016-05-17 00:00:00.0; 315(19), p. 2067-8.
PMID: 27089237
Related Citations

Variation in Screening Abnormality Rates and Follow-Up of Breast, Cervical and Colorectal Cancer Screening within the PROSPR Consortium.
Authors: Tosteson A.N. , Beaber E.F. , Tiro J. , Kim J. , McCarthy A.M. , Quinn V.P. , Doria-Rose V.P. , Wheeler C.M. , Barlow W.E. , Bronson M. , et al. .
Source: Journal Of General Internal Medicine, 2016 Apr; 31(4), p. 372-9.
PMID: 26658934
Related Citations

Time to Colonoscopy after Positive Fecal Blood Test in Four U.S. Health Care Systems.
Authors: Chubak J. , Garcia M.P. , Burnett-Hartman A.N. , Zheng Y. , Corley D.A. , Halm E.A. , Singal A.G. , Klabunde C.N. , Doubeni C.A. , Kamineni A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016 Feb; 25(2), p. 344-50.
PMID: 26843520
Related Citations

Breast cancer screening using tomosynthesis in combination with digital mammography compared to digital mammography alone: a cohort study within the PROSPR consortium.
Authors: Conant E.F. , Beaber E.F. , Sprague B.L. , Herschorn S.D. , Weaver D.L. , Onega T. , Tosteson A.N. , McCarthy A.M. , Poplack S.P. , Haas J.S. , et al. .
Source: Breast Cancer Research And Treatment, 2016 Feb; 156(1), p. 109-16.
PMID: 26931450
Related Citations

Provider Attitudes and Screening Practices Following Changes in Breast and Cervical Cancer Screening Guidelines.
Authors: Haas J.S. , Sprague B.L. , Klabunde C.N. , Tosteson A.N. , Chen J.S. , Bitton A. , Beaber E.F. , Onega T. , Kim J.J. , MacLean C.D. , et al. .
Source: Journal Of General Internal Medicine, 2016 Jan; 31(1), p. 52-9.
PMID: 26129780
Related Citations

Unifying screening processes within the PROSPR consortium: a conceptual model for breast, cervical, and colorectal cancer screening.
Authors: Beaber E.F. , Kim J.J. , Schapira M.M. , Tosteson A.N. , Zauber A.G. , Geiger A.M. , Kamineni A. , Weaver D.L. , Tiro J.A. , Population-based Research Optimizing Screening through Personalized Regimens Consortium .
Source: Journal Of The National Cancer Institute, 2015 Jun; 107(6), p. djv120.
PMID: 25957378
Related Citations

Breast cancer screening in an era of personalized regimens: a conceptual model and National Cancer Institute initiative for risk-based and preference-based approaches at a population level.
Authors: Onega T. , Beaber E.F. , Sprague B.L. , Barlow W.E. , Haas J.S. , Tosteson A.N. , D Schnall M. , Armstrong K. , Schapira M.M. , Geller B. , et al. .
Source: Cancer, 2014-10-01 00:00:00.0; 120(19), p. 2955-64.
EPub date: 2014-10-01 00:00:00.0.
PMID: 24830599
Related Citations

The colorectal cancer screening process in community settings: a conceptual model for the population-based research optimizing screening through personalized regimens consortium.
Authors: Tiro J.A. , Kamineni A. , Levin T.R. , Zheng Y. , Schottinger J.S. , Rutter C.M. , Corley D.A. , Skinner C.S. , Chubak J. , Doubeni C.A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Jul; 23(7), p. 1147-58.
PMID: 24917182
Related Citations

Molecular alterations and biomarkers in colorectal cancer.
Authors: Grady W.M. , Pritchard C.C. .
Source: Toxicologic Pathology, 2014 Jan; 42(1), p. 124-39.
PMID: 24178577
Related Citations