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Grant Details

Grant Number: 5R01CA168778-03 Interpret this number
Primary Investigator: Brunette, Mary
Organization: Dartmouth College
Project Title: Rct of a Motivational Decision Support System for Smokers with Smi
Fiscal Year: 2015


DESCRIPTION (provided by applicant): Up to 80% of people with schizophrenia and schizoaffective disorders smoke - a rate that is four times the rate in the general population. This high rate of smoking leads to early mortality due in large part to smoking-related cancers, lung diseases and cardiovascular diseases. Cessation treatments are effective, but these smokers don't use them. In order to provide an easy-to-use, cost-effective strategy to engage this group of smokers into effective treatments, we developed a single-session; web-based, motivational decision support system, Let's Talk About Smoking. The system incorporates features that insure high usability among those who can't use current websites due to cognitive impairments and low computer skills. It provides compelling content that engages users into evidence-based cessation treatments. In our pilot work, almost half (47%) of smokers with severe mental illnesses who used this system initiated evidence-based cessation treatments, compared to only 10% of those who received a public health pamphlet. The proposed three-year study will definitively test this highly promising web-based intervention in a randomized, controlled trial among 162 smokers with schizophrenia and schizoaffective disorders who are stable in community mental health treatment. After baseline assessment, participants will be randomly assigned to use the decision support system or a computerized educational pamphlet (control condition). Participants will be assessed three and six months after receiving the intervention for initiation of and engagement in evidence-based cessation treatment, biologically confirmed abstinence, and other quit behaviors, smoking behaviors and outcome expectancies, level of dependence, and intention to quit and to use cessation treatment. Analyses will assess whether this system, designed for a cognitively impaired population, is effective among smokers schizophrenia and schizoaffective disorders with a range of cognitive abilities. If we are able to show that this system is effective, it will become part of a comprehensive, web-based treatment approach to reduce smoking in people with schizophrenia that can dramatically expand the reach of smoking cessation treatment for this population. Further, this system may become a model strategy to reach other populations of disadvantaged smokers with low education and computer experience.


Characteristics of and reasons for electronic cigarette use among adult smokers with schizophrenia/schizoaffective disorder.
Authors: Wong J.A. , Pratt S.I. , Ferron J.C. , Gowarty M. , Brunette M.F. .
Source: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2022 Feb; 34(1), p. 89-96.
PMID: 35166668
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Brief, Web-Based Interventions to Motivate Smokers With Schizophrenia: Randomized Trial.
Authors: Brunette M.F. , Ferron J.C. , McGurk S.R. , Williams J.M. , Harrington A. , Devitt T. , Xie H. .
Source: JMIR mental health, 2020-02-08; 7(2), p. e16524.
EPub date: 2020-02-08.
PMID: 32039811
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Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.
Authors: Whitton A.E. , Green A.I. , Pizzagalli D.A. , Roth R.M. , Williams J.M. , Brunette M.F. .
Source: Schizophrenia bulletin, 2019-10-24; 45(6), p. 1300-1308.
PMID: 30690638
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Use of Smartphones, Computers and Social Media Among People with SMI: Opportunity for Intervention.
Authors: Brunette M.F. , Achtyes E. , Pratt S. , Stilwell K. , Opperman M. , Guarino S. , Kay-Lambkin F. .
Source: Community mental health journal, 2019 Aug; 55(6), p. 973-978.
EPub date: 2019-06-08.
PMID: 31175518
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Treating tobacco use disorder in pregnant women in medication-assisted treatment for an opioid use disorder: a systematic review.
Authors: Akerman S.C. , Brunette M.F. , Green A.I. , Goodman D.J. , Blunt H.B. , Heil S.H. .
Source: Journal of substance abuse treatment, 2015 May; 52, p. 40-7.
EPub date: 2014-12-22.
PMID: 25592332
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Pharmacotherapy of Co-Occurring Schizophrenia and Substance Use Disorders.
Authors: Akerman S.C. , Brunette M.F. , Noordsy D.L. , Green A.I. .
Source: Current addiction reports, 2014 Dec; 1(4), p. 251-260.
EPub date: 2014-09-27.
PMID: 27226947
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