Grant Number:	5R01CA160104-05 Interpret this number
Primary Investigator:	Craig, Benjamin
Organization:	H. Lee Moffitt Cancer Ctr & Res Inst
Project Title:	Hrqol Values for Cancer Survivors: Enhancing Promis Measures for Cer
Fiscal Year:	2015

DESCRIPTION (provided by applicant): Cancer is predicted to be the leading cause of death in 2010 and with 1.5 million newly diagnosed cases for this year alone, cancer survivors are becoming an increasingly large part of the US population. Patient- reported outcomes (PROs) instruments of health-related quality of life (HRQoL) can capture the experiences of cancer patients, and are increasingly used in clinical trials and other forms of comparative effectiveness research (CER) to characterize decision-relevant health outcomes. The NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Network has developed standardized, valid, and precise PROs measures for CER. While these tools provide domain-specific scores, scores alone do not express the value or importance of specific domains or summarize HRQoL across domains from the perspective of cancer patients. Thus, there is a need to facilitate CER by translating PROMIS PROs into decision-relevant health outcome values. In the proposed study, we will recruit members of the general public and cancer survivors (breast, prostate, colorectal) to complete a discrete choice experiment (DCE) to value PROMIS-29 outcomes. The PROMIS-29 instrument includes 7 HRQoL scales (physical function, pain interference, fatigue, depression, anxiety, sleep disturbance, and social role-participation) measured by 4 items/questions each, and a pain intensity scale measured by a single item. Specific aims of the project are (1) to value PROMIS-29 outcomes from a societal perspective, and (2) to value PROMIS-29 outcomes from a cancer survivor perspective. By aggregating HRQoL domains into decision-relevant values from a societal and cancer survivor perspective, CER can better differentiate treatment outcomes and enhance the translation of its findings to clinical practice. Since living with cancer may alter a person's values for HRQoL outcomes, discrepancies between cancer survivor and general public values must be understood and accounted for in CER, patient-centered decision- making, and public health resource allocation. Although the general public is considered the central stakeholder for CER and allocation of public resources, the values of experienced patients may better inform prospective patients of the burden associated with cancer therapies. Incorporating these values with PROs in CER can help NIH achieve its goal of improving the Nation's health and economic well-being by increasing the availability of decision-relevant information that can be applied at the patient and societal level.




Examining the Association Between Maternal Smoking During Pregnancy and Child Behavior Problems Using Quality-Adjusted Life Years.
Authors: Hartman J.D. , Craig B.M. .
Source: Maternal And Child Health Journal, 2018-07-11 00:00:00.0; , .
EPub date: 2018-07-11 00:00:00.0.
PMID: 29995297
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Choice Defines QALYs: A US Valuation of the EQ-5D-5L.
Authors: Craig B.M. , Rand K. .
Source: Medical Care, 2018 06; 56(6), p. 529-536.
PMID: 29668646
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Comparing and transforming PROMIS utility values to the EQ-5D.
Authors: Hartman J.D. , Craig B.M. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2017-12-20 00:00:00.0; , .
EPub date: 2017-12-20 00:00:00.0.
PMID: 29264776
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Further evidence on EQ-5D-5L preference inversion: a Brazil/U.S. collaboration.
Authors: Craig B.M. , Monteiro A.L. , Herdman M. , Santos M. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2017 Sep; 26(9), p. 2489-2496.
EPub date: 2017-05-08 00:00:00.0.
PMID: 28484914
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Valuation of Child Health-Related Quality of Life in the United States.
Authors: Craig B.M. , Greiner W. , Brown D.S. , Reeve B.B. .
Source: Health Economics, 2016 06; 25(6), p. 768-77.
EPub date: 2015-04-28 00:00:00.0.
PMID: 25926161
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Prevalence and Losses in Quality-Adjusted Life Years of Child Health Conditions: A Burden of Disease Analysis.
Authors: Craig B.M. , Hartman J.D. , Owens M.A. , Brown D.S. .
Source: Maternal And Child Health Journal, 2016 Apr; 20(4), p. 862-9.
PMID: 26645618
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Valuation of Child Behavioral Problems from the Perspective of US Adults.
Authors: Craig B.M. , Brown D.S. , Reeve B.B. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2016 Feb; 36(2), p. 199-209.
PMID: 26209476
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Do health preferences contradict ordering of EQ-5D labels?
Authors: Craig B.M. , Pickard A.S. , Rand-Hendriksen K. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2015 Jul; 24(7), p. 1759-65.
PMID: 25519940
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The Value Adults Place on Child Health and Functional Status.
Authors: Craig B.M. , Brown D.S. , Reeve B.B. .
Source: Value In Health : The Journal Of The International Society For Pharmacoeconomics And Outcomes Research, 2015 Jun; 18(4), p. 449-56.
PMID: 26091599
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Birth desires and intentions of women diagnosed with a meningioma.
Authors: Owens M.A. , Craig B.M. , Egan K.M. , Reed D.R. .
Source: Journal Of Neurosurgery, 2015 May; 122(5), p. 1151-6.
PMID: 25623387
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Learning and satisficing: an analysis of sequence effects in health valuation.
Authors: Craig B.M. , Runge S.K. , Rand-Hendriksen K. , Ramos-Goñi J.M. , Oppe M. .
Source: Value In Health : The Journal Of The International Society For Pharmacoeconomics And Outcomes Research, 2015 Mar; 18(2), p. 217-23.
PMID: 25773557
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US valuation of health outcomes measured using the PROMIS-29.
Authors: Craig B.M. , Reeve B.B. , Brown P.M. , Cella D. , Hays R.D. , Lipscomb J. , Simon Pickard A. , Revicki D.A. .
Source: Value In Health : The Journal Of The International Society For Pharmacoeconomics And Outcomes Research, 2014 Dec; 17(8), p. 846-53.
PMID: 25498780
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Demographic differences in health preferences in the United States.
Authors: Craig B.M. , Reeve B.B. , Cella D. , Hays R.D. , Pickard A.S. , Revicki D.A. .
Source: Medical Care, 2014 Apr; 52(4), p. 307-13.
PMID: 24374420
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Health problems are more common, but less severe when measured using newer EQ-5D versions.
Authors: Craig B.M. , Pickard A.S. , Lubetkin E.I. .
Source: Journal Of Clinical Epidemiology, 2014 Jan; 67(1), p. 93-9.
PMID: 24075597
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Comparison of US panel vendors for online surveys.
Authors: Craig B.M. , Hays R.D. , Pickard A.S. , Cella D. , Revicki D.A. , Reeve B.B. .
Source: Journal Of Medical Internet Research, 2013-11-29 00:00:00.0; 15(11), p. e260.
EPub date: 2013-11-29 00:00:00.0.
PMID: 24292159
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Infertility evaluation and treatment among women in the United States.
Authors: Kessler L.M. , Craig B.M. , Plosker S.M. , Reed D.R. , Quinn G.P. .
Source: Fertility And Sterility, 2013 Oct; 100(4), p. 1025-32.
PMID: 23849845
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US valuation of the SF-6D.
Authors: Craig B.M. , Pickard A.S. , Stolk E. , Brazier J.E. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2013 Aug; 33(6), p. 793-803.
PMID: 23629865
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Starting a family: characteristics associated with men's reproductive preferences.
Authors: Kessler L.M. , Craig B.M. , Saigal C. , Quinn G.P. .
Source: American Journal Of Men's Health, 2013 May; 7(3), p. 198-205.
PMID: 23112251
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Proceedings of the Modeling Evidence in HPV Pre-Conference Workshop in Malmö, Sweden, May 9-10, 2009.
Authors: Craig B.M. , Brisson M. , Chesson H. , Giuliano A.R. , Jit M. .
Source: Clinical Therapeutics, 2010 Aug; 32(8), p. 1546-64.
PMID: 20728767
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