Grant Number:	5U54CA164336-05 Interpret this number
Primary Investigator:	Wheeler, Cosette
Organization:	University Of New Mexico Health Scis Ctr
Project Title:	New Mexico HPV Outcomes, Practice Effectiveness and Surveillance (NM-Hopes)
Fiscal Year:	2015

DESCRIPTION (provided by applicant): Approximately 15 HPV types cause virtually all cervical cancers; however, the current HPV vaccines cover only 2 HPV types causing ~70% of invasive cervical cancer and have no therapeutic effect on established infections that place women at risk. Thus, all women will need some kind of routine cervical screening for the foreseeable future. Importantly, the majority of women alive today have not been vaccinated and therefore are at risk for cervical cancer. The US Preventive Services Task Force recommendations on cervical cancer screening have not been updated for nearly a decade and performance measures for cervical cancer screening focus on population coverage rather than on follow-up among women with positive screening and diagnostic tests. Toward improving US cervical cancer prevention, we propose multi-tiered assessments at the statewide, systems, provider and patient levels including targeted medical record review of failures in the screening process; geospatial mapping of population-based screening, diagnosis and treatment; and application of community-based participatory approaches (CBPR) in clinical settings to identify barriers and facilitators across the processes of care including those that may enable novel patient-centered screening options. The cornerstone of our coordinated, multidisciplinary program is the New Mexico HPV Pap Registry which transcends limitations of organizational monitoring by mandating statewide surveillance of all cervical cancer screening, diagnosis and treatment. New Mexico is home to a high proportion of ethnically diverse (i.e., American Indian and Hispanic), rural, impoverished, medically disenfranchised and health-disparate populations at high-risk for cervical cancer. The specific aims of this application are to 1) Establish the New Mexico HPV Outcomes, Practice Effectiveness and Surveillance (NM-HOPES) PROSPR Research Center; 2) Establish a sustainable Screening Process Documentation Unit providing data on patients during their course of cervical cancer screening care; and 3) Integrate and fund 3 research projects with the overarching aim of informing practice and targeted interventions supported by comparative effectiveness evaluations of real-world cervical cancer screening practice and outcomes versus guidelines and innovations.




Screening Beyond the Evidence: Patterns of Age and Comorbidity for Breast, Cervical, and Colorectal Cancer Screening.
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Provider- and Facility-Level Variation in Pre-Cancerous Cervical Biopsy Diagnoses.
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Gaps in the screening process for women diagnosed with cervical cancer in four diverse US health care settings.
Authors: Chao C.R. , Chubak J. , Beaber E.F. , Kamineni A. , Mao C. , Silverberg M.J. , Tiro J.A. , Skinner C. , Garcia M. , Corley D.A. , et al. .
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Erratum to 'A state-wide population-based evaluation of cervical cancers arising during opportunistic screening in the United States' [Gynecologic Oncology 159 (2020) 344-353].
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A state-wide population-based evaluation of cervical cancers arising during opportunistic screening in the United States.
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Impact of screening on cervical cancer incidence: A population-based case-control study in the United States.
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Evaluating screening participation, follow-up and outcomes for breast, cervical and colorectal cancer in the PROSPR consortium.
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Cervical Cancer Screening Research in the PROSPR I Consortium: Rationale, Methods, and Baseline Findings from a U.S. Cohort.
Authors: Kamineni A. , Tiro J.A. , Beaber E.F. , Silverberg M.J. , Wheeler C.M. , Chao C.R. , Chubak J. , Skinner C.S. , Corley D.A. , Kim J.J. , et al. .
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The Mastery Matrix for Integration Praxis: The development of a rubric for integration practice in addressing weight-related public health problems.
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Timely follow-up of positive cancer screening results: A systematic review and recommendations from the PROSPR Consortium.
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Inefficiencies of over-screening and under-screening for cervical cancer prevention in the U.S.
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Effect of Time to Diagnostic Testing for Breast, Cervical, and Colorectal Cancer Screening Abnormalities on Screening Efficacy: A Modeling Study.
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Outcomes in Women With Cytology Showing Atypical Squamous Cells of Undetermined Significance With vs Without Human Papillomavirus Testing.
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An analysis of the process and results of manual geocode correction.
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Similar Risk Patterns After Cervical Screening In Two Large U.s. Populations: Implications For Clinical Guidelines
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Follow-Up of Abnormal Breast and Colorectal Cancer Screening by Race/Ethnicity.
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Health Service Accessibility And Risk In Cervical Cancer Prevention: Comparing Rural Versus Nonrural Residence In New Mexico
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Reducing Variation in the "Standard of Care" for Cancer Screening: Recommendations From the PROSPR Consortium.
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Using lessons from breast, cervical, and colorectal cancer screening to inform the development of lung cancer screening programs.
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Variation in Screening Abnormality Rates and Follow-Up of Breast, Cervical and Colorectal Cancer Screening within the PROSPR Consortium.
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Cancer Models and Real-world Data: Better Together.
Authors: Kim J.J. , Tosteson A.N. , Zauber A.G. , Sprague B.L. , Stout N.K. , Alagoz O. , Trentham-Dietz A. , Armstrong K. , Pruitt S.L. , Rutter C.M. , et al. .
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Provider Attitudes and Screening Practices Following Changes in Breast and Cervical Cancer Screening Guidelines.
Authors: Haas J.S. , Sprague B.L. , Klabunde C.N. , Tosteson A.N. , Chen J.S. , Bitton A. , Beaber E.F. , Onega T. , Kim J.J. , MacLean C.D. , et al. .
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Risk Stratification Using Human Papillomavirus Testing among Women with Equivocally Abnormal Cytology: Results from a State-Wide Surveillance Program.
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Inefficiencies and High-Value Improvements in U.S. Cervical Cancer Screening Practice: A Cost-Effectiveness Analysis.
Authors: Kim J.J. , Campos N.G. , Sy S. , Burger E.A. , Cuzick J. , Castle P.E. , Hunt W.C. , Waxman A. , Wheeler C.M. , New Mexico HPV Pap Registry Steering Committee .
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Human papillomavirus testing 2007-2012: co-testing and triage utilization and impact on subsequent clinical management.
Authors: Cuzick J. , Myers O. , Hunt W.C. , Saslow D. , Castle P.E. , Kinney W. , Waxman A. , Robertson M. , Wheeler C.M. , New Mexico HPV Pap Registry Steering Committee .
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Unifying screening processes within the PROSPR consortium: a conceptual model for breast, cervical, and colorectal cancer screening.
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The value of improving failures within a cervical cancer screening program: an example from Norway.
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An updated natural history model of cervical cancer: derivation of model parameters.
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Practice-based evidence for primary HPV testing in the United States.
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A population-based evaluation of cervical screening in the United States: 2008-2011.
Authors: Cuzick J. , Myers O. , Hunt W.C. , Robertson M. , Joste N.E. , Castle P.E. , Benard V.B. , Wheeler C.M. , New Mexico HPV Pap Registry Steering Committee .
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Cervical excisional treatment of young women: a population-based study.
Authors: Kinney W. , Hunt W.C. , Dinkelspiel H. , Robertson M. , Cuzick J. , Wheeler C.M. , New Mexico HPV Pap Registry Steering Committee .
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Prevention of HPV-related cancers in Norway: cost-effectiveness of expanding the HPV vaccination program to include pre-adolescent boys.
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Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
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Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
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Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
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Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
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The natural history of cervical human papillomavirus infections and cervical cancer: gaps in knowledge and future horizons.
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Optimal interval for routine cytologic screening in the United States.
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Modeling preventative strategies against human papillomavirus-related disease in developed countries.
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