Grant Number:	5U54CA155435-05 Interpret this number
Primary Investigator:	Patterson, Ruth
Organization:	University Of California, San Diego
Project Title:	Energetics & Breast Cancer: Obesity, Inflammation, Insulin Resistance & Risk
Fiscal Year:	2015

The overall objective of the UCSD TREC Center is to assemble transdisciplinary scientific collaborators to address questions regarding insulin resistance and inflammation underlying the association of energetics with breast cancer carcinogenesis, from the cell to the community. In Project 1, we will use obese mouse models to investigate whether the beneficial anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids will reduce breast tumor growth and metastasis and whether the w3 fatty acid receptor GPR120 is the critical mediator of those cancer-protective effects. In Project 2, we will conduct a trial in obese women to examine differential response (depending on insulin resistance status) to dietary macronutrient composition. Outcomes will include weight loss, hormonal factors, and markers of inflammation as well as nutrient-gene interactions associated with polymorphisms in IL-6 and TNF-a genes. Project 3 will investigate the degree to which metformin, a lifestyle intervention, or both, can reduce breast cancer mortality among overweight/obese, postmenopausal breast cancer survivors. We will use an innovative Biomarker Bridge design that links clinical outcomes from a breast cancer survivor cohort with intermediate outcomes from a randomized controlled trial. Project 4 will advance the science of energy expenditure estimation by using branched equation modeling techniques and artificial neural networks to analyze accelerometer and heart rate data from participants in Projects 2 and 3. Global Positioning System data, which track individuals' spatial-temporal paths, combined with existing Geographic Information Systems data for San Diego County, will allow us to develop obesogenic environmental exposure estimates and relate these to metabolic risk factors. Dr. Patterson, the PI for this proposed Center, has considerable research experience in nutrition and breast cancer prevention and a strong background in leadership and management in academia and industry. The central leadership entity of the UCSD TREC Center will be the Executive Scientific Committee, composed of Project and Core leaders. This Committee, assisted by the Administrative Core, will provide scientific and operational oversight of the Shared Resources (Biostatistics & Bioinformatics and Biorepository) as well as the transdisciplinary Training Program and the Developmental and cross-TREC Pilot Project Core. We believe that the TREC Center proposed herein has the potential to make significant contributions to understanding the link between obesity and breast cancer and provide insight regarding interventions with broad population impact for prevention and control of disease.




Multilevel Longitudinal Functional Principal Component Model.
Authors: Lin W. , Zou J. , Di C. , Rock C.L. , Natarajan L. .
Source: Statistics In Medicine, 2024-09-03 00:00:00.0; , .
EPub date: 2024-09-03 00:00:00.0.
PMID: 39226919
Related Citations

Exploring the impact of environmental exposure changes on metabolic biomarkers: A 6-month GPS-GIS study among women with overweight or obesity.
Authors: Letellier N. , Yang J.A. , Alismail S. , Nukavarapu N. , Hartman S.J. , Rock C.L. , Sears D.D. , Jankowska M.M. , Benmarhnia T. .
Source: Environmental Research, 2024-02-15 00:00:00.0; 243, p. 117881.
EPub date: 2023-12-07 00:00:00.0.
PMID: 38070847
Related Citations

Effect of metformin and lifestyle intervention on adipokines and hormones in breast cancer survivors: a pooled analysis from two randomized controlled trials.
Authors: Johansson H. , Bellerba F. , Macis D. , Bertelsen B.E. , Guerrieri-Gonzaga A. , Aristarco V. , Viste K. , Mellgren G. , Di Cola G. , Costantino J. , et al. .
Source: Breast Cancer Research And Treatment, 2024-01-26 00:00:00.0; , .
EPub date: 2024-01-26 00:00:00.0.
PMID: 38279016
Related Citations

A RIEMANN MANIFOLD MODEL FRAMEWORK FOR LONGITUDINAL CHANGES IN PHYSICAL ACTIVITY PATTERNS.
Authors: Zou J. , Lin T. , Di C. , Bellettiere J. , Jankowska M.M. , Hartman S.J. , Sears D.D. , LaCroix A.Z. , Rock C.L. , Natarajan L. .
Source: The Annals Of Applied Statistics, 2023 Dec; 17(4), p. 3216-3240.
EPub date: 2023-10-30 00:00:00.0.
PMID: 38835721
Related Citations

WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity.
Authors: Lin D. , Sturgeon K.M. , Gordon B.R. , Brown J.C. , Sears D.D. , Sarwer D.B. , Schmitz K.H. .
Source: Nutrients, 2023-08-04 00:00:00.0; 15(15), .
EPub date: 2023-08-04 00:00:00.0.
PMID: 37571390
Related Citations

Longitudinal Associations Between Timing of Physical Activity Accumulation and Health: Application of Functional Data Methods.
Authors: Lin W. , Zou J. , Di C. , Sears D.D. , Rock C.L. , Natarajan L. .
Source: Statistics In Biosciences, 2023 Jul; 15(2), p. 309-329.
EPub date: 2022-09-29 00:00:00.0.
PMID: 37383028
Related Citations

WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Inflammation in Breast Cancer Survivors.
Authors: Sturgeon K.M. , Brown J.C. , Sears D.D. , Sarwer D.B. , Schmitz K.H. .
Source: Medicine And Science In Sports And Exercise, 2023-02-01 00:00:00.0; 55(2), p. 209-215.
EPub date: 2022-09-29 00:00:00.0.
PMID: 36170550
Related Citations

Metabolomic profiles of metformin in breast cancer survivors: a pooled analysis of plasmas from two randomized placebo-controlled trials.
Authors: Bellerba F. , Chatziioannou A.C. , Jasbi P. , Robinot N. , Keski-Rahkonen P. , Trolat A. , Vozar B. , Hartman S.J. , Scalbert A. , Bonanni B. , et al. .
Source: Journal Of Translational Medicine, 2022-12-29 00:00:00.0; 20(1), p. 629.
EPub date: 2022-12-29 00:00:00.0.
PMID: 36581893
Related Citations

GPS-based activity space exposure to greenness and walkability is associated with increased accelerometer-based physical activity.
Authors: Marquet O. , Hirsch J.A. , Kerr J. , Jankowska M.M. , Mitchell J. , Hart J.E. , Laden F. , Hipp J.A. , James P. .
Source: Environment International, 2022 07; 165, p. 107317.
EPub date: 2022-05-23 00:00:00.0.
PMID: 35660954
Related Citations

GPS-based activity space exposure to greenness and walkability is associated with increased accelerometer-based physical activity.
Authors: Marquet O. , Hirsch J.A. , Kerr J. , Jankowska M.M. , Mitchell J. , Hart J.E. , Laden F. , Hipp J.A. , James P. .
Source: Environment International, 2022 07; 165, p. 107317.
EPub date: 2022-05-23 00:00:00.0.
PMID: 35660954
Related Citations

An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors.
Authors: Nwanaji-Enwerem J.C. , Chung F.F. , Van der Laan L. , Novoloaca A. , Cuenin C. , Johansson H. , Bonanni B. , Hubbard A.E. , Smith M.T. , Hartman S.J. , et al. .
Source: Clinical Epigenetics, 2021-12-17 00:00:00.0; 13(1), p. 224.
EPub date: 2021-12-17 00:00:00.0.
PMID: 34920739
Related Citations

Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women.
Authors: Chang Y.J. , Tuz-Zahra F. , Godbole S. , Avitia Y. , Bellettiere J. , Rock C.L. , Jankowska M.M. , Allison M.A. , Dunstan D.W. , Rana B. , et al. .
Source: Scientific Reports, 2021-06-03 00:00:00.0; 11(1), p. 11766.
EPub date: 2021-06-03 00:00:00.0.
PMID: 34083573
Related Citations

Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models.
Authors: Das M. , Ellies L.G. , Kumar D. , Sauceda C. , Oberg A. , Gross E. , Mandt T. , Newton I.G. , Kaur M. , Sears D.D. , et al. .
Source: Nature Communications, 2021-01-25 00:00:00.0; 12(1), p. 565.
EPub date: 2021-01-25 00:00:00.0.
PMID: 33495474
Related Citations

Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers.
Authors: Chang Y.J. , Bellettiere J. , Godbole S. , Keshavarz S. , Maestas J.P. , Unkart J.T. , Ervin D. , Allison M.A. , Rock C.L. , Patterson R.E. , et al. .
Source: Journal Of The American Heart Association, 2020-02-18 00:00:00.0; 9(4), p. e013403.
EPub date: 2020-02-17 00:00:00.0.
PMID: 32063113
Related Citations

Using Isotemporal Analyses to Examine the Relationships Between Daytime Activities and Cancer Recurrence Biomarkers in Breast Cancer Survivors.
Authors: Full K.M. , Johnson E. , Takemoto M. , Hartman S.J. , Kerr J. , Natarajan L. , Patterson R.E. , Sears D.D. .
Source: Journal Of Physical Activity & Health, 2020-02-01 00:00:00.0; 17(2), p. 217-224.
EPub date: 2020-02-01 00:00:00.0.
PMID: 31923899
Related Citations

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection.
Authors: Ryan A.F. , Nasamran C.A. , Pak K. , Draf C. , Fisch K.M. , Webster N. , Kurabi A. .
Source: Frontiers In Genetics, 2020; 11, p. 358.
EPub date: 2020-04-15 00:00:00.0.
PMID: 32351546
Related Citations

Changes in Moderate Intensity Physical Activity Are Associated With Better Cognition in the Multilevel Intervention for Physical Activity in Retirement Communities (MIPARC) Study.
Authors: Zlatar Z.Z. , Godbole S. , Takemoto M. , Crist K. , Sweet C.M.C. , Kerr J. , Rosenberg D.E. .
Source: The American Journal Of Geriatric Psychiatry : Official Journal Of The American Association For Geriatric Psychiatry, 2019 Oct; 27(10), p. 1110-1121.
EPub date: 2019-04-29 00:00:00.0.
PMID: 31138456
Related Citations

Degradation of splicing factor SRSF3 contributes to progressive liver disease.
Authors: Kumar D. , Das M. , Sauceda C. , Ellies L.G. , Kuo K. , Parwal P. , Kaur M. , Jih L. , Bandyopadhyay G.K. , Burton D. , et al. .
Source: The Journal Of Clinical Investigation, 2019-08-08 00:00:00.0; 129(10), p. 4477-4491.
EPub date: 2019-08-08 00:00:00.0.
PMID: 31393851
Related Citations

SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function.
Authors: Choi I. , Rickert E. , Fernandez M. , Webster N.J.G. .
Source: Endocrinology, 2019-06-01 00:00:00.0; 160(6), p. 1547-1560.
PMID: 31127273
Related Citations

Continuous, objective measurement of physical activity during chemotherapy for breast cancer: the Activity in Treatment pilot study.
Authors: Nelson S.H. , Weiner L.S. , Natarajan L. , Parker B.A. , Patterson R.E. , Hartman S.J. .
Source: Translational Behavioral Medicine, 2019-05-29 00:00:00.0; , .
EPub date: 2019-05-29 00:00:00.0.
PMID: 31141593
Related Citations

The effects of weight loss and metformin on cognition among breast cancer survivors: Evidence from the Reach for Health study.
Authors: Hartman S.J. , Nelson S.H. , Marinac C.R. , Natarajan L. , Parker B.A. , Patterson R.E. .
Source: Psycho-oncology, 2019-05-28 00:00:00.0; , .
EPub date: 2019-05-28 00:00:00.0.
PMID: 31140202
Related Citations

Physical Activity Change in an RCT: Comparison of Measurement Methods.
Authors: Nelson S.H. , Natarajan L. , Patterson R.E. , Hartman S.J. , Thompson C.A. , Godbole S.V. , Johnson E. , Marinac C.R. , Kerr J. .
Source: American Journal Of Health Behavior, 2019-05-01 00:00:00.0; 43(3), p. 543-555.
PMID: 31046885
Related Citations

Associations Between Timing of Meals, Physical Activity, Light Exposure, and Sleep With Body Mass Index in Free-Living Adults.
Authors: Marinac C.R. , Quante M. , Mariani S. , Weng J. , Redline S. , Cespedes Feliciano E.M. , Hipp J.A. , Wang D. , Kaplan E.R. , James P. , et al. .
Source: Journal Of Physical Activity & Health, 2019-03-01 00:00:00.0; 16(3), p. 214-221.
EPub date: 2019-02-24 00:00:00.0.
PMID: 30798690
Related Citations

Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction.
Authors: Rickert E. , Fernandez M.O. , Choi I. , Gorman M. , Olefsky J.M. , Webster N.J.G. .
Source: Journal Of The Endocrine Society, 2019-02-01 00:00:00.0; 3(2), p. 427-445.
EPub date: 2018-12-24 00:00:00.0.
PMID: 30746504
Related Citations

Latent profile analysis of accelerometer-measured sleep, physical activity, and sedentary time and differences in health characteristics in adult women.
Authors: Full K.M. , Moran K. , Carlson J. , Godbole S. , Natarajan L. , Hipp A. , Glanz K. , Mitchell J. , Laden F. , James P. , et al. .
Source: Plos One, 2019; 14(6), p. e0218595.
EPub date: 2019-06-27 00:00:00.0.
PMID: 31247051
Related Citations

The Effects of Metformin and Weight Loss on Biomarkers Associated With Breast Cancer Outcomes.
Authors: Patterson R.E. , Marinac C.R. , Sears D.D. , Kerr J. , Hartman S.J. , Cadmus-Bertram L. , Villaseñor A. , Flatt S.W. , Godbole S. , Li H. , et al. .
Source: Journal Of The National Cancer Institute, 2018-11-01 00:00:00.0; 110(11), p. 1239-1247.
PMID: 29788487
Related Citations

Zeitgebers and their association with rest-activity patterns.
Authors: Quante M. , Mariani S. , Weng J. , Marinac C.R. , Kaplan E.R. , Rueschman M. , Mitchell J.A. , James P. , Hipp J.A. , Cespedes Feliciano E.M. , et al. .
Source: Chronobiology International, 2018-10-26 00:00:00.0; , p. 1-11.
EPub date: 2018-10-26 00:00:00.0.
PMID: 30365354
Related Citations

Statistical approaches to account for missing values in accelerometer data: Applications to modeling physical activity.
Authors: Yue Xu S. , Nelson S. , Kerr J. , Godbole S. , Patterson R. , Merchant G. , Abramson I. , Staudenmayer J. , Natarajan L. .
Source: Statistical Methods In Medical Research, 2018 04; 27(4), p. 1168-1186.
EPub date: 2016-07-10 00:00:00.0.
PMID: 27405327
Related Citations

Validation of a physical activity accelerometer device worn on the hip and wrist against polysomnography.
Authors: Full K.M. , Kerr J. , Grandner M.A. , Malhotra A. , Moran K. , Godoble S. , Natarajan L. , Soler X. .
Source: Sleep Health, 2018 Apr; 4(2), p. 209-216.
EPub date: 2018-01-17 00:00:00.0.
PMID: 29555136
Related Citations

Modeling interrelationships between health behaviors in overweight breast cancer survivors: Applying Bayesian networks.
Authors: Xu S. , Thompson W. , Kerr J. , Godbole S. , Sears D.D. , Patterson R. , Natarajan L. .
Source: Plos One, 2018; 13(9), p. e0202923.
EPub date: 2018-09-04 00:00:00.0.
PMID: 30180192
Related Citations

Actigraphy-Derived Daily Rest-Activity Patterns and Body Mass Index in Community-Dwelling Adults.
Authors: Cespedes Feliciano E.M. , Quante M. , Weng J. , Mitchell J.A. , James P. , Marinac C.R. , Mariani S. , Redline S. , Kerr J. , Godbole S. , et al. .
Source: Sleep, 2017-12-01 00:00:00.0; 40(12), .
PMID: 29029250
Related Citations

Bicycle Trains, Cycling, and Physical Activity: A Pilot Cluster RCT.
Authors: Mendoza J.A. , Haaland W. , Jacobs M. , Abbey-Lambertz M. , Miller J. , Salls D. , Todd W. , Madding R. , Ellis K. , Kerr J. .
Source: American Journal Of Preventive Medicine, 2017 Oct; 53(4), p. 481-489.
EPub date: 2017-06-28 00:00:00.0.
PMID: 28668251
Related Citations

Metabolic Effects of Intermittent Fasting.
Authors: Patterson R.E. , Sears D.D. .
Source: Annual Review Of Nutrition, 2017-08-21 00:00:00.0; 37, p. 371-393.
EPub date: 2017-07-17 00:00:00.0.
PMID: 28715993
Related Citations

Objectively measured sedentary behavior and quality of life among survivors of early stage breast cancer.
Authors: Hartman S.J. , Marinac C.R. , Bellettiere J. , Godbole S. , Natarajan L. , Patterson R.E. , Kerr J. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2017 Aug; 25(8), p. 2495-2503.
EPub date: 2017-03-22 00:00:00.0.
PMID: 28326507
Related Citations

The IL-6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention.
Authors: Rana B.K. , Flatt S.W. , Health D.D. , Pakiz B. , Quintana E.L. , Natarajan L. , Rock C.L. .
Source: Nutrients, 2017-05-27 00:00:00.0; 9(6), .
EPub date: 2017-05-27 00:00:00.0.
PMID: 28555011
Related Citations

Sleep duration and breast cancer prognosis: perspectives from the Women's Healthy Eating and Living Study.
Authors: Marinac C.R. , Nelson S.H. , Flatt S.W. , Natarajan L. , Pierce J.P. , Patterson R.E. .
Source: Breast Cancer Research And Treatment, 2017 04; 162(3), p. 581-589.
EPub date: 2017-02-11 00:00:00.0.
PMID: 28190251
Related Citations

GPS-Based Exposure to Greenness and Walkability and Accelerometry-Based Physical Activity.
Authors: James P. , Hart J.E. , Hipp J.A. , Mitchell J.A. , Kerr J. , Hurvitz P.M. , Glanz K. , Laden F. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 Apr; 26(4), p. 525-532.
EPub date: 2017-02-14 00:00:00.0.
PMID: 28196848
Related Citations

Kernel Density Estimation As A Measure Of Environmental Exposure Related To Insulin Resistance In Breast Cancer Survivors
Authors: Jankowska M.M. , Natarajan L. , Godbole S. , Meseck K. , Sears D.D. , Patterson R.E. , Kerr J. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-03-03 00:00:00.0; , .
PMID: 28258052
Related Citations

Comparison Of Accelerometry Methods For Estimating Physical Activity
Authors: Kerr J. , Marinac C.R. , Ellis K. , Godbole S. , Hipp A. , Glanz K. , Mitchell J. , Laden F. , James P. , Berrigan D. .
Source: Medicine And Science In Sports And Exercise, 2017 Mar; 49(3), p. 617-624.
PMID: 27755355
Related Citations

Muscle Injury, Impaired Muscle Function And Insulin Resistance In Chromogranin A-knockout Mice
Authors: Tang K. , Pasqua T. , Biswas A. , Mahata S. , Tang J. , Tang A. , Bandyopadhyay G.K. , Sinha-Hikim A.P. , Chi N.W. , Webster N.J. , et al. .
Source: The Journal Of Endocrinology, 2017 Feb; 232(2), p. 137-153.
PMID: 27799464
Related Citations

Variation in actigraphy-estimated rest-activity patterns by demographic factors.
Authors: Mitchell J.A. , Quante M. , Godbole S. , James P. , Hipp J.A. , Marinac C.R. , Mariani S. , Cespedes Feliciano E.M. , Glanz K. , Laden F. , et al. .
Source: Chronobiology International, 2017; 34(8), p. 1042-1056.
EPub date: 2017-06-26 00:00:00.0.
PMID: 28650674
Related Citations

The relations between sleep, time of physical activity, and time outdoors among adult women.
Authors: Murray K. , Godbole S. , Natarajan L. , Full K. , Hipp J.A. , Glanz K. , Mitchell J. , Laden F. , James P. , Quante M. , et al. .
Source: Plos One, 2017; 12(9), p. e0182013.
EPub date: 2017-09-06 00:00:00.0.
PMID: 28877192
Related Citations

Time-restricted Feeding Improves Insulin Resistance And Hepatic Steatosis In A Mouse Model Of Postmenopausal Obesity
Authors: Chung H. , Chou W. , Sears D.D. , Patterson R.E. , Webster N.J. , Ellies L.G. .
Source: Metabolism: Clinical And Experimental, 2016 Dec; 65(12), p. 1743-1754.
PMID: 27832862
Related Citations

Obese Neuronal Ppar¿ Knock-out Mice Are Leptin Sensitive But Show Impaired Glucose Tolerance And Fertility
Authors: Fernandez M.O. , Sharma S. , Kim S. , Rickert E. , Hsueh K. , Hwang V. , Olefsky J.M. , Webster N.J. .
Source: Endocrinology, 2016-11-14 00:00:00.0; , p. en20161818.
PMID: 27841948
Related Citations

"Spatial Energetics": Integrating Data From GPS, Accelerometry, and GIS to Address Obesity and Inactivity.
Authors: James P. , Jankowska M. , Marx C. , Hart J.E. , Berrigan D. , Kerr J. , Hurvitz P.M. , Hipp J.A. , Laden F. .
Source: American Journal Of Preventive Medicine, 2016 Nov; 51(5), p. 792-800.
PMID: 27528538
Related Citations

Both Canonical And Non-canonical Nf-¿b Activation Contribute To The Proliferative Response Of The Middle Ear Mucosa During Bacterial Infection
Authors: Cho C.G. , Pak K. , Webster N. , Kurabi A. , Ryan A.F. .
Source: Innate Immunity, 2016 Nov; 22(8), p. 626-634.
PMID: 27655045
Related Citations

Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status.
Authors: Rock C.L. , Flatt S.W. , Pakiz B. , Quintana E.L. , Heath D.D. , Rana B.K. , Natarajan L. .
Source: Metabolism: Clinical And Experimental, 2016 Nov; 65(11), p. 1605-1613.
EPub date: 2016-07-25 00:00:00.0.
PMID: 27733248
Related Citations

No Evidence of Reciprocal Associations between Daily Sleep and Physical Activity.
Authors: Mitchell J.A. , Godbole S. , Moran K. , Murray K. , James P. , Laden F. , Hipp J.A. , Kerr J. , Glanz K. .
Source: Medicine And Science In Sports And Exercise, 2016 Oct; 48(10), p. 1950-6.
PMID: 27285490
Related Citations

Prolonged Nightly Fasting and Breast Cancer Prognosis.
Authors: Marinac C.R. , Nelson S.H. , Breen C.I. , Hartman S.J. , Natarajan L. , Pierce J.P. , Flatt S.W. , Sears D.D. , Patterson R.E. .
Source: Jama Oncology, 2016-08-01 00:00:00.0; 2(8), p. 1049-55.
PMID: 27032109
Related Citations

Objective Assessment of Physical Activity: Classifiers for Public Health.
Authors: Kerr J. , Patterson R.E. , Ellis K. , Godbole S. , Johnson E. , Lanckriet G. , Staudenmayer J. .
Source: Medicine And Science In Sports And Exercise, 2016 May; 48(5), p. 951-7.
PMID: 27089222
Related Citations