Skip to main content
Grant Details

Grant Number: 5R03CA176717-02 Interpret this number
Primary Investigator: Zhang, Xuehong
Organization: Brigham And Women'S Hospital
Project Title: Calcium Intake and Colorectal Cancer Incidence and Survival
Fiscal Year: 2015
Back to top


Abstract

DESCRIPTION (provided by applicant): Colorectal cancer (CRC) remains the third most common cancer and cancer-related death in US women and men. Although the totality of evidence in aggregate supports a beneficial role of calcium in colorectal carcinogenesis, three major unresolved outstanding questions exist. First, the optimal dose and timing of calcium intake for CRC prevention remains unknown. Second, although several proposed mechanisms for calcium's role in risk may also influence cancer progression, no study has yet examined whether post-diagnostic calcium intake will improve survival among CRC patients. Lastly, the biological pathways by which calcium influences CRC risk remain unknown. Because future randomized controlled trials may not be feasible to test different doses with long or unknown latency between start intervention and CRC onset, we propose to examine the following specific aims using the resources of two large, well- characterized cohorts of women (the Nurses' Health Study, NHS) and men (the Health Professionals Follow-up Study, HPFS), in which calcium intake was assessed every 4 years since 1980 and 1986 respectively, using validated food frequency questionnaires. With up to 3 decades of follow-up, long-term effects can be studied. Aim 1 is to investigate the optimal dose and timing of calcium intake for CRC prevention. Aim 2 is to assess whether adequate post- diagnostic calcium intake is associated with better CRC survival. Aim 3 is to discover biological pathways through which calcium might operate to reduce risk of CRC using pre-existing mRNA expression data from the CRC tumors. Two large cohort studies of women and men with multiple calcium assessments and pre-existing validated mRNA expression data provide a unique opportunity to address the proposed aims in a cost-effective manner. Completion of this project will make important contributions towards informing future dietary recommendations of calcium intake for CRC prevention and survival in US adults.

Back to top


Publications

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women.
Authors: Ma Y. , Yang W. , Simon T.G. , Smith-Warner S.A. , Fung T.T. , Sui J. , Chong D. , VoPham T. , Meyerhardt J.A. , Wen D. , et al. .
Source: Hepatology (Baltimore, Md.), 2019 Aug; 70(2), p. 577-586.
EPub date: 2019-03-05.
PMID: 30506561
Related Citations

A Prospective Study of Nut Consumption and Risk of Primary Hepatocellular Carcinoma in the U.S. Women and Men.
Authors: Sui J. , Yang W. , Ma Y. , Li T.Y. , Simon T.G. , Meyerhardt J.A. , Liang G. , Giovannucci E.L. , Chan A.T. , Zhang X. .
Source: Cancer prevention research (Philadelphia, Pa.), 2019 Jun; 12(6), p. 367-374.
EPub date: 2019-04-30.
PMID: 31040153
Related Citations

Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study.
Authors: Momen-Heravi F. , Masugi Y. , Qian Z.R. , Nishihara R. , Liu L. , Smith-Warner S.A. , Keum N. , Zhang L. , Tchrakian N. , Nowak J.A. , et al. .
Source: International journal of cancer, 2017-12-15; 141(12), p. 2471-2479.
EPub date: 2017-09-20.
PMID: 28856682
Related Citations

Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR).
Authors: Yang W. , Liu L. , Masugi Y. , Qian Z.R. , Nishihara R. , Keum N. , Wu K. , Smith-Warner S. , Ma Y. , Nowak J.A. , et al. .
Source: Gut, 2018 08; 67(8), p. 1475-1483.
EPub date: 2017-07-04.
PMID: 28676564
Related Citations

Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses' Health Study.
Authors: Momen-Heravi F. , Babic A. , Tworoger S.S. , Zhang L. , Wu K. , Smith-Warner S.A. , Ogino S. , Chan A.T. , Meyerhardt J. , Giovannucci E. , et al. .
Source: International journal of cancer, 2017-02-01; 140(3), p. 646-652.
EPub date: 2016-11-23.
PMID: 27778343
Related Citations

Calcium intake and colorectal cancer risk: Results from the nurses' health study and health professionals follow-up study.
Authors: Zhang X. , Keum N. , Wu K. , Smith-Warner S.A. , Ogino S. , Chan A.T. , Fuchs C.S. , Giovannucci E.L. .
Source: International journal of cancer, 2016-11-15; 139(10), p. 2232-42.
EPub date: 2016-08-09.
PMID: 27466215
Related Citations

Marine ?-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis.
Authors: Song M. , Zhang X. , Meyerhardt J.A. , Giovannucci E.L. , Ogino S. , Fuchs C.S. , Chan A.T. .
Source: Gut, 2017 10; 66(10), p. 1790-1796.
EPub date: 2016-07-19.
PMID: 27436272
Related Citations

Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study.
Authors: Kantor E.D. , Zhang X. , Wu K. , Signorello L.B. , Chan A.T. , Fuchs C.S. , Giovannucci E.L. .
Source: International journal of cancer, 2016-11-01; 139(9), p. 1949-57.
EPub date: 2016-07-18.
PMID: 27357024
Related Citations

Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival.
Authors: Mima K. , Nowak J.A. , Qian Z.R. , Cao Y. , Song M. , Masugi Y. , Shi Y. , da Silva A. , Gu M. , Li W. , et al. .
Source: Oncotarget, 2016-08-23; 7(34), p. 55098-55109.
PMID: 27391152
Related Citations

Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
Authors: Song M. , Nishihara R. , Wang M. , Chan A.T. , Qian Z.R. , Inamura K. , Zhang X. , Ng K. , Kim S.A. , Mima K. , et al. .
Source: Gut, 2016 Feb; 65(2), p. 296-304.
EPub date: 2015-01-15.
PMID: 25591978
Related Citations

Proportion of colon cancer attributable to lifestyle in a cohort of US women.
Authors: Erdrich J. , Zhang X. , Giovannucci E. , Willett W. .
Source: Cancer causes & control : CCC, 2015 Sep; 26(9), p. 1271-1279.
EPub date: 2015-06-20.
PMID: 26092381
Related Citations

Early life body fatness and risk of colorectal cancer in u.s. Women and men-results from two large cohort studies.
Authors: Zhang X. , Wu K. , Giovannucci E.L. , Ma J. , Colditz G.A. , Fuchs C.S. , Willett W.C. , Stampfer M.J. , Nimptsch K. , Ogino S. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015 Apr; 24(4), p. 690-7.
EPub date: 2015-03-16.
PMID: 25777804
Related Citations

Calcium intake and colorectal adenoma risk: dose-response meta-analysis of prospective observational studies.
Authors: Keum N. , Lee D.H. , Greenwood D.C. , Zhang X. , Giovannucci E.L. .
Source: International journal of cancer, 2015-04-01; 136(7), p. 1680-7.
EPub date: 2014-09-04.
PMID: 25156950
Related Citations




Back to Top