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Grant Details

Grant Number: 5R01CA151899-05 Interpret this number
Primary Investigator: Horwitz, Steven
Organization: Sloan-Kettering Inst Can Research
Project Title: Communication Skills Intervention to Promote Transition Into Survivorship
Fiscal Year: 2015


Abstract

DESCRIPTION (provided by applicant): Preparation for survivorship beyond primary cancer treatment is vital so that each patient understands their ongoing care plan. Our proposal is to introduce a new clinical consultation that focuses deliberately on survivorship, promotes knowledge about long term and late effects of anti-cancer treatment and discusses the health promotion and lifestyle risk reduction approaches for future wellbeing. Such consultations are not current standard practice. This is a radical shift in clinical practice and gives each patient a document termed "Treatment Summary and Future Care Plan." Our study involves a Communication Skills Training (CST) intervention to train clinicians in the use of this new survivorship consultation. The excellent survival rates for Hodgkin's and Diffuse Large B-cell Lymphoma create an ideal study population. In a four-site, randomized controlled trial, we will compare this CST-based consultation by 18 clinicians with an attention-time control intervention by 18 clinicians who discuss diet and exercise. Our primary outcomes will be change in patient's knowledge about survivorship and adherence to health recommendations, while secondary outcomes will include satisfaction with care, perception of alliance with their clinician, decreased cancer worry and improved quality of life over time. We will also examine the uptake and utilization by clinicians of the strategies, tasks and skills taught in the CST workshop. At baseline, we will establish current patterns of communication by recording 2 patients per clinician to enable us to later control for site variations in practice. In our RCT, we will randomize by site to protect against contamination effects and will examine outcomes for 288 patients, eight nested within each clinician. These patients will be followed longitudinally for 12 months with outcome questionnaires. Patients in our control arm will receive matched timing of consultations, which will follow a structured manual that standardizes the focus on diet and exercise. We will monitor for contamination effects by recording consultations in intervention and control arms once chemotherapy is concluded, at the key new survivorship consultation and again three months later. Our study will explore the moderators and mediators of change in the use of health information to build up the patient's understanding of their survivorship care plan and of cancer survivorship as a prototype of the common- sense model of illness representation and behavioral self-regulation. We anticipate that more empathic communication will support the integration of greater knowledge and adherence to recommended health- promotion behaviors, leading to reduced worry, improved quality of life and better utilization of health care resources over time.



Publications

The ECHELON-2 Trial: 5-year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma.
Authors: Horwitz S. , O'Connor O.A. , Pro B. , Trümper L. , Iyer S. , Advani R. , Bartlett N.L. , Christensen J.H. , Morschhauser F. , Domingo-Domenech E. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2022 Mar; 33(3), p. 288-298.
EPub date: 2021-12-16.
PMID: 34921960
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Camidanlumab tesirine in patients with relapsed or refractory lymphoma: a phase 1, open-label, multicentre, dose-escalation, dose-expansion study.
Authors: Hamadani M. , Collins G.P. , Caimi P.F. , Samaniego F. , Spira A. , Davies A. , Radford J. , Menne T. , Karnad A. , Zain J.M. , et al. .
Source: The Lancet. Haematology, 2021 Jun; 8(6), p. e433-e445.
PMID: 34048682
Related Citations

Cancer worry and empathy moderate the effect of a survivorship-focused intervention on quality of life.
Authors: Parker P.A. , Banerjee S.C. , Matasar M.J. , Bylund C.L. , Schofield E. , Li Y. , Jacobsen P.B. , Astrow A.B. , Leventhal H. , Horwitz S. , et al. .
Source: Psycho-oncology, 2020 Jun; 29(6), p. 1012-1018.
EPub date: 2020-03-11.
PMID: 32128909
Related Citations

Fear of cancer recurrence in lymphoma survivors: A descriptive study.
Authors: Latella L.E. , Rogers M. , Leventhal H. , Parker P.A. , Horwitz S. , Matasar M.J. , Bylund C.L. , Kissane D.W. , Franco K. , Banerjee S.C. .
Source: Journal of psychosocial oncology, 2020 May-Jun; 38(3), p. 251-271.
EPub date: 2019-10-16.
PMID: 31617830
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Efficacy of a survivorship-focused consultation versus a time-controlled rehabilitation consultation in patients with lymphoma: A cluster randomized controlled trial.
Authors: Parker P.A. , Banerjee S.C. , Matasar M.J. , Bylund C.L. , Rogers M. , Franco K. , Schofield E. , Li Y. , Levin T.T. , Jacobsen P.B. , et al. .
Source: Cancer, 2018-12-01; 124(23), p. 4567-4576.
EPub date: 2018-10-18.
PMID: 30335188
Related Citations

Peripheral T-cell lymphoma - are we making progress?
Authors: Khan N. , Ozkaya N. , Moskowitz A. , Dogan A. , Horwitz S. .
Source: Best practice & research. Clinical haematology, 2018 Sep; 31(3), p. 306-314.
EPub date: 2018-07-17.
PMID: 30213401
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Communication between oncologists and lymphoma survivors during follow-up consultations: A qualitative analysis.
Authors: Franco K. , Shuk E. , Philip E. , Blanch-Hartigan D. , Parker P.A. , Matasar M. , Horwitz S. , Kissane D. , Banerjee S.C. , Bylund C.L. .
Source: Journal of psychosocial oncology, 2017 Sep-Oct; 35(5), p. 513-530.
EPub date: 2017-03-30.
PMID: 28358241
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Protocol for a cluster randomised trial of a communication skills intervention for physicians to facilitate survivorship transition in patients with lymphoma.
Authors: Parker P.A. , Banerjee S.C. , Matasar M.J. , Bylund C.L. , Franco K. , Li Y. , Levin T.T. , Jacobsen P.B. , Astrow A.B. , Leventhal H. , et al. .
Source: BMJ open, 2016-06-28; 6(6), p. e011581.
EPub date: 2016-06-28.
PMID: 27354079
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Survivorship care planning after participation in communication skills training intervention for a consultation about lymphoma survivorship.
Authors: Banerjee S.C. , Matasar M.J. , Bylund C.L. , Horwitz S. , McLarney K. , Levin T. , Jacobsen P.B. , Parker P. , Astrow A. , Kissane D.W. .
Source: Translational behavioral medicine, 2015 Dec; 5(4), p. 393-400.
EPub date: 2015-06-02.
PMID: 26622912
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