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Grant Details

Grant Number: 5R21CA175959-02 Interpret this number
Primary Investigator: Heck, Julia
Organization: University Of California Los Angeles
Project Title: Maternal Comorbidities, Prescription Drug Use in Pregnancy and Childhood Cancer
Fiscal Year: 2015
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Abstract

DESCRIPTION (provided by applicant): In recent years there has been a growing recognition of the importance of maternal health and the uterine environment in the later health of children. Many women experience chronic or acute health conditions while pregnant, and a few studies have linked certain conditions with increased pediatric cancer risk. Maternal health care may further involve the use of medications to treat a preexisting condition or a condition that develops during the prenatal period. It is well-established that maternal intake of diethylstilbestrol (DES) causes cancer in offspring, however for most drugs, the evidence on safety in pregnancy is limited. The aim of this study is to examine common maternal health conditions and prescription drug use in pregnancy in relation to later childhood cancer development. Specific aims: (1) Create a linked database of all childhood cancers in Denmark (1977-2012) with information on maternal comorbidities and medication use. (2) Examine the relation between maternal comorbid conditions and childhood cancers. (3) Examine the relation between maternal prescription drug use in pregnancy and childhood cancers. Design and methods: A national case-control study using national registries in Denmark, using data from an existing study on childhood cancers in Denmark (n=537,000). Maternal comorbidity information will be available from the Danish National Patient Register (1977-2012), and prescription drug use in pregnancy from the Danish National Prescription Register (1994-2012). Data on demographic, gestational, and other factors will be available from other national registers. Implications: the findings will add evidence on childhood cancer risk among children of mothers with certain health conditions or who took specific medications during pregnancy. The results will indicate if more active monitoring and screening is needed to reduce the potentially increased risk for the unborn child, and can help guide recommendations on medication use in pregnancy.

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Publications

Risk of selected childhood cancers and parental employment in painting and printing industries: A register-based case‚Äícontrol study in Denmark 1968-2015.
Authors: Volk J. , Heck J.E. , Schmiegelow K. , Hansen J. .
Source: Scandinavian journal of work, environment & health, 2019-09-01; 45(5), p. 475-482.
EPub date: 2019-03-06.
PMID: 30838423
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Parental occupational exposure to benzene and the risk of childhood and adolescent acute lymphoblastic leukaemia: a population-based study.
Authors: Heck J.E. , He D. , Contreras Z.A. , Ritz B. , Olsen J. , Hansen J. .
Source: Occupational and environmental medicine, 2019 Aug; 76(8), p. 527-529.
EPub date: 2019-05-28.
PMID: 31138675
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Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.
Authors: Panagopoulou P. , Skalkidou A. , Marcotte E. , Erdmann F. , Ma X. , Heck J.E. , Auvinen A. , Mueller B.A. , Spector L.G. , Roman E. , et al. .
Source: Cancer epidemiology, 2019 Apr; 59, p. 158-165.
EPub date: 2019-02-15.
PMID: 30776582
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Fetal programming and Wilms tumor.
Authors: Heck J.E. , He D. , Janzen C. , Federman N. , Olsen J. , Ritz B. , Hansen J. .
Source: Pediatric blood & cancer, 2019 Jan; 66(1), p. e27461.
EPub date: 2018-09-25.
PMID: 30255546
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Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium.
Authors: Petridou E.T. , Georgakis M.K. , Erdmann F. , Ma X. , Heck J.E. , Auvinen A. , Mueller B.A. , Spector L.G. , Roman E. , Metayer C. , et al. .
Source: European journal of epidemiology, 2018 Oct; 33(10), p. 965-976.
EPub date: 2018-05-14.
PMID: 29761423
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Disparities in Adverse Perinatal Outcomes Among Pacific Islanders in the Commonwealth of the Northern Mariana Islands.
Authors: Dela Cruz R. , Grant J. , Heck J.E. , Cash H.L. .
Source: Preventing chronic disease, 2018-03-08; 15, p. E29.
EPub date: 2018-03-08.
PMID: 29522702
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Parental age and childhood cancer risk: A Danish population-based registry study.
Authors: Contreras Z.A. , Hansen J. , Ritz B. , Olsen J. , Yu F. , Heck J.E. .
Source: Cancer epidemiology, 2017 08; 49, p. 202-215.
EPub date: 2017-07-14.
PMID: 28715709
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Residential Pesticide Exposures in Pregnancy and the Risk of Sporadic Retinoblastoma: A Report From the Children's Oncology Group.
Authors: Omidakhsh N. , Ganguly A. , Bunin G.R. , von Ehrenstein O.S. , Ritz B. , Heck J.E. .
Source: American journal of ophthalmology, 2017 Apr; 176, p. 166-173.
EPub date: 2017-01-26.
PMID: 28131887
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Maternal Preeclampsia and Odds of Childhood Cancers in Offspring: A California Statewide Case-Control Study.
Authors: Xu X. , Ritz B. , Cockburn M. , Lombardi C. , Heck J.E. .
Source: Paediatric and perinatal epidemiology, 2017 03; 31(2), p. 157-164.
EPub date: 2017-01-26.
PMID: 28124497
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Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics.
Authors: Hall C. , Ritz B. , Cockburn M. , Davidson T.B. , Heck J.E. .
Source: Cancer epidemiology, 2017 02; 46, p. 42-49.
EPub date: 2016-12-23.
PMID: 28013088
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Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community.
Authors: Malagoli C. , Costanzini S. , Heck J.E. , Malavolti M. , De Girolamo G. , Oleari P. , Palazzi G. , Teggi S. , Vinceti M. .
Source: International journal of hygiene and environmental health, 2016 11; 219(8), p. 742-748.
EPub date: 2016-09-21.
PMID: 27693118
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Smoking in pregnancy and risk of cancer among young children: A population-based study.
Authors: Heck J.E. , Contreras Z.A. , Park A.S. , Davidson T.B. , Cockburn M. , Ritz B. .
Source: International journal of cancer, 2016-08-01; 139(3), p. 613-6.
EPub date: 2016-04-15.
PMID: 27016137
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Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study.
Authors: Vinceti M. , Malagoli C. , Malavolti M. , Cherubini A. , Maffeis G. , Rodolfi R. , Heck J.E. , Astolfi G. , Calzolari E. , Nicolini F. .
Source: The Science of the total environment, 2016-01-15; 541, p. 444-450.
EPub date: 2015-09-26.
PMID: 26410719
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A case-control study of sporadic retinoblastoma in relation to maternal health conditions and reproductive factors: a report from the Children's Oncology group.
Authors: Heck J.E. , Omidakhsh N. , Azary S. , Ritz B. , von Ehrenstein O.S. , Bunin G.R. , Ganguly A. .
Source: BMC cancer, 2015-10-19; 15, p. 735.
EPub date: 2015-10-19.
PMID: 26481585
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A review and meta-analysis of outdoor air pollution and risk of childhood leukemia.
Authors: Filippini T. , Heck J.E. , Malagoli C. , Del Giovane C. , Vinceti M. .
Source: Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 2015; 33(1), p. 36-66.
PMID: 25803195
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