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Grant Details

Grant Number: 5R03CA176702-02 Interpret this number
Primary Investigator: Lawson, Andrew
Organization: Medical University Of South Carolina
Project Title: Advances in Geospatial Survival Modeling for Small Area Cancer Data
Fiscal Year: 2015


Abstract

DESCRIPTION (provided by applicant): Abstract It is the primary focus of this aim to broaden the definition of the survivor, density and hazard function to include spatial labeling by explicit modeling of the spatial dependency. This involves the direct derivation of (s,t), S(s,t), and h(s,t and their related marginal and conditional functions. The application of these novel derivations with standard geographically-augmented survival distributions will be examined. Spatially dependent censoring is also a focus as a sub- aim. We plan to model this aspect and evaluate the role of this in direct spatial and contextual survival models. Predictors in survival modeling can be individual (age, gender, race etc) or contextual (e. g. census tract demographics). They can also vary spatially in their linkage to survival risk. We propose to examine the development of models where predictor selection has a spatial label and where some regions do include and other exclude predictors in models. We plan to implement the modeling approaches above via the use of the Bayesian paradigm and will likely use McMC based packages or, if appropriate, INLA. Evaluation will be simulation based and we will use R and associated linked software (MCMCpack, BRugs, R2WinBUGS, R2OpenBUGS) for this purpose.



Publications

Spatially-explicit survival modeling with discrete grouping of cancer predictors.
Authors: Onicescu G. , Lawson A.B. , Zhang J. , Gebregziabher M. , Wallace K. , Eberth J.M. .
Source: Spatial and spatio-temporal epidemiology, 2019 06; 29, p. 139-148.
EPub date: 2018-06-21.
PMID: 31128623
Related Citations

Bayesian cure-rate survival model with spatially structured censoring.
Authors: Onicescu G. , Lawson A.B. .
Source: Spatial statistics, 2018 Dec; 28, p. 352-364.
EPub date: 2018-09-12.
PMID: 32855903
Related Citations

Spatially explicit survival modeling for small area cancer data.
Authors: Onicescu G. , Lawson A. , Zhang J. , Gebregziabher M. , Wallace K. , Eberth J.M. .
Source: Journal of applied statistics, 2018; 45(3), p. 568-585.
EPub date: 2017-02-11.
PMID: 30906096
Related Citations

Bayesian accelerated failure time model for space-time dependency in a geographically augmented survival model.
Authors: Onicescu G. , Lawson A. , Zhang J. , Gebregziabher M. , Wallace K. , Eberth J.M. .
Source: Statistical methods in medical research, 2017 Oct; 26(5), p. 2244-2256.
EPub date: 2015-07-28.
PMID: 26220537
Related Citations




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