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Grant Details

Grant Number: 5R01CA154596-05 Interpret this number
Primary Investigator: Simmons, Vani
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Smoking Relapse-Prevention Intervention for Cancer Patients
Fiscal Year: 2015


DESCRIPTION (provided by applicant): A growing body of literature illustrates that once a smoker has been diagnosed with cancer, immediate smoking cessation is medically warranted because continued smoking contributes to several adverse health outcomes for cancer patients (e.g., reduction in treatment efficacy, increased risk of developing a second primary cancer, poorer survival). Given the large number of cancer patients making a quit attempt and the high rate of smoking relapse, there is a critical need for evidence-based smoking relapse-prevention interventions for this population. To our knowledge, no smoking relapse-prevention interventions exist for cancer patients. Therefore, the primary aim of this study is to address this gap by testing the efficacy of an empirically based, targeted smoking relapse-prevention intervention for cancer patients. We propose a multimodal intervention comprised of a targeted digital videodisc (DVD) designed specifically for cancer patients and accompanying relapse prevention booklets (Forever Free) that have been previously demonstrated efficacious with the general smoking population. The key content of the targeted DVD is based on Witkiewitz and Marlatt's cognitive-behavioral model of relapse, existing literature, and our prior qualitative and quantitative smoking relapse research conducted with cancer patients. Examples of targeted content include: the effects of continued tobacco use on cancer treatment; benefits of quitting for cancer patients; and interviews with cancer patients who have been successful at maintaining their smoking abstinence. Participants (N = 414) will be randomized to receive usual care (UC) or usual care plus our Smoking Relapse Prevention for Cancer Patients (SRP-CaP) intervention. Based on previous research, we hypothesize that cancer patients who receive the SRP-CaP intervention will demonstrate lower rates of smoking relapse at 6 and 12-month follow-up, relative to patients in the UC condition. Secondary aims of this study are to evaluate the impact of potential mediating and moderating variables on intervention outcomes. The inclusion of possible moderators will allow us to examine whether future relapse-prevention interventions with cancer patients should include additional tailoring. The identification of mediators of intervention effects will guide the development of future smoking interventions as well as aid in the conceptualization of a smoking relapse framework for cancer patients. If demonstrated effective, the proposed intervention would represent an easily disseminable and low-cost intervention with significant public health implications, including improved physical functioning, quality of life, and survival for cancer patients.


Preventing smoking relapse in patients with cancer: A randomized controlled trial.
Authors: Simmons V.N. , Sutton S.K. , Meltzer L.R. , Martinez U. , Palmer A.M. , Meade C.D. , Jacobsen P.B. , McCaffrey J.C. , Haura E.B. , Brandon T.H. .
Source: Cancer, 2020-12-01; 126(23), p. 5165-5172.
EPub date: 2020-09-09.
PMID: 32902856
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Does smoking abstinence predict cancer patients' quality of life over time?
Authors: Martínez Ú. , Brandon K.O. , Sutton S.K. , Brandon T.H. , Simmons V.N. .
Source: Psycho-oncology, 2019 Aug; 28(8), p. 1702-1711.
EPub date: 2019-07-02.
PMID: 31212391
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Associations between the smoking-relatedness of a cancer type, cessation attitudes and beliefs, and future abstinence among recent quitters.
Authors: Martínez Ú. , Brandon T.H. , Sutton S.K. , Simmons V.N. .
Source: Psycho-oncology, 2018 Sep; 27(9), p. 2104-2110.
EPub date: 2018-06-14.
PMID: 29785718
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Electronic cigarette use among patients with cancer: Reasons for use, beliefs, and patient-provider communication.
Authors: Correa J.B. , Brandon K.O. , Meltzer L.R. , Hoehn H.J. , Piñeiro B. , Brandon T.H. , Simmons V.N. .
Source: Psycho-oncology, 2018 Jul; 27(7), p. 1757-1764.
EPub date: 2018-04-25.
PMID: 29671928
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Development of a Targeted Smoking Relapse-Prevention Intervention for Cancer Patients.
Authors: Meltzer L.R. , Meade C.D. , Diaz D.B. , Carrington M.S. , Brandon T.H. , Jacobsen P.B. , McCaffrey J.C. , Haura E.B. , Simmons V.N. .
Source: Journal of cancer education : the official journal of the American Association for Cancer Education, 2018 Apr; 33(2), p. 440-447.
PMID: 27476432
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Smoking relapse-prevention intervention for cancer patients: Study design and baseline data from the surviving SmokeFree randomized controlled trial.
Authors: Díaz D.B. , Brandon T.H. , Sutton S.K. , Meltzer L.R. , Hoehn H.J. , Meade C.D. , Jacobsen P.B. , McCaffrey J.C. , Haura E.B. , Lin H.Y. , et al. .
Source: Contemporary clinical trials, 2016 Sep; 50, p. 84-9.
EPub date: 2016-07-25.
PMID: 27468664
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E-cigarette use in adults: a qualitative study of users' perceptions and future use intentions.
Authors: Simmons V.N. , Quinn G.P. , Harrell P.T. , Meltzer L.R. , Correa J.B. , Unrod M. , Brandon T.H. .
Source: Addiction research & theory, 2016; 24(4), p. 313-321.
EPub date: 2016-02-23.
PMID: 27725794
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Gender differences in use and expectancies of e-cigarettes: Online survey results.
Authors: Piñeiro B. , Correa J.B. , Simmons V.N. , Harrell P.T. , Menzie N.S. , Unrod M. , Meltzer L.R. , Brandon T.H. .
Source: Addictive behaviors, 2016 Jan; 52, p. 91-7.
EPub date: 2015-09-14.
PMID: 26406973
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Personality and smoking: individual-participant meta-analysis of nine cohort studies.
Authors: Hakulinen C. , Hintsanen M. , Munafò M.R. , Virtanen M. , Kivimäki M. , Batty G.D. , Jokela M. .
Source: Addiction (Abingdon, England), 2015 Nov; 110(11), p. 1844-52.
EPub date: 2015-08-22.
PMID: 26227786
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E-cigarettes and expectancies: why do some users keep smoking?
Authors: Harrell P.T. , Simmons V.N. , Piñeiro B. , Correa J.B. , Menzie N.S. , Meltzer L.R. , Unrod M. , Brandon T.H. .
Source: Addiction (Abingdon, England), 2015 Nov; 110(11), p. 1833-43.
EPub date: 2015-08-18.
PMID: 26173651
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Post-operative smoking status in lung and head and neck cancer patients: association with depressive symptomatology, pain, and fatigue.
Authors: Bloom E.L. , Oliver J.A. , Sutton S.K. , Brandon T.H. , Jacobsen P.B. , Simmons V.N. .
Source: Psycho-oncology, 2015 Sep; 24(9), p. 1012-9.
EPub date: 2014-09-25.
PMID: 25257853
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Expectancies for cigarettes, e-cigarettes, and nicotine replacement therapies among e-cigarette users (aka vapers).
Authors: Harrell P.T. , Marquinez N.S. , Correa J.B. , Meltzer L.R. , Unrod M. , Sutton S.K. , Simmons V.N. , Brandon T.H. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015 Feb; 17(2), p. 193-200.
EPub date: 2014-08-28.
PMID: 25168035
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Electronic nicotine delivery systems ("e-cigarettes"): review of safety and smoking cessation efficacy.
Authors: Harrell P.T. , Simmons V.N. , Correa J.B. , Padhya T.A. , Brandon T.H. .
Source: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2014 Sep; 151(3), p. 381-93.
EPub date: 2014-06-04.
PMID: 24898072
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