Skip to main content
Grant Details

Grant Number: 5R01CA151973-05 Interpret this number
Primary Investigator: Luke, Barbara
Organization: Michigan State University
Project Title: Assisted Reproductive Technology & Risk of Childhood Cancer
Fiscal Year: 2015
Back to top


Abstract

DESCRIPTION (provided by applicant): Use of assisted reproductive technology (ART) has risen steadily in the United States during the past two decades due to several reasons, including childbearing at older maternal ages and increasing insurance coverage. Studies have reported significantly higher risks of adverse perinatal outcomes in assisted- versus spontaneous-conception pregnancies, including an excess of prematurity, low birthweight, and birth defects. ART and/or infertility may influence the incidence of other conditions with prenatal origins, such as childhood cancer. In addition, the prevalence of imprinting disorders such as Beckwith-Wiedemann and Angelman syndromes is elevated among children conceived by ART; some of these disorders, in turn, drastically raise the risk of several embryonal cancers that occur in early childhood. Several cohort, case-control, and case- series studies of assisted reproduction and childhood cancer have reported null results, although all were limited by small sample size and could not differentiate specific cancer types. One study that focused specifically on hepatoblastoma found that use of infertility treatment or assisted reproduction was associated with a nine-fold increased risk of disease. Using the resources of the Society for Assisted Reproductive Technology (SART) and the birth and cancer registries in 20 States and New York City, we propose to conduct the largest study to date of ART and childhood cancer risk. SART maintains an ongoing national database of programs that provide ART services in the United States as mandated by the federal Fertility Success Rate and Certification Act of 1992 [PL 102-493]. As of 2006, the latest year of data available, this included comprehensive data (including identifiers sufficient for linkage) on 138,198 ART cycles from 483 clinics resulting in 41,343 pregnancies and 54,656 infants for a single year. We propose to link the data from the SART database from 2004-2013 to the birth and cancer registries of 20 states and New York City, including the five states with the highest numbers of ART births (California, New York, Illinois, New Jersey, and Massachusetts), to create a cohort of approximately 30 million children, including over 467,000 conceived by ART to evaluate the association between assisted reproduction and the risk for childhood cancer. The specific aim of this study is to compare the incidence of childhood cancer in children with assisted conception to that in the general population.

Back to top


Publications

Risk of severe maternal morbidity by maternal fertility status: a US study in 8 states.
Authors: Luke B. , Brown M.B. , Wantman E. , Baker V.L. , Doody K.J. , Seifer D.B. , Spector L.G. .
Source: American journal of obstetrics and gynecology, 2019 Feb; 220(2), p. 195.e1-195.e12.
EPub date: 2018-10-12.
PMID: 30321527
Related Citations

Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality.
Authors: Luke B. , Brown M.B. , Wantman E. , Seifer D.B. , Sparks A.T. , Lin P.C. , Doody K.J. , Van Voorhis B.J. , Spector L.G. .
Source: Journal of assisted reproduction and genetics, 2019 Jan; 36(1), p. 121-138.
EPub date: 2018-10-17.
PMID: 30328574
Related Citations

Validation of infertility treatment and assisted reproductive technology use on the birth certificate ineight states.
Authors: Luke B. , Brown M.B. , Spector L.G. .
Source: American journal of obstetrics and gynecology, 2016 07; 215(1), p. 126-7.
EPub date: 2016-03-02.
PMID: 26945609
Related Citations

Embryo banking among women diagnosed with cancer: a pilot population-based study in New York, Texas, and Illinois.
Authors: Luke B. , Brown M.B. , Spector L.G. , Stern J.E. , Smith Y.R. , Williams M. , Koch L. , Schymura M.J. .
Source: Journal of assisted reproduction and genetics, 2016 May; 33(5), p. 667-674.
EPub date: 2016-02-03.
PMID: 26843393
Related Citations

Assisted reproductive technology use and outcomes among women with a history of cancer.
Authors: Luke B. , Brown M.B. , Missmer S.A. , Spector L.G. , Leach R.E. , Williams M. , Koch L. , Smith Y.R. , Stern J.E. , Ball G.D. , et al. .
Source: Human reproduction (Oxford, England), 2016 Jan; 31(1), p. 183-9.
EPub date: 2015-11-17.
PMID: 26577302
Related Citations

Cancer in women after assisted reproductive technology.
Authors: Luke B. , Brown M.B. , Spector L.G. , Missmer S.A. , Leach R.E. , Williams M. , Koch L. , Smith Y. , Stern J.E. , Ball G.D. , et al. .
Source: Fertility and sterility, 2015 Nov; 104(5), p. 1218-26.
EPub date: 2015-08-10.
PMID: 26271227
Related Citations

Use of assisted reproductive technology treatment as reported by mothers in comparison with registry data: the Upstate KIDS Study.
Authors: Buck Louis G.M. , Druschel C. , Bell E. , Stern J.E. , Luke B. , McLain A. , Sundaram R. , Yeung E. .
Source: Fertility and sterility, 2015 Jun; 103(6), p. 1461-8.
EPub date: 2015-03-23.
PMID: 25813287
Related Citations

Application of a validated prediction model for invitro fertilization: comparison of live birth rates and multiple birth rates with 1 embryo transferred over 2 cycles vs 2 embryos in 1 cycle.
Authors: Luke B. , Brown M.B. , Wantman E. , Stern J.E. , Baker V.L. , Widra E. , Coddington C.C. , Gibbons W.E. , Van Voorhis B.J. , Ball G.D. .
Source: American journal of obstetrics and gynecology, 2015 May; 212(5), p. 676.e1-7.
EPub date: 2015-02-13.
PMID: 25683965
Related Citations

Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology.
Authors: Luke B. , Brown M.B. , Stern J.E. , Jindal S.K. , Racowsky C. , Ball G.D. .
Source: Fertility and sterility, 2014 Nov; 102(5), p. 1338-44.
EPub date: 2014-09-11.
PMID: 25217871
Related Citations

A prediction model for live birth and multiple births within the first three cycles of assisted reproductive technology.
Authors: Luke B. , Brown M.B. , Wantman E. , Stern J.E. , Baker V.L. , Widra E. , Coddington C.C. , Gibbons W.E. , Ball G.D. .
Source: Fertility and sterility, 2014 Sep; 102(3), p. 744-52.
EPub date: 2014-06-14.
PMID: 24934487
Related Citations

Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles.
Authors: Luke B. , Brown M.B. , Wantman E. , Stern J.E. .
Source: Fertility and sterility, 2014 Mar; 101(3), p. 683-9.
EPub date: 2014-01-02.
PMID: 24388206
Related Citations

Second try: who returns for additional assisted reproductive technology treatment and the effect of a prior assisted reproductive technology birth.
Authors: Luke B. , Brown M.B. , Wantman E. , Baker V.L. , Grow D.R. , Stern J.E. .
Source: Fertility and sterility, 2013 Dec; 100(6), p. 1580-4.
EPub date: 2013-08-26.
PMID: 23987515
Related Citations

Cumulative birth rates with linked assisted reproductive technology cycles.
Authors: Luke B. , Brown M.B. , Wantman E. , Lederman A. , Gibbons W. , Schattman G.L. , Lobo R.A. , Leach R.E. , Stern J.E. .
Source: The New England journal of medicine, 2012-06-28; 366(26), p. 2483-91.
PMID: 22738098
Related Citations




Back to Top