Skip to main content
An official website of the United States government
Grant Details

Grant Number: 5R21CA175983-02 Interpret this number
Primary Investigator: Henderson, Louise
Organization: Univ Of North Carolina Chapel Hill
Project Title: Developing a Lung Cancer Screening Registry in a State with a High Smoking Rate
Fiscal Year: 2015


DESCRIPTION (provided by applicant): There is a gap in our knowledge of how the results of the National Lung Screening Trial (NLST) will impact the use of low dose computed tomography (LDCT) for lung cancer screening in the general population. Given the high incidence and mortality rates of lung cancer, developing evidence on the utility of a screening test that can reduce lung cancer mortality will likely lead to a significant improvement in public health. The long-term goal is to examine the delivery and quality of lung cancer screening across the U.S. by creating a prospective population based registry that captures patient, radiologist, and outcome information on the use of LDCT for screening. The objective of this application is to pilot test a population based lung cancer screening registry and determine the extent to which lung cancer screening with LDCT has diffused across the state. We plan to accomplish these objectives by pursuing the following two specific aims: (1) Develop and implement the tools required to establish a population-based lung cancer screening registry; and (2) Examine the availability of lung cancer screening with LDCT among radiology practices in the state. The study will focus on developing and implementing data collection elements as well as constructing a secure data entry system for capturing screening information from patients and radiologists. By conducting a survey of CT accredited radiology facilities we will investigate the characteristics o facilities currently performing screening in the state and also identify facilities for partnershipin the subsequent expansion phase. Currently, recommendations for LDCT for lung cancer screening are mixed, yet there is a growing need to monitor the screening experience as academic centers and community practices begin to adopt this technology for early detection in high-risk groups. This is an innovative pilot study that uses established methods in population based registry development and survey methodology to explore an emerging clinically relevant cancer screening area which is widely debated. The proposed research is significant because it will provide preliminary data on the use of LDCT for lung cancer screening in the non-clinical trial population and will also create a system for ongoing data capture that will inform the delivery and quality of lung cancer screening as this technology diffuses into the community.


Opinions and Practices of Lung Cancer Screening by Physician Specialty.
Authors: Henderson L.M. , Marsh M.W. , Benefield T.S. , Jones L.M. , Reuland D.S. , Brenner A.T. , Goldstein A.O. , Molina P.L. , Maygarden S.J. , Rivera M.P. .
Source: North Carolina medical journal, 2019 Jan-Feb; 80(1), p. 19-26.
PMID: 30622199
Related Citations

Multidisciplinary quality improvement initiative to standardize reporting of lung cancer screening.
Authors: Cubillos L. , Brenner A.T. , Birchard K. , Henderson L.M. , Molina P.L. , Pignone M. , Ratner S. , Rivera M.P. , Jones L. , Reuland D.S. .
Source: Translational lung cancer research, 2018 Sep; 7(Suppl 3), p. S297-S301.
PMID: 30393627
Related Citations

Differential Use of Screening Mammography in Older Women Initiating Metformin versus Sulfonylurea.
Authors: Hong J.L. , Henderson L.M. , Jonsson Funk M. , Lund J.L. , Buse J.B. , Pate V. , Stürmer T. .
Source: Pharmacoepidemiology and drug safety, 2017 Jun; 26(6), p. 666-675.
EPub date: 2017-03-29.
PMID: 28370798
Related Citations

Comparative Effect of Initiating Metformin Versus Sulfonylureas on Breast Cancer Risk in Older Women.
Authors: Hong J.L. , Jonsson Funk M. , Buse J.B. , Henderson L.M. , Lund J.L. , Pate V. , Stürmer T. .
Source: Epidemiology (Cambridge, Mass.), 2017 May; 28(3), p. 446-454.
PMID: 28166101
Related Citations

Lung Cancer Screening Practices in North Carolina CT Facilities.
Authors: Henderson L.M. , Jones L.M. , Marsh M.W. , Benefield T. , Rivera M.P. , Molina P.L. .
Source: Journal of the American College of Radiology : JACR, 2017 Feb; 14(2), p. 166-170.
EPub date: 2016-10-27.
PMID: 28341213
Related Citations

Opinions, practice patterns, and perceived barriers to lung cancer screening among attending and resident primary care physicians.
Authors: Henderson L.M. , Jones L.M. , Marsh M.W. , Brenner A.T. , Goldstein A.O. , Benefield T.S. , Greenwood-Hickman M.A. , Molina P.L. , Rivera M.P. , Reuland D.S. .
Source: Risk management and healthcare policy, 2017; 10, p. 189-195.
EPub date: 2018-01-22.
PMID: 29403320
Related Citations

Back to Top