Skip to main content
An official website of the United States government
Grant Details

Grant Number: 1R03CA183021-01A1 Interpret this number
Primary Investigator: Shu, Xiao-Ou
Organization: Vanderbilt University
Project Title: Calcium Intake and Lung Cancer: Effect Modification By Sex and Smoking Status
Fiscal Year: 2014


Abstract

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer deaths worldwide and in the United States. Although cigarette smoking is the major cause, up to 25% of lung cancer cases are never smokers and female never smokers have a higher risk of incident lung cancer than male never smokers. The etiology of non-smoking-related lung cancer is poorly understood. Nutritional factors may affect multiple steps in lung carcinogenesis. Using data from the Shanghai Women's Health Study, a large population-based, prospective cohort study in China, we recently reported a strong inverse association between dietary calcium intake and lung cancer risk among female never smokers (34% risk reduction for the top 25% of calcium intake compared with the bottom 25%). Our study is the first prospective study to report this finding, which needs to be confirmed in other populations. Calcium may interact with vitamin D and estrogens in carcinogenesis, but this hypothesis has not been investigated for non-smoking-related lung cancer. We propose here to conduct a pooling analysis involving thirteen large prospective cohorts and including approximately two million men and women from the United States and countries in Europe and Asia. The specific aims of this study are: 1) to prospectively investigate whether calcium intake is associated with the risk of non-smoking-related or smoking-related lung cancer and to evaluate whether such associations differ by sex, race/ethnicity, or major determinants of vitamin D status and 2) to evaluate whether associations between calcium intake and lung cancer risk among women are modified by menopausal status, or hormone therapy use. This proposed study, with its large sample size, wide range of calcium intake, and previously-collected detailed exposure and covariate data, is extremely cost- efficient and provides an exceptional opportunity to comprehensively evaluate the association of calcium intake with the risk of non-smoking-related lung cancer. Results of this study would be directly translatable to lung cancer prevention. The infrastructure and networks established by this project would set the stage for future international collaborations on lung cancer risk and prognosis.



Publications

Calcium Intake and Lung Cancer Risk: A Pooled Analysis of 12 Prospective Cohort Studies.
Authors: Takata Y. , Yang J.J. , Yu D. , Smith-Warner S.A. , Blot W.J. , White E. , Robien K. , Prizment A. , Wu K. , Sawada N. , et al. .
Source: The Journal Of Nutrition, 2023 Jul; 153(7), p. 2051-2060.
EPub date: 2023-03-11 00:00:00.0.
PMID: 36907443
Related Citations

Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts.
Authors: Yang J.J. , Yu D. , White E. , Lee D.H. , Blot W. , Robien K. , Sinha R. , Park Y. , Takata Y. , Gao Y.T. , et al. .
Source: Jnci Cancer Spectrum, 2022-03-02 00:00:00.0; 6(2), .
PMID: 35603841
Related Citations

Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts.
Authors: Yang J.J. , Yu D. , White E. , Lee D.H. , Blot W. , Robien K. , Sinha R. , Park Y. , Takata Y. , Gao Y.T. , et al. .
Source: Jnci Cancer Spectrum, 2022-03-02 00:00:00.0; 6(2), .
PMID: 35603841
Related Citations

Associations of coffee and tea consumption with lung cancer risk.
Authors: Zhu J. , Smith-Warner S.A. , Yu D. , Zhang X. , Blot W.J. , Xiang Y.B. , Sinha R. , Park Y. , Tsugane S. , White E. , et al. .
Source: International Journal Of Cancer, 2020-12-16 00:00:00.0; , .
EPub date: 2020-12-16 00:00:00.0.
PMID: 33326609
Related Citations

Overall and Central Obesity and Risk of Lung Cancer: A Pooled Analysis.
Authors: Yu D. , Zheng W. , Johansson M. , Lan Q. , Park Y. , White E. , Matthews C.E. , Sawada N. , Gao Y.T. , Robien K. , et al. .
Source: Journal Of The National Cancer Institute, 2018-08-01 00:00:00.0; 110(8), p. 831-842.
PMID: 29518203
Related Citations

Dietary Fat Intake and Lung Cancer Risk: A Pooled Analysis.
Authors: Yang J.J. , Yu D. , Takata Y. , Smith-Warner S.A. , Blot W. , White E. , Robien K. , Park Y. , Xiang Y.B. , Sinha R. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-09-10 00:00:00.0; 35(26), p. 3055-3064.
EPub date: 2017-07-25 00:00:00.0.
PMID: 28742456
Related Citations

Prediagnostic Calcium Intake and Lung Cancer Survival: A Pooled Analysis of 12 Cohort Studies.
Authors: Yu D. , Takata Y. , Smith-Warner S.A. , Blot W. , Sawada N. , White E. , Freedman N. , Robien K. , Giovannucci E.L. , Zhang X. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-03-06 00:00:00.0; , .
EPub date: 2017-03-06 00:00:00.0.
PMID: 28264875
Related Citations

Association of hypertension and obesity with renal cell carcinoma risk: a report from the Shanghai Men's and Women's Health Studies.
Authors: Shen T. , Shu X.O. , Xiang Y.B. , Li H.L. , Cai H. , Gao Y.T. , Zheng W. , Lipworth L. .
Source: Cancer Causes & Control : Ccc, 2015 Aug; 26(8), p. 1173-80.
PMID: 26081424
Related Citations




Back to Top