Grant Number:	1U01CA188392-01 Interpret this number
Primary Investigator:	Schumacher, Fredrick
Organization:	University Of Southern California
Project Title:	Imputation-Based Approach to Identify Low Frequency Variants in Prostate Cancer
Fiscal Year:	2014

DESCRIPTION (provided by applicant): Genome-wide association studies (GWAS) have been highly successful identifying loci associated with complex traits, including prostate cancer (PrCa). Although these newly discovered loci have shed some light into the underlying biology, the clinical impact for preventing or treating PrCa has been limited. Furthermore, the known variation fails to explain a majority of PrCa. GWAS primarily focus on common genetic variation (MAF>5%), however, empirical evidence suggests low-frequency variants play a role in cancer, including PrCa. Although low-frequency variants will explain a portion of the missing heritability for PrCa and could lead to actionable targets for prevention or treatment, current discovery strategies are not feasible. Whole-genome sequencing studies are too costly for the sample sizes needed to adequately evaluate low-frequency variants in PrCa. Innovative strategies are needed. Several studies have demonstrated that the accuracy of imputation for low-frequency variants improves with increasing size of the reference panel. Here, we propose the following: AIM 1 - Assemble an enhanced reference panel of over 10,000 whole-genomes and perform imputation for 83,991 PrCa cases and 58,430 disease-free controls assembled from available GWAS data (Aim 1a). Using the above data, define operating characteristics of imputation for less common and rare variants using existing GWAS data. Clarify statistical relationship between GWAS marker frequency spectrum, target market frequency spectrum, reference panel size, and imputation success as measured by imputation R2, determine for above data a target set of imputable common, less common, and rare variants (Aim 1b); AIM 2 - Perform a whole-genome scan of imputable common, less common, and rare variants associated with overall and aggressive PrCa susceptibility and PSA levels among disease-free controls; AIM 3 - Develop novel statistical approaches to improve estimation and partition of heritability by incorporating genomic annotation (e.g. exonic, regulatory regions, pathways, etc.) while accounting for imputation error to improve risk prediction models. Recently, we performed a meta-analysis for PrCa utilizing GWAS data imputed to the 1000 Genomes Project for 31,663 PrCa cases and 35,870 disease-free controls identifying over 30 common novel susceptibility loci that are currently being validated. Furthermore, we will be genotyping an additional 90,000 individuals of European ancestry (2/3 PrCa cases and 1/3 controls) using a customized array with a GWAS backbone as part of the NCI Genetic Associations and Mechanisms in Oncology "post-GWAS" initiative (GAME-ON). Our recent experience demonstrates our ability to implement imputation in a large data resource and our strong collaborations to assemble the world's largest PrCa case-control series with available GWAS data. We are collaborating with several groups to coordinate efforts assembling an enhanced reference panel for imputation and will provide access to the research community. This proposal not only addresses a fundamental question in PrCa but will greatly aid quantifying the role of genetics in other complex phenotypes.




Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers.
Authors: Went M. , Sud A. , Mills C. , Hyde A. , Culliford R. , Law P. , Vijayakrishnan J. , Gockel I. , Maj C. , Schumacher J. , et al. .
Source: Nature Communications, 2024-03-25 00:00:00.0; 15(1), p. 2637.
EPub date: 2024-03-25 00:00:00.0.
PMID: 38527997
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Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects.
Authors: Zhong H. , Zhu J. , Liu S. , Ghoneim D.H. , Surendran P. , Liu T. , Fahle S. , Butterworth A. , Ashad Alam M. , Deng H.W. , et al. .
Source: Human Molecular Genetics, 2023-11-03 00:00:00.0; 32(22), p. 3181-3193.
PMID: 37622920
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Germline genetic variants associated with somatic TMPRSS2:ERG fusion status in prostate cancer: a genome-wide association study.
Authors: Ma C. , Wang X. , Dai J.Y. , Turman C. , Kraft P. , Stopsack K.H. , Loda M. , Pettersson A. , Mucci L.A. , Stanford J.L. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-08-09 00:00:00.0; , .
EPub date: 2023-08-09 00:00:00.0.
PMID: 37555839
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Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls.
Authors: Went M. , Sud A. , Mills C. , Hyde A. , Culliford R. , Law P. , Vijayakrishnan J. , Gockel I. , Maj C. , Schumacher J. , et al. .
Source: Medrxiv : The Preprint Server For Health Sciences, 2023-04-06 00:00:00.0; , .
EPub date: 2023-04-06 00:00:00.0.
PMID: 37066289
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Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls.
Authors: Went M. , Sud A. , Mills C. , Hyde A. , Culliford R. , Law P. , Vijayakrishnan J. , Gockel I. , Maj C. , Schumacher J. , et al. .
Source: Research Square, 2023-03-17 00:00:00.0; , .
EPub date: 2023-03-17 00:00:00.0.
PMID: 36993383
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Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.
Authors: Sugier P.E. , Lucotte E.A. , Domenighetti C. , Law M.H. , Iles M.M. , Brown K. , Amos C. , McKay J.D. , Hung R.J. , Karimi M. , et al. .
Source: Movement Disorders : Official Journal Of The Movement Disorder Society, 2023-02-14 00:00:00.0; , .
EPub date: 2023-02-14 00:00:00.0.
PMID: 36788297
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A saturated map of common genetic variants associated with human height.
Authors: Yengo L. , Vedantam S. , Marouli E. , Sidorenko J. , Bartell E. , Sakaue S. , Graff M. , Eliasen A.U. , Jiang Y. , Raghavan S. , et al. .
Source: Nature, 2022 Oct; 610(7933), p. 704-712.
EPub date: 2022-10-12 00:00:00.0.
PMID: 36224396
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Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.
Authors: Morales Berstein F. , McCartney D.L. , Lu A.T. , Tsilidis K.K. , Bouras E. , Haycock P. , Burrows K. , Phipps A.I. , Buchanan D.D. , Cheng I. , et al. .
Source: Elife, 2022-03-29 00:00:00.0; 11, .
EPub date: 2022-03-29 00:00:00.0.
PMID: 35346416
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Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer.
Authors: Wu C. , Zhu J. , King A. , Tong X. , Lu Q. , Park J.Y. , Wang L. , Gao G. , Deng H.W. , Yang Y. , et al. .
Source: Cancer Communications (london, England), 2021-09-14 00:00:00.0; , .
EPub date: 2021-09-14 00:00:00.0.
PMID: 34520132
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A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk.
Authors: Liu D. , Zhu J. , Zhou D. , Nikas E.G. , Mitanis N.T. , Sun Y. , Wu C. , Mancuso N. , Cox N.J. , Wang L. , et al. .
Source: International Journal Of Cancer, 2021-09-14 00:00:00.0; , .
EPub date: 2021-09-14 00:00:00.0.
PMID: 34520569
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Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200 000 men in UK Biobank.
Authors: Watts E.L. , Fensom G.K. , Smith Byrne K. , Perez-Cornago A. , Allen N.E. , Knuppel A. , Gunter M.J. , Holmes M.V. , Martin R.M. , Murphy N. , et al. .
Source: International Journal Of Cancer, 2021-05-01 00:00:00.0; 148(9), p. 2274-2288.
EPub date: 2020-12-11 00:00:00.0.
PMID: 33252839
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No Evidence for a Causal Relationship Between Cancers and Parkinson's Disease.
Authors: Senkevich K. , Bandres-Ciga S. , Yu E. , Liyanage U.E. , International Parkinson Disease Genomics Consortium (IPDGC) , Noyce A.J. , Gan-Or Z. .
Source: Journal Of Parkinson's Disease, 2021; 11(2), p. 801-809.
PMID: 33646179
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The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor.
Authors: Brandão A. , Paulo P. , Maia S. , Pinheiro M. , Peixoto A. , Cardoso M. , Silva M.P. , Santos C. , Eeles R.A. , Kote-Jarai Z. , et al. .
Source: Cancers, 2020-11-04 00:00:00.0; 12(11), .
EPub date: 2020-11-04 00:00:00.0.
PMID: 33158149
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Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk.
Authors: Liu J. , Prager-van der Smissen W.J.C. , Collée J.M. , Bolla M.K. , Wang Q. , Michailidou K. , Dennis J. , Ahearn T.U. , Aittomäki K. , Ambrosone C.B. , et al. .
Source: Scientific Reports, 2020-06-16 00:00:00.0; 10(1), p. 9688.
EPub date: 2020-06-16 00:00:00.0.
PMID: 32546843
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Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.
Authors: Hollis B. , Day F.R. , Busch A.S. , Thompson D.J. , Soares A.L.G. , Timmers P.R.H.J. , Kwong A. , Easton D.F. , Joshi P.K. , Timpson N.J. , et al. .
Source: Nature Communications, 2020-03-24 00:00:00.0; 11(1), p. 1536.
EPub date: 2020-03-24 00:00:00.0.
PMID: 32210231
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Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.
Authors: Kerns S.L. , Fachal L. , Dorling L. , Barnett G.C. , Baran A. , Peterson D.R. , Hollenberg M. , Hao K. , Narzo A.D. , Ahsen M.E. , et al. .
Source: Journal Of The National Cancer Institute, 2020-02-01 00:00:00.0; 112(2), p. 179-190.
PMID: 31095341
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Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent.
Authors: Joslin S.E.K. , Durbin-Johnson B.P. , Britton M. , Settles M.L. , Korf I. , Lemay D.G. .
Source: Frontiers In Genetics, 2020; 11, p. 558762.
EPub date: 2020-10-29 00:00:00.0.
PMID: 33193640
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Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT.
Authors: Ahmed M. , Goh C. , Saunders E. , Cieza-Borrella C. , PRACTICAL consortium , Kote-Jarai Z. , Schumacher F.R. , Eeles R. .
Source: Prostate Cancer And Prostatic Diseases, 2019-11-27 00:00:00.0; , .
EPub date: 2019-11-27 00:00:00.0.
PMID: 31776447
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Genome-wide association study of circulating folate one-carbon metabolites.
Authors: Wang J. , Asante I. , Baron J.A. , Figueiredo J.C. , Haile R. , Joan Levine A. , Newcomb P.A. , Templeton A.S. , Schumacher F.R. , Louie S.G. , et al. .
Source: Genetic Epidemiology, 2019-09-10 00:00:00.0; , .
EPub date: 2019-09-10 00:00:00.0.
PMID: 31502714
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Alterations in folate-dependent one-carbon metabolism as colon cell transition from normal to cancerous.
Authors: Asante I. , Chui D. , Pei H. , Zhou E. , De Giovanni C. , Conti D. , Louie S. .
Source: The Journal Of Nutritional Biochemistry, 2019 Jul; 69, p. 1-9.
EPub date: 2019-03-12 00:00:00.0.
PMID: 31035100
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Runs of homozygosity and testicular cancer risk.
Authors: Loveday C. , Sud A. , Litchfield K. , Levy M. , Holroyd A. , Broderick P. , Kote-Jarai Z. , Dunning A.M. , Muir K. , Peto J. , et al. .
Source: Andrology, 2019 Jul; 7(4), p. 555-564.
PMID: 31310061
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Genetic associations of breast and prostate cancer are enriched for regulatory elements identified in disease-related tissues.
Authors: Chen H. , Kichaev G. , Bien S.A. , MacDonald J.W. , Wang L. , Bammler T.K. , Auer P. , Pasaniuc B. , Lindström S. .
Source: Human Genetics, 2019-06-22 00:00:00.0; , .
EPub date: 2019-06-22 00:00:00.0.
PMID: 31230194
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Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Authors: Law P.J. , Timofeeva M. , Fernandez-Rozadilla C. , Broderick P. , Studd J. , Fernandez-Tajes J. , Farrington S. , Svinti V. , Palles C. , Orlando G. , et al. .
Source: Nature Communications, 2019-05-14 00:00:00.0; 10(1), p. 2154.
EPub date: 2019-05-14 00:00:00.0.
PMID: 31089142
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Shared heritability and functional enrichment across six solid cancers.
Authors: Jiang X. , Finucane H.K. , Schumacher F.R. , Schmit S.L. , Tyrer J.P. , Han Y. , Michailidou K. , Lesseur C. , Kuchenbaecker K.B. , Dennis J. , et al. .
Source: Nature Communications, 2019-01-25 00:00:00.0; 10(1), p. 431.
EPub date: 2019-01-25 00:00:00.0.
PMID: 30683880
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Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.
Authors: Adams C.D. , Richmond R. , Ferreira D.L.S. , Spiller W. , Tan V. , Zheng J. , Würtz P. , Donovan J. , Hamdy F. , Neal D. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019 Jan; 28(1), p. 208-216.
EPub date: 2018-10-23 00:00:00.0.
PMID: 30352818
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Prostate Cancer Risk-Associated Single-Nucleotide Polymorphism Affects Prostate-Specific Antigen Glycosylation and Its Function.
Authors: Srinivasan S. , Stephens C. , Wilson E. , Panchadsaram J. , DeVoss K. , Koistinen H. , Stenman U.H. , Brook M.N. , Buckle A.M. , Klein R.J. , et al. .
Source: Clinical Chemistry, 2019 01; 65(1), p. e1-e9.
EPub date: 2018-12-11 00:00:00.0.
PMID: 30538125
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Impact of glycemic traits, type 2 diabetes and metformin use on breast and prostate cancer risk: a Mendelian randomization study.
Authors: Au Yeung S.L. , Schooling C.M. .
Source: Bmj Open Diabetes Research & Care, 2019; 7(1), p. e000872.
EPub date: 2019-12-29 00:00:00.0.
PMID: 31908803
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Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology.
Authors: Went M. , Sud A. , Speedy H. , Sunter N.J. , Försti A. , Law P.J. , Johnson D.C. , Mirabella F. , Holroyd A. , Li N. , et al. .
Source: Blood Cancer Journal, 2018-12-21 00:00:00.0; 9(1), p. 1.
EPub date: 2018-12-21 00:00:00.0.
PMID: 30602759
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Using Bayes model averaging to leverage both gene main effects and G ×  E interactions to identify genomic regions in genome-wide association studies.
Authors: Moss L.C. , Gauderman W.J. , Lewinger J.P. , Conti D.V. .
Source: Genetic Epidemiology, 2018-11-19 00:00:00.0; , .
EPub date: 2018-11-19 00:00:00.0.
PMID: 30456811
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Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Authors: Sud A. , Thomsen H. , Orlando G. , Försti A. , Law P.J. , Broderick P. , Cooke R. , Hariri F. , Pastinen T. , Easton D.F. , et al. .
Source: Blood, 2018-11-08 00:00:00.0; 132(19), p. 2040-2052.
EPub date: 2018-09-07 00:00:00.0.
PMID: 30194254
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Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
Authors: Matejcic M. , Saunders E.J. , Dadaev T. , Brook M.N. , Wang K. , Sheng X. , Olama A.A.A. , Schumacher F.R. , Ingles S.A. , Govindasami K. , et al. .
Source: Nature Communications, 2018-11-05 00:00:00.0; 9(1), p. 4616.
EPub date: 2018-11-05 00:00:00.0.
PMID: 30397198
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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.
Authors: Mancuso N. , Gayther S. , Gusev A. , Zheng W. , Penney K.L. , Kote-Jarai Z. , Eeles R. , Freedman M. , Haiman C. , Pasaniuc B. , et al. .
Source: Nature Communications, 2018-10-04 00:00:00.0; 9(1), p. 4079.
EPub date: 2018-10-04 00:00:00.0.
PMID: 30287866
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Authors: Went M. , Sud A. , Försti A. , Halvarsson B.M. , Weinhold N. , Kimber S. , van Duin M. , Thorleifsson G. , Holroyd A. , Johnson D.C. , et al. .
Source: Nature Communications, 2018-09-13 00:00:00.0; 9(1), p. 3707.
EPub date: 2018-09-13 00:00:00.0.
PMID: 30213928
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Authors: Sipeky C. , Gao P. , Zhang Q. , Wang L. , Ettala O. , Talala K.M. , Tammela T.L.J. , Auvinen A. , Wiklund F. , Wei G.H. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2018-09-04 00:00:00.0; , .
EPub date: 2018-09-04 00:00:00.0.
PMID: 30181389
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Authors: Loveday C. , Law P. , Litchfield K. , Levy M. , Holroyd A. , Broderick P. , Kote-Jarai Z. , Dunning A.M. , Muir K. , Peto J. , et al. .
Source: European Urology, 2018 Sep; 74(3), p. 248-252.
EPub date: 2018-06-21 00:00:00.0.
PMID: 29935977
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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Authors: Schumacher F.R. , Al Olama A.A. , Berndt S.I. , Benlloch S. , Ahmed M. , Saunders E.J. , Dadaev T. , Leongamornlert D. , Anokian E. , Cieza-Borrella C. , et al. .
Source: Nature Genetics, 2018 Jul; 50(7), p. 928-936.
EPub date: 2018-06-11 00:00:00.0.
PMID: 29892016
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Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.
Authors: Fejzo M.S. , Sazonova O.V. , Sathirapongsasuti J.F. , Hallgrímsdóttir I.B. , Vacic V. , MacGibbon K.W. , Schoenberg F.P. , Mancuso N. , Slamon D.J. , Mullin P.M. , et al. .
Source: Nature Communications, 2018-03-21 00:00:00.0; 9(1), p. 1178.
EPub date: 2018-03-21 00:00:00.0.
PMID: 29563502
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Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.
Authors: Loveday C. , Litchfield K. , Levy M. , Holroyd A. , Broderick P. , Kote-Jarai Z. , Dunning A.M. , Muir K. , Peto J. , Eeles R. , et al. .
Source: Oncotarget, 2018-02-27 00:00:00.0; 9(16), p. 12630-12638.
EPub date: 2017-12-07 00:00:00.0.
PMID: 29560096
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Genetic susceptibility markers for a breast-colorectal cancer phenotype: Exploratory results from genome-wide association studies.
Authors: Pande M. , Joon A. , Brewster A.M. , Chen W.V. , Hopper J.L. , Eng C. , Shete S. , Casey G. , Schumacher F. , Lin Y. , et al. .
Source: Plos One, 2018; 13(4), p. e0196245.
EPub date: 2018-04-26 00:00:00.0.
PMID: 29698419
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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
Authors: Sud A. , Thomsen H. , Law P.J. , Försti A. , Filho M.I.D.S. , Holroyd A. , Broderick P. , Orlando G. , Lenive O. , Wright L. , et al. .
Source: Nature Communications, 2017-12-01 00:00:00.0; 8(1), p. 1892.
EPub date: 2017-12-01 00:00:00.0.
PMID: 29196614
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Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions.
Authors: Ritchie M.D. , Davis J.R. , Aschard H. , Battle A. , Conti D. , Du M. , Eskin E. , Fallin M.D. , Hsu L. , Kraft P. , et al. .
Source: American Journal Of Epidemiology, 2017-10-01 00:00:00.0; 186(7), p. 771-777.
PMID: 28978191
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Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor.
Authors: Litchfield K. , Levy M. , Orlando G. , Loveday C. , Law P.J. , Migliorini G. , Holroyd A. , Broderick P. , Karlsson R. , Haugen T.B. , et al. .
Source: Nature Genetics, 2017 Jul; 49(7), p. 1133-1140.
EPub date: 2017-06-12 00:00:00.0.
PMID: 28604728
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Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.
Authors: Wang H. , Schmit S.L. , Haiman C.A. , Keku T.O. , Kato I. , Palmer J.R. , van den Berg D. , Wilkens L.R. , Burnett T. , Conti D.V. , et al. .
Source: International Journal Of Cancer, 2017-06-15 00:00:00.0; 140(12), p. 2728-2733.
EPub date: 2017-06-15 00:00:00.0.
PMID: 28295283
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Authors: Schmit S.L. , Schumacher F.R. , Edlund C.K. , Conti D.V. , Ihenacho U. , Wan P. , Van Den Berg D. , Casey G. , Fortini B.K. , Lenz H.J. , et al. .
Source: Carcinogenesis, 2016 06; 37(6), p. 547-56.
PMID: 27207650
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
Authors: Gusev A. , Shi H. , Kichaev G. , Pomerantz M. , Li F. , Long H.W. , Ingles S.A. , Kittles R.A. , Strom S.S. , Rybicki B.A. , et al. .
Source: Nature Communications, 2016-04-07 00:00:00.0; 7, p. 10979.
EPub date: 2016-04-07 00:00:00.0.
PMID: 27052111
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Authors: Mancuso N. , Rohland N. , Rand K.A. , Tandon A. , Allen A. , Quinque D. , Mallick S. , Li H. , Stram A. , Sheng X. , et al. .
Source: Nature Genetics, 2016 Jan; 48(1), p. 30-5.
PMID: 26569126
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Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Authors: Schumacher F.R. , Schmit S.L. , Jiao S. , Edlund C.K. , Wang H. , Zhang B. , Hsu L. , Huang S.C. , Fischer C.P. , Harju J.F. , et al. .
Source: Nature Communications, 2015-07-07 00:00:00.0; 6, p. 7138.
EPub date: 2015-07-07 00:00:00.0.
PMID: 26151821
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