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Grant Details

Grant Number: 5U01CA150387-06 Interpret this number
Primary Investigator: Wing, Rena
Organization: Miriam Hospital
Project Title: Increasing Sleep Duration: a Novel Approach to Weight Control
Fiscal Year: 2014


DESCRIPTION (provided by applicant): Simultaneous with the epidemic of obesity, there has been an epidemic of short sleep duration. Epidemiological studies have documented a link between short sleep duration and both obesity and obesity- related health problems including hypertension, diabetes, and mortality and basic laboratory studies have identified physiological mechanisms that may explain this association. However, to date, there have been no intervention studies examining the impact of changes in sleep duration on changes in body weight. The Center for Behavioral Intervention Development (CBID) proposed in this application seeks to translate the basic science on sleep duration into a novel intervention to reduce obesity and obesity-related co- morbidities. We propose a programmatic series of studies to develop a sleep + weight loss intervention. The target population for our studies will be young adults (age 25 - 45) where the association between sleep duration and obesity appears strongest, who are overweight or obese (BIVII 25 - 40), and who currently sleep less than six and a half hours per night. This series of studies will be used to examine the effects of increases in sleep duration alone and in combination with a weight loss program on eating and exercise behaviors (measured objectively), and ultimately on body weight. We will also examine the effects of increasing sleep duration on physiological, psychological and cognitive changes that may relate to the changes in eating and activity and adherence to weight control recommendations. The proposed CBID creates a new interdisciplinary team, including investigators in the areas of behavioral weight control, basic and clinical aspects of sleep, fMRI and neuropsychological assessment of cognitive function, eating and exercise behavior, and physiological changes associated with sleep and weight. RELEVANCE: Both obesity and short sleep duration are major health problems, with a variety of negative consequences. Given that short sleep may contribute to the problem of obesity, this proposal seeks to develop an intervention to increase sleep duration and to determine whether increasing sleep alone, or in combination with a weight loss program, can have positive effects on eating, exercise, and ultimately weight control. (End of Abstract)


The Effects of Experimental Manipulation of Sleep Duration on Neural Response to Food Cues.
Authors: Demos K.E. , Sweet L.H. , Hart C.N. , McCaffery J.M. , Williams S.E. , Mailloux K.A. , Trautvetter J. , Owens M.M. , Wing R.R. .
Source: Sleep, 2017-11-01; 40(11), .
PMID: 28977574
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Partial sleep deprivation impacts impulsive action but not impulsive decision-making.
Authors: Demos K.E. , Hart C.N. , Sweet L.H. , Mailloux K.A. , Trautvetter J. , Williams S.E. , Wing R.R. , McCaffery J.M. .
Source: Physiology & behavior, 2016-10-01; 164(Pt A), p. 214-9.
EPub date: 2016-06-04.
PMID: 27267950
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Discrepancies Between Self-Reported Usual Sleep Duration and Objective Measures of Total Sleep Time in Treatment-Seeking Overweight and Obese Individuals.
Authors: O'Brien E. , Hart C. , Wing R.R. .
Source: Behavioral sleep medicine, 2016 Sep-Oct; 14(5), p. 539-49.
EPub date: 2015-10-27.
PMID: 26503348
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Successful weight loss maintenance associated with morning chronotype and better sleep quality.
Authors: Ross K.M. , Graham Thomas J. , Wing R.R. .
Source: Journal of behavioral medicine, 2016 Jun; 39(3), p. 465-71.
EPub date: 2015-12-10.
PMID: 26660638
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A pilot randomized controlled trial testing the effects of a routine-based intervention on outcomes in a behavioural weight loss programme.
Authors: Demos K.E. , Leahey T.M. , Hart C.N. , Trautvetter J. , Coward P.R. , Duszlak J. , Wing R.R. .
Source: Obesity science & practice, 2015 Dec; 1(2), p. 110-118.
EPub date: 2015-12-10.
PMID: 29071095
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Estimating sleep from multisensory armband measurements: validity and reliability in teens.
Authors: Roane B.M. , Van Reen E. , Hart C.N. , Wing R. , Carskadon M.A. .
Source: Journal of sleep research, 2015 Dec; 24(6), p. 714-21.
EPub date: 2015-07-01.
PMID: 26126746
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From ideas to efficacy: The ORBIT model for developing behavioral treatments for chronic diseases.
Authors: Czajkowski S.M. , Powell L.H. , Adler N. , Naar-King S. , Reynolds K.D. , Hunter C.M. , Laraia B. , Olster D.H. , Perna F.M. , Peterson J.C. , et al. .
Source: Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2015 Oct; 34(10), p. 971-82.
EPub date: 2015-02-02.
PMID: 25642841
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Association of fish oil supplement use with preservation of brain volume and cognitive function.
Authors: Daiello L.A. , Gongvatana A. , Dunsiger S. , Cohen R.A. , Ott B.R. , Alzheimer's Disease Neuroimaging Initiative .
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association, 2015 Feb; 11(2), p. 226-35.
EPub date: 2014-06-18.
PMID: 24954371
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Acute Changes in Sleep Duration on Eating Behaviors and Appetite-Regulating Hormones in Overweight/Obese Adults.
Authors: Hart C.N. , Carskadon M.A. , Demos K.E. , Van Reen E. , Sharkey K.M. , Raynor H.A. , Considine R.V. , Jones R.N. , Wing R.R. .
Source: Behavioral sleep medicine, 2015; 13(5), p. 424-36.
EPub date: 2014-08-08.
PMID: 25105727
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Failure to replicate depletion of self-control.
Authors: Xu X. , Demos K.E. , Leahey T.M. , Hart C.N. , Trautvetter J. , Coward P. , Middleton K.R. , Wing R.R. .
Source: PloS one, 2014; 9(10), p. e109950.
EPub date: 2014-10-21.
PMID: 25333564
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Associations of self-reported and actigraphy-assessed sleep characteristics with body mass index and waist circumference in adults: moderation by gender.
Authors: Mezick E.J. , Wing R.R. , McCaffery J.M. .
Source: Sleep medicine, 2014 Jan; 15(1), p. 64-70.
EPub date: 2013-10-14.
PMID: 24239499
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Enrollment and retention challenges in early-phase intervention development studies: the obesity-related behavioral intervention trials (ORBIT).
Authors: Boyington J.E. , Czajkowski S. .
Source: Preventing chronic disease, 2013; 10, .
PMID: 23469764
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The association between time in bed and obesity risk in young adults.
Authors: Hart C.N. , Larose J.G. , Fava J.L. , James B.L. , Wing R.R. .
Source: Behavioral sleep medicine, 2013; 11(5), p. 321-7.
EPub date: 2013-01-03.
PMID: 23286548
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Sleep duration and weight loss among overweight/obese women enrolled in a behavioral weight loss program.
Authors: O'Brien E.M. , Fava J. , Subak L.L. , Stone K. , Hart C.N. , Demos K. , Wing R. .
Source: Nutrition & diabetes, 2012-09-10; 2(9), p. e43.
EPub date: 2012-09-10.
PMID: 23446658
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Time in Bed is Associated with Decreased Physical Activity and Higher BMI in Women Seeking Weight Loss Treatment.
Authors: Hart C.N. , Fava J.L. , Subak L.L. , Stone K. , Vittinghoff E. , Demos K. , O'Brien E. , Cairns A. , Wing R. .
Source: ISRN obesity, 2012; 2012, .
PMID: 24198999
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Sleep and obesity in children and adolescents.
Authors: Hart C.N. , Cairns A. , Jelalian E. .
Source: Pediatric clinics of North America, 2011 Jun; 58(3), p. 715-33.
EPub date: 2011-04-13.
PMID: 21600351
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Pilot pharmacologic randomized controlled trial for psychogenic nonepileptic seizures.
Authors: LaFrance W.C. , Keitner G.I. , Papandonatos G.D. , Blum A.S. , Machan J.T. , Ryan C.E. , Miller I.W. .
Source: Neurology, 2010-09-28; 75(13), p. 1166-73.
EPub date: 2010-08-25.
PMID: 20739647
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