Grant Number:	5U01CA152959-05 Interpret this number
Primary Investigator:	Zauber, Ann
Organization:	Sloan-Kettering Inst Can Research
Project Title:	Modeling Effective Health Policies for Colorectal Cancer
Fiscal Year:	2014

DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is still the second most common cause of cancer death in the United States, despite the availability of a range of interventions to reduce the burden of CRC. Microsimulation modeling can inform policy makers in prioritizing among these cancer-control interventions. The CISNET-CRC team includes three collaborative modeling groups, each with a state-of-the-art, population-based microsimulation model for CRC: MISCAN, SimCRC, and CRC-SPIN. These three modeling groups have collaborated for eight years and have delivered a substantial body of policy-oriented work. We propose to continue this collaboration, further developing our models and using them to identify optimal cancer-control policies and practices to reduce the burden of CRC. Our proposed work centers around three specific aims. In Aim 1 we extend our models to reflect the evolving understanding of the CRC disease processes and to incorporate new and updated screening modalities, allowing us to address new policy questions. Here we focus on new data on genomics, biomarkers, pathways, and the upcoming data from randomized controlled trials of flexible sigmoidoscopy screening. In Aim 2 we apply our updated models to inform health policy, including evaluation of interventions across the cancer-control spectrum. New technologies and more individually tailored screening and treatment strategies will be evaluated with a special focus on health disparities. In Aim 3 we disseminate results from our models to inform health policy, via methods that engage policy makers and encourage appropriate use of modeling in policy making and decision support. Here we envision innovation using open-access web-based model applications. We will begin with model extensions required for specific applications, with the balance of the work shifting heavily toward applications over the course of the funding period. Dissemination of our findings will occur throughout the funding period.




Cost-Effectiveness of Risk-Stratified Colorectal Cancer Screening Based on Polygenic Risk: Current Status and Future Potential.
Authors: Naber S.K. , Kundu S. , Kuntz K.M. , Dotson W.D. , Williams M.S. , Zauber A.G. , Calonge N. , Zallen D.T. , Ganiats T.G. , Webber E.M. , et al. .
Source: Jnci Cancer Spectrum, 2020 Feb; 4(1), p. pkz086.
EPub date: 2019-10-14 00:00:00.0.
PMID: 32025627
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Evidence-based sizing of non-inferiority trials using decision models.
Authors: Lansdorp-Vogelaar I. , Jagsi R. , Jayasekera J. , Stout N.K. , Mitchell S.A. , Feuer E.J. .
Source: Bmc Medical Research Methodology, 2019-01-07 00:00:00.0; 19(1), p. 3.
EPub date: 2019-01-07 00:00:00.0.
PMID: 30612554
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Cost-effectiveness of a multitarget stool DNA test for colorectal cancer screening of Medicare beneficiaries.
Authors: Naber S.K. , Knudsen A.B. , Zauber A.G. , Rutter C.M. , Fischer S.E. , Pabiniak C.J. , Soto B. , Kuntz K.M. , Lansdorp-Vogelaar I. .
Source: Plos One, 2019; 14(9), p. e0220234.
EPub date: 2019-09-04 00:00:00.0.
PMID: 31483796
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Cost Effectiveness of Age-Specific Screening Intervals for People With Family Histories of Colorectal Cancer.
Authors: Naber S.K. , Kuntz K.M. , Henrikson N.B. , Williams M.S. , Calonge N. , Goddard K.A.B. , Zallen D.T. , Ganiats T.G. , Webber E.M. , Janssens A.C.J.W. , et al. .
Source: Gastroenterology, 2018 01; 154(1), p. 105-116.e20.
EPub date: 2017-09-28 00:00:00.0.
PMID: 28964749
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Impact of adenoma detection on the benefit of faecal testing vs. colonoscopy for colorectal cancer.
Authors: Meester R.G.S. , Doubeni C.A. , Zauber A.G. , van Ballegooijen M. , Corley D.A. , Lansdorp-Vogelaar I. .
Source: International Journal Of Cancer, 2017-12-01 00:00:00.0; 141(11), p. 2359-2367.
EPub date: 2017-08-31 00:00:00.0.
PMID: 28815573
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Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Non-Invasive Colorectal Cancer Screening.
Authors: Lansdorp-Vogelaar I. , Goede S.L. , Bosch L.J.W. , Melotte V. , Carvalho B. , van Engeland M. , Meijer G.A. , de Koning H.J. , van Ballegooijen M. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2017-07-18 00:00:00.0; , .
EPub date: 2017-07-18 00:00:00.0.
PMID: 28733262
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Accounting for misclassification in electronic health records-derived exposures using generalized linear finite mixture models.
Authors: Hubbard R.A. , Johnson E. , Chubak J. , Wernli K.J. , Kamineni A. , Bogart A. , Rutter C.M. .
Source: Health Services & Outcomes Research Methodology, 2017 Jun; 17(2), p. 101-112.
EPub date: 2016-06-03 00:00:00.0.
PMID: 28943779
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Harms, benefits and costs of fecal immunochemical testing versus guaiac fecal occult blood testing for colorectal cancer screening.
Authors: Goede S.L. , Rabeneck L. , van Ballegooijen M. , Zauber A.G. , Paszat L.F. , Hoch J.S. , Yong J.H. , Kroep S. , Tinmouth J. , Lansdorp-Vogelaar I. .
Source: Plos One, 2017; 12(3), p. e0172864.
EPub date: 2017-03-15 00:00:00.0.
PMID: 28296927
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Consequences of Increasing Time to Colonoscopy Examination After Positive Result From Fecal Colorectal Cancer Screening Test.
Authors: Meester R.G. , Zauber A.G. , Doubeni C.A. , Jensen C.D. , Quinn V.P. , Helfand M. , Dominitz J.A. , Levin T.R. , Corley D.A. , Lansdorp-Vogelaar I. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2016 Oct; 14(10), p. 1445-1451.e8.
PMID: 27211498
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Estimation Of Benefits, Burden, And Harms Of Colorectal Cancer Screening Strategies: Modeling Study For The Us Preventive Services Task Force
Authors: Knudsen A.B. , Zauber A.G. , Rutter C.M. , Naber S.K. , Doria-Rose V.P. , Pabiniak C. , Johanson C. , Fischer S.E. , Lansdorp-Vogelaar I. , Kuntz K.M. .
Source: Jama, 2016-06-21 00:00:00.0; 315(23), p. 2595-609.
PMID: 27305518
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Validation Of Models Used To Inform Colorectal Cancer Screening Guidelines: Accuracy And Implications
Authors: Rutter C.M. , Knudsen A.B. , Marsh T.L. , Doria-Rose V.P. , Johnson E. , Pabiniak C. , Kuntz K.M. , van Ballegooijen M. , Zauber A.G. , Lansdorp-Vogelaar I. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2016-01-08 00:00:00.0; , .
PMID: 26746432
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The Value Of Models In Informing Resource Allocation In Colorectal Cancer Screening: The Case Of The Netherlands
Authors: van Hees F. , Zauber A.G. , van Veldhuizen H. , Heijnen M.L. , Penning C. , de Koning H.J. , van Ballegooijen M. , Lansdorp-Vogelaar I. .
Source: Gut, 2015 Dec; 64(12), p. 1985-97.
PMID: 26063755
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Personalizing Colonoscopy Screening For Elderly Individuals Based On Screening History, Cancer Risk, And Comorbidity Status Could Increase Cost Effectiveness
Authors: van Hees F. , Saini S.D. , Lansdorp-Vogelaar I. , Vijan S. , Meester R.G. , de Koning H.J. , Zauber A.G. , van Ballegooijen M. .
Source: Gastroenterology, 2015 Nov; 149(6), p. 1425-37.
PMID: 26253304
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State Disparities In Colorectal Cancer Rates: Contributions Of Risk Factors, Screening, And Survival Differences
Authors: Lansdorp-Vogelaar I. , Goede S.L. , Ma J. , Xiau-Cheng W. , Pawlish K. , van Ballegooijen M. , Jemal A. .
Source: Cancer, 2015-10-15 00:00:00.0; 121(20), p. 3676-83.
PMID: 26150014
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The impact of stratifying by family history in colorectal cancer screening programs.
Authors: Goede S.L. , Rabeneck L. , Lansdorp-Vogelaar I. , Zauber A.G. , Paszat L.F. , Hoch J.S. , Yong J.H. , van Hees F. , Tinmouth J. , van Ballegooijen M. .
Source: International Journal Of Cancer, 2015-09-01 00:00:00.0; 137(5), p. 1119-27.
EPub date: 2015-09-01 00:00:00.0.
PMID: 25663135
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Faecal Immunochemical Tests Versus Guaiac Faecal Occult Blood Tests: What Clinicians And Colorectal Cancer Screening Programme Organisers Need To Know
Authors: Tinmouth J. , Lansdorp-Vogelaar I. , Allison J.E. .
Source: Gut, 2015 Aug; 64(8), p. 1327-37.
PMID: 26041750
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Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018.
Authors: Meester R.G. , Doubeni C.A. , Zauber A.G. , Goede S.L. , Levin T.R. , Corley D.A. , Jemal A. , Lansdorp-Vogelaar I. .
Source: Cancer, 2015-07-01 00:00:00.0; 121(13), p. 2281-5.
EPub date: 2015-07-01 00:00:00.0.
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Cost-Savings to Medicare From Pre-Medicare Colorectal Cancer Screening.
Authors: Goede S.L. , Kuntz K.M. , van Ballegooijen M. , Knudsen A.B. , Lansdorp-Vogelaar I. , Tangka F.K. , Howard D.H. , Chin J. , Zauber A.G. , Seeff L.C. .
Source: Medical Care, 2015 Jul; 53(7), p. 630-8.
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Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model.
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Source: Jama, 2015-06-16 00:00:00.0; 313(23), p. 2349-58.
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Development Of New Non-invasive Tests For Colorectal Cancer Screening: The Relevance Of Information On Adenoma Detection
Authors: Haug U. , Knudsen A.B. , Lansdorp-Vogelaar I. , Kuntz K.M. .
Source: International Journal Of Cancer, 2015-06-15 00:00:00.0; 136(12), p. 2864-74.
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Optimal Colorectal Cancer Screening In States' Low-income, Uninsured Populations¿the Case Of South Carolina
Authors: van der Steen A. , Knudsen A.B. , van Hees F. , Walter G.P. , Berger F.G. , Daguise V.G. , Kuntz K.M. , Zauber A.G. , van Ballegooijen M. , Lansdorp-Vogelaar I. .
Source: Health Services Research, 2015 Jun; 50(3), p. 768-89.
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Colorectal cancer deaths attributable to nonuse of screening in the United States.
Authors: Meester R.G. , Doubeni C.A. , Lansdorp-Vogelaar I. , Goede S.L. , Levin T.R. , Quinn V.P. , Ballegooijen M. , Corley D.A. , Zauber A.G. .
Source: Annals Of Epidemiology, 2015 Mar; 25(3), p. 208-213.e1.
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The impact of screening on colorectal cancer mortality and incidence: has it really made a difference?
Authors: Zauber A.G. .
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Smarter screening for cancer: possibilities and challenges of personalization.
Authors: Saini S.D. , van Hees F. , Vijan S. .
Source: Jama, 2014-12-03 00:00:00.0; 312(21), p. 2211-2.
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Estimating screening test utilization using electronic health records data.
Authors: Hubbard R. , Chubak J. , Rutter C. .
Source: Egems (washington, Dc), 2014-11-04 00:00:00.0; 2(1), p. 14.
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Optimising The Expansion Of The National Bowel Cancer Screening Program
Authors: Cenin D.R. , St John D.J. , Ledger M.J. , Slevin T. , Lansdorp-Vogelaar I. .
Source: The Medical Journal Of Australia, 2014-10-20 00:00:00.0; 201(8), p. 456-61.
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The Appropriateness Of More Intensive Colonoscopy Screening Than Recommended In Medicare Beneficiaries: A Modeling Study
Authors: van Hees F. , Zauber A.G. , Klabunde C.N. , Goede S.L. , Lansdorp-Vogelaar I. , van Ballegooijen M. .
Source: Jama Internal Medicine, 2014 Oct; 174(10), p. 1568-76.
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Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms and benefits.
Authors: Lansdorp-Vogelaar I. , Gulati R. , Mariotto A.B. , Schechter C.B. , de Carvalho T.M. , Knudsen A.B. , van Ravesteyn N.T. , Heijnsdijk E.A. , Pabiniak C. , van Ballegooijen M. , et al. .
Source: Annals Of Internal Medicine, 2014-07-15 00:00:00.0; 161(2), p. 104-12.
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Should Colorectal Cancer Screening Be Considered In Elderly Persons Without Previous Screening? A Cost-effectiveness Analysis
Authors: van Hees F. , Habbema J.D. , Meester R.G. , Lansdorp-Vogelaar I. , van Ballegooijen M. , Zauber A.G. .
Source: Annals Of Internal Medicine, 2014-06-03 00:00:00.0; 160(11), p. 750-9.
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Utilization of surveillance after polypectomy in the medicare population--a cohort study.
Authors: Lansdorp-Vogelaar I. , Fedewa S. , Lin C.C. , Virgo K.S. , Jemal A. .
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Cost-effectiveness Of Screening And Treating Helicobacter Pylori For Gastric Cancer Prevention
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The Cumulative Risk Of False-positive Fecal Occult Blood Test After 10 Years Of Colorectal Cancer Screening
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Multicohort models in cost-effectiveness analysis: why aggregating estimates over multiple cohorts can hide useful information.
Authors: O'Mahony J.F. , van Rosmalen J. , Zauber A.G. , van Ballegooijen M. .
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Evaluation Of New Technologies For Cancer Control Based On Population Trends In Disease Incidence And Mortality
Authors: Etzioni R. , Durand-Zaleski I. , Lansdorp-Vogelaar I. .
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Rescreening of persons with a negative colonoscopy result: results from a microsimulation model.
Authors: Knudsen A.B. , Hur C. , Gazelle G.S. , Schrag D. , McFarland E.G. , Kuntz K.M. .
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How Should Individuals With A False-positive Fecal Occult Blood Test For Colorectal Cancer Be Managed? A Decision Analysis
Authors: Haug U. , Knudsen A.B. , Kuntz K.M. .
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Contribution of screening and survival differences to racial disparities in colorectal cancer rates.
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Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 May; 21(5), p. 728-36.
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Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.
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Adverse events after screening and follow-up colonoscopy.
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Computer Disease Simulation Models: Integrating Evidence For Health Policy
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