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Grant Details

Grant Number: 1R01CA186720-01 Interpret this number
Primary Investigator: Kiecolt-Glaser, Janice
Organization: Ohio State University
Project Title: Breast Cancer Survivors Cardiovascular Risks: Treatment and Behavioral Influences
Fiscal Year: 2014


DESCRIPTION (provided by applicant): Adjuvant anticancer therapies have enhanced breast cancer survival, but they can also induce important short- and long-term cardiovascular side effects. Preliminary data from our laboratory suggest a novel cardiovascular risk factor not previously documented: chemotherapy-treated breast cancer survivors have an abnormally delayed and persistent rise in triglycerides after a high fat meal compared with survivors who did not receive chemotherapy. Larger and/or more prolonged postprandial triglyceride responses are reliably associated with enhanced cardiovascular risk. Our preliminary data also show that depression substantially augments triglyceride responses to high saturated fat meals. Depression has well-established effects on cardiovascular morbidity and mortality, and these meal-related changes highlight a previously unrecognized depression-sensitive mechanistic pathway. Accordingly, we will assess lipid and atherogenic responses (triglycerides, VLDLs, adhesion molecules) to a typical Westernized high saturated fat meal in stage I-IIIA breast cancer survivors before any adjuvant treatment, and two years after completion of all primary cancer treatment except for longer-term hormonal therapies. We will compare responses of women who do not receive any chemotherapy with women who receive one of the two most common chemotherapy regimens. In addition to primary analyses by treatment group, secondary analyses will use post-treatment cumulative dose information for each chemotherapy drug to examine the effect of specific agents and their dose intensity. Changes in coronary artery calcification scores will provide an anatomic endpoint. Specific Aims: (1) To prospectively evaluate the impact of chemotherapy treatment on postprandial responses to a high saturated fat meal in women diagnosed with breast cancer. (2) To assess relationships between depression and postprandial responses to a high saturated fat meal before and after cancer treatment. (3) To appraise the relative impact of chemotherapy-related changes in menopausal status, cardiorespiratory fitness, and central adiposity as correlates and predictors of postprandial responses. (4) To evaluate treatment-related postprandial responses to a high saturated fat meal as predictors of coronary artery calcification scores. The data from this study would improve our understanding of the enhanced cardiovascular risks associated with both chemotherapy and depression, and would thus lead to new models for assessment and treatment.


Distress Disorder Histories Relate to Greater Physical Symptoms Among Breast Cancer Patients and Survivors: Findings Across the Cancer Trajectory.
Authors: Renna M.E. , Shrout M.R. , Madison A.A. , Lustberg M. , Povoski S.P. , Agnese D.M. , Reinbolt R.E. , Wesolowski R. , Williams N.O. , Ramaswamy B. , et al. .
Source: International journal of behavioral medicine, 2022-07-13; , .
EPub date: 2022-07-13.
PMID: 35831698
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Distress Trajectories in Black and White Breast Cancer Survivors: From Diagnosis to Survivorship.
Authors: Madison A.A. , Peng J. , Shrout M.R. , Renna M.E. , Alfano C.M. , Povoski S.P. , Lipari A.M. , Agnese D.M. , Carson W.E. , Malarkey W.B. , et al. .
Source: Psychoneuroendocrinology, 2021 Sep; 131, p. 105288.
EPub date: 2021-05-27.
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Erythrocyte Long-Chain ω-3 Fatty Acids Are Positively Associated with Lean Mass and Grip Strength in Women with Recent Diagnoses of Breast Cancer.
Authors: Belury M.A. , Cole R.M. , Andridge R. , Keiter A. , Raman S.V. , Lustberg M.B. , Kiecolt-Glaser J.K. .
Source: The Journal of nutrition, 2021-08-07; 151(8), p. 2125-2133.
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The gut microbiota and nervous system: Age-defined and age-defying.
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Source: Seminars in cell & developmental biology, 2021 Aug; 116, p. 98-107.
EPub date: 2021-01-06.
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Worry and rumination in breast cancer patients: perseveration worsens self-rated health.
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Source: Journal of behavioral medicine, 2021 Apr; 44(2), p. 253-259.
EPub date: 2020-11-01.
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Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19.
Authors: Madison A.A. , Shrout M.R. , Renna M.E. , Kiecolt-Glaser J.K. .
Source: Perspectives on psychological science : a journal of the Association for Psychological Science, 2021 Mar; 16(2), p. 191-203.
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Endotoxemia coupled with heightened inflammation predicts future depressive symptoms.
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Stress Reactivity: What Pushes Us Higher, Faster, and Longer - and Why It Matters.
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Source: Current directions in psychological science, 2020-10-01; 29(5), p. 492-498.
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Cognitive problems of breast cancer survivors on proton pump inhibitors.
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Multiple imputation by predictive mean matching in cluster-randomized trials.
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Source: BMC medical research methodology, 2020-03-30; 20(1), p. 72.
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A proinflammatory diet is associated with inflammatory gene expression among healthy, non-obese adults: Can social ties protect against the risks?
Authors: Padin A.C. , H├ębert J.R. , Woody A. , Wilson S.J. , Shivappa N. , Belury M.A. , Malarkey W.B. , Sheridan J.F. , Kiecolt-Glaser J.K. .
Source: Brain, behavior, and immunity, 2019 Nov; 82, p. 36-44.
EPub date: 2019-07-26.
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Stress, depression, diet, and the gut microbiota: human-bacteria interactions at the core of psychoneuroimmunology and nutrition.
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Source: Current opinion in behavioral sciences, 2019 Aug; 28, p. 105-110.
EPub date: 2019-03-25.
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Physical Activity After Breast Cancer Surgery: Does Depression Make Exercise Feel More Effortful than It Actually Is?
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Self-Regulation and Implicit Attitudes Toward Physical Activity Influence Exercise Behavior.
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Inflammatory Cytokines and Comorbidity Development in Breast Cancer Survivors Versus Noncancer Controls: Evidence for Accelerated Aging?
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Source: Molecular nutrition & food research, 2016 May; 60(5), p. 1206-12.
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Inflammation: depression fans the flames and feasts on the heat.
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