Skip to main content

COVID-19 is an emerging, rapidly evolving situation.

What people with cancer should know:

Guidance for cancer researchers:

Get the latest public health information from CDC:

Get the latest research information from NIH:

Grant Details

Grant Number: 5R21CA183492-02 Interpret this number
Primary Investigator: Wallace, Mark
Organization: Vanderbilt University
Project Title: Multisensory Processing Across Lifespan and Links to Cognition
Fiscal Year: 2014


DESCRIPTION (provided by applicant): The long-term objective of the proposed work is to provide the first comprehensive view of how multisensory function changes across lifespan. Emerging literature suggests a surprisingly long development process leading up to the mature multisensory state, and intriguingly that multisensory function in later life may compensate to some degree for age-related loss of acuity within the individual senses. In addition to being the first project to detail these changes across lifespan, the work will provide important windows into individual variability in multisensory function, and how certain domains of multisensory function map onto other domains (e.g., spatial vs. temporal function). Finally, the work seeks to detail relationships between multisensory abilities and higher cognitive processes, given that cognition is grounded in both the integrity of the information contained within the incoming sensory streams and the integration between these streams. The experimental approach will employ a sophisticated battery of tasks to assess and relate multisensory and cognitive function. The proposed studies are oriented around two specific aims. The first is to characterize multisensory function in individuals ranging in age from 5 to 85. The second is to relate performance on our battery of multisensory tasks to performance on well-established cognitive tasks that index domains such as attention and working memory. Collectively these studies are predicated on the framework that multisensory function will change in systematic ways across lifespan, and that these changes will have important relationships to cognition. The significance of work lay in its potential to establish these relationships, which will have important implications for furtherig our understanding of the maturation and aging of perceptual and cognitive representations - issues of powerful


Atypical audiovisual temporal function in autism and schizophrenia: similar phenotype, different cause.
Authors: Noel J.P. , Stevenson R.A. , Wallace M.T. .
Source: The European journal of neuroscience, 2018 05; 47(10), p. 1230-1241.
EPub date: 2018-04-02.
PMID: 29575155
Related Citations

Links between temporal acuity and multisensory integration across life span.
Authors: Stevenson R.A. , Baum S.H. , Krueger J. , Newhouse P.A. , Wallace M.T. .
Source: Journal of experimental psychology. Human perception and performance, 2018 Jan; 44(1), p. 106-116.
EPub date: 2017-04-27.
PMID: 28447850
Related Citations

A multisensory perspective on object memory.
Authors: Matusz P.J. , Wallace M.T. , Murray M.M. .
Source: Neuropsychologia, 2017 Oct; 105, p. 243-252.
EPub date: 2017-04-08.
PMID: 28400327
Related Citations

Rhythmic Modulation of Entrained Auditory Oscillations by Visual Inputs.
Authors: Simon D.M. , Wallace M.T. .
Source: Brain topography, 2017 Sep; 30(5), p. 565-578.
EPub date: 2017-03-24.
PMID: 28341920
Related Citations

Multisensory speech perception in autism spectrum disorder: From phoneme to whole-word perception.
Authors: Stevenson R.A. , Baum S.H. , Segers M. , Ferber S. , Barense M.D. , Wallace M.T. .
Source: Autism research : official journal of the International Society for Autism Research, 2017 Jul; 10(7), p. 1280-1290.
EPub date: 2017-03-24.
PMID: 28339177
Related Citations

Multisensory temporal function and EEG complexity in patients with epilepsy and psychogenic nonepileptic events.
Authors: Noel J.P. , Kurela L. , Baum S.H. , Yu H. , Neimat J.S. , Gallagher M.J. , Wallace M. .
Source: Epilepsy & behavior : E&B, 2017 05; 70(Pt A), p. 166-172.
EPub date: 2017-04-17.
PMID: 28427027
Related Citations

The Impact of Feedback on the Different Time Courses of Multisensory Temporal Recalibration.
Authors: De Niear M.A. , Noel J.P. , Wallace M.T. .
Source: Neural plasticity, 2017; 2017, p. 3478742.
EPub date: 2017-02-21.
PMID: 28316841
Related Citations

The associations between multisensory temporal processing and symptoms of schizophrenia.
Authors: Stevenson R.A. , Park S. , Cochran C. , McIntosh L.G. , Noel J.P. , Barense M.D. , Ferber S. , Wallace M.T. .
Source: Schizophrenia research, 2017 01; 179, p. 97-103.
EPub date: 2016-10-13.
PMID: 27746052
Related Citations

Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naïve patients with nonaffective psychosis.
Authors: Greenhalgh A.M. , Gonzalez-Blanco L. , Garcia-Rizo C. , Fernandez-Egea E. , Miller B. , Arroyo M.B. , Kirkpatrick B. .
Source: Schizophrenia research, 2017 01; 179, p. 57-63.
EPub date: 2016-10-17.
PMID: 27743650
Related Citations

The spatial self in schizophrenia and autism spectrum disorder.
Authors: Noel J.P. , Cascio C.J. , Wallace M.T. , Park S. .
Source: Schizophrenia research, 2017 01; 179, p. 8-12.
EPub date: 2016-09-17.
PMID: 27650196
Related Citations

Multisensory perceptual learning is dependent upon task difficulty.
Authors: De Niear M.A. , Koo B. , Wallace M.T. .
Source: Experimental brain research, 2016 11; 234(11), p. 3269-3277.
EPub date: 2016-07-11.
PMID: 27401473
Related Citations

Dysfunction of sensory oscillations in Autism Spectrum Disorder.
Authors: Simon D.M. , Wallace M.T. .
Source: Neuroscience and biobehavioral reviews, 2016 Sep; 68, p. 848-861.
EPub date: 2016-07-19.
PMID: 27451342
Related Citations

Multisensory Processes: A Balancing Act across the Lifespan.
Authors: Murray M.M. , Lewkowicz D.J. , Amedi A. , Wallace M.T. .
Source: Trends in neurosciences, 2016 08; 39(8), p. 567-579.
EPub date: 2016-06-06.
PMID: 27282408
Related Citations

The temporal binding window for audiovisual speech: Children are like little adults.
Authors: Hillock-Dunn A. , Grantham D.W. , Wallace M.T. .
Source: Neuropsychologia, 2016-07-29; 88, p. 74-82.
EPub date: 2016-02-23.
PMID: 26920938
Related Citations

Stimulus intensity modulates multisensory temporal processing.
Authors: Krueger Fister J. , Stevenson R.A. , Nidiffer A.R. , Barnett Z.P. , Wallace M.T. .
Source: Neuropsychologia, 2016-07-29; 88, p. 92-100.
EPub date: 2016-02-23.
PMID: 26920937
Related Citations

Interactions between space and effectiveness in human multisensory performance.
Authors: Nidiffer A.R. , Stevenson R.A. , Krueger Fister J. , Barnett Z.P. , Wallace M.T. .
Source: Neuropsychologia, 2016-07-29; 88, p. 83-91.
EPub date: 2016-01-27.
PMID: 26826522
Related Citations

Relative contributions of visual and auditory spatial representations to tactile localization.
Authors: Noel J.P. , Wallace M. .
Source: Neuropsychologia, 2016 Feb; 82, p. 84-90.
EPub date: 2016-01-06.
PMID: 26768124
Related Citations

Audiovisual Simultaneity Judgment and Rapid Recalibration throughout the Lifespan.
Authors: Noel J.P. , De Niear M. , Van der Burg E. , Wallace M.T. .
Source: PloS one, 2016; 11(8), p. e0161698.
EPub date: 2016-08-23.
PMID: 27551918
Related Citations

Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder.
Authors: Baum S.H. , Stevenson R.A. , Wallace M.T. .
Source: Progress in neurobiology, 2015 Nov; 134, p. 140-60.
EPub date: 2015-10-09.
PMID: 26455789
Related Citations

Testing sensory and multisensory function in children with autism spectrum disorder.
Authors: Baum S.H. , Stevenson R.A. , Wallace M.T. .
Source: Journal of visualized experiments : JoVE, 2015-04-22; (98), p. e52677.
EPub date: 2015-04-22.
PMID: 25938209
Related Citations

Deficits in audiovisual speech perception in normal aging emerge at the level of whole-word recognition.
Authors: Stevenson R.A. , Nelms C.E. , Baum S.H. , Zurkovsky L. , Barense M.D. , Newhouse P.A. , Wallace M.T. .
Source: Neurobiology of aging, 2015 Jan; 36(1), p. 283-91.
EPub date: 2014-08-07.
PMID: 25282337
Related Citations

The construct of the multisensory temporal binding window and its dysregulation in developmental disabilities.
Authors: Wallace M.T. , Stevenson R.A. .
Source: Neuropsychologia, 2014 11; 64, p. 105-23.
EPub date: 2014-08-13.
PMID: 25128432
Related Citations

Multisensory temporal integration in autism spectrum disorders.
Authors: Stevenson R.A. , Siemann J.K. , Schneider B.C. , Eberly H.E. , Woynaroski T.G. , Camarata S.M. , Wallace M.T. .
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-01-15; 34(3), p. 691-7.
PMID: 24431427
Related Citations

The impact of multisensory integration deficits on speech perception in children with autism spectrum disorders.
Authors: Stevenson R.A. , Segers M. , Ferber S. , Barense M.D. , Wallace M.T. .
Source: Frontiers in psychology, 2014; 5, p. 379.
EPub date: 2014-05-21.
PMID: 24904448
Related Citations

Multisensory Integration in Cochlear Implant Recipients.
Authors: Stevenson R.A. , Sheffield S.W. , Butera I.M. , Gifford R.H. , Wallace M.T. .
Source: Ear and hearing, 2017 Sep/Oct; 38(5), p. 521-538.
PMID: 28399064
Related Citations

Visual Temporal Acuity Is Related to Auditory Speech Perception Abilities in Cochlear Implant Users.
Authors: Jahn K.N. , Stevenson R.A. , Wallace M.T. .
Source: Ear and hearing, 2017 Mar/Apr; 38(2), p. 236-243.
PMID: 27764001
Related Citations

Back to Top