Skip to main content
Grant Details

Grant Number: 5R01CA158045-03 Interpret this number
Primary Investigator: Pickworth, Wallace
Organization: Battelle Centers/Pub Hlth Res & Evaluatn
Project Title: Mainstream Smoke Composition and Toxin Exposure From Prototypical Cigar Products
Fiscal Year: 2014


DESCRIPTION (provided by applicant): Although domestic cigarette smoking is decreasing, there has been a threefold increase in small cigar smoking, and further increases are expected because cigars are not subject to the restrictions of the Family Smoking Prevention & Tobacco Control Act. The societal and personal health consequences of any tobacco consumption are intimately related to the characteristics of the product and how the product is used. Despite evidence suggesting that cigar smoke delivers nicotine (the addictive component) and more than 60 carcinogens, there are no systematic studies that consider both toxin delivery and the smoking behavior of various cigar products. The present proposal answers this deficiency by comparing cigarettes to three prototypical cigar products (PCP) (i.e., cigarillo, small cigar and conventional cigar) by examining behavioral aspects of smoking in a clinical study and the chemistry and particle distribution of mainstream smoke. In the clinical study, participants who smoke both cigarettes and cigars will be assigned to one of three experimental groups (cigarillo, small cigar, conventional cigar), based on their usual cigar product-25 participants/group. Puff topography and inhalation measures will be collected simultaneously while they smoke the cigar (at one visit) and their own brand cigarette (other visit). The prevailing view that cigar smoke is puffed only-not inhaled-may not be true for cigarillos and small cigars and may depend on the participant's smoking history. Chemical measures of acute (nicotine and CO boost) and chronic exposure (cotinine and 3-OH-cotinine NNAL, 1-HOP) will be obtained from the participants. The puffing profiles from the cigar and cigarette smoking will be recorded and used to drive the machine smoking of the PCPs and cigarettes in the chemical laboratory study. The mainstream smoke generated by machine smoking will be characterized by particle size (fine and ultrafine), distribution and gas-phase toxic/carcinogenic components. Identical analyses will be used on mainstream smoke from PCPs and five selected cigarettes (full flavor, light, ultra light, unfiltered and menthol) will be generated using two machine smoking protocols: one designed especially for cigars, and the other historically used for cigarettes. We will compare the delivery of nicotine and various carcinogens between cigarettes and PCPs, compare delivery between the three PCPs and compare nicotine and toxin exposure, puffing, and inhalation between the PCPs and cigarettes.


Cigarillo and Little Cigar Mainstream Smoke Constituents from Replicated Human Smoking.
Authors: Pickworth W.B. , Rosenberry Z.R. , Yi D. , Pitts E.N. , Lord-Adem W. , Koszowski B. .
Source: Chemical research in toxicology, 2018-04-16; 31(4), p. 251-258.
EPub date: 2018-04-04.
PMID: 29582659
Related Citations

Large Cigars: Smoking Topography and Toxicant Exposure.
Authors: Rosenberry Z.R. , Pickworth W.B. , Koszowski B. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2018-01-05; 20(2), p. 183-191.
PMID: 27798089
Related Citations

Toxicant exposure from smoking a little cigar: further support for product regulation.
Authors: Pickworth W.B. , Rosenberry Z.R. , Koszowski B. .
Source: Tobacco control, 2017 May; 26(3), p. 269-276.
EPub date: 2016-04-27.
PMID: 27122063
Related Citations

Cigar Use Symposium: Epidemiology, Toxicant Exposure, Health and Policy Implications.
Authors: Pickworth W.B. , Thanner M.H. .
Source: Tobacco regulatory science, 2017 Apr; 3(Suppl 1), p. S3-S7.
PMID: 28983497
Related Citations

Dual Use of Cigarettes, Little Cigars, Cigarillos, and Large Cigars: Smoking Topography and Toxicant Exposure.
Authors: Pickworth W.B. , Rosenberry Z.R. , O'Grady K.E. , Koszowski B. .
Source: Tobacco regulatory science, 2017 Apr; 3(Suppl 1), p. S72-S83.
PMID: 28966952
Related Citations

Smoking Behavior and Smoke Constituents from Cigarillos and Little Cigars.
Authors: Koszowski B. , Rosenberry Z.R. , Yi D. , Stewart S. , Pickworth W.B. .
Source: Tobacco regulatory science, 2017 Apr; 3(Suppl 1), p. S31-S40.
PMID: 28944278
Related Citations

Nicotine and carbon monoxide exposure from inhalation of cigarillo smoke.
Authors: Koszowski B. , Rosenberry Z.R. , Kanu A. , Viray L.C. , Potts J.L. , Pickworth W.B. .
Source: Pharmacology, biochemistry, and behavior, 2015 Dec; 139(Pt A), p. 7-14.
EPub date: 2015-10-13.
PMID: 26459155
Related Citations

Back to Top