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Grant Details

Grant Number: 5U01ES019457-05 Interpret this number
Primary Investigator: Hiatt, Robert
Organization: University Of California, San Francisco
Project Title: Breast Cancer and the Environment Research Program Coordinating Center
Fiscal Year: 2014


Abstract

DESCRIPTION (provided by applicant): The National Institute for Environmental Health Sciences and the National Cancer Institute propose to continue support for studies of the environmental impact on the etiology of breast cancer, especially through understanding the role of the environment on puberty and early development. As part of this initiative, the Breast Cancer and the Environment Program (BCERP), they will support the continuation of a cohort of young girls through puberty and into adolescence to assess a broad range of environmental factors on pubertal outcomes and intermediate markers of breast cancer risk. The investigators herein propose to be the Coordinating Center for the BCERP. Their specific aims will be: 1) To act as a central repository and clearinghouse for cross-site data from the epidemiologic study of girls early development through puberty and into adolescence; be responsible for the entry, coordination, monitoring, and harmonization of all data collected for cross-site analysis, basic analytic support and facilitation of data sharing and cross-site activities;. 2) To organize meetings and regular conference calls for all organizational entities within the BCERP, including annual business and scientific meetings and meetings to promote transdisciplinary science and other functions required of the BCERP; 3) To facilitate the monthly meetings and other activities of the BCERP Steering Committee; 4) To compile for the Steering Committee regular reports of research activities and accomplishments of the epidemiologic studies; facilitate the NIH oversight and administration of the BCERP and the Pilot Project/Opportunity Fund; and, 5) To support the operations of an expert Working Group on Breast Cancer and the Environment. The investigators believe that they have several significant strengths to be considered in this application, which include; highly experienced and relevant leadership; the highly experienced and well established San Francisco Coordinating Center at the University of California San Francisco (UCSF); and an organizational structure that takes advantage of their past experience of seven years in the Breast Cancer and the Environment Research Centers, which was the first phase of this research initiative.



Publications

Exposure to Perfluoroalkyl Substances and Associations with Pubertal Onset and Serum Reproductive Hormones in a Longitudinal Study of Young Girls in Greater Cincinnati and the San Francisco Bay Area.
Authors: Pinney S.M. , Fassler C.S. , Windham G.C. , Herrick R.L. , Xie C. , Kushi L.H. , Biro F.M. .
Source: Environmental Health Perspectives, 2023 Sep; 131(9), p. 97009.
EPub date: 2023-09-26 00:00:00.0.
PMID: 37751325
Related Citations

Migraine and its association with pubertal maturation and behavioral traits among adolescent girls.
Authors: Martin V.T. , Fassler C.S. , Brunst K.J. , Ying J. , Teitelbaum S. , Windham G.C. , Deardorff J. , Wolff M.S. , Kushi L.H. , Biro F.M. , et al. .
Source: Acta Neurologica Belgica, 2023-01-11 00:00:00.0; , .
EPub date: 2023-01-11 00:00:00.0.
PMID: 36631631
Related Citations

Childhood Socioeconomic Status and Menarche: A Prospective Study.
Authors: Hiatt R.A. , Stewart S.L. , Deardorff J. , Danial E. , Abdiwahab E. , Pinney S.M. , Teitelbaum S.L. , Windham G.C. , Wolff M.S. , Kushi L.H. , et al. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2021 Jul; 69(1), p. 33-40.
PMID: 34172141
Related Citations

Girls' Pubertal Timing and Tempo and Mental Health: A Longitudinal Examination in an Ethnically Diverse Sample.
Authors: Deardorff J. , Marceau K. , Johnson M. , Reeves J.W. , Biro F.M. , Kubo A. , Greenspan L.C. , Laurent C.A. , Windham G.C. , Pinney S.M. , et al. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2021 Jun; 68(6), p. 1197-1203.
EPub date: 2021-02-23 00:00:00.0.
PMID: 33637403
Related Citations

Sex Hormone Phenotypes in Young Girls and the Age at Pubertal Milestones.
Authors: Fassler C.S. , Gutmark-Little I. , Xie C. , Giannini C.M. , Chandler D.W. , Biro F.M. , Pinney S.M. .
Source: The Journal Of Clinical Endocrinology And Metabolism, 2019-12-01 00:00:00.0; 104(12), p. 6079-6089.
PMID: 31408174
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In utero DDT exposure and breast density in early menopause by maternal history of breast cancer.
Authors: McDonald J.A. , Cirillo P.M. , Tehranifar P. , Krigbaum N.Y. , Engmann N.J. , Cohn B.A. , Terry M.B. .
Source: Reproductive Toxicology (elmsford, N.y.), 2019-08-14 00:00:00.0; , .
EPub date: 2019-08-14 00:00:00.0.
PMID: 31421228
Related Citations

Perfluorooctanoate and changes in anthropometric parameters with age in young girls in the Greater Cincinnati and San Francisco Bay Area.
Authors: Pinney S.M. , Windham G.C. , Xie C. , Herrick R.L. , Calafat A.M. , McWhorter K. , Fassler C.S. , Hiatt R.A. , Kushi L.H. , Biro F.M. , et al. .
Source: International Journal Of Hygiene And Environmental Health, 2019-07-09 00:00:00.0; , .
EPub date: 2019-07-09 00:00:00.0.
PMID: 31300293
Related Citations

Complex relationships between perfluorooctanoate, body mass index, insulin resistance and serum lipids in young girls.
Authors: Fassler C.S. , Pinney S.E. , Xie C. , Biro F.M. , Pinney S.M. .
Source: Environmental Research, 2019-06-26 00:00:00.0; 176, p. 108558.
EPub date: 2019-06-26 00:00:00.0.
PMID: 31271921
Related Citations

DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.
Authors: Wu H.C. , Cohn B.A. , Cirillo P.M. , Santella R.M. , Terry M.B. .
Source: Reproductive Toxicology (elmsford, N.y.), 2019-02-26 00:00:00.0; , .
EPub date: 2019-02-26 00:00:00.0.
PMID: 30822522
Related Citations

Lead exposure during childhood and subsequent anthropometry through adolescence in girls.
Authors: Deierlein A.L. , Teitelbaum S.L. , Windham G.C. , Pinney S.M. , Galvez M.P. , Caldwell K.L. , Jarrett J.M. , Gajek R. , Kushi L.H. , Biro F. , et al. .
Source: Environment International, 2019 01; 122, p. 310-315.
EPub date: 2018-11-29 00:00:00.0.
PMID: 30503317
Related Citations

Girls' Sleep Trajectories Across the Pubertal Transition: Emerging Racial/Ethnic Differences.
Authors: Hoyt L.T. , Deardorff J. , Marceau K. , Laurent C.A. , Windham G.C. , Greenspan L.C. , Pinney S.M. , Teitelbaum S. , Grimm K.J. , Hagan M.J. , et al. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2018-01-25 00:00:00.0; , .
EPub date: 2018-01-25 00:00:00.0.
PMID: 29396081
Related Citations

Childhood Socioeconomic Position and Pubertal Onset in a Cohort of Multiethnic Girls: Implications for Breast Cancer.
Authors: Hiatt R.A. , Stewart S.L. , Hoeft K.S. , Kushi L.H. , Windham G.C. , Biro F.M. , Pinney S.M. , Wolff M.S. , Teitelbaum S.L. , Braithwaite D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 Dec; 26(12), p. 1714-1721.
EPub date: 2017-09-22 00:00:00.0.
PMID: 28939588
Related Citations

Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows.
Authors: Windham G.C. , Lum R. , Voss R. , Wolff M. , Pinney S.M. , Teteilbaum S.L. , Sosnoff C.S. , Dobraca D. , Biro F. , Hiatt R.A. , et al. .
Source: Epidemiology (cambridge, Mass.), 2017-06-28 00:00:00.0; , .
EPub date: 2017-06-28 00:00:00.0.
PMID: 28661938
Related Citations

Phenol concentrations during childhood and subsequent measures of adiposity among young girls.
Authors: Deierlein A.L. , Wolff M.S. , Pajak A. , Pinney S.M. , Windham G.C. , Galvez M.P. , Rybak M. , Calafat A.M. , Kushi L.H. , Biro F.M. , et al. .
Source: American Journal Of Epidemiology, 2017-05-19 00:00:00.0; , .
EPub date: 2017-05-19 00:00:00.0.
PMID: 28525533
Related Citations

Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012.
Authors: Herrick R.L. , Buckholz J. , Biro F.M. , Calafat A.M. , Ye X. , Xie C. , Pinney S.M. .
Source: Environmental Pollution (barking, Essex : 1987), 2017-05-12 00:00:00.0; 228, p. 50-60.
EPub date: 2017-05-12 00:00:00.0.
PMID: 28505513
Related Citations

Peripubertal Dietary Flavonol And Lignan Intake And Age At Menarche In A Longitudinal Cohort Of Girls
Authors: Mervish N.A. , Teitelbaum S.L. , Pajak A. , Windham G.C. , Pinney S.M. , Kushi L.H. , Biro F.M. , Wolff M.S. .
Source: Pediatric Research, 2017-02-07 00:00:00.0; , .
PMID: 28170386
Related Citations

Associations Of Urinary Phthalate And Phenol Biomarkers With Menarche In A Multiethnic Cohort Of Young Girls
Authors: Wolff M.S. , Pajak A. , Pinney S.M. , Windham G.C. , Galvez M. , Rybak M. , Silva M.J. , Ye X. , Calafat A.M. , Kushi L.H. , et al. .
Source: Reproductive Toxicology (elmsford, N.y.), 2017 Jan; 67, p. 56-64.
PMID: 27851993
Related Citations

Transdisciplinary Approaches Enhance The Production Of Translational Knowledge
Authors: Ciesielski T.H. , Aldrich M.C. , Marsit C.J. , Hiatt R.A. , Williams S.M. .
Source: Translational Research : The Journal Of Laboratory And Clinical Medicine, 2016-11-10 00:00:00.0; , .
PMID: 27893987
Related Citations

Longitudinal Associations Of Phthalate Exposures During Childhood And Body Size Measurements In Young Girls
Authors: Deierlein A.L. , Wolff M.S. , Pajak A. , Pinney S.M. , Windham G.C. , Galvez M.P. , Silva M.J. , Calafat A.M. , Kushi L.H. , Biro F.M. , et al. .
Source: Epidemiology (cambridge, Mass.), 2016 Jul; 27(4), p. 492-9.
PMID: 27031039
Related Citations

Thyroid Hormones and Timing of Pubertal Onset in a Longitudinal Cohort of Females, Northern California, 2006-11.
Authors: Wilken J.A. , Greenspan L.C. , Kushi L.H. , Voss R.W. , Windham G.C. .
Source: Paediatric And Perinatal Epidemiology, 2016 May; 30(3), p. 285-93.
PMID: 26849015
Related Citations

Neighborhood deprivation, race/ethnicity, and urinary metal concentrations among young girls in California.
Authors: Gonzales F.A. , Jones R.R. , Deardorff J. , Windham G.C. , Hiatt R.A. , Kushi L.H. .
Source: Environment International, 2016 May; 91, p. 29-39.
PMID: 26908165
Related Citations

Thyroid Antagonists (Perchlorate, Thiocyanate, and Nitrate) and Childhood Growth in a Longitudinal Study of U.S. Girls.
Authors: Mervish N.A. , Pajak A. , Teitelbaum S.L. , Pinney S.M. , Windham G.C. , Kushi L.H. , Biro F.M. , Valentin-Blasini L. , Blount B.C. , Wolff M.S. , et al. .
Source: Environmental Health Perspectives, 2016 Apr; 124(4), p. 542-9.
PMID: 26151950
Related Citations

Environmental phenols and pubertal development in girls.
Authors: Wolff M.S. , Teitelbaum S.L. , McGovern K. , Pinney S.M. , Windham G.C. , Galvez M. , Pajak A. , Rybak M. , Calafat A.M. , Kushi L.H. , et al. .
Source: Environment International, 2015 Nov; 84, p. 174-80.
PMID: 26335517
Related Citations

Letter To The Editor Re Morollo-frosh "communicating Results In Post-belmont Era Biomonitoring Studies"
Authors: Pinney S.M. , Biro F.M. .
Source: Environmental Research, 2015 Oct; 142, p. 756.
PMID: 26076818
Related Citations

Breastfeeding versus formula-feeding and girls' pubertal development.
Authors: Kale A. , Deardorff J. , Lahiff M. , Laurent C. , Greenspan L.C. , Hiatt R.A. , Windham G. , Galvez M.P. , Biro F.M. , Pinney S.M. , et al. .
Source: Maternal And Child Health Journal, 2015 Mar; 19(3), p. 519-27.
PMID: 24916206
Related Citations

Altered blood proteome in girls with high urine concentrations of bisphenol a, genistein, mono-ethyl hexylphthalate and mono-benzyl phthalate.
Authors: Wang J. , Betancourt A. , Jenkins S. , Biro F. , Pinney S.M. , Chen D. , Russo J. , Lamartiniere C.A. .
Source: Moj Proteomics & Bioinformatics, 2015; 2(2), p. 44-57.
EPub date: 2015-03-10 00:00:00.0.
PMID: 31360934
Related Citations

Younger pubertal age is associated with allergy and other atopic conditions in girls.
Authors: Hong C.C. , Pajak A. , Teitelbaum S.L. , Vangeepuram N. , Galvez M. , Pinney S.M. , Windham G. , Kushi L.H. , Biro F.M. , Wolff M.S. , et al. .
Source: Pediatric Allergy And Immunology : Official Publication Of The European Society Of Pediatric Allergy And Immunology, 2014 Dec; 25(8), p. 773-80.
PMID: 25387609
Related Citations

Neighborhood influences on girls' obesity risk across the transition to adolescence.
Authors: Hoyt L.T. , Kushi L.H. , Leung C.W. , Nickleach D.C. , Adler N. , Laraia B.A. , Hiatt R.A. , Yen I.H. .
Source: Pediatrics, 2014 Nov; 134(5), p. 942-9.
PMID: 25311606
Related Citations

Local food environments are associated with girls' energy, sugar-sweetened beverage and snack-food intakes.
Authors: Deierlein A.L. , Galvez M.P. , Yen I.H. , Pinney S.M. , Biro F.M. , Kushi L.H. , Teitelbaum S. , Wolff M.S. .
Source: Public Health Nutrition, 2014 Oct; 17(10), p. 2194-200.
PMID: 24821228
Related Citations

Phthalate exposure and pubertal development in a longitudinal study of US girls.
Authors: Wolff M.S. , Teitelbaum S.L. , McGovern K. , Windham G.C. , Pinney S.M. , Galvez M. , Calafat A.M. , Kushi L.H. , Biro F.M. , Breast Cancer and Environment Research Program .
Source: Human Reproduction (oxford, England), 2014 Jul; 29(7), p. 1558-66.
PMID: 24781428
Related Citations

CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls.
Authors: Stueve T.R. , Wolff M.S. , Pajak A. , Teitelbaum S.L. , Chen J. .
Source: Bmc Pediatrics, 2014-03-20 00:00:00.0; 14, p. 78.
EPub date: 2014-03-20 00:00:00.0.
PMID: 24649863
Related Citations

Asthma and physical activity in multiracial girls from three US sites.
Authors: Vangeepuram N. , McGovern K.J. , Teitelbaum S. , Galvez M.P. , Pinney S.M. , Biro F.M. , Kushi L.H. , Wolff M.S. .
Source: The Journal Of Asthma : Official Journal Of The Association For The Care Of Asthma, 2014 Mar; 51(2), p. 193-9.
PMID: 24192016
Related Citations

Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA.
Authors: Pinney S.M. , Biro F.M. , Windham G.C. , Herrick R.L. , Yaghjyan L. , Calafat A.M. , Succop P. , Sucharew H. , Ball K.M. , Kato K. , et al. .
Source: Environmental Pollution (barking, Essex : 1987), 2014 Jan; 184, p. 327-34.
PMID: 24095703
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Onset of breast development in a longitudinal cohort.
Authors: Biro F.M. , Greenspan L.C. , Galvez M.P. , Pinney S.M. , Teitelbaum S. , Windham G.C. , Deardorff J. , Herrick R.L. , Succop P.A. , Hiatt R.A. , et al. .
Source: Pediatrics, 2013 Dec; 132(6), p. 1019-27.
PMID: 24190685
Related Citations

Dietary flavonol intake is associated with age of puberty in a longitudinal cohort of girls.
Authors: Mervish N.A. , Gardiner E.W. , Galvez M.P. , Kushi L.H. , Windham G.C. , Biro F.M. , Pinney S.M. , Rybak M.E. , Teitelbaum S.L. , Wolff M.S. , et al. .
Source: Nutrition Research (new York, N.y.), 2013 Jul; 33(7), p. 534-42.
PMID: 23827127
Related Citations

Early pubertal development and insulin sensitivity among school-aged girls: mediation via adiposity.
Authors: Hillman J.B. , Huang B. , Pinney S.M. , Biro F.M. .
Source: Journal Of Pediatric And Adolescent Gynecology, 2013 Feb; 26(1), p. 47-50.
PMID: 23158754
Related Citations

Puberty in girls of the 21st century.
Authors: Biro F.M. , Greenspan L.C. , Galvez M.P. .
Source: Journal Of Pediatric And Adolescent Gynecology, 2012 Oct; 25(5), p. 289-94.
PMID: 22841372
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Cancer screening: the journey from epidemiology to policy.
Authors: Deppen S.A. , Aldrich M.C. , Hartge P. , Berg C.D. , Colditz G.A. , Petitti D.B. , Hiatt R.A. .
Source: Annals Of Epidemiology, 2012 Jun; 22(6), p. 439-45.
PMID: 22626002
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The Social Determinants Of Cancer: A Challenge For Transdisciplinary Science
Authors: Hiatt,R.A. , Breen,N. .
Source: American Journal Of Preventive Medicine, 2008 Aug; 35(2 Suppl), p. S141-50.
PMID: 18619394
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