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Grant Details

Grant Number: 5R03CA167451-02 Interpret this number
Primary Investigator: Chow, Eric
Organization: Fred Hutchinson Cancer Research Center
Project Title: Analysis of Morbidity and Mortality Among Hematopoietic Cell Transplantation Surv
Fiscal Year: 2014
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Abstract

DESCRIPTION (provided by applicant): With the increasing use of hematopoietic cell transplantation (HCT) and the corresponding increase in the number of long-term survivors, there is an important need to better characterize causes of late morbidity and mortality in this population beyond description of primary disease relapse and graft vs. host disease (GVHD). Using available population-based hospital discharge and death registry data, our existing work has elucidated the magnitude of serious cardiovascular disease among long-term (e2-yr) transplant survivors and is leading to a better understanding of associated pre-HCT and HCT-related risk factors. We now propose to extend this methodology to comprehensively examine all other important health outcomes in this population of e2-yr HCT survivors who are Washington State (WA) residents and treated at the Fred Hutchinson Cancer Research Center (FHCRC) from 1985-2011 (n=2096, 53% allogeneic). In particular, we will focus on serious late pulmonary and infectious complications and 2nd cancers, which along with cardiovascular disease have been identified as leading causes of non-relapse related mortality in prior studies. Pre-HCT and HCT-related exposures from this cohort will be linked to state hospital discharge, death, and cancer registries from the concurrent time period. This will allow us to: 1) compare outcome rates in HCT survivors with those derived from the general population as well as a non-HCT cancer population matched on original cancer diagnosis; 2) examine the association of both pre-HCT and HCT-related exposures with our outcomes of interest. The proposed study takes advantage of existing datasets and one of the world's largest HCT cohorts, uses population-based methods, and circumvents survival and response biases that have affected many existing HCT studies dependent on patient self-report and/or long-term follow-up clinic visits. A cohort of affected long- term survivors also will be identified for whom secondary validation of outcomes via direct medical record review and more in-depth assessment of potential modifiable risk factors can occur. This proposal incorporates methodology and combines data sources not previously used by HCT researchers, including those from FHCRC, and has potential to greatly extend the understanding of the entire spectrum of health outcomes that occur in this at-risk cancer population. Overall, these results may then ultimately influence post-HCT screening guidelines, including the design of risk prediction algorithms to identify those who will be at increased risk for late adverse outcomes. Findings also will be directly relevant to the larger population of cancer patients who often receive similar treatment exposures.

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Publications

New Agents, Emerging Late Effects, and the Development of Precision Survivorship.
Authors: Chow E.J. , Antal Z. , Constine L.S. , Gardner R. , Wallace W.H. , Weil B.R. , Yeh J.M. , Fox E. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-07-20; 36(21), p. 2231-2240.
EPub date: 2018-06-06.
PMID: 29874142
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Lifestyle factors and subsequent ischemic heart disease risk after hematopoietic cell transplantation.
Authors: Leger K.J. , Baker K.S. , Cushing-Haugen K.L. , Flowers M.E.D. , Leisenring W.M. , Martin P.J. , Mendoza J.A. , Reding K.W. , Syrjala K.L. , Lee S.J. , et al. .
Source: Cancer, 2018-04-01; 124(7), p. 1507-1515.
EPub date: 2018-01-09.
PMID: 29315507
Related Citations

Morbidity and Mortality Differences Between Hematopoietic Cell Transplantation Survivors and Other Cancer Survivors.
Authors: Chow E.J. , Cushing-Haugen K.L. , Cheng G.S. , Boeckh M. , Khera N. , Lee S.J. , Leisenring W.M. , Martin P.J. , Mueller B.A. , Schwartz S.M. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-01-20; 35(3), p. 306-313.
EPub date: 2016-11-21.
PMID: 27870568
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Clinical and Genetic Determinants of Cardiomyopathy Risk among Hematopoietic Cell Transplantation Survivors.
Authors: Leger K.J. , Cushing-Haugen K. , Hansen J.A. , Fan W. , Leisenring W.M. , Martin P.J. , Zhao L.P. , Chow E.J. .
Source: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2016 06; 22(6), p. 1094-1101.
EPub date: 2016-03-08.
PMID: 26968791
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Late cardiovascular complications after hematopoietic cell transplantation.
Authors: Chow E.J. , Wong K. , Lee S.J. , Cushing-Haugen K.L. , Flowers M.E. , Friedman D.L. , Leisenring W.M. , Martin P.J. , Mueller B.A. , Baker K.S. .
Source: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014 Jun; 20(6), p. 794-800.
EPub date: 2014-02-22.
PMID: 24565992
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