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Grant Details

Grant Number: 5R03CA171017-02 Interpret this number
Primary Investigator: Crump, Casey
Organization: Lund University
Project Title: Perinatal, Familial, and Neighborhood Risk Factors for Childhood Cancer
Fiscal Year: 2014
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Abstract

DESCRIPTION (provided by applicant): Childhood cancer has steadily increased in incidence over the past 60 years, and is the second leading cause of death among children in developed countries. Most childhood cancers have an unknown etiology but are hypothesized to originate in utero due to perinatal, familial, and environmental risk factors that have yet to be identified. We propose to conduct the largest population-based cohort studies to date to identify perinatal, familial, and neighborhood risk factors for specific childhood cancers using comprehensive data for the entire population of Sweden. Perinatal, familial, and neighborhood factors will be identified from the Swedish Birth Registry and census data for all individuals born in Sweden from 1973 through 2008 (N=~3.5 million children). These data will be linked to the Swedish Cancer Registry for complete ascertainment of the most common childhood cancers (including leukemias, brain tumors, lymphomas, neuroblastomas, Wilms tumors, soft tissue sarcomas, retinoblastomas, bone tumors, and hepatoblastomas), diagnosed from birth through 2009. The specific aims are to: 1) Examine the association between perinatal, familial, and neighborhood characteristics and the risk of specific childhood cancers and histologic subtypes; 2) Explore potential interactions among perinatal, familial, and neighborhood characteristics with respect to the risk of specific childhood cancers; and 3) Characterize time trends in the risk of specific childhood cancers during the study period. This cost-effective study will advance the understanding of childhood cancer etiologies, facilitate the identification of high-risk infants, ad ultimately may enable earlier preventive and therapeutic interventions to reduce childhood cancer incidence and mortality.

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Publications

YAP and the Hippo pathway in cholangiocarcinoma.
Authors: Sugihara T. , Isomoto H. , Gores G. , Smoot R. .
Source: Journal of gastroenterology, 2019 Jun; 54(6), p. 485-491.
EPub date: 2019-02-27.
PMID: 30815737
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YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity.
Authors: Sugihara T. , Werneburg N.W. , Hernandez M.C. , Yang L. , Kabashima A. , Hirsova P. , Yohanathan L. , Sosa C. , Truty M.J. , Vasmatzis G. , et al. .
Source: Molecular cancer research : MCR, 2018 10; 16(10), p. 1556-1567.
EPub date: 2018-06-14.
PMID: 29903769
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ENHANCING COMMUNITY HEALTH BY IMPROVING PHYSICIAN PARTICIPATION.
Authors: Crump C. , Arniella G. , Calman N.S. .
Source: Journal of community medicine & health education, 2016 Oct; 6(5), .
EPub date: 2016-10-17.
PMID: 28663932
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Fetal growth and subsequent maternal risk of thyroid cancer.
Authors: Crump C. , Sundquist J. , Sieh W. , Winkleby M.A. , Sundquist K. .
Source: International journal of cancer, 2016-03-01; 138(5), p. 1085-93.
EPub date: 2015-10-05.
PMID: 26379007
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Perinatal risk factors for acute myeloid leukemia.
Authors: Crump C. , Sundquist J. , Sieh W. , Winkleby M.A. , Sundquist K. .
Source: European journal of epidemiology, 2015 Dec; 30(12), p. 1277-85.
EPub date: 2015-06-26.
PMID: 26113060
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Fetal growth and subsequent maternal risk of colorectal cancer.
Authors: Crump C. , Sundquist J. , Sieh W. , Winkleby M.A. , Sundquist K. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015 Aug; 24(8), p. 1184-9.
EPub date: 2015-06-02.
PMID: 26038389
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Perinatal and familial risk factors for acute lymphoblastic leukemia in a Swedish national cohort.
Authors: Crump C. , Sundquist J. , Sieh W. , Winkleby M.A. , Sundquist K. .
Source: Cancer, 2015-04-01; 121(7), p. 1040-7.
EPub date: 2014-11-21.
PMID: 25417823
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Perinatal and familial risk factors for brain tumors in childhood through young adulthood.
Authors: Crump C. , Sundquist J. , Sieh W. , Winkleby M.A. , Sundquist K. .
Source: Cancer research, 2015-02-01; 75(3), p. 576-83.
EPub date: 2014-12-15.
PMID: 25511376
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Season of birth and risk of Hodgkin and non-Hodgkin lymphoma.
Authors: Crump C. , Sundquist J. , Sieh W. , Winkleby M.A. , Sundquist K. .
Source: International journal of cancer, 2014-12-01; 135(11), p. 2735-9.
EPub date: 2014-04-25.
PMID: 24752499
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Season of birth and other perinatal risk factors for melanoma.
Authors: Crump C. , Sundquist K. , Sieh W. , Winkleby M.A. , Sundquist J. .
Source: International journal of epidemiology, 2014 Jun; 43(3), p. 793-801.
EPub date: 2014-01-22.
PMID: 24453238
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Intrauterine factors and risk of nonepithelial ovarian cancers.
Authors: Sieh W. , Sundquist K. , Sundquist J. , Winkleby M.A. , Crump C. .
Source: Gynecologic oncology, 2014 May; 133(2), p. 293-7.
EPub date: 2014-02-14.
PMID: 24530563
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Perinatal risk factors for Wilms tumor in a Swedish national cohort.
Authors: Crump C. , Sundquist J. , Sieh W. , Winkleby M.A. , Sundquist K. .
Source: European journal of epidemiology, 2014 Mar; 29(3), p. 191-7.
EPub date: 2014-02-08.
PMID: 24510487
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