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Grant Details

Grant Number: 5R03CA169888-02 Interpret this number
Primary Investigator: Wise, Lauren
Organization: Boston University Medical Campus
Project Title: Endometrial Cancer in Black Women
Fiscal Year: 2014
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Abstract

DESCRIPTION (provided by applicant): Although the age-adjusted incidence of endometrial cancer is 12% lower among black women than white women, age-adjusted mortality among black women is 87% higher and this racial disparity has continued to increase over the past two decades. Preliminary evidence from the Epidemiology of Endometrial Cancer Consortium (E2C2) suggests that oral contraceptive use, parity, and older age at first and last birth are not as protective against endometrial cancer in black women as they are in white women. We propose to assess the influence of anthropometric, reproductive, hormonal, and metabolic factors on incident endometrial cancer diagnosed over 18 years of follow-up (1995-2013) in the Black Women's Health Study (BWHS), a large prospective cohort study of U.S. black women. We then propose to perform a meta-analysis of results from the BWHS, the Case-Control Surveillance Study (CCS), and 10 additional studies from the E2C2 that include black women to investigate predictors of incidence and histology (types I, II, and II). Type II and II tumors are more aggressive than type I tumors, and they are also more prevalent in black women. Little is known about risk factors for type II and III tumors. Our assessment of different histologic types for endometrial cancer has the potential to address important questions about the black-white discrepancy in mortality. The meta-analysis will involve more than 800 black cases of endometrial cancer. We will compute a relative risk (RR) for each study, evaluate heterogeneity in the RRs, and then estimate a RR for all studies combined and according to study design (e.g., cohort vs. case-control). In addition, we will perform separate analyses of histologic type to assess whether the environmental factors of interest predict types II and III cancer, which are more prevalent in black women. Black women are understudied with regard to endometrial cancer etiology. Many of the putative risk factors that we propose to study are of particular relevance to black women; for example, U.S. black women have significantly higher rates of obesity, type 2 diabetes, and uterine fibroids, and give birth at earlier ages and have more children than white women. New data about modifiable risk factors has the potential to influence primary prevention of disease. The proposed study of an underserved minority population at increasing risk of death from endometrial cancer will address gaps in research, as almost all data on determinants of endometrial cancer come from studies of white women. The proposed study can be carried out at modest cost because data collection and infrastructure are supported by other grants.

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Publications

Use of aspirin, other nonsteroidal anti-inflammatory drugs and acetaminophen and risk of endometrial cancer: the Epidemiology of Endometrial Cancer Consortium.
Authors: Webb P.M. , Na R. , Weiderpass E. , Adami H.O. , Anderson K.E. , Bertrand K.A. , Botteri E. , Brasky T.M. , Brinton L.A. , Chen C. , et al. .
Source: Annals of oncology : official journal of the European Society for Medical Oncology, 2019-02-01; 30(2), p. 310-316.
PMID: 30566587
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Exogenous Hormone Use and Endometrial Cancer in U.S. Black Women.
Authors: Sponholtz T.R. , Palmer J.R. , Rosenberg L.A. , Hatch E.E. , Adams-Campbell L.L. , Wise L.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 05; 27(5), p. 558-565.
EPub date: 2018-02-23.
PMID: 29475971
Related Citations

Breastfeeding and Endometrial Cancer Risk: An Analysis From the Epidemiology of Endometrial Cancer Consortium.
Authors: Jordan S.J. , Na R. , Johnatty S.E. , Wise L.A. , Adami H.O. , Brinton L.A. , Chen C. , Cook L.S. , Dal Maso L. , De Vivo I. , et al. .
Source: Obstetrics and gynecology, 2017 06; 129(6), p. 1059-1067.
PMID: 28486362
Related Citations

Reproductive factors and incidence of endometrial cancer in U.S. black women.
Authors: Sponholtz T.R. , Palmer J.R. , Rosenberg L. , Hatch E.E. , Adams-Campbell L.L. , Wise L.A. .
Source: Cancer causes & control : CCC, 2017 Jun; 28(6), p. 579-588.
EPub date: 2017-03-30.
PMID: 28361447
Related Citations

History of uterine leiomyoma and risk of endometrial cancer in black women.
Authors: Wise L.A. , Sponholtz T.R. , Rosenberg L. , Adams-Campbell L.L. , Kuohung W. , LaValley M.P. , Palmer J.R. .
Source: Cancer causes & control : CCC, 2016 Apr; 27(4), p. 545-52.
EPub date: 2016-02-29.
PMID: 26923705
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Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women.
Authors: Sponholtz T.R. , Palmer J.R. , Rosenberg L. , Hatch E.E. , Adams-Campbell L.L. , Wise L.A. .
Source: American journal of epidemiology, 2016-02-15; 183(4), p. 259-68.
EPub date: 2016-01-27.
PMID: 26823438
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Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study.
Authors: Brasky T.M. , Sponholtz T.R. , Palmer J.R. , Rosenberg L. , Ruiz-Narváez E.A. , Wise L.A. .
Source: American journal of epidemiology, 2016-02-01; 183(3), p. 199-209.
EPub date: 2016-01-10.
PMID: 26755676
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Intrauterine devices and endometrial cancer risk: a pooled analysis of the Epidemiology of Endometrial Cancer Consortium.
Authors: Felix A.S. , Gaudet M.M. , La Vecchia C. , Nagle C.M. , Shu X.O. , Weiderpass E. , Adami H.O. , Beresford S. , Bernstein L. , Chen C. , et al. .
Source: International journal of cancer, 2015-03-01; 136(5), p. E410-22.
EPub date: 2014-09-30.
PMID: 25242594
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