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Grant Details

Grant Number: 5R01CA074592-13 Interpret this number
Primary Investigator: Crane, Lori
Organization: University Of Colorado Denver
Project Title: Risk Factors for Nevus Development in Children
Fiscal Year: 2014


Abstract

DESCRIPTION (provided by applicant): Both malignant melanoma and nevi (moles) arise from melanocytes, and in many cases, nevi are thought to be intermediate in the pathway from melanocyte to melanoma. The presence of nevi is the strongest predictor of melanoma risk, and individuals who have higher numbers of nevi have an estimated 6 to 7-fold increased risk of developing malignant melanoma. Most nevi are developed in childhood and an understanding of the genetic, environmental, and behavioral factors that contribute to nevus development and growth is essential for understanding the pathways to melanoma. This study began in 1998 with a sun protection intervention study of newborns, in which sun exposure and sun protection data were collected beginning at birth and nevus exams were conducted starting at age 3. In 2004, additional children were added to the cohort, for which sun exposure, sun protection, and skin exam data were collected annually at ages 6-10. This study is now the longest running annual longitudinal study of childhood nevus development in the world. The overall aim of this project is to continue studying this cohort (n=936) with nevus counts and interviews for five additional years, from 2010 - 2014, and to add two new data collection components: a genetic component and more detailed data collection on changes in growth and shape of individual nevi. Previous research indicates that the 12 - 16 age range covered by the 2010 - 2014 funding period will be the most critical period for emergent nevi during the lifespan. This study will examine increases in number of nevi, and changes in individual nevi, and how these are influenced by the interaction of genes, UV exposure, and sun protection behavior during this critical period. Up to 100 SNPs in genes already known to be associated with nevi or identified recently through genome wide studies (conducted by other researchers) as related to pigmentation, nevus development, or melanoma will be assessed. The comprehensive nature of the data collected through age 10, the data that will be collected during the course of the proposed study, and the availability of newly described genes that influence human pigmentation, nevus development and melanoma will allow for the most complete analysis of influences on nevus formation yet undertaken. The long-term clinical and public health significance of this research include: 1) a better understanding of the biological mechanisms that result in both nevus and melanoma development, which could lead to new treatments for melanoma; 2) possible chemo-preventive agents to prevent nevus development and/or melanoma; and 3) more targeted public health recommendations regarding sun protective behaviors.



Publications

Trajectories of Nevus Development From Age 3 to 16 Years in the Colorado Kids Sun Care Program Cohort.
Authors: Asdigian N.L. , Barón A.E. , Morelli J.G. , Mokrohisky S.T. , Aalborg J. , Dellavalle R.P. , Daley M.F. , Berwick M. , Muller K.E. , Box N.F. , et al. .
Source: JAMA dermatology, 2018-11-01; 154(11), p. 1272-1280.
PMID: 30208471
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Senescence-Like Phenotypes in Human Nevi.
Authors: Joselow A. , Lynn D. , Terzian T. , Box N.F. .
Source: Methods in molecular biology (Clifton, N.J.), 2017; 1534, p. 175-184.
PMID: 27812879
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Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes.
Authors: Barón A.E. , Asdigian N.L. , Gonzalez V. , Aalborg J. , Terzian T. , Stiegmann R.A. , Torchia E.C. , Berwick M. , Dellavalle R.P. , Morelli J.G. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Dec; 23(12), p. 2829-39.
PMID: 25410285
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Mailed intervention to promote sun protection of children: a randomized controlled trial.
Authors: Crane L.A. , Asdigian N.L. , Barón A.E. , Aalborg J. , Marcus A.C. , Mokrohisky S.T. , Byers T.E. , Dellavalle R.P. , Morelli J.G. .
Source: American journal of preventive medicine, 2012 Oct; 43(4), p. 399-410.
PMID: 22992358
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Sun damage in ultraviolet photographs correlates with phenotypic melanoma risk factors in 12-year-old children.
Authors: Gamble R.G. , Asdigian N.L. , Aalborg J. , Gonzalez V. , Box N.F. , Huff L.S. , Barón A.E. , Morelli J.G. , Mokrohisky S.T. , Crane L.A. , et al. .
Source: Journal of the American Academy of Dermatology, 2012 Oct; 67(4), p. 587-97.
EPub date: 2012-03-09.
PMID: 22406230
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Parents' perceptions of skin cancer threat and children's physical activity.
Authors: Tran A.D. , Aalborg J. , Asdigian N.L. , Morelli J.G. , Mokrohisky S.T. , Dellavalle R.P. , Berwick M. , Box N.F. , Crane L.A. .
Source: Preventing chronic disease, 2012; 9, p. E143.
PMID: 22935145
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Effect of hair color and sun sensitivity on nevus counts in white children in Colorado.
Authors: Aalborg J. , Morelli J.G. , Byers T.E. , Mokrohisky S.T. , Crane L.A. .
Source: Journal of the American Academy of Dermatology, 2010 Sep; 63(3), p. 430-9.
EPub date: 2010-06-26.
PMID: 20584558
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Tanning and increased nevus development in very-light-skinned children without red hair.
Authors: Aalborg J. , Morelli J.G. , Mokrohisky S.T. , Asdigian N.L. , Byers T.E. , Dellavalle R.P. , Box N.F. , Crane L.A. .
Source: Archives of dermatology, 2009 Sep; 145(9), p. 989-96.
PMID: 19770437
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The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado.
Authors: Juhl A.L. , Byers T.E. , Robinson W.A. , Morelli J.G. , Crane L.A. .
Source: Melanoma research, 2009 Aug; 19(4), p. 252-9.
PMID: 19543126
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The benefits and risks of ultraviolet tanning and its alternatives: the role of prudent sun exposure.
Authors: Sivamani R.K. , Crane L.A. , Dellavalle R.P. .
Source: Dermatologic clinics, 2009 Apr; 27(2), p. 149-54, vi.
PMID: 19254658
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Melanocytic nevus development in Colorado children born in 1998: a longitudinal study.
Authors: Crane L.A. , Mokrohisky S.T. , Dellavalle R.P. , Asdigian N.L. , Aalborg J. , Byers T.E. , Zeng C. , Barón A.E. , Burch J.M. , Morelli J.G. .
Source: Archives of dermatology, 2009 Feb; 145(2), p. 148-56.
PMID: 19221259
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Vacations to waterside locations result in nevus development in Colorado children.
Authors: Pettijohn K.J. , Asdigian N.L. , Aalborg J. , Morelli J.G. , Mokrohisky S.T. , Dellavalle R.P. , Crane L.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009 Feb; 18(2), p. 454-63.
EPub date: 2009-02-03.
PMID: 19190148
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Melanocytic nevi and sun exposure in a cohort of colorado children: anatomic distribution and site-specific sunburn.
Authors: Dodd A.T. , Morelli J. , Mokrohisky S.T. , Asdigian N. , Byers T.E. , Crane L.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007 Oct; 16(10), p. 2136-43.
PMID: 17932362
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A randomized intervention study of sun protection promotion in well-child care.
Authors: Crane L.A. , Deas A. , Mokrohisky S.T. , Ehrsam G. , Jones R.H. , Dellavalle R. , Byers T.E. , Morelli J. .
Source: Preventive medicine, 2006 Mar; 42(3), p. 162-70.
EPub date: 2005-12-27.
PMID: 16376977
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Children with red hair have more freckles but fewer melanocytic nevi: results from a cohort study of 280 three-year-olds.
Authors: Dellavalle R.P. , Johnson K.R. , Hester E.J. , Deas A.M. , Mokrohisky S. , Morelli J.G. , Crane L.A. .
Source: Archives of dermatology, 2005 Aug; 141(8), p. 1042-3.
PMID: 16103341
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Is high mole count a marker of more than melanoma risk? Eczema diagnosis is associated with melanocytic nevi in children.
Authors: Dellavalle R.P. , Hester E.J. , Stegner D.L. , Deas A.M. , Pacheco T.R. , Mokrohisky S. , Morelli J.G. , Crane L.A. .
Source: Archives of dermatology, 2004 May; 140(5), p. 577-80.
PMID: 15148102
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