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Grant Details

Grant Number: 5R01CA154647-04 Interpret this number
Primary Investigator: Lee, I-Min
Organization: Brigham And Women'S Hospital
Project Title: Objectively Measured Physical Activity and Mortality in Women
Fiscal Year: 2014


Abstract

DESCRIPTION (provided by applicant): This proposal seeks funding to measure physical activity objectively using the Actigraph GT3X accelerometer, a device that can accurately measure movement accelerations in three planes, among 21,249 women in the Women's Health Study and to follow them over 4 years for mortality. Already available are data from annual questionnaires over 15 years on risk factors (including self-reported physical activity every 2-3 years) and medical history in women, as well as plasma biomarker and whole genome scan data from blood samples collected at baseline. Morbidity follow-up is well over 90% and mortality follow-up is virtually 100%. In 2008, the federal government released its first-ever Physical Activity Guidelines for Americans, recommending the types and amounts of physical activity believed to offer substantial health benefits. The basis for these guidelines comes almost exclusively from observational epidemiologic studies of clinical endpoints, with physical activity assessed by self-report. Supporting such studies are data from randomized controlled trials of supervised exercise and cardiovascular risk factors, providing plausible biologic underpinnings for the lower risks of chronic diseases with physical activity. However, national surveys using self-reported physical activity show 47-50% of American adults meet physical activity recommendations, but national surveys measuring physical activity objectively using accelerometers indicate that <5% do so. Additionally, recent data suggest that sedentary behavior (e.g., time sitting) may be an independent risk factor, separate from physical activity, for chronic diseases. Sedentary behavior is imprecisely measured using self- reports, but can be accurately determined using accelerometers. Thus, the present proposal seeks to clarify the relations between physical activity, as well as sedentary behavior, and mortality by objectively measuring physical activity and sedentary behavior. Women will be asked to wear the Actigraph accelerometer for 1 week. Women will be recruited on a rolling basis over 2 years. Data from the accelerometers will classify women according to the time spent in light, moderate, and vigorous intensity physical activity (or combinations thereof), and sedentary behavior. At the end of the study, we will use the National Death Index to ascertain decedents. We will have sufficient statistical power to determine associations between physical activity, or sedentary behavior, and all-cause mortality. We also will be able to compare self-reported and accelerometer-measured physical activity, providing useful data on measurement error correction for other epidemiologic studies which may not have the resources to objectively measure physical activity. Finally, this study will be of tremendous advantage for future grant applications to cost- efficiently address the associations of objectively measured physical activity with other clinical endpoints which will accumulate in sufficient numbers over time, such as incident cardiovascular disease, cancer, and type 2 diabetes, all major causes of morbidity and mortality, as well as to examine physical activity-gene interactions. 1



Publications

Revisiting the association of sedentary behavior and physical activity with all-cause mortality using a compositional approach: the Women's Health Study.
Authors: Migueles J.H. , Lee I.M. , Sanchez C.C. , Ortega F.B. , Buring J.E. , Shiroma E.J. .
Source: The international journal of behavioral nutrition and physical activity, 2021-08-10; 18(1), p. 104.
EPub date: 2021-08-10.
PMID: 34376213
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Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis.
Authors: Ekelund U. , Tarp J. , Steene-Johannessen J. , Hansen B.H. , Jefferis B. , Fagerland M.W. , Whincup P. , Diaz K.M. , Hooker S.P. , Chernofsky A. , et al. .
Source: BMJ (Clinical research ed.), 2019-08-21; 366, p. l4570.
EPub date: 2019-08-21.
PMID: 31434697
Related Citations

Response by Lee et al to Letter Regarding Article, "Accelerometer-Measured Physical Activity and Sedentary Behavior in Relation to All-Cause Mortality: The Women's Health Study".
Authors: Lee I.M. , Shiroma E.J. , Buring J.E. .
Source: Circulation, 2018-07-03; 138(1), p. 116-117.
PMID: 29967238
Related Citations

Using Devices to Assess Physical Activity and Sedentary Behavior in a Large Cohort Study, the Women's Health Study.
Authors: Lee I.M. , Shiroma E.J. , Evenson K.R. , Kamada M. , LaCroix A.Z. , Buring J.E. .
Source: Journal for the measurement of physical behaviour, 2018 Jun; 1(2), p. 60-69.
PMID: 30666321
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Day length is associated with physical activity and sedentary behavior among older women.
Authors: Schepps M.A. , Shiroma E.J. , Kamada M. , Harris T.B. , Lee I.M. .
Source: Scientific reports, 2018-04-26; 8(1), p. 6602.
EPub date: 2018-04-26.
PMID: 29700376
Related Citations

Accelerometer-Measured Physical Activity and Sedentary Behavior in Relation to All-Cause Mortality: The Women's Health Study.
Authors: Lee I.M. , Shiroma E.J. , Evenson K.R. , Kamada M. , LaCroix A.Z. , Buring J.E. .
Source: Circulation, 2018-01-09; 137(2), p. 203-205.
EPub date: 2017-11-06.
PMID: 29109088
Related Citations

Reproducibility of Accelerometer-Assessed Physical Activity and Sedentary Time.
Authors: Keadle S.K. , Shiroma E.J. , Kamada M. , Matthews C.E. , Harris T.B. , Lee I.M. .
Source: American journal of preventive medicine, 2017 Apr; 52(4), p. 541-548.
EPub date: 2017-01-03.
PMID: 28062274
Related Citations

Bidirectional associations of accelerometer-determined sedentary behavior and physical activity with reported time in bed: Women's Health Study.
Authors: Pettee Gabriel K. , Sternfeld B. , Shiroma E.J. , PĂ©rez A. , Cheung J. , Lee I.M. .
Source: Sleep health, 2017 02; 3(1), p. 49-55.
EPub date: 2016-11-04.
PMID: 28346151
Related Citations

Strength Training and the Risk of Type 2 Diabetes and Cardiovascular Disease.
Authors: Shiroma E.J. , Cook N.R. , Manson J.E. , Moorthy M.V. , Buring J.E. , Rimm E.B. , Lee I.M. .
Source: Medicine and science in sports and exercise, 2017 01; 49(1), p. 40-46.
PMID: 27580152
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Objectively measured physical activity and sedentary behaviour and ankle brachial index: Cross-sectional and longitudinal associations in older men.
Authors: Parsons T.J. , Sartini C. , Ellins E.A. , Halcox J.P. , Smith K.E. , Ash S. , Lennon L.T. , Wannamethee S.G. , Lee I.M. , Whincup P.H. , et al. .
Source: Atherosclerosis, 2016 Apr; 247, p. 28-34.
EPub date: 2016-01-25.
PMID: 26854973
Related Citations

The Relationship Between Time of Day of Physical Activity and Obesity in Older Women.
Authors: Chomistek A.K. , Shiroma E.J. , Lee I.M. .
Source: Journal of physical activity & health, 2016 04; 13(4), p. 416-8.
EPub date: 2015-10-07.
PMID: 26445277
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Does duration of physical activity bouts matter for adiposity and metabolic syndrome? A cross-sectional study of older British men.
Authors: Jefferis B.J. , Parsons T.J. , Sartini C. , Ash S. , Lennon L.T. , Wannamethee S.G. , Lee I.M. , Whincup P.H. .
Source: The international journal of behavioral nutrition and physical activity, 2016-03-15; 13, p. 36.
EPub date: 2016-03-15.
PMID: 26980183
Related Citations

Comparison of physical activity assessed using hip- and wrist-worn accelerometers.
Authors: Kamada M. , Shiroma E.J. , Harris T.B. , Lee I.M. .
Source: Gait & posture, 2016 Feb; 44, p. 23-8.
EPub date: 2015-11-12.
PMID: 27004628
Related Citations

Visual Inspection for Determining Days When Accelerometer Is Worn: Is This Valid?
Authors: Shiroma E.J. , Kamada M. , Smith C. , Harris T.B. , Lee I.M. .
Source: Medicine and science in sports and exercise, 2015 Dec; 47(12), p. 2558-62.
PMID: 26110697
Related Citations

Duration and breaks in sedentary behaviour: accelerometer data from 1566 community-dwelling older men (British Regional Heart Study).
Authors: Jefferis B.J. , Sartini C. , Shiroma E. , Whincup P.H. , Wannamethee S.G. , Lee I.M. .
Source: British journal of sports medicine, 2015 Dec; 49(24), p. 1591-4.
EPub date: 2014-09-17.
PMID: 25232029
Related Citations

Novel strategies for sedentary behavior research.
Authors: Rosenberg D.E. , Lee I.M. , Young D.R. , Prohaska T.R. , Owen N. , Buchner D.M. .
Source: Medicine and science in sports and exercise, 2015 Jun; 47(6), p. 1311-5.
PMID: 25222817
Related Citations

Definition, measurement, and health risks associated with sedentary behavior.
Authors: Gibbs B.B. , Hergenroeder A.L. , Katzmarzyk P.T. , Lee I.M. , Jakicic J.M. .
Source: Medicine and science in sports and exercise, 2015 Jun; 47(6), p. 1295-300.
PMID: 25222816
Related Citations

Trajectories of objectively measured physical activity in free-living older men.
Authors: Jefferis B.J. , Sartini C. , Ash S. , Lennon L.T. , Wannamethee S.G. , Lee I.M. , Whincup P.H. .
Source: Medicine and science in sports and exercise, 2015 Feb; 47(2), p. 343-9.
PMID: 24988411
Related Citations

Comparison of Self-Reported and Accelerometer-Assessed Physical Activity in Older Women.
Authors: Shiroma E.J. , Cook N.R. , Manson J.E. , Buring J.E. , Rimm E.B. , Lee I.M. .
Source: PloS one, 2015; 10(12), p. e0145950.
EPub date: 2015-12-29.
PMID: 26713857
Related Citations

Impact of accelerometer data processing decisions on the sample size, wear time and physical activity level of a large cohort study.
Authors: Keadle S.K. , Shiroma E.J. , Freedson P.S. , Lee I.M. .
Source: BMC public health, 2014-11-24; 14, p. 1210.
EPub date: 2014-11-24.
PMID: 25421941
Related Citations

Do moderate-intensity and vigorous-intensity physical activities reduce mortality rates to the same extent?
Authors: Shiroma E.J. , Sesso H.D. , Moorthy M.V. , Buring J.E. , Lee I.M. .
Source: Journal of the American Heart Association, 2014-10-17; 3(5), p. e000802.
EPub date: 2014-10-17.
PMID: 25326527
Related Citations

Adiposity and insufficient MVPA predict cardiometabolic abnormalities in adults.
Authors: Peterson M.D. , Al Snih S. , Stoddard J. , McClain J. , Lee I.M. .
Source: Medicine and science in sports and exercise, 2014 Jun; 46(6), p. 1133-9.
PMID: 24389519
Related Citations

Adherence to physical activity guidelines in older adults, using objectively measured physical activity in a population-based study.
Authors: Jefferis B.J. , Sartini C. , Lee I.M. , Choi M. , Amuzu A. , Gutierrez C. , Casas J.P. , Ash S. , Lennnon L.T. , Wannamethee S.G. , et al. .
Source: BMC public health, 2014-04-19; 14, p. 382.
EPub date: 2014-04-19.
PMID: 24745369
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Using accelerometers to measure physical activity in large-scale epidemiological studies: issues and challenges.
Authors: Lee I.M. , Shiroma E.J. .
Source: British journal of sports medicine, 2014 Feb; 48(3), p. 197-201.
EPub date: 2013-12-02.
PMID: 24297837
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Patterns of accelerometer-assessed sedentary behavior in older women.
Authors: Shiroma E.J. , Freedson P.S. , Trost S.G. , Lee I.M. .
Source: JAMA, 2013-12-18; 310(23), p. 2562-3.
PMID: 24346993
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Years of life gained due to leisure-time physical activity in the U.S.
Authors: Janssen I. , Carson V. , Lee I.M. , Katzmarzyk P.T. , Blair S.N. .
Source: American journal of preventive medicine, 2013 Jan; 44(1), p. 23-9.
PMID: 23253646
Related Citations

Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy.
Authors: Lee I.M. , Shiroma E.J. , Lobelo F. , Puska P. , Blair S.N. , Katzmarzyk P.T. , Lancet Physical Activity Series Working Group .
Source: Lancet (London, England), 2012-07-21; 380(9838), p. 219-29.
PMID: 22818936
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