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Grant Details

Grant Number: 5R01CA133081-05 Interpret this number
Primary Investigator: Stanton, Annette
Organization: University Of California Los Angeles
Project Title: Emotion Regulation and Depression in Breast Cancer Survivorship
Fiscal Year: 2014


Abstract

DESCRIPTION (provided by applicant): Both in individuals living with cancer and in the general population, the experience of clinical depression exacts a profound psychological, physical, and economic toll. Little research has examined the unfolding risk for depressive symptoms and episodes after a breast cancer diagnosis with careful assessments repeated over time. Moreover, theory and research in depression and in emotion science have not been integrated and tested in sophisticated biopsychosocial models to advance understanding of risk and protective factors/processes for depression in cancer patients. Accordingly, this study has three specific aims. Aim 1 is to investigate how personal vulnerabilities, cancer-related (e.g., treatments/side effects) and noncancer-related stressors, and emotion regulation processes shape trajectories of depression in women following diagnosis of breast cancer. Personal vulnerabilities include general depressive diatheses (history of depression, neuroticism, harsh early environment) and emotion dysregulation diatheses (low emotional awareness and acceptance, high emotional suppression, no intimate confiding relationship). Aim 2 is to examine a diathesis- stress model, in which interactions of personal vulnerabilities, genetic factors (a functional polymorphism of the serotonin transporter gene), and stressors shape depressive response. Aim 3 is to examine a proximal model of how emotion regulation processes (approach and avoidance) mediate the effects of personal vulnerabilities on depressive symptoms and episodes. We will accomplish these aims in longitudinal research beginning within three months of diagnosis (Time 1) of 450 women (study completers) with new diagnoses of initial or recurrent invasive breast cancer and subsequent assessments every six weeks through six months (Time 2-5) and at 9 months (Time 6) and 12 months (Time 7). DNA extraction, validated questionnaires and interviews, and measures of expressive behavior will be administered. Primary dependent variables are depressive symptoms and depressive disorder. Effects of age, ethnicity, and mental health treatment receipt will be explored. Findings will influence public health by informing the next generation of targeted preventive and therapeutic interventions for depression in cancer patients, thereby reducing the disorder's health and economic burden.



Publications

Transitions in coping profiles after breast cancer diagnosis: implications for depressive and physical symptoms.
Authors: Kim J.H.J. , Bright E.E. , Williamson T.J. , Krull J.L. , Weihs K.L. , Stanton A.L. .
Source: Journal of behavioral medicine, 2021 Feb; 44(1), p. 1-17.
EPub date: 2020-06-13.
PMID: 32535673
Related Citations

Longitudinal dyadic interdependence in psychological distress among Latinas with breast cancer and their caregivers.
Authors: Segrin C. , Badger T.A. , Sikorskii A. , Pasvogel A. , Weihs K. , Lopez A.M. , Chalasani P. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020 Jun; 28(6), p. 2735-2743.
EPub date: 2019-11-09.
PMID: 31707502
Related Citations

A preventive intervention to modify depression risk targets after breast cancer diagnosis: Design and single-arm pilot study.
Authors: Weihs K.L. , McConnell M.H. , Wiley J.F. , Crespi C.M. , Sauer-Zavala S. , Stanton A.L. .
Source: Psycho-oncology, 2019 04; 28(4), p. 880-887.
EPub date: 2019-03-15.
PMID: 30803095
Related Citations

Chronic Stress in Vocational and Intimate Partner Domains as Predictors of Depressive Symptoms After Breast Cancer Diagnosis.
Authors: Stinesen Kollberg K. , Wiley J.F. , Ross K.M. , Jorge-Miller A. , Hammen C. , Weihs K.L. , Stanton A.L. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2019-03-20; 53(4), p. 333-344.
PMID: 29931262
Related Citations

Cancer-related coping processes as predictors of depressive symptoms, trajectories, and episodes.
Authors: Stanton A.L. , Wiley J.F. , Krull J.L. , Crespi C.M. , Weihs K.L. .
Source: Journal of consulting and clinical psychology, 2018 Oct; 86(10), p. 820-830.
PMID: 30265041
Related Citations

Predicting future major depression and persistent depressive symptoms: Development of a prognostic screener and PHQ-4 cutoffs in breast cancer patients.
Authors: Weihs K.L. , Wiley J.F. , Crespi C.M. , Krull J.L. , Stanton A.L. .
Source: Psycho-oncology, 2018 02; 27(2), p. 420-426.
EPub date: 2017-07-26.
PMID: 28600855
Related Citations

Chronic and episodic stress predict physical symptom bother following breast cancer diagnosis.
Authors: Harris L.N. , Bauer M.R. , Wiley J.F. , Hammen C. , Krull J.L. , Crespi C.M. , Weihs K.L. , Stanton A.L. .
Source: Journal of behavioral medicine, 2017 Dec; 40(6), p. 875-885.
EPub date: 2017-05-20.
PMID: 28528393
Related Citations

Stuck in the spin cycle: Avoidance and intrusions following breast cancer diagnosis.
Authors: Bauer M.R. , Wiley J.F. , Weihs K.L. , Stanton A.L. .
Source: British journal of health psychology, 2017 09; 22(3), p. 609-626.
EPub date: 2017-06-19.
PMID: 28628740
Related Citations

Implicit loneliness, emotion regulation, and depressive symptoms in breast cancer survivors.
Authors: Marroquín B. , Czamanski-Cohen J. , Weihs K.L. , Stanton A.L. .
Source: Journal of behavioral medicine, 2016 Oct; 39(5), p. 832-44.
EPub date: 2016-06-10.
PMID: 27287618
Related Citations

Emotional acceptance, inflammation, and sickness symptoms across the first two years following breast cancer diagnosis.
Authors: Reed R.G. , Weihs K.L. , Sbarra D.A. , Breen E.C. , Irwin M.R. , Butler E.A. .
Source: Brain, behavior, and immunity, 2016 Aug; 56, p. 165-74.
EPub date: 2016-02-23.
PMID: 26916219
Related Citations

Dispositional and Situational Avoidance and Approach as Predictors of Physical Symptom Bother Following Breast Cancer Diagnosis.
Authors: Bauer M.R. , Harris L.N. , Wiley J.F. , Crespi C.M. , Krull J.L. , Weihs K.L. , Stanton A.L. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2016 06; 50(3), p. 370-84.
PMID: 26769023
Related Citations

Depressive episodes, symptoms, and trajectories in women recently diagnosed with breast cancer.
Authors: Stanton A.L. , Wiley J.F. , Krull J.L. , Crespi C.M. , Hammen C. , Allen J.J. , Barrón M.L. , Jorge A. , Weihs K.L. .
Source: Breast cancer research and treatment, 2015 Nov; 154(1), p. 105-15.
EPub date: 2015-09-29.
PMID: 26420401
Related Citations

Addressing Missing Data Mechanism Uncertainty using Multiple-Model Multiple Imputation: Application to a Longitudinal Clinical Trial.
Authors: Siddique J. , Harel O. , Crespi C.M. .
Source: The annals of applied statistics, 2012-12-01; 6(4), p. 1814-1837.
PMID: 23503984
Related Citations

Meta-analysis of efficacy of interventions for elevated depressive symptoms in adults diagnosed with cancer.
Authors: Hart S.L. , Hoyt M.A. , Diefenbach M. , Anderson D.R. , Kilbourn K.M. , Craft L.L. , Steel J.L. , Cuijpers P. , Mohr D.C. , Berendsen M. , et al. .
Source: Journal of the National Cancer Institute, 2012-07-03; 104(13), p. 990-1004.
EPub date: 2012-07-05.
PMID: 22767203
Related Citations

A primary care focus on the treatment of patients with major depressive disorder.
Authors: Weihs K. , Wert J.M. .
Source: The American journal of the medical sciences, 2011 Oct; 342(4), p. 324-30.
PMID: 21642822
Related Citations




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