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Grant Details

Grant Number: 1R01CA172415-01A1 Interpret this number
Primary Investigator: Chen, Ying
Organization: Fred Hutchinson Cancer Research Center
Project Title: Methods for Time-Varying Disease Attribution in Chronic Disease Prevention
Fiscal Year: 2013


DESCRIPTION (provided by applicant): The objective of this methods proposal is to develop and apply new statistical methods to improve scientific inferences on the disease attribution associated with risk factors, such as obesity and tobacco smoking, for data collected from longitudinal cohort studies in chronic disease prevention research, specifically aiming to: (1) develop general statistical methods for time-varying attributable risk functions (ARF) to assess and compare prevention strategies; (2) develop statistical methods for a set of pairwise ARF's to assess and identify practically optimal prevention strategies; (3) develop statistical methods to evaluate the disease attribution in residual time; (4) develop statistical software and apply the developed methods to a large collection of cohort data from the Asia Cohort Consortium.


On estimation of time-dependent attributable fraction from population-based case-control studies.
Authors: Zhao W. , Chen Y.Q. , Hsu L. .
Source: Biometrics, 2017 Sep; 73(3), p. 866-875.
EPub date: 2017-01-18.
PMID: 28099992
Related Citations

Estimating a Treatment Effect in Residual Time Quantiles under the Additive Hazards Model.
Authors: Crouch L.A. , Zheng C. , Chen Y.Q. .
Source: Statistics in biosciences, 2017 Jun; 9(1), p. 298-315.
EPub date: 2016-10-28.
PMID: 28694879
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On estimation of covariate-specific residual time quantiles under the proportional hazards model.
Authors: Crouch L.A. , May S. , Chen Y.Q. .
Source: Lifetime data analysis, 2016 Apr; 22(2), p. 299-319.
EPub date: 2015-06-10.
PMID: 26058825
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Adherence to Early Antiretroviral Therapy: Results From HPTN 052, a Phase III, Multinational Randomized Trial of ART to Prevent HIV-1 Sexual Transmission in Serodiscordant Couples.
Authors: Safren S.A. , Mayer K.H. , Ou S.S. , McCauley M. , Grinsztejn B. , Hosseinipour M.C. , Kumarasamy N. , Gamble T. , Hoffman I. , Celentano D. , et al. .
Source: Journal of acquired immune deficiency syndromes (1999), 2015-06-01; 69(2), p. 234-40.
PMID: 26009832
Related Citations

Hypothesis testing for an extended cox model with time-varying coefficients.
Authors: Saegusa T. , Di C. , Chen Y.Q. .
Source: Biometrics, 2014 Sep; 70(3), p. 619-28.
EPub date: 2014-05-29.
PMID: 24888739
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Performance of goodness-of-fit tests for the Cox proportional hazards model with time-varying covariates.
Authors: Grant S. , Chen Y.Q. , May S. .
Source: Lifetime data analysis, 2014 Jul; 20(3), p. 355-68.
EPub date: 2013-08-09.
PMID: 23925703
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